Activation of muscle genes without myogenesis by ectopic expression of MyoD in frog embryo cells.

abstract：:High-temperature superconductivity is achieved by doping copper oxide insulators with charge carriers. The density of carriers in conducting materials can be determined from measurements of the Hall voltage--the voltage transverse to the flow of the electrical current that is proportional to an applied magnetic field....

journal_title：Nature

authors： Balakirev FF,Betts JB,Migliori A,Ono S,Ando Y,Boebinger GS

更新日期：2003-08-21 00:00:00

abstract：:Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient mice have shown that this lipid chaperone has a significant role in several aspects of metabolic syndrome, including type 2 diabetes and atheroscle...

journal_title：Nature

authors： Furuhashi M,Tuncman G,Görgün CZ,Makowski L,Atsumi G,Vaillancourt E,Kono K,Babaev VR,Fazio S,Linton MF,Sulsky R,Robl JA,Parker RA,Hotamisligil GS

更新日期：2007-06-21 00:00:00

abstract：:The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report ...

journal_title：Nature

authors： Peeper DS,Upton TM,Ladha MH,Neuman E,Zalvide J,Bernards R,DeCaprio JA,Ewen ME

更新日期：1997-03-13 00:00:00

abstract：:The mouse major transplantation antigens H-2K, H-2D and H-2L are highly polymorphic cell-surface glycoproteins which may serve as recognition elements in cell-cell interactions. Each antigen possesses a number of alloantigenic determinants defined by antisera of various specificities. Recently, monoclonal antibodies h...

journal_title：Nature

authors： Evans GA,Margulies DH,Shykind B,Seidman JG,Ozato K

更新日期：1982-12-23 00:00:00

abstract：:The growth cycle in nutrient-rich, aquatic environments starts with a diatom bloom that ends in mass sinking of ungrazed cells and phytodetritus. The low grazing pressure on these blooms has been attributed to the inability of overwintering copepod populations to track them temporally. We tested an alternative explana...

journal_title：Nature

authors： Ianora A,Miralto A,Poulet SA,Carotenuto Y,Buttino I,Romano G,Casotti R,Pohnert G,Wichard T,Colucci-D'Amato L,Terrazzano G,Smetacek V

更新日期：2004-05-27 00:00:00

abstract：:The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...

journal_title：Nature

authors： Zhang G,Fang X,Guo X,Li L,Luo R,Xu F,Yang P,Zhang L,Wang X,Qi H,Xiong Z,Que H,Xie Y,Holland PW,Paps J,Zhu Y,Wu F,Chen Y,Wang J,Peng C,Meng J,Yang L,Liu J,Wen B,Zhang N,Huang Z,Zhu Q,Feng Y,Mount A

更新日期：2012-10-04 00:00:00

abstract：:The degradation of cytosolic proteins is carried out predominantly by the proteasome, which generates peptides of 7-9 amino acids long. These products need further processing. Recently, a proteolytic system was identified in the model organism Thermoplasma acidophilum that performs this processing. The hexameric core ...

journal_title：Nature

authors： Brandstetter H,Kim JS,Groll M,Huber R

更新日期：2001-11-22 00:00:00

abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...

journal_title：Nature

authors： Png KJ,Halberg N,Yoshida M,Tavazoie SF

更新日期：2011-12-14 00:00:00

abstract：:IN 1969, Murozumi et al.1 demonstrated that the concentration of lead in Greenland snow had increased by a factor of 200 since ancient times, and concluded that most of this increase was a result of the use of alkyl-leaded petrol. Partly because of these findings, the United States and other western countries limited ...

journal_title：Nature

authors： Rosman KJR,Chisholm W,Boutron CF,Candelone JP,Görlach U

更新日期：1993-03-25 00:00:00

abstract：:Over the last twenty years classical views of how compound eyes work optically have undergone a series of overhauls. Exner's central concept of an optically inhomogeneous lens cylinder has survived, and such devices are now made commercially. He was wrong, however, about some crustacean eyes. They produce images by a ...

