Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated states.


:Keratinocytes of three different epithelia grown in cell culture express a large number of differentiation markers with either no differences or relatively small differences, depending on the species. Much of the distinctive phenotype of these epithelia in vivo must be due to external modulation and relatively little, at least in the case of the human, to permanent intrinsic divergence during development.






Sun TT,Green H




Has Abstract


1977-10-06 00:00:00














  • Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism.

    abstract::Morphogens act in developing tissues to control the spatial arrangement of cellular differentiation. The activity of a morphogen has generally been viewed as a concentration-dependent response to a diffusible signal, but the duration of morphogen signalling can also affect cellular responses. One such example is the m...


    pub_type: 杂志文章


    authors: Dessaud E,Yang LL,Hill K,Cox B,Ulloa F,Ribeiro A,Mynett A,Novitch BG,Briscoe J

    更新日期:2007-11-29 00:00:00

  • Temporal integration by a slowly inactivating K+ current in hippocampal neurons.

    abstract::A central aspect of neuronal function is how each nerve cell translated synaptic input into a sequence of action potentials that carry information along the axon, coded as spike frequency. When transduction from a graded depolarizing input to spikes is studied by injecting a depolarizing current, there is often a rema...


    pub_type: 杂志文章


    authors: Storm JF

    更新日期:1988-11-24 00:00:00

  • Ab initio alpha-alpha scattering.

    abstract::Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning...


    pub_type: 杂志文章


    authors: Elhatisari S,Lee D,Rupak G,Epelbaum E,Krebs H,Lähde TA,Luu T,Meißner UG

    更新日期:2015-12-03 00:00:00

  • Robustness in bacterial chemotaxis.

    abstract::Networks of interacting proteins orchestrate the responses of living cells to a variety of external stimuli, but how sensitive is the functioning of these protein networks to variations in their biochemical parameters? One possibility is that to achieve appropriate function, the reaction rate constants and enzyme conc...


    pub_type: 杂志文章


    authors: Alon U,Surette MG,Barkai N,Leibler S

    更新日期:1999-01-14 00:00:00

  • Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.

    abstract::Many cellular functions involve multi-domain proteins, which are composed of structurally independent modules connected by flexible linkers. Although it is often well understood how a given domain recognizes a cognate oligonucleotide or peptide motif, the dynamic interaction of multiple domains in the recognition of t...


    pub_type: 杂志文章


    authors: Mackereth CD,Madl T,Bonnal S,Simon B,Zanier K,Gasch A,Rybin V,Valcárcel J,Sattler M

    更新日期:2011-07-13 00:00:00

  • A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans.

    abstract::How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (ASER), display a left/right asymmetrical expression pattern of putative ...


    pub_type: 杂志文章


    authors: Johnston RJ,Hobert O

    更新日期:2003-12-18 00:00:00

  • Frequency of word-use predicts rates of lexical evolution throughout Indo-European history.

    abstract::Greek speakers say "omicronupsilonrho", Germans "schwanz" and the French "queue" to describe what English speakers call a 'tail', but all of these languages use a related form of 'two' to describe the number after one. Among more than 100 Indo-European languages and dialects, the words for some meanings (such as 'tail...


    pub_type: 杂志文章


    authors: Pagel M,Atkinson QD,Meade A

    更新日期:2007-10-11 00:00:00

  • Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.

    abstract::Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration1,2. This adaptability is lost in cultured adult endothelial cells, which do not vascularize tissues in an organotypic manner. Here, we show that transient reactivation of the embryonic-restricted ETS variant transcri...


    pub_type: 杂志文章


    authors: Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ

    更新日期:2020-09-01 00:00:00

  • The perception of heading during eye movements.

    abstract::When a person walks through a rigid environment while holding eyes and head fixed, the pattern of retinal motion flows radially away from a point, the focus of expansion (Fig. 1a). Under such conditions of translation, heading corresponds to the focus of expansion and people identify it readily. But when making an eye...


    pub_type: 杂志文章


    authors: Royden CS,Banks MS,Crowell JA

    更新日期:1992-12-10 00:00:00

  • Lentil lectin effectively induces allotransplantation tolerance in mice.

    abstract::The interaction of lectins with carbohydrate receptors on the plasma membrane of eukaryotic cells results in a wide variety of biological effects. One effect which has been extensively studied is the stimulation of lymphocytes to blastogenesis and proliferation. High doses of concanavalin A (Con A) and phytohaemagglut...


    pub_type: 杂志文章


    authors: Hilgert I,Horejsí V,Angelisová P,Kristofová H

    更新日期:1980-03-20 00:00:00

  • Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements.

