Repeated tricyclics induce a progressive dopamine autoreceptor subsensitivity independent of daily drug treatment.

Abstract:

:Dopamine (DA) has largely been ignored in considering possible mechanisms underlying the therapeutic effects of tricyclic anti-depressants (TCA). Most previous work done has focused on the ability of some TCAs to block the in vitro re-uptake of DA--an effect which unfortunately requires very high doses. Recently, however, Serra et al. proposed that TCAs may exert their therapeutic effects by inducing a subsensitivity of presynaptic receptors located on the dendrites and soma of DA neurones (DA autoreceptors). This hypothesis was directly tested by examining the influence of TCAs on the demonstrated ability of the DA agonist, apomorphine, to depress selectively the spontaneous activity of single DA cells. We now report that repeated administration of both typical and atypical TCAs induces a progressive subsensitivity of DA autoreceptors, and that this gradual augmentation of DA autoreceptor subsensitivity depends on the passage of time rather than daily TCA administration. The latter finding suggests that daily drug administration may not be therapeutically necessary.

journal_name

Nature

journal_title

Nature

authors

Chiodo LA,Antelman SM

doi

10.1038/287451a0

subject

Has Abstract

pub_date

1980-10-02 00:00:00

pages

451-4

issue

5781

eissn

0028-0836

issn

1476-4687

journal_volume

287

pub_type

杂志文章

相关文献

NATURE文献大全
  • Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin.

    abstract::The primary action of a family of mitogens including bombesin, bradykinin, vasopressin and alpha-thrombin is to activate the hydrolysis of polyphosphoinositides. Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phospholipase C is mediated through coupling of surface receptors to a GTP-binding pro...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/326800a0

    authors: Chambard JC,Paris S,L'Allemain G,Pouysségur J

    更新日期:1987-04-23 00:00:00

  • Recent global-warming hiatus tied to equatorial Pacific surface cooling.

    abstract::Despite the continued increase in atmospheric greenhouse gas concentrations, the annual-mean global temperature has not risen in the twenty-first century, challenging the prevailing view that anthropogenic forcing causes climate warming. Various mechanisms have been proposed for this hiatus in global warming, but thei...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature12534

    authors: Kosaka Y,Xie SP

    更新日期:2013-09-19 00:00:00

  • Diet-microbiota interactions as moderators of human metabolism.

    abstract::It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light thr...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature18846

    authors: Sonnenburg JL,Bäckhed F

    更新日期:2016-07-07 00:00:00

  • Journal blacklists: show your working.

    abstract:: ...

    journal_title:Nature

    pub_type: 社论

    doi:10.1038/d41586-018-07033-5

    authors:

    更新日期:2018-10-01 00:00:00

  • Energy dependence and reversibility of membrane alterations induced by polyene macrolide antibiotics in Chlorella vulgaris.

    abstract::The requirement of metabolic energy for the interaction of polyene macrolide antibiotics with eukaryotic organisms remains a controversial subject (for review see ref. 1) It has been claimed that the lethal binding of these antibiotics to the sterol target component of the hydrophobic core of the membrane, in accordan...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/281080a0

    authors: Malewicz B,Borowski E

    更新日期:1979-09-06 00:00:00

  • Embryology of Early Jurassic dinosaur from China with evidence of preserved organic remains.

    abstract::Fossil dinosaur embryos are surprisingly rare, being almost entirely restricted to Upper Cretaceous strata that record the late stages of non-avian dinosaur evolution. Notable exceptions are the oldest known embryos from the Early Jurassic South African sauropodomorph Massospondylus and Late Jurassic embryos of a ther...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11978

    authors: Reisz RR,Huang TD,Roberts EM,Peng S,Sullivan C,Stein K,LeBlanc AR,Shieh D,Chang R,Chiang C,Yang C,Zhong S

    更新日期:2013-04-11 00:00:00

  • Systematic variation of the stellar initial mass function in early-type galaxies.

    abstract::Much of our knowledge of galaxies comes from analysing the radiation emitted by their stars, which depends on the present number of each type of star in the galaxy. The present number depends on the stellar initial mass function (IMF), which describes the distribution of stellar masses when the population formed, and ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10972

    authors: Cappellari M,McDermid RM,Alatalo K,Blitz L,Bois M,Bournaud F,Bureau M,Crocker AF,Davies RL,Davis TA,de Zeeuw PT,Duc PA,Emsellem E,Khochfar S,Krajnović D,Kuntschner H,Lablanche PY,Morganti R,Naab T,Oosterloo T,Sarz

    更新日期:2012-04-25 00:00:00

  • Superconductivity at 250 K in lanthanum hydride under high pressures.

