Towards complete cofactor arrangement in the 3.0 A resolution structure of photosystem II.

abstract：:Gap junction channels are structurally distinct from other ion channels in that they comprise two hemichannels which interact head-to-head to form an aqueous channel between cells. Intercellular voltage differences together with increased intracellular concentrations of H+ and Ca2+ cause closure of these normally pate...

journal_title：Nature

authors： Suchyna TM,Xu LX,Gao F,Fourtner CR,Nicholson BJ

更新日期：1993-10-28 00:00:00

abstract：:Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases where they have successfully invaded target populations. Population transformation using the intracellular bacterium Wolbach...

journal_title：Nature

authors： Hoffmann AA,Montgomery BL,Popovici J,Iturbe-Ormaetxe I,Johnson PH,Muzzi F,Greenfield M,Durkan M,Leong YS,Dong Y,Cook H,Axford J,Callahan AG,Kenny N,Omodei C,McGraw EA,Ryan PA,Ritchie SA,Turelli M,O'Neill SL

更新日期：2011-08-24 00:00:00

abstract：:Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life1. Although there have been comprehensive stu...

journal_title：Nature

authors： Rosental B,Kowarsky M,Seita J,Corey DM,Ishizuka KJ,Palmeri KJ,Chen SY,Sinha R,Okamoto J,Mantalas G,Manni L,Raveh T,Clarke DN,Tsai JM,Newman AM,Neff NF,Nolan GP,Quake SR,Weissman IL,Voskoboynik A

更新日期：2018-12-01 00:00:00

abstract：:Transition-metal complexes are widely used in the physical and biological sciences. They have essential roles in catalysis, synthesis, materials science, photophysics and bioinorganic chemistry. Our understanding of transition-metal complexes originates from Alfred Werner's realization that their three-dimensional sha...

journal_title：Nature

authors： Garçon M,Bakewell C,Sackman GA,White AJP,Cooper RI,Edwards AJ,Crimmin MR

更新日期：2019-10-01 00:00:00

abstract：:The molecular mechanisms controlling the process of myelination by Schwann cells remain elusive, despite recent progress in the identification and characterization of genes encoding myelin components (reviewed in ref. 1). We have created a null allele in the mouse Krox-20 gene, which encodes a zinc-finger transcriptio...

journal_title：Nature

authors： Topilko P,Schneider-Maunoury S,Levi G,Baron-Van Evercooren A,Chennoufi AB,Seitanidou T,Babinet C,Charnay P

更新日期：1994-10-27 00:00:00

abstract：:Temperature-dependent transition of conductance in ionic channels has been described in several membrane systems. We report here an abrupt change in the maximal rate of rise of the action potentials of the rat extensor digitorum longus (EDL) at 32 degrees C, indicating alteration in the functional characteristics of t...

journal_title：Nature

authors： Cheung DW,Daniel EE

更新日期：1980-01-31 00:00:00

abstract：:The question of whether DNA is able to transport electrons has attracted much interest, particularly as this ability may play a role as a repair mechanism after radiation damage to the DNA helix. Experiments addressing DNA conductivity have involved a large number of DNA strands doped with intercalated donor and accep...

journal_title：Nature

authors： Fink HW,Schönenberger C

更新日期：1999-04-01 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable levels of antibodies with neutralizing activity that can protect against infection in animal models1,2. Antibody ...

journal_title：Nature

authors： Gaebler C,Wang Z,Lorenzi JCC,Muecksch F,Finkin S,Tokuyama M,Cho A,Jankovic M,Schaefer-Babajew D,Oliveira TY,Cipolla M,Viant C,Barnes CO,Bram Y,Breton G,Hägglöf T,Mendoza P,Hurley A,Turroja M,Gordon K,Millard KG,

更新日期：2021-01-18 00:00:00

abstract：:Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...

journal_title：Nature

authors： Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD

更新日期：2018-01-11 00:00:00

abstract：:Electromagnetically induced transparency is a quantum interference effect that permits the propagation of light through an otherwise opaque atomic medium; a 'coupling' laser is used to create the interference necessary to allow the transmission of resonant pulses from a 'probe' laser. This technique has been used to s...

journal_title：Nature

authors： Liu C,Dutton Z,Behroozi CH,Hau LV

更新日期：2001-01-25 00:00:00

abstract：:The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain or...

journal_title：Nature

authors： Jones EY,Davis SJ,Williams AF,Harlos K,Stuart DI

更新日期：1992-11-19 00:00:00

abstract：:Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates...

journal_title：Nature

authors： Glotzer M,Murray AW,Kirschner MW

更新日期：1991-01-10 00:00:00

abstract：:Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...

journal_title：Nature

authors： Siller S,Department of Zoology, University of Oxford, UK. steven.siller@zoo.ox.ac.uk.