    abstract::The split promoter sequences of a tRNALeuCUG gene of Xenopus laevis have been mapped to nucleotides 13-20 and 51-64 of the tRNALeu coding sequences. The sequences closely coincide with two conserved sequence blocks present in all eukaryotic tRNA genes. The two conserved sequence blocks were found to be exchangeable be...


    pub_type: 杂志文章


    authors: Galli G,Hofstetter H,Birnstiel ML

    更新日期:1981-12-17 00:00:00

  • Loss of genes on the short arm of chromosome 11 in bladder cancer.

    abstract::Recent studies have shown that normal cellular sequences on chromosome 13 are lost during the development of retinoblastomas and that sequences on chromosome 11 are similarly lost during the development of Wilms' kidney tumours and embryonal tumours. Cells from these tumors have been found to contain either the patern...


    pub_type: 杂志文章


    authors: Fearon ER,Feinberg AP,Hamilton SH,Vogelstein B

    更新日期:1985-11-28 00:00:00

  • m6A RNA methylation regulates the fate of endogenous retroviruses.

    abstract::Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3. Here, using an...


    pub_type: 杂志文章


    authors: Chelmicki T,Roger E,Teissandier A,Dura M,Bonneville L,Rucli S,Dossin F,Fouassier C,Lameiras S,Bourc'his D

    更新日期:2021-01-13 00:00:00

  • Imaging the granular structure of high-Tc superconductivity in underdoped Bi2Sr2CaCu2O8+delta.

    abstract::Granular superconductivity occurs when microscopic superconducting grains are separated by non-superconducting regions; Josephson tunnelling between the grains establishes the macroscopic superconducting state. Although crystals of the copper oxide high-transition-temperature (high-Tc) superconductors are not granular...


    pub_type: 杂志文章


    authors: Lang KM,Madhavan V,Hoffman JE,Hudson EW,Eisaki H,Uchida S,Davis JC

    更新日期:2002-01-24 00:00:00

  • Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

    abstract::The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor po...


    pub_type: 杂志文章


    authors: Derynck R,Jarrett JA,Chen EY,Eaton DH,Bell JR,Assoian RK,Roberts AB,Sporn MB,Goeddel DV

    更新日期:1985-08-22 00:00:00

  • Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences.

    abstract::The remarkable antiquity, diversity and ecological significance of arthropods have inspired numerous attempts to resolve their deep phylogenetic history, but the results of two decades of intensive molecular phylogenetics have been mixed. The discovery that terrestrial insects (Hexapoda) are more closely related to aq...


    pub_type: 杂志文章


    authors: Regier JC,Shultz JW,Zwick A,Hussey A,Ball B,Wetzer R,Martin JW,Cunningham CW

    更新日期:2010-02-25 00:00:00

  • Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids.

    abstract::L-GLUTAMATE and L-aspartate are thought to have a widespread function as synaptic transmitters in the mammalian central nervous system and there are at least three types of neuronal glutamate receptors, which can be activated by the selective agonists N-methyl-D-aspartate (NMDA), quisqualate and kainate. Recent experi...


    pub_type: 杂志文章


    authors: Usowicz MM,Gallo V,Cull-Candy SG

    更新日期:1989-06-01 00:00:00

  • Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.

    abstract::Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic cleft. NSSs are essential to the function of chemical synapses, are associated with multiple neurological diseases and disorders, and are the targets of therapeutic ...


    pub_type: 杂志文章


    authors: Piscitelli CL,Krishnamurthy H,Gouaux E

    更新日期:2010-12-23 00:00:00

  • Inhibition of giant-planet formation by rapid gas depletion around young stars.

    abstract::Although stars form from clouds of gas and dust, there are insignificant amounts of gas around ordinary (Sun-like) stars. This suggests that hydrogen and helium, the primary constituents of planets such as Jupiter and Saturn, are not easily retained in orbit as a star matures. The gas-giant planets in the Solar System...


    pub_type: 杂志文章


    authors: Zuckerman B,Forveille T,Kastner JH

    更新日期:1995-02-09 00:00:00

  • Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.

    abstract::Cell surface molecules have been implicated in cell interactions which underlie formation of the nervous system. The analysis of the functional properties of such molecules has profited from the combined use of antibodies and cell culture systems. It has been suggested that the interplay between these molecules modula...


    pub_type: 杂志文章


    authors: Kruse J,Mailhammer R,Wernecke H,Faissner A,Sommer I,Goridis C,Schachner M

    更新日期:1984-09-13 00:00:00

  • Science without borders: 4 big questions.

    abstract:: ...


