Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons.

abstract：:The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...

journal_title：Nature

authors： Hilbert P,Lindpaintner K,Beckmann JS,Serikawa T,Soubrier F,Dubay C,Cartwright P,De Gouyon B,Julier C,Takahasi S

更新日期：1991-10-10 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) c...

journal_title：Nature

authors： Brunet JF,Denizot F,Luciani MF,Roux-Dosseto M,Suzan M,Mattei MG,Golstein P

更新日期：1987-07-16 00:00:00

abstract：:Individuals with congenital or acquired prolongation of the QT interval, or long QT syndrome (LQTS), are at risk of life-threatening ventricular arrhythmia. LQTS is commonly genetic in origin but can also be caused or exacerbated by environmental factors. A missense mutation in the L-type calcium channel Ca(V)1.2 lead...

journal_title：Nature

authors： Yazawa M,Hsueh B,Jia X,Pasca AM,Bernstein JA,Hallmayer J,Dolmetsch RE

更新日期：2011-03-10 00:00:00

abstract：:Numerous reports have emphasized the need for major changes in the global food system: agriculture must meet the twin challenge of feeding a growing population, with rising demand for meat and high-calorie diets, while simultaneously minimizing its global environmental impacts. Organic farming—a system aimed at produc...

journal_title：Nature

authors： Seufert V,Ramankutty N,Foley JA

更新日期：2012-05-10 00:00:00

abstract：:The sequence-specific DNA-binding protein, MyoD, can activate muscle-specific gene expression in some cells in culture. Xenopus MyoD (XMyoD) transcription is activated as a consequence of mesoderm induction in the early myotomes, from which the axial musculature develops. XMyoD RNA accumulates about two hours before m...

journal_title：Nature

authors： Hopwood ND,Gurdon JB

更新日期：1990-09-13 00:00:00

abstract：:In vertebrates the developing hindbrain is organized in segmental units. These units provide the primary grid for differentiation and axonal outgrowth. In the more anterior regions of the brain, however, the subdivisions remain more controversial. Cellular and molecular studies of the embryonic brain in lower vertebra...

journal_title：Nature

authors： Krauss S,Johansen T,Korzh V,Fjose A

更新日期：1991-09-19 00:00:00

abstract：:Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hith...

journal_title：Nature

authors： Barclay T,Rowe JF,Lissauer JJ,Huber D,Fressin F,Howell SB,Bryson ST,Chaplin WJ,Désert JM,Lopez ED,Marcy GW,Mullally F,Ragozzine D,Torres G,Adams ER,Agol E,Barrado D,Basu S,Bedding TR,Buchhave LA,Charbonneau D,Ch

更新日期：2013-02-28 00:00:00

abstract：:The TE1 family of transposable elements (TEs) of Drosophila consists of unusually large transposons, cytologically visible in larval polytene chromosomes as one or more bands. They are composite elements, as their termini consist of foldback (FB) sequences which are themselves transposable. The location of FB elements...

journal_title：Nature

authors： Chia W,McGill S,Karp R,Gubb D,Ashburner M

更新日期：1985-07-04 00:00:00

abstract：:The quest for higher data density in information storage is motivating investigations into approaches for manipulating magnetization by means other than magnetic fields. This is evidenced by the recent boom in magnetoelectronics and 'spintronics', where phenomena such as carrier effects in magnetic semiconductors and ...

journal_title：Nature

authors： Lottermoser T,Lonkai T,Amann U,Hohlwein D,Ihringer J,Fiebig M

更新日期：2004-07-29 00:00:00

abstract：:Early sensory experience instructs the maturation of neural circuitry in the cortex. This has been studied extensively in the primary visual cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye, a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition ...

journal_title：Nature

authors： Kuhlman SJ,Olivas ND,Tring E,Ikrar T,Xu X,Trachtenberg JT

更新日期：2013-09-26 00:00:00

abstract：:The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...

journal_title：Nature

authors： Schlacher K,Cox MM,Woodgate R,Goodman MF

更新日期：2006-08-24 00:00:00

abstract：:The internal organization of eukaryotic cells into functionally specialized, membrane-delimited organelles of unique composition implies a need for active, regulated lipid transport. Phosphatidylserine (PS), for example, is synthesized in the endoplasmic reticulum and then preferentially associates--through mechanisms...

journal_title：Nature

authors： Maeda K,Anand K,Chiapparino A,Kumar A,Poletto M,Kaksonen M,Gavin AC

更新日期：2013-09-12 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:To trigger class II-restricted T cells, antigen presenting cells have to capture antigens, process them and display their fragments in association with class II molecules. In most species, activated T cells express class II molecules; however, no evidence has been found that these cells can present soluble antigens. T...

journal_title：Nature

authors： Lanzavecchia A,Roosnek E,Gregory T,Berman P,Abrignani S

更新日期：1988-08-11 00:00:00

abstract：:Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle disorder citrullinaemia...

journal_title：Nature

authors： Rabinovich S,Adler L,Yizhak K,Sarver A,Silberman A,Agron S,Stettner N,Sun Q,Brandis A,Helbling D,Korman S,Itzkovitz S,Dimmock D,Ulitsky I,Nagamani SC,Ruppin E,Erez A

