Underdetection of cases of COVID-19 in France threatens epidemic control.

abstract：:The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...

journal_title：Nature

authors： Schlacher K,Cox MM,Woodgate R,Goodman MF

更新日期：2006-08-24 00:00:00

abstract：:The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation by repressing a subset of genes that are controlled by the E2F family of transcription factors and which are involved in progression from the G1 to the S phase of the cell cycle. Rb, which is recruited to target promoters by E2F1, represses tr...

journal_title：Nature

authors： Magnaghi-Jaulin L,Groisman R,Naguibneva I,Robin P,Lorain S,Le Villain JP,Troalen F,Trouche D,Harel-Bellan A

更新日期：1998-02-05 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord. Its cause is unknown and it is uniformly fatal, typically within five years. About 10% of cases are inherited as an autosomal dominant trait, with high penetrance after the sixth decade. In most in...

journal_title：Nature

authors： Rosen DR,Siddique T,Patterson D,Figlewicz DA,Sapp P,Hentati A,Donaldson D,Goto J,O'Regan JP,Deng HX

更新日期：1993-03-04 00:00:00

abstract：:Although the nuclear properties of the late actinides (plutonium, americium and curium) are fully understood and widely applied to energy generation, their solid-state properties do not fit within standard models and are the subject of active research. Plutonium displays phases with enormous volume differences, and bo...

journal_title：Nature

authors： Shim JH,Haule K,Kotliar G

更新日期：2007-03-29 00:00:00

abstract：:Changes in redox status are a conspicuous feature of immune responses in a variety of eukaryotes, but the associated signalling mechanisms are not well understood. In plants, attempted microbial infection triggers the rapid synthesis of nitric oxide and a parallel accumulation of reactive oxygen intermediates, the lat...

journal_title：Nature

authors： Yun BW,Feechan A,Yin M,Saidi NB,Le Bihan T,Yu M,Moore JW,Kang JG,Kwon E,Spoel SH,Pallas JA,Loake GJ

更新日期：2011-10-13 00:00:00

abstract：:Mice of the AKR strain are characterised by a high incidence of spontaneous thymic lymphomas. AKR chromosomes contain the genomes of ecotropic murine leukaemia virus (MuLV) at two loci, termed Akv-1 and Akv-2 (refs 2-6). Shortly after birth, the normal tissues of AKR mice begin to produce high levels of this XC-positi...

journal_title：Nature

authors： Rein A,Athan E,Benjers BM,Bassin RH,Gerwin BI,Slocum DR

更新日期：1979-12-13 00:00:00

abstract：:Sounds heard over headphones are typically perceived inside the head (internalized), unlike real sound sources which are perceived outside the head (externalized). If the acoustical waveforms from a real sound source are reproduced precisely using headphones, auditory images are appropriately externalized and localize...

journal_title：Nature

authors： Kulkarni A,Colburn HS

更新日期：1998-12-24 00:00:00

abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...

journal_title：Nature

authors： Kocot KM,Cannon JT,Todt C,Citarella MR,Kohn AB,Meyer A,Santos SR,Schander C,Moroz LL,Lieb B,Halanych KM

更新日期：2011-09-04 00:00:00

abstract：:Recent studies have shown that developing nerve fibres grow directly to their targets and are guided by specific cues, but the nature of these cues and the mechanism of guidance remain unknown. The growth of sympathetic axons towards an artificial source of nerve growth factor (NGF) in vivo and of sensory neurites up ...

journal_title：Nature

authors： Lumsden AG,Davies AM

更新日期：1983-12-22 00:00:00

abstract：:Introns are removed from nuclear messenger RNA precursors through two sequential phospho-transesterification reactions in a dynamic RNA-protein complex called the spliceosome. But whether splicing is catalysed by small nuclear RNAs in the spliceosome is unresolved. As the spliceosome is a metalloenzyme, it is importan...

journal_title：Nature

authors： Yean SL,Wuenschell G,Termini J,Lin RJ

更新日期：2000-12-14 00:00:00

abstract：:Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[...

journal_title：Nature

authors： Ames JB,Ishima R,Tanaka T,Gordon JI,Stryer L,Ikura M

更新日期：1997-09-11 00:00:00

abstract：:The ability to control the quantum state of a single electron spin in a quantum dot is at the heart of recent developments towards a scalable spin-based quantum computer. In combination with the recently demonstrated controlled exchange gate between two neighbouring spins, driven coherent single spin rotations would p...

journal_title：Nature

authors： Koppens FH,Buizert C,Tielrooij KJ,Vink IT,Nowack KC,Meunier T,Kouwenhoven LP,Vandersypen LM

更新日期：2006-08-17 00:00:00

abstract：:The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...

journal_title：Nature

authors： Rossier J,Audigier Y,Ling N,Cros J,Udenfriend S

更新日期：1980-11-06 00:00:00

abstract：:The evolutionary biologist "studies the steps by which the miraculous adaptations so characteristic of every aspect of the organic world have evolved". But the general nature of such adaptive steps is still unclear. Evolution is often thought to be random and dependent on unpredictable events. In this light, one might...

journal_title：Nature

authors： Gerrish P

更新日期：2001-09-20 00:00:00

abstract：:Little is known about virus-host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus in the alphavirus genus (family Togaviridae), results in lytic infection in most vertebrate cell lines, but persistent productive...

journal_title：Nature

authors： Levine B,Huang Q,Isaacs JT,Reed JC,Griffin DE,Hardwick JM

更新日期：1993-02-25 00:00:00

abstract：:B lymphocytes originate from pluripotential haematopoietic stem cells and differentiate into immunoglobulin (Ig)-producing cells. B-cell lineage differentiation is accompanied by two types of immunoglobulin gene rearrangements--rearrangement of V, D and J gene segments to create a functional V gene and rearrangement o...

