Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans.

abstract：:Originally described by Lugaresi et al. in 1986 (ref. 1), fatal familial insomnia (FFI) is a rare inherited neurological disease characterized by the subacute progression of intractable insomnia and other autonomic abnormalities, cerebellar and pyramidal signs, myoclonus and dementia; neuropathologically, the major fe...

journal_title：Nature

authors： Tateishi J,Brown P,Kitamoto T,Hoque ZM,Roos R,Wollman R,Cervenáková L,Gajdusek DC

更新日期：1995-08-03 00:00:00

abstract：:Hydrophobic signal-sequences direct the transfer of secretory proteins across the inner membrane of prokaryotes and the endoplasmic reticulum membranes of eukaryotes. In mammalian cells, signal-sequences are recognized by the 54K protein (M(r) 54,000) of the signal recognition particle (SRP) which is believed to hold ...

journal_title：Nature

authors： Luirink J,High S,Wood H,Giner A,Tollervey D,Dobberstein B

更新日期：1992-10-22 00:00:00

abstract：:How black holes accrete surrounding matter is a fundamental yet unsolved question in astrophysics. It is generally believed that matter is absorbed into black holes via accretion disks, the state of which depends primarily on the mass-accretion rate. When this rate approaches the critical rate (the Eddington limit), t...

journal_title：Nature

authors： Kimura M,Isogai K,Kato T,Ueda Y,Nakahira S,Shidatsu M,Enoto T,Hori T,Nogami D,Littlefield C,Ishioka R,Chen YT,King SK,Wen CY,Wang SY,Lehner MJ,Schwamb ME,Wang JH,Zhang ZW,Alcock C,Axelrod T,Bianco FB,Byun YI,

更新日期：2016-01-07 00:00:00

abstract：:The degradation of cytosolic proteins is carried out predominantly by the proteasome, which generates peptides of 7-9 amino acids long. These products need further processing. Recently, a proteolytic system was identified in the model organism Thermoplasma acidophilum that performs this processing. The hexameric core ...

journal_title：Nature

authors： Brandstetter H,Kim JS,Groll M,Huber R

更新日期：2001-11-22 00:00:00

abstract：:Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor...

journal_title：Nature

authors： Trainor CD,Evans T,Felsenfeld G,Boguski MS

更新日期：1990-01-04 00:00:00

abstract：:The extensive literature on the origin of the ratites focuses mainly on three questions: are the ratites mono- or polyphyletic, did they evolve from flying ancestors, and are they primitive or advanced? Opinion tends to accept a common descent from flying ancestors for the large ratites (for a summary of ideas see ref...

journal_title：Nature

authors： de Boer LE

更新日期：1980-09-04 00:00:00

abstract：:The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. The characteristics of pheromone signal detection by vomeronasal neurons remain unclear. Here we use a mouse VNO slice preparation...

journal_title：Nature

authors： Leinders-Zufall T,Lane AP,Puche AC,Ma W,Novotny MV,Shipley MT,Zufall F

更新日期：2000-06-15 00:00:00

abstract：:Visual transduction in vertebrate photoreceptors is thought to involve a diffusible internal transmitter which links photon absorption in disk membranes to the conductance decrease in the plasma membrane of the outer segment. The desensitisation of the photoresponse which occurs during and after illumination may also ...

journal_title：Nature

authors： McNaughton PA,Yau KW,Lamb TD

更新日期：1980-01-03 00:00:00

abstract：:Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data and comp...

journal_title：Nature

authors： Ko K,Araúzo-Bravo MJ,Tapia N,Kim J,Lin Q,Bernemann C,Han DW,Gentile L,Reinhardt P,Greber B,Schneider RK,Kliesch S,Zenke M,Schöler HR

更新日期：2010-06-24 00:00:00

abstract：:Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...

journal_title：Nature

authors： Jin R,Cao YC,Hao E,Métraux GS,Schatz GC,Mirkin CA

更新日期：2003-10-02 00:00:00

abstract：:The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental stages from 10.5 days after conception until birth, including transcriptomes, methylomes and chromatin states. Here we systematically examined th...

journal_title：Nature

authors： Gorkin DU,Barozzi I,Zhao Y,Zhang Y,Huang H,Lee AY,Li B,Chiou J,Wildberg A,Ding B,Zhang B,Wang M,Strattan JS,Davidson JM,Qiu Y,Afzal V,Akiyama JA,Plajzer-Frick I,Novak CS,Kato M,Garvin TH,Pham QT,Harrington AN

更新日期：2020-07-01 00:00:00

abstract：:During fertilization, an egg and a sperm fuse to form a new embryo. Eggs develop from oocytes in a process called meiosis. Meiosis in human oocytes is highly error-prone, and defective eggs are the leading cause of pregnancy loss and several genetic disorders such as Down's syndrome. Which genes safeguard accurate pro...

journal_title：Nature

authors： Pfender S,Kuznetsov V,Pasternak M,Tischer T,Santhanam B,Schuh M

更新日期：2015-08-13 00:00:00

abstract：:It is commonly assumed that certain features are so elementary to the visual system that they require no attentional resources to be perceived. Such 'preattentive' features are traditionally identified by visual search performance, in which the reaction time for detecting a feature difference against a set of distract...

journal_title：Nature

authors： Joseph JS,Chun MM,Nakayama K

更新日期：1997-06-19 00:00:00

abstract：:The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation o...

journal_title：Nature

authors： Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S

更新日期：2018-01-18 00:00:00

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00

abstract：:The mitotic recombination behaviour of a duplication of the his4 region on chromosome III in the yeast Saccharomyces cerevisiae was studied. The major recombination event between the duplicated segments is gene conversion unassociated with reciprocal recombination. The rad52-1 mutation preferentially decreases mitotic...

