Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.

abstract：:It is generally accepted that the oscillatory beating characteristic of sperm flagella is the result of an ATP-induced sliding between the doublet microtubules of the flagellar axoneme, with these longitudinal forces being converted into a lateral bending moment by resistive components of the structure that limit the ...

journal_title：Nature

authors： Gibbons IR,Shingyoji C,Murakami A,Takahashi K

更新日期：1987-01-22 00:00:00

abstract：:Assembly of multi-component supramolecular machines is fundamental to biology, yet in most cases, assembly pathways and their control are poorly understood. An example is the type III secretion machine, which mediates the transfer of bacterial virulence proteins into host cells. A central component of this nanomachine...

journal_title：Nature

authors： Marlovits TC,Kubori T,Lara-Tejero M,Thomas D,Unger VM,Galán JE

更新日期：2006-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%1. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielde...

journal_title：Nature

authors： Yao W,Rose JL,Wang W,Seth S,Jiang H,Taguchi A,Liu J,Yan L,Kapoor A,Hou P,Chen Z,Wang Q,Nezi L,Xu Z,Yao J,Hu B,Pettazzoni PF,Ho IL,Feng N,Ramamoorthy V,Jiang S,Deng P,Ma GJ,Den P,Tan Z,Zhang SX,Wang H,

更新日期：2019-04-01 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00

abstract：:Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of li...

journal_title：Nature

authors： Guyader M,Emerman M,Sonigo P,Clavel F,Montagnier L,Alizon M

更新日期：1987-04-16 00:00:00

abstract：:The lysis of murine sarcoma virus-murine leukaemia virus (MSV-MuLV)-induced tumour cells by cytotoxic T lymphocytes (CTL) appears to require that an antigen specified by MSV-MuLV, or induced by the infection, be presented in association with class I major histocompatibility complex antigens. The viral proteins of the ...

journal_title：Nature

authors： Flyer DC,Burakoff SJ,Faller DV

更新日期：1983-10-27 00:00:00

abstract：:Lake Victoria, together with its satellite lakes, harbours roughly 200 endemic forms of cichlid fishes that are classified as 'haplochromines' and yet the lake system is less than a million years old. This 'flock' has attracted attention because of the possibility that it evolved within the lake from one ancestral spe...

journal_title：Nature

authors： Meyer A,Kocher TD,Basasibwaki P,Wilson AC

更新日期：1990-10-11 00:00:00

abstract：:Below water depths of about 300 metres, pressure and temperature conditions cause methane to form ice-like crystals of methane hydrate. Marine deposits of methane hydrate are estimated to be large, amassing about 10,000 gigatonnes of carbon, and are thought to be important to global change and seafloor stability, as w...

journal_title：Nature

authors： Wood WT,Gettrust JF,Chapman NR,Spence GD,Hyndman RD

更新日期：2002-12-12 00:00:00

abstract：:Binocular coordination of eye movements is essential for stereopsis (depth perception) and to prevent double vision. More than a century ago, Hering and Helmholtz debated the neural basis of binocular coordination. Helmholtz believed that each eye is controlled independently and that binocular coordination is learned....

journal_title：Nature

authors： Zhou W,King WM

更新日期：1998-06-18 00:00:00

abstract：:Growth of basal cell carcinomas (BCCs) requires high levels of hedgehog (HH) signalling through the transcription factor GLI. Although inhibitors of membrane protein smoothened (SMO) effectively suppress HH signalling, early tumour resistance illustrates the need for additional downstream targets for therapy. Here we ...

journal_title：Nature

authors： Atwood SX,Li M,Lee A,Tang JY,Oro AE

更新日期：2013-02-28 00:00:00

abstract：:Long-term reconstitution of the lymphohaematopoietic cells of a mouse after lethal irradiation requires the transplantation of at least (5-10) x 10(3) bone marrow cells. Several cell-separation techniques based on cell-surface characteristics have been used in attempts to identify the pluripotent haematopoietic stem c...

journal_title：Nature

authors： Jones RJ,Wagner JE,Celano P,Zicha MS,Sharkis SJ

更新日期：1990-09-13 00:00:00

abstract：:Solitons are large-amplitude, spatially confined wave packets in nonlinear media. They occur in a wide range of physical systems, such as water surfaces, optical fibres, plasmas, Bose-Einstein condensates and magnetically ordered media. A distinguishing feature of soliton behaviour that is common to all systems, is th...

journal_title：Nature

authors： Demokritov SO,Serga AA,Demidov VE,Hillebrands B,Kostylev MP,Kalinikos BA

更新日期：2003-11-13 00:00:00

abstract：:Nuclear exclusion of the PTEN (phosphatase and tensin homologue deleted in chromosome 10) tumour suppressor has been associated with cancer progression. However, the mechanisms leading to this aberrant PTEN localization in human cancers are currently unknown. We have previously reported that ubiquitinylation of PTEN a...

journal_title：Nature

authors： Song MS,Salmena L,Carracedo A,Egia A,Lo-Coco F,Teruya-Feldstein J,Pandolfi PP

更新日期：2008-10-09 00:00:00

abstract：:The most striking feature of the Sun's magnetic field is its cyclic behaviour. The number of sunspots, which are dark regions of strong magnetic field on the Sun's surface, varies with a period of about 11 years. Superposed on this cycle are secular changes that occur on timescales of centuries and events like the Mau...