    abstract::With the discovery1 of superconductivity at 203 kelvin in H3S, attention returned to conventional superconductors with properties that can be described by the Bardeen-Cooper-Schrieffer and the Migdal-Eliashberg theories. Although these theories predict the possibility of room-temperature superconductivity in metals th...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1201-8

    authors: Drozdov AP,Kong PP,Minkov VS,Besedin SP,Kuzovnikov MA,Mozaffari S,Balicas L,Balakirev FF,Graf DE,Prakapenka VB,Greenberg E,Knyazev DA,Tkacz M,Eremets MI

    更新日期:2019-05-01 00:00:00

  • The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.

    abstract::Somatic sexual differentiation in Drosophila melanogaster involves a cascade of regulated splicing events and provides an attractive model system for the analysis of alternative splicing mechanisms. The protein Sex-lethal (Sxl) activates a female-specific 3' splice site in the first intron of transformer (tra) pre-mRN...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/362171a0

    authors: Valcárcel J,Singh R,Zamore PD,Green MR

    更新日期:1993-03-11 00:00:00

  • Mox2 is a component of the genetic hierarchy controlling limb muscle development.

    abstract::The skeletal muscles of the limbs develop from myogenic progenitors that originate in the paraxial mesoderm and migrate into the limb-bud mesenchyme. Among the genes known to be important for muscle development in mammalian embryos are those encoding the basic helix-loop-helix (bHLH) myogenic regulatory factors (MRFs;...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/21892

    authors: Mankoo BS,Collins NS,Ashby P,Grigorieva E,Pevny LH,Candia A,Wright CV,Rigby PW,Pachnis V

    更新日期:1999-07-01 00:00:00

  • Differences in the kinetics of rod and cone synaptic transmission.

    abstract::Photoreceptors of the vertebrate retina hyperpolarize in response to light. The hyperpolarization elicited by a brief flash is approximately ten times slower in rods than in cones of the same retina. We have examined the amplification and temporal properties of synaptic transfer of rod and cone signals to a common pos...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/296862a0

    authors: Schnapf JL,Copenhagen DR

    更新日期:1982-04-29 00:00:00

  • Anthropogenic influences on major tropical cyclone events.

    abstract::There is no consensus on whether climate change has yet affected the statistics of tropical cyclones, owing to their large natural variability and the limited period of consistent observations. In addition, projections of future tropical cyclone activity are uncertain, because they often rely on coarse-resolution clim...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0673-2

    authors: Patricola CM,Wehner MF

    更新日期:2018-11-01 00:00:00

  • ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion.

    abstract::Regulated fusion of secretory granules with the plasma membrane in secretory cells requires ATP, Ca2+ and cytosolic as well as membrane proteins. ATP-dependent steps in Ca(2+)-activated secretion from PC12 cells require three cytosolic PEP proteins (priming in exocytosis proteins, PEP1-3), the identity of which will p...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/374173a0

    authors: Hay JC,Fisette PL,Jenkins GH,Fukami K,Takenawa T,Anderson RA,Martin TF

    更新日期:1995-03-09 00:00:00

  • Microscopy of the interacting Harper-Hofstadter model in the two-body limit.

    abstract::The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature22811

    authors: Tai ME,Lukin A,Rispoli M,Schittko R,Menke T,Dan Borgnia,Preiss PM,Grusdt F,Kaufman AM,Greiner M

    更新日期:2017-06-21 00:00:00

  • Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells.

    abstract::The presence of homoeo box sequences in the genomes of vertebrates has suggested that these metazoans possess the equivalent of the homoeotic genes that have a key role in regulating the development of the fruitfly Drosophila melanogaster. We report here that a novel murine homoeo box-containing gene is expressed in e...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/314713a0

    authors: Colberg-Poley AM,Voss SD,Chowdhury K,Gruss P

    更新日期:1985-04-25 00:00:00

  • Male-female differences in fertility and blood pressure in ACE-deficient mice.

    abstract::Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme. Experiments with hypertens...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/375146a0

    authors: Krege JH,John SW,Langenbach LL,Hodgin JB,Hagaman JR,Bachman ES,Jennette JC,O'Brien DA,Smithies O

    更新日期:1995-05-11 00:00:00

  • Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus.

    abstract::The glyceraldehyde 3-phosphate dehydogenase holoenzyme of Bacillus stearothermophilus possesses precise 222 symmetry: in this respect it differs from the reported structure of the lobster muscle enzyme. Pairs of active sites are linked through a flexible polypeptide loop which probably mediates the structural changes ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/266328a0

    authors: Biesecker G,Harris JI,Thierry JC,Walker JE,Wonacott AJ

    更新日期:1977-03-24 00:00:00

  • Electrophoretic movement and localisation of acetylcholine receptors in the embryonic muscle cell membrane.

    abstract::A steady electric field of 30 mV across a single embryonic muscle cell produces accumulation of acetylcholine receptors toward one pole of the cell within 1 h. The movement is electrophoretic in nature and the accumulation results in the formation of stable, metabolically independent receptor aggregates. ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/275031a0

    authors: Orida N,Poo MM

    更新日期:1978-09-07 00:00:00

  • Renewing Felsenstein's phylogenetic bootstrap in the era of big data.