    pub_type: 社论


    authors: Hodson R

    更新日期:2018-10-01 00:00:00

  • Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin.

    abstract::The formation of disulphide bonds is essential to the structure and function of proteins. These bonds rapidly form either cotranslationally or immediately post-translationally in the lumen of the endoplasmic reticulum. Native disulphide pairing for such proteins has been achieved in vitro; however, the rates of reasse...


    pub_type: 杂志文章


    authors: Edman JC,Ellis L,Blacher RW,Roth RA,Rutter WJ

    更新日期:1985-09-19 00:00:00

  • Origin of the dielectric dead layer in nanoscale capacitors.

    abstract::Capacitors are a mainstay of electronic integrated circuits and devices, where they perform essential functions such as storing electrical charge, and blocking direct current while allowing alternating currents to propagate. Because they are often the largest components in circuits, extensive efforts are directed at r...


    pub_type: 杂志文章


    authors: Stengel M,Spaldin NA

    更新日期:2006-10-12 00:00:00

  • S-nitrosylation of NADPH oxidase regulates cell death in plant immunity.

    abstract::Changes in redox status are a conspicuous feature of immune responses in a variety of eukaryotes, but the associated signalling mechanisms are not well understood. In plants, attempted microbial infection triggers the rapid synthesis of nitric oxide and a parallel accumulation of reactive oxygen intermediates, the lat...


    pub_type: 杂志文章


    authors: Yun BW,Feechan A,Yin M,Saidi NB,Le Bihan T,Yu M,Moore JW,Kang JG,Kwon E,Spoel SH,Pallas JA,Loake GJ

    更新日期:2011-10-13 00:00:00

  • Diabetes mellitus and genetically programmed defects in beta-cell function.

    abstract::The pathways that control insulin secretion and regulate pancreatic beta-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a number of single-gene disorders affecting pancreatic beta-cell function, and the consequences of mutations in these genes are so serio...


    pub_type: 杂志文章,评审


    authors: Bell GI,Polonsky KS

    更新日期:2001-12-13 00:00:00

  • Long-range transport in excitonic dark states in coupled quantum wells.

    abstract::During the past ten years, coupled quantum wells have emerged as a promising system for experiments on Bose condensation of excitons, with numerous theoretical and experimental studies aimed at the demonstration of this effect. One of the issues driving these studies is the possibility of long-range coherent transport...


    pub_type: 杂志文章


    authors: Snoke D,Denev S,Liu Y,Pfeiffer L,West K

    更新日期:2002-08-15 00:00:00

  • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.

    abstract::Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating, better understanding of the mechanisms underlying obesity-associated cancer...


    pub_type: 杂志文章


    authors: Yoshimoto S,Loo TM,Atarashi K,Kanda H,Sato S,Oyadomari S,Iwakura Y,Oshima K,Morita H,Hattori M,Honda K,Ishikawa Y,Hara E,Ohtani N

    更新日期:2013-07-04 00:00:00

  • Pro-gamma-melanocyte-stimulating hormone cleavage in adrenal gland undergoing compensatory growth.

    abstract::Regulation of the rapid compensatory growth seen in the remaining adrenal gland of rats following unilateral adrenalectomy is poorly understood. The role of adrenocorticotropic hormone (ACTH) is obscure as immunoneutralization of circulating ACTH does not affect the observed compensatory growth or hyperplasia. This fi...


    pub_type: 杂志文章


    authors: Lowry PJ,Silas L,McLean C,Linton EA,Estivariz FE

    更新日期:1983-11-03 00:00:00

  • The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.

    abstract::Retinoic acid is a vitamin A derivative with striking effects on development and cell differentiation. Several nuclear retinoic acid receptors (RARs), acting as ligand-inducible transcription factors, have been characterized and indirect evidence suggests that they have distinct roles. One of the most intriguing prope...


    pub_type: 杂志文章


    authors: de Thé H,Chomienne C,Lanotte M,Degos L,Dejean A

    更新日期:1990-10-11 00:00:00

  • Gas-phase production and photoelectron spectroscopy of the smallest fullerene, C20

    abstract::Fullerenes are graphitic cage structures incorporating exactly twelve pentagons. The smallest possible fullerene is thus C20, which consists solely of pentagons. But the extreme curvature and reactivity of this structure have led to doubts about its existence and stability. Although theoretical calculations have ident...


    pub_type: 杂志文章


    authors: Prinzbach H,Weiler A,Landenberger P,Wahl F,Worth J,Scott LT,Gelmont M,Olevano D,v. Issendorff B

    更新日期:2000-09-07 00:00:00