journal_title：Nature

authors： Solanki SK,Schüssler M,Fligge M

更新日期：2000-11-23 00:00:00

abstract：:It is commonly assumed that certain features are so elementary to the visual system that they require no attentional resources to be perceived. Such 'preattentive' features are traditionally identified by visual search performance, in which the reaction time for detecting a feature difference against a set of distract...

journal_title：Nature

authors： Joseph JS,Chun MM,Nakayama K

更新日期：1997-06-19 00:00:00

abstract：:Coherent light sources can be used to manipulate the outcome of light-matter interactions by exploiting interference phenomena in the time and frequency domain. A powerful tool in this emerging field of 'quantum control' is the adaptive shaping of femtosecond laser pulses, resulting, for instance, in selective molecul...

journal_title：Nature

authors： Brixner T,Damrauer NH,Niklaus P,Gerber G

更新日期：2001-11-01 00:00:00

abstract：:Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of death due to disease in young people, but the biological determinants of treatment failure remain poorly understood. Recent genome-wide profiling of structural DNA alterations in ALL have identified multiple submicroscopic somatic mutations targeting k...

journal_title：Nature

authors： Mullighan CG,Zhang J,Kasper LH,Lerach S,Payne-Turner D,Phillips LA,Heatley SL,Holmfeldt L,Collins-Underwood JR,Ma J,Buetow KH,Pui CH,Baker SD,Brindle PK,Downing JR

更新日期：2011-03-10 00:00:00

abstract：:The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...

journal_title：Nature

authors： Reymond CD,Gomer RH,Nellen W,Theibert A,Devreotes P,Firtel RA

更新日期：1986-09-25 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-12-01 00:00:00

abstract：:In this Letter, the top structure of the right panel of Fig. 1a should be that of cis-9-octadecenoic acid, not trans-9-octadecenoic acid. Please see the accompanying Author Correction. This error has not been corrected online. ...

journal_title：Nature

authors： Yang Z,Wei J,Sobolev YI,Grzybowski BA

更新日期：2019-03-01 00:00:00

abstract：:The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...

journal_title：Nature

authors： Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

更新日期：2020-01-01 00:00:00

abstract：:Insect eyes have an anti-reflective coating, owing to nanostructures on the corneal surface creating a gradient of refractive index between that of air and that of the lens material1,2. These nanocoatings have also been shown to provide anti-adhesive functionality3. The morphology of corneal nanocoatings are very dive...

journal_title：Nature

authors： Kryuchkov M,Bilousov O,Lehmann J,Fiebig M,Katanaev VL

更新日期：2020-09-01 00:00:00

abstract：:During development, neuronal survival is regulated by the limited availability of neurotrophins, which are proteins of the nerve growth factor (NGF) family. Activation of specific trk tyrosine kinase receptors by the neurotrophins blocks programmed cell death. The trkA-specific ligand NGF has also been shown to activa...

journal_title：Nature

authors： Frade JM,Rodríguez-Tébar A,Barde YA

更新日期：1996-09-12 00:00:00

abstract：:Braunwald, a professor at Harvard Medical School, responds to a paper by Walter W. Stewart and Ned Feder ("The integrity of the scientific literature," Nature 1987 Jan 15; 325(6101): 207-214) concerning their findings of errors, discrepancies, and other lapses in publications coauthored by John Darsee, a biomedical re...

journal_title：Nature

authors： Braunwald E

更新日期：1987-01-15 00:00:00

abstract：:A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic u...

journal_title：Nature

authors： Capon DJ,Chamow SM,Mordenti J,Marsters SA,Gregory T,Mitsuya H,Byrn RA,Lucas C,Wurm FM,Groopman JE

更新日期：1989-02-09 00:00:00

abstract：:Carbon chemistry exhibits a rich variety in bonding patterns, with homo- or heteronuclear multiple bonds involving sp-hybridized carbon atoms as found in molecules such as acetylenes, nitriles, allenes and carbon dioxide. Carbon's heavier homologues in group 14 of the periodic table--including silicon, germanium and t...

journal_title：Nature

authors： Ishida S,Iwamoto T,Kabuto C,Kira M

更新日期：2003-02-13 00:00:00

abstract：:Protons participate in most biologically important reactions, as substrates, products, cofactors and modulators, and proton transport is an essential step in energy transduction. The dynamics of protonation reactions have been studied extensively in solution and in model systems involving lipid-water interfaces, but h...

journal_title：Nature

authors： Prod'hom B,Pietrobon D,Hess P

更新日期：1987-09-17 00:00:00

abstract：:Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influe...

journal_title：Nature

authors： Wen L,Ley RE,Volchkov PY,Stranges PB,Avanesyan L,Stonebraker AC,Hu C,Wong FS,Szot GL,Bluestone JA,Gordon JI,Chervonsky AV

更新日期：2008-10-23 00:00:00

abstract：:To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...

journal_title：Nature

authors： Gilbert MJ,Thornton CR,Wakley GE,Talbot NJ

更新日期：2006-03-23 00:00:00

abstract：:The three-dimensional organization of the genome supports regulated gene expression, recombination, DNA repair, and chromosome segregation during mitosis. Chromosome conformation capture (Hi-C)1,2 analysis has revealed a complex genomic landscape of internal chromosomal structures in vertebrate cells3-7, but the ident...

journal_title：Nature

authors： Mitter M,Gasser C,Takacs Z,Langer CCH,Tang W,Jessberger G,Beales CT,Neuner E,Ameres SL,Peters JM,Goloborodko A,Micura R,Gerlich DW

更新日期：2020-10-01 00:00:00