Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins.

abstract：:Recent studies have demonstrated that monkeys and humans can use signals from the brain to guide computer cursors. Brain-computer interfaces (BCIs) may one day assist patients suffering from neurological injury or disease, but relatively low system performance remains a major obstacle. In fact, the speed and accuracy ...

journal_title：Nature

authors： Santhanam G,Ryu SI,Yu BM,Afshar A,Shenoy KV

更新日期：2006-07-13 00:00:00

abstract：:Apart from the retroviral gag, pol and env the HIV genome contains the F (3' orf) gene which encodes a polypeptide of 206 amino acids which is myristylated at the N-terminal and whose function is unknown. We have expressed the F gene in Escherichia coli and from a recombinant vaccinia virus, VVTGfHIV. The F-protein pr...

journal_title：Nature

authors： Guy B,Kieny MP,Riviere Y,Le Peuch C,Dott K,Girard M,Montagnier L,Lecocq JP

更新日期：1987-11-19 00:00:00

abstract：:The origin and growth of magnetic fields in galaxies is still something of an enigma. It is generally assumed that seed fields are amplified over time through the dynamo effect, but there are few constraints on the timescale. It was recently demonstrated that field strengths as traced by rotation measures of distant (...

journal_title：Nature

authors： Bernet ML,Miniati F,Lilly SJ,Kronberg PP,Dessauges-Zavadsky M

更新日期：2008-07-17 00:00:00

abstract：:With the world's focus on reducing our dependency on fossil-fuel energy, the scientific community can investigate new plastic materials that are much less dependent on petroleum than are conventional plastics. Given increasing environmental issues, the idea of replacing plastics with water-based gels, so-called hydrog...

journal_title：Nature

authors： Wang Q,Mynar JL,Yoshida M,Lee E,Lee M,Okuro K,Kinbara K,Aida T

更新日期：2010-01-21 00:00:00

abstract：:To understand the processes that regulate the abundance and persistence of wild populations is a fundamental goal of ecology and a prerequisite for the management of living resources. Variable abundance data, however, make the demonstration of regulation processes challenging. A previously overlooked aspect in underst...

journal_title：Nature

authors： Minto C,Myers RA,Blanchard W

更新日期：2008-03-20 00:00:00

abstract：:Ultra-compact dwarf galaxies are among the densest stellar systems in the Universe. These systems have masses of up to 2 × 10(8) solar masses, but half-light radii of just 3-50 parsecs. Dynamical mass estimates show that many such dwarfs are more massive than expected from their luminosity. It remains unclear whether ...

journal_title：Nature

authors： Seth AC,van den Bosch R,Mieske S,Baumgardt H,den Brok M,Strader J,Neumayer N,Chilingarian I,Hilker M,McDermid R,Spitler L,Brodie J,Frank MJ,Walsh JL

更新日期：2014-09-18 00:00:00

abstract：:A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...

journal_title：Nature

authors： Nguyen NUN,Canseco DC,Xiao F,Nakada Y,Li S,Lam NT,Muralidhar SA,Savla JJ,Hill JA,Le V,Zidan KA,El-Feky HW,Wang Z,Ahmed MS,Hubbi ME,Menendez-Montes I,Moon J,Ali SR,Le V,Villalobos E,Mohamed MS,Elhelaly WM,Thet

更新日期：2020-06-01 00:00:00

abstract：:The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physiological effects suc...

journal_title：Nature

authors： Saxton RA,Chantranupong L,Knockenhauer KE,Schwartz TU,Sabatini DM

更新日期：2016-08-11 00:00:00

abstract：:The Milankovitch theory states that global climate variability on orbital timescales from tens to hundreds of thousands of years is dominated by the summer insolation at high northern latitudes. The supporting evidence includes reconstructed air temperatures in Antarctica that are nearly in phase with boreal summer in...

journal_title：Nature

authors： Laepple T,Werner M,Lohmann G

更新日期：2011-03-03 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Aveline DC,Williams JR,Elliott ER,Dutenhoffer C,Kellogg JR,Kohel JM,Lay NE,Oudrhiri K,Shotwell RF,Yu N,Thompson RJ

更新日期：2020-08-01 00:00:00

abstract：:We describe here a new view of primary visual cortex (V1) based on measurements of neural responses in V1 to patterns called 'illusory contours' (Fig. 1a, b). Detection of an object's boundary contours is a fundamental visual task. Boundary contours are defined by discontinuities not only in luminance and colour, but ...

journal_title：Nature

authors： Grosof DH,Shapley RM,Hawken MJ

更新日期：1993-10-07 00:00:00

abstract：:The capacity of the rough endoplasmic reticulum (RER) membrane of eukaryotic cells in translocate nascent presecretory proteins from the cytosol to the intracisternal space is preserved on cell fractionation and can be assayed in vitro. Two attempts to characterize this translocation activity have been reported. Warre...

journal_title：Nature

authors： Jackson RC,Walter P,Blobel G

更新日期：1980-07-10 00:00:00

abstract：: ...

journal_title：Nature

authors： Rivest S

更新日期：2018-11-01 00:00:00

abstract：:The presence of homoeo box sequences in the genomes of vertebrates has suggested that these metazoans possess the equivalent of the homoeotic genes that have a key role in regulating the development of the fruitfly Drosophila melanogaster. We report here that a novel murine homoeo box-containing gene is expressed in e...

journal_title：Nature

authors： Colberg-Poley AM,Voss SD,Chowdhury K,Gruss P

更新日期：1985-04-25 00:00:00

abstract：:Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

journal_title：Nature

authors： Ramila G,Erb P

更新日期：1983-08-04 00:00:00

abstract：:The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...

journal_title：Nature

authors： van Houten M,Posner BI

更新日期：1979-12-06 00:00:00

abstract：:Eukaryotes and archaea use a protease called the proteasome that has an integral role in maintaining cellular function through the selective degradation of proteins. Proteolysis occurs in a barrel-shaped 20S core particle, which in Thermoplasma acidophilum is built from four stacked homoheptameric rings of