journal_title：Nature

authors： Sugiyama H,Akira S,Kikutani H,Kishimoto S,Yamamura Y,Kishimoto T

更新日期：1983-06-30 00:00:00

abstract：:The concept of hierarchical bottom-up structuring commonly encountered in natural materials provides inspiration for the design of complex artificial materials with advanced functionalities. Natural processes have achieved the orchestration of multicomponent systems across many length scales with very high precision, ...

journal_title：Nature

authors： Gröschel AH,Walther A,Löbling TI,Schacher FH,Schmalz H,Müller AH

更新日期：2013-11-14 00:00:00

abstract：:In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferato...

journal_title：Nature

authors： Kersten S,Desvergne B,Wahli W

更新日期：2000-05-25 00:00:00

abstract：:One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this ...

journal_title：Nature

authors： Weaver BA,Silk AD,Cleveland DW

更新日期：2006-08-17 00:00:00

abstract：:Muscle actin genes are the earliest yet described to show cell type-specific activation in amphibian embryos. Gene-specific probes show that alpha-skeletal and alpha-cardiac actin genes start to be transcribed simultaneously at the end of gastrulation, but only in those regions of the mesoderm that subsequently form e...

journal_title：Nature

authors： Mohun TJ,Brennan S,Dathan N,Fairman S,Gurdon JB

更新日期：1984-10-25 00:00:00

abstract：:Platelet-derived growth factor (PDGF), as purified from fresh human platelets, is a protein of relative molecular mass (Mr) 30,000 composed of two disulphide-linked subunit chains of similar size, named A and B (ref. 1). The dimer structure of PDGRF seems to be important for its biological effects, as reduction irreve...

journal_title：Nature

authors： Heldin CH,Johnsson A,Wennergren S,Wernstedt C,Betsholtz C,Westermark B

更新日期：1986-02-06 00:00:00

abstract：:There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous studies reported that acute lung injury caused by chemical or microbial insults is secondary to the generation of host-derived, oxidized phospholipid that potently st...

journal_title：Nature

authors： Shirey KA,Lai W,Scott AJ,Lipsky M,Mistry P,Pletneva LM,Karp CL,McAlees J,Gioannini TL,Weiss J,Chen WH,Ernst RK,Rossignol DP,Gusovsky F,Blanco JC,Vogel SN

更新日期：2013-05-23 00:00:00

abstract：:The origins of the building blocks of the Solar System can be studied using the isotopic composition of early planetary and meteoritic material. Oxygen isotopes in planetary materials show variations at the per cent level that are not related to the mass of the isotopes; rather, they result from the mixture of compone...

journal_title：Nature

authors： Aléon J,Robert F,Duprat J,Derenne S

更新日期：2005-09-15 00:00:00

abstract：:The discovery of Higgs-boson decays in a background of standard-model processes was assisted by machine learning methods. The classifiers used to separate signals such as these from background are trained using highly unerring but not completely perfect simulations of the physical processes involved, often resulting i...

journal_title：Nature

authors： Mott A,Job J,Vlimant JR,Lidar D,Spiropulu M

更新日期：2017-10-18 00:00:00

abstract：:Oxygen consumption by carnivorous reptiles increases enormously after they have eaten a large meal in order to meet metabolic demands, and this places an extra load on the cardiovascular system. Here we show that there is an extraordinarily rapid 40% increase in ventricular muscle mass in Burmese pythons (Python molur...

journal_title：Nature

authors： Andersen JB,Rourke BC,Caiozzo VJ,Bennett AF,Hicks JW

更新日期：2005-03-03 00:00:00

abstract：:Recent advances in understanding the molecular basis of human X-linked muscular dystrophies have come from the identification of dystrophin, a cytoskeletal protein associated with the surface membrane. Although there is little or virtually no dystrophin in affected individuals, it is not known how this causes muscle d...

journal_title：Nature

authors： Franco A Jr,Lansman JB

更新日期：1990-04-12 00:00:00

abstract：:A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphylatoxins. The...

journal_title：Nature

authors： Höpken UE,Lu B,Gerard NP,Gerard C

更新日期：1996-09-05 00:00:00

abstract：:In 2001 the Intergovernmental Panel on Climate Change projected the contribution to sea level rise from the Greenland ice sheet to be between -0.02 and +0.09 m from 1990 to 2100 (ref. 1). However, recent work has suggested that the ice sheet responds more quickly to climate perturbations than previously thought, parti...

journal_title：Nature

authors： Velicogna I,Wahr J

更新日期：2006-09-21 00:00:00

abstract：:The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways1, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metaboli...

journal_title：Nature

authors： He S,Kahles F,Rattik S,Nairz M,McAlpine CS,Anzai A,Selgrade D,Fenn AM,Chan CT,Mindur JE,Valet C,Poller WC,Halle L,Rotllan N,Iwamoto Y,Wojtkiewicz GR,Weissleder R,Libby P,Fernández-Hernando C,Drucker DJ,Nahrendorf

更新日期：2019-02-01 00:00:00

abstract：:Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly d...

journal_title：Nature

authors： Ng SW,Mitchell A,Kennedy JA,Chen WC,McLeod J,Ibrahimova N,Arruda A,Popescu A,Gupta V,Schimmer AD,Schuh AC,Yee KW,Bullinger L,Herold T,Görlich D,Büchner T,Hiddemann W,Berdel WE,Wörmann B,Cheok M,Preudhomme C,Domb

更新日期：2016-12-15 00:00:00