journal_title：Nature

authors： Land MF

更新日期：1980-10-23 00:00:00

abstract：:Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell culture-adaptive mutations. We hypothesized that cultured cells lack one ...

journal_title：Nature

authors： Saeed M,Andreo U,Chung HY,Espiritu C,Branch AD,Silva JM,Rice CM

更新日期：2015-08-27 00:00:00

abstract：:One of the earliest computational principles attributed to the cerebellum was the measurement of time. This idea was originally suggested on anatomical grounds, and was taken up again to explain some of the deficits in cerebellar patients. The contribution of the cerebellum to eye movements, in contrast, has tradition...

journal_title：Nature

authors： Thier P,Dicke PW,Haas R,Barash S

更新日期：2000-05-04 00:00:00

abstract：:During the biosynthesis of selenoproteins in both prokaryotes and eukaryotes, selenocysteine is cotranslationally incorporated into the nascent polypeptide chain through a process directed by a UGA codon that normally functions as a stop codon. Recently, four genes have been identified whose products are required for ...

journal_title：Nature

authors： Forchhammer K,Leinfelder W,Böck A

更新日期：1989-11-23 00:00:00

abstract：:Distance determination in animals can be achieved by visual or non-visual cues. Weakly electric fish use active electrolocation for orientation in the dark. By perceiving self-produced electric signals with epidermal electroreceptors, fish can detect, locate and analyse nearby objects. Distance discrimination, however...

journal_title：Nature

authors： von der Emde G,Schwarz S,Gomez L,Budelli R,Grant K

更新日期：1998-10-29 00:00:00

abstract：:Rac signalling to actin -- a pathway that is thought to be mediated by the protein Scar/WAVE (WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein -- has a principal role in cell motility. In an analogous pathway, direct interaction of Cdc42 with the related protein N-WASP stimulates actin polym...

journal_title：Nature

authors： Eden S,Rohatgi R,Podtelejnikov AV,Mann M,Kirschner MW

更新日期：2002-08-15 00:00:00

abstract：:The computations performed by local neural populations, such as a cortical layer, are typically inferred from anatomical connectivity and observations of neural activity. Here we describe a method-influence mapping-that uses single-neuron perturbations to directly measure how cortical neurons reshape sensory represent...

journal_title：Nature

authors： Chettih SN,Harvey CD

更新日期：2019-03-01 00:00:00

abstract：:Modification of tyrosine residues of proteins has attracted great interest. Although phosphorylation has received most attention, tyrosine-O-sulphation is also common and has been closely investigated in the hormones gastrin and cholecystokinin (CCK). CCK regulates pancreatic enzyme secretion. It is always sulphated a...

journal_title：Nature

authors： Brand SJ,Andersen BN,Rehfeld JF

更新日期：1984-05-31 00:00:00

abstract：:Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice ...

journal_title：Nature

authors： Neumann CA,Krause DS,Carman CV,Das S,Dubey DP,Abraham JL,Bronson RT,Fujiwara Y,Orkin SH,Van Etten RA

更新日期：2003-07-31 00:00:00

abstract：:Language is a uniquely human ability that evolved at some point in the roughly 6,000,000 years since human and chimpanzee lines diverged. Even in the most linguistically impoverished environments, children naturally develop sophisticated language systems. In contrast, reading is a learnt skill that does not develop wi...

journal_title：Nature

authors： Carreiras M,Seghier ML,Baquero S,Estévez A,Lozano A,Devlin JT,Price CJ

更新日期：2009-10-15 00:00:00

abstract：:Certain cell fate decisions are specified by cell-cell interactions during the development of the nematode Caenorhabditis elegans. For example, in a wild-type hermaphrodite gonad, two cells, Z1.ppp and Z4.aaa, have the potential to become the anchor cell (AC). Intercellular communication establishes their fates and en...

journal_title：Nature

authors： Greenwald I,Seydoux G

更新日期：1990-07-12 00:00:00

abstract：:The fossil record of the living great apes is poor. New fossils from undocumented areas, particularly the equatorial forested habitats of extant hominoids, are therefore crucial for understanding their origins and evolution. Two main competing hypotheses have been proposed for orang-utan origins: dental similarities s...