journal_title：Nature

authors： Jackson JA,Fink GR

更新日期：1981-07-23 00:00:00

abstract：:A popular metaphor for the representation of numbers in the brain is the 'mental number line', in which numbers are represented in a continuous, quantity-based analogical format. Here we show that patients with hemispatial neglect misplace the midpoint of a numerical interval when asked to bisect it (for example, stat...

journal_title：Nature

authors： Zorzi M,Priftis K,Umiltà C

更新日期：2002-05-09 00:00:00

abstract：:Phototransduction in invertebrate microvillar photoreceptors is thought to be mediated by the activation of phospholipase C (PLC), but how this leads to gating of the light-sensitive channels is unknown. Most attention has focused on inositol-1,4,5-trisphosphate, a second messenger produced by PLC from phosphatidylino...

journal_title：Nature

authors： Chyb S,Raghu P,Hardie RC

更新日期：1999-01-21 00:00:00

abstract：:Some observations suggest that very massive stars experience extreme mass-loss episodes shortly before they explode as supernovae, as do several models. Establishing a causal connection between these mass-loss episodes and the final explosion would provide a novel way to study pre-supernova massive-star evolution. Her...

journal_title：Nature

authors： Ofek EO,Sullivan M,Cenko SB,Kasliwal MM,Gal-Yam A,Kulkarni SR,Arcavi I,Bildsten L,Bloom JS,Horesh A,Howell DA,Filippenko AV,Laher R,Murray D,Nakar E,Nugent PE,Silverman JM,Shaviv NJ,Surace J,Yaron O

更新日期：2013-02-07 00:00:00

abstract：:Sodium channels and receptors to serotonin and kainate were 'transplanted' from human brain into frog oocytes, by isolating messenger RNA from a fetal brain, and injecting it into Xenopus laevis oocytes. The mRNA was translated by the oocyte and induced the appearance of functional receptors and channels in its membra...

journal_title：Nature

authors： Gundersen CB,Miledi R,Parker I

更新日期：1984-03-29 00:00:00

abstract：:Tumour necrosis factor (TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75). Most TNF-mediated biological responses, such as cell death, gene induction, antiviral activity and cytokine production, have been attributed to TNF-R1 (refs 1-5). Gene targeting ...

journal_title：Nature

authors： Erickson SL,de Sauvage FJ,Kikly K,Carver-Moore K,Pitts-Meek S,Gillett N,Sheehan KC,Schreiber RD,Goeddel DV,Moore MW

更新日期：1994-12-08 00:00:00

abstract：:The recurrent patterns in the commonness and rarity of species in ecological communities--the relative species abundance--have puzzled ecologists for more than half a century. Here we show that the framework of the current neutral theory in ecology can easily be generalized to incorporate symmetric density dependence....

journal_title：Nature

authors： Volkov I,Banavar JR,He F,Hubbell SP,Maritan A

更新日期：2005-12-01 00:00:00

abstract：:Therapies for patients with cancer have changed gradually over the past decade, moving away from the administration of broadly acting cytotoxic drugs towards the use of more-specific therapies that are targeted to each tumour. To facilitate this shift, tests need to be developed to identify those individuals who requi...

journal_title：Nature

authors： van't Veer LJ,Bernards R

更新日期：2008-04-03 00:00:00

abstract：:T lymphocytes are predisposed to recognition of foreign protein fragments bound to cell-surface molecules encoded by the major histocompatibility complex (MHC). There is now compelling evidence that this specificity is a consequence of a selection process operating on developing T lymphocytes in the thymus. As a resul...

journal_title：Nature

authors： Kaye J,Hsu ML,Sauron ME,Jameson SC,Gascoigne NR,Hedrick SM

更新日期：1989-10-26 00:00:00

abstract：:Models and simulations of the epoch of reionization predict that spectra of the 21-centimetre transition of atomic hydrogen will show a clear fluctuation peak, at a redshift and scale, respectively, that mark the central stage of reionization and the characteristic size of ionized bubbles. This is based on the assumpt...

journal_title：Nature

authors： Fialkov A,Barkana R,Visbal E

更新日期：2014-02-13 00:00:00

abstract：:Bilingual individuals need effective mechanisms to prevent interference from one language while processing material in the other. Here we show, using event-related brain potentials and functional magnetic resonance imaging (fMRI), that words from the non-target language are rejected at an early stage before semantic a...

journal_title：Nature

authors： Rodriguez-Fornells A,Rotte M,Heinze HJ,Nösselt T,Münte TF

更新日期：2002-02-28 00:00:00

abstract：:While progress in fusion research continues with magnetic and inertial confinement, alternative approaches--such as Coulomb explosions of deuterium clusters and ultrafast laser-plasma interactions--also provide insight into basic processes and technological applications. However, attempts to produce fusion in a room t...

journal_title：Nature

authors： Naranjo B,Gimzewski JK,Putterman S

更新日期：2005-04-28 00:00:00

abstract：:Eukaryotes and archaea use a protease called the proteasome that has an integral role in maintaining cellular function through the selective degradation of proteins. Proteolysis occurs in a barrel-shaped 20S core particle, which in Thermoplasma acidophilum is built from four stacked homoheptameric rings of subunits, α...

journal_title：Nature

authors： Ruschak AM,Religa TL,Breuer S,Witt S,Kay LE

更新日期：2010-10-14 00:00:00

abstract：:The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis an...

journal_title：Nature

authors： Herndon LA,Schmeissner PJ,Dudaronek JM,Brown PA,Listner KM,Sakano Y,Paupard MC,Hall DH,Driscoll M

更新日期：2002-10-24 00:00:00

abstract：:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, c...

journal_title：Nature

authors： Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

更新日期：2004-02-19 00:00:00