更新日期：2015-11-19 00:00:00

abstract：:Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced...

journal_title：Nature

authors： Chung WH,Hung SI,Hong HS,Hsih MS,Yang LC,Ho HC,Wu JY,Chen YT

更新日期：2004-04-01 00:00:00

abstract：:Tuberculosis is the leading cause of death in the world resulting from a single bacterial infection. Despite its enormous burden on world health, little is known about the molecular mechanisms of pathogenesis of Mycobacterium tuberculosis. Bacterial multiplication and concomitant tissue damage within an infected host,...

journal_title：Nature

authors： Cox JS,Chen B,McNeil M,Jacobs WR Jr

更新日期：1999-11-04 00:00:00

abstract：:A significant portion of prebiotic organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets. The distribution and stable-isotope composition of individual organic compounds in carbonaceous meteorites, which are thought to be derived from asteroidal parent bodies, may therefore pr...

journal_title：Nature

authors： Engel MH,Macko SA,Silfer JA

更新日期：1990-11-01 00:00:00

abstract：:Piezoelectric materials, which convert mechanical to electrical energy (and vice versa), are crucial in medical imaging, telecommunication and ultrasonic devices. A new generation of single-crystal materials, such as Pb(Zn1/3Nb2/3)O3-PbTiO3 (PZN-PT) and Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT), exhibit a piezoelectric effect ...

journal_title：Nature

authors： Fu H,Cohen RE

更新日期：2000-01-20 00:00:00

abstract：:Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. 'No-take' marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits for adjacent fisheries are maximized when reserve design fosters synergies among nearby reserves...

journal_title：Nature

authors： Koning AA,Perales KM,Fluet-Chouinard E,McIntyre PB

更新日期：2020-12-01 00:00:00

abstract：:From drug delivery to chemical and biological catalysis and cosmetics, the need for efficient fabrication pathways for particles over a wide range of sizes, from a variety of materials, and in many different structures has been well established. Here we harness the inherent scalability of fibre production and an in-fi...

journal_title：Nature

authors： Kaufman JJ,Tao G,Shabahang S,Banaei EH,Deng DS,Liang X,Johnson SG,Fink Y,Abouraddy AF

更新日期：2012-07-26 00:00:00

abstract：:Cocaine is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulati...

journal_title：Nature

authors： Carrera MR,Ashley JA,Parsons LH,Wirsching P,Koob GF,Janda KD

更新日期：1995-12-14 00:00:00

abstract：:Many tissues including blood, skin, gut and germ cells are continuously maintained by tissue stem cells. Under certain conditions, however, other organs can undergo repair using stem-cell-like progenitors generated by cell de-differentiation. Cell fates have been broadened experimentally, but mechanisms allowing de-di...

journal_title：Nature

authors： Kai T,Spradling A

更新日期：2004-04-01 00:00:00

abstract：:Gradual accumulation of evidence is thought to be fundamental for decision-making, and its neural correlates have been found in several brain regions. Here we develop a generalizable method to measure tuning curves that specify the relationship between neural responses and mentally accumulated evidence, and apply it t...

journal_title：Nature

authors： Hanks TD,Kopec CD,Brunton BW,Duan CA,Erlich JC,Brody CD

更新日期：2015-04-09 00:00:00

abstract：:The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New a...

journal_title：Nature

authors： Barker RA,Götz M,Parmar M

更新日期：2018-05-01 00:00:00

abstract：:Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome b...

journal_title：Nature

authors： Chailangkarn T,Trujillo CA,Freitas BC,Hrvoj-Mihic B,Herai RH,Yu DX,Brown TT,Marchetto MC,Bardy C,McHenry L,Stefanacci L,Järvinen A,Searcy YM,DeWitt M,Wong W,Lai P,Ard MC,Hanson KL,Romero S,Jacobs B,Dale AM,Dai L

更新日期：2016-08-18 00:00:00

abstract：:The development of colloidal quantum dots has led to practical applications of quantum confinement, such as in solution-processed solar cells, lasers and as biological labels. Further scientific and technological advances should be achievable if these colloidal quantum systems could be electronically coupled in a gene...

journal_title：Nature

authors： Milliron DJ,Hughes SM,Cui Y,Manna L,Li J,Wang LW,Alivisatos AP

更新日期：2004-07-08 00:00:00

abstract：:Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥50% of tumours expressing the BRAF(V600E) oncoprotein. Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemurafenib demonstrates the ess...

journal_title：Nature

authors： Das Thakur M,Salangsang F,Landman AS,Sellers WR,Pryer NK,Levesque MP,Dummer R,McMahon M,Stuart DD

更新日期：2013-02-14 00:00:00

abstract：:CYCLINS are proteins synthesized during each cell cycle and abruptly destroyed in each mitosis. Cyclins have been implicated in the induction of mitosis and are associated with the serine-threonine protein kinase p34cdc2 as components of mitosis promoting factor (MPF). On the basis of conserved sequence motifs cyclins...

journal_title：Nature

authors： Pines J,Hunter T

更新日期：1990-08-23 00:00:00