journal_title：Nature

authors： Chaimanee Y,Suteethorn V,Jintasakul P,Vidthayanon C,Marandat B,Jaeger JJ

更新日期：2004-01-29 00:00:00

abstract：:Climate models with increased levels of carbon dioxide predict that global warming causes heating in the tropics, but investigations of ancient climates based on palaeodata have generally indicated cool tropical temperatures during supposed greenhouse episodes. For example, in the Late Cretaceous and Eocene epochs the...

journal_title：Nature

authors： Pearson PN,Ditchfield PW,Singano J,Harcourt-Brown KG,Nicholas CJ,Olsson RK,Shackleton NJ,Hall MA

更新日期：2001-10-04 00:00:00

abstract：:The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals have therefore evolved in the mammalian brain to enhance attention, perception and memory1,2. Although the importance of regions such as the ventral tegmental area3,4 and locus coeruleus5 in broa...

journal_title：Nature

authors： Chen S,He L,Huang AJY,Boehringer R,Robert V,Wintzer ME,Polygalov D,Weitemier AZ,Tao Y,Gu M,Middleton SJ,Namiki K,Hama H,Therreau L,Chevaleyre V,Hioki H,Miyawaki A,Piskorowski RA,McHugh TJ

更新日期：2020-10-01 00:00:00

abstract：:The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...

journal_title：Nature

authors： Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

更新日期：1995-09-21 00:00:00

abstract：:During cellular translation of messenger RNAs by ribosomes, the translation apparatus sometimes pauses or stalls at the elongation and termination steps. With the exception of programmed stalling, which is usually used by cells for regulatory purposes, ribosomes stalled on mRNAs need to be terminated and recycled to m...

journal_title：Nature

authors： Ma C,Kurita D,Li N,Chen Y,Himeno H,Gao N

更新日期：2017-01-26 00:00:00

abstract：:Blood vessel growth in the skeletal system and osteogenesis seem to be coupled, suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells. Understanding the nature of the mechanisms linking angiogenesis and bone formation should be of great relevance for improved fracture healing or pr...

journal_title：Nature

authors： Ramasamy SK,Kusumbe AP,Wang L,Adams RH

更新日期：2014-03-20 00:00:00

abstract：:Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective osteoclast activity leads to osteopetrosis and bone marrow failure1-9, whereas excess activity can contribute to bone loss and osteoporosis10....

journal_title：Nature

authors： Jacome-Galarza CE,Percin GI,Muller JT,Mass E,Lazarov T,Eitler J,Rauner M,Yadav VK,Crozet L,Bohm M,Loyher PL,Karsenty G,Waskow C,Geissmann F

更新日期：2019-04-01 00:00:00

abstract：:Since the discovery of graphene, the family of two-dimensional materials has grown, displaying a broad range of electronic properties. Recent additions include semiconductors with spin-valley coupling, Ising superconductors that can be tuned into a quantum metal, possible Mott insulators with tunable charge-density wa...

journal_title：Nature

authors： Huang B,Clark G,Navarro-Moratalla E,Klein DR,Cheng R,Seyler KL,Zhong D,Schmidgall E,McGuire MA,Cobden DH,Yao W,Xiao D,Jarillo-Herrero P,Xu X

更新日期：2017-06-07 00:00:00

abstract：:Deposition of amyoid-beta peptide in the central nervous system is a hallmark of Alzheimer's disease and a possible cause of neurodegeneration. The factors that initiate or promote deposition of amyloid-beta peptide are not known. The transforming growth factor TGF-beta1 plays a central role in the response of the bra...

journal_title：Nature

authors： Wyss-Coray T,Masliah E,Mallory M,McConlogue L,Johnson-Wood K,Lin C,Mucke L

更新日期：1997-10-09 00:00:00

abstract：:The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we perform comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys (Macaca fasciculari...

journal_title：Nature

authors： Nakamura T,Okamoto I,Sasaki K,Yabuta Y,Iwatani C,Tsuchiya H,Seita Y,Nakamura S,Yamamoto T,Saitou M

更新日期：2016-09-01 00:00:00