    abstract::Felsenstein's application of the bootstrap method to evolutionary trees is one of the most cited scientific papers of all time. The bootstrap method, which is based on resampling and replications, is used extensively to assess the robustness of phylogenetic inferences. However, increasing numbers of sequences are now ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0043-0

    authors: Lemoine F,Domelevo Entfellner JB,Wilkinson E,Correia D,Dávila Felipe M,De Oliveira T,Gascuel O

    更新日期:2018-04-01 00:00:00

  • Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.

    abstract::Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01672

    authors: Snaith HA,Sawin KE

    更新日期:2003-06-05 00:00:00

  • Chemical and behavioural characterization of the rabbit mammary pheromone.

    abstract::Mammals owe part of their evolutionary success to the harmonious exchanges of information, energy and immunity between females and their offspring. This functional reciprocity is vital for the survival and normal development of infants, and for the inclusive fitness of parents. It is best seen in the intense exchanges...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01739

    authors: Schaal B,Coureaud G,Langlois D,Giniès C,Sémon E,Perrier G

    更新日期:2003-07-03 00:00:00

  • Terminal pattern elements in Drosophila embryo induced by the torso-like protein.

    abstract::The genes torso (tor) and torso-like (tsl) are two of the Drosophila maternal group genes implicated in a receptor tyrosine kinase signalling pathway that specifies terminal cell fate (reviewed in ref. 3). Loss-of-function mutations in these loci cause an identical phenotype in which pattern elements from the anterior...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/367741a0

    authors: Martin JR,Raibaud A,Ollo R

    更新日期:1994-02-24 00:00:00

  • Heterointerface effects in the electrointercalation of van der Waals heterostructures.

    abstract::Molecular-scale manipulation of electronic and ionic charge accumulation in materials is the backbone of electrochemical energy storage1-4. Layered van der Waals (vdW) crystals are a diverse family of materials into which mobile ions can electrochemically intercalate into the interlamellar gaps of the host atomic latt...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-018-0205-0

    authors: Bediako DK,Rezaee M,Yoo H,Larson DT,Zhao SYF,Taniguchi T,Watanabe K,Brower-Thomas TL,Kaxiras E,Kim P

    更新日期:2018-06-01 00:00:00

  • Palaeo-altimetry of the late Eocene to Miocene Lunpola basin, central Tibet.

    abstract::The elevation history of the Tibetan plateau provides direct insight into the tectonic processes associated with continent-continent collisions. Here we present oxygen-isotope-based estimates of the palaeo-altimetry of late Eocene and younger deposits of the Lunpola basin in the centre of the plateau, which indicate t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04506

    authors: Rowley DB,Currie BS

    更新日期:2006-02-09 00:00:00

  • How AI and satellites could help predict volcanic eruptions.

    abstract:: ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/d41586-019-00752-3

    authors: Witze A

    更新日期:2019-03-01 00:00:00

  • Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.

    abstract::The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively hig...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/333742a0

    authors: Kisielow P,Blüthmann H,Staerz UD,Steinmetz M,von Boehmer H

    更新日期:1988-06-23 00:00:00

  • Contact inhibition of locomotion in vivo controls neural crest directional migration.

    abstract::Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago and describes the behaviour of fibroblast cells confronting each other in vitro, where they retract their protrusions and change direction on contact. Its failure was suggested to contribute to malignant invasion. However, the molecu...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07441

    authors: Carmona-Fontaine C,Matthews HK,Kuriyama S,Moreno M,Dunn GA,Parsons M,Stern CD,Mayor R

    更新日期:2008-12-18 00:00:00

  • Nanosecond X-ray diffraction of shock-compressed superionic water ice.

    abstract::Since Bridgman's discovery of five solid water (H2O) ice phases1 in 1912, studies on the extraordinary polymorphism of H2O have documented more than seventeen crystalline and several amorphous ice structures2,3, as well as rich metastability and kinetic effects4,5. This unique behaviour is due in part to the geometric...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1114-6

    authors: Millot M,Coppari F,Rygg JR,Correa Barrios A,Hamel S,Swift DC,Eggert JH

    更新日期:2019-05-01 00:00:00

  • Aggregation and vesiculation of membrane proteins by curvature-mediated interactions.

    abstract::Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05840

    authors: Reynwar BJ,Illya G,Harmandaris VA,Müller MM,Kremer K,Deserno M

    更新日期:2007-05-24 00:00:00

  • Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor.

    abstract::Recent studies have shown that developing nerve fibres grow directly to their targets and are guided by specific cues, but the nature of these cues and the mechanism of guidance remain unknown. The growth of sympathetic axons towards an artificial source of nerve growth factor (NGF) in vivo and of sensory neurites up ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/306786a0

    authors: Lumsden AG,Davies AM

    更新日期:1983-12-22 00:00:00