更新日期：2001-06-07 00:00:00

abstract：:The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...

journal_title：Nature

authors： Widmer MB,Grabstein KH

更新日期：1987-04-23 00:00:00

abstract：:Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...

journal_title：Nature

authors： Lawrence MS,Stojanov P,Mermel CH,Robinson JT,Garraway LA,Golub TR,Meyerson M,Gabriel SB,Lander ES,Getz G

更新日期：2014-01-23 00:00:00

abstract：:The seemingly endless studies of the ethical connotations of genetics serve a valuable role in general understanding even if the ethical problems involved are often insubstantial. ...

journal_title：Nature

authors：

更新日期：1992-04-02 00:00:00

abstract：:The RNA polymerase II large subunit contains an essential carboxy-terminal domain (CTD) believed to be involved in the response to regulators during transcription initiation. The CTD is phosphorylated on a portion of RNA polymerase II molecules in vivo and it can be phosphorylated by the general transcription factor T...

journal_title：Nature

authors： Serizawa H,Mäkelä TP,Conaway JW,Conaway RC,Weinberg RA,Young RA

更新日期：1995-03-16 00:00:00

abstract：:Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have constructed a first-generation CNV map of the human genome through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia (the HapMap collection). DNA from these ind...

journal_title：Nature

authors： Redon R,Ishikawa S,Fitch KR,Feuk L,Perry GH,Andrews TD,Fiegler H,Shapero MH,Carson AR,Chen W,Cho EK,Dallaire S,Freeman JL,González JR,Gratacòs M,Huang J,Kalaitzopoulos D,Komura D,MacDonald JR,Marshall CR,Mei R,M

更新日期：2006-11-23 00:00:00

abstract：:Red colobus are one of a small number of primate species in which females have been reported to transfer between breeding groups more commonly than males. Several authors have hypothesised that in such species transference may serve to reduce the risk to females of producing offspring of lower fitness through inbreedi...

journal_title：Nature

authors： Marsh CW

更新日期：1979-10-18 00:00:00

abstract：:Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,...

journal_title：Nature

authors： Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs

更新日期：2016-09-22 00:00:00

abstract：:The determination of molecular masses from barometric sedimentation profiles, a main topic in ultracentrifugal analysis, is thought to be quantitatively correct for non-interacting particles. Whereas this expectation is justified for uncharged colloids or macromolecules at low volume fractions, early ultracentrifugati...

journal_title：Nature

authors： Raşa M,Philipse AP

更新日期：2004-06-24 00:00:00

abstract：:Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specif...

journal_title：Nature

authors： Wagner RW

更新日期：1994-11-24 00:00:00

abstract：:Two approaches to the antibody-directed targeting of toxic or cytolytic activity and augmentation of cellular immune responses have been explored for tumour immunotherapy, but so far success has been limited. Obstacles facing immunotherapy are the limited accessibility of antibodies or antibody conjugates to solid tum...

journal_title：Nature

authors： Chen SY,Yang AG,Chen JD,Kute T,King CR,Collier J,Cong Y,Yao C,Huang XF

更新日期：1997-01-02 00:00:00

abstract：:The medial entorhinal cortex (MEC) is part of the brain's circuit for dynamic representation of self-location. The metric of this representation is provided by grid cells, cells with spatial firing fields that tile environments in a periodic hexagonal pattern. Limited anatomical sampling has obscured whether the grid ...

journal_title：Nature

authors： Stensola H,Stensola T,Solstad T,Frøland K,Moser MB,Moser EI

更新日期：2012-12-06 00:00:00

abstract：:Observations show that the seismic normal modes of the Earth at frequencies near 10 mHz are excited at a nearly constant level in the absence of large earthquakes. This background level of excitation has been called the 'hum' of the Earth, and is equivalent to the maximum excitation from a magnitude 5.75 earthquake. I...

journal_title：Nature

authors： Webb SC

更新日期：2007-02-15 00:00:00

abstract：:Activation of a visual pigment molecule to initiate phototransduction requires a minimum energy, Ea, that need not be wholly derived from a photon, but may be supplemented by heat. Theory predicts that absorbance at very long wavelengths declines with the fraction of molecules that have a sufficient complement of ther...

journal_title：Nature

authors： Koskelainen A,Ala-Laurila P,Fyhrquist N,Donner K

更新日期：2000-01-13 00:00:00

abstract：:The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix fr...

journal_title：Nature

authors： Boriack-Sjodin PA,Margarit SM,Bar-Sagi D,Kuriyan J

更新日期：1998-07-23 00:00:00

abstract：:The beta, gamma-crystallins form a class of homologous proteins in the eye lens. Each gamma-crystallin comprises four topologically equivalent, Greek key motifs; pairs of motifs are organized around a local dyad to give domains and two similar domains are in turn related by a further local dyad. Sequence comparisons a...

journal_title：Nature

authors： Bax B,Lapatto R,Nalini V,Driessen H,Lindley PF,Mahadevan D,Blundell TL,Slingsby C

更新日期：1990-10-25 00:00:00

abstract：:Quantum superposition lies at the heart of quantum mechanics and gives rise to many of its paradoxes. Superposition of de Broglie matter waves' has been observed for massive particles such as electrons, atoms and dimers, small van der Waals clusters, and neutrons. But matter wave interferometry with larger objects has...

journal_title：Nature

authors： Arndt M,Nairz O,Vos-Andreae J,Keller C,van der Zouw G,Zeilinger A

更新日期：1999-10-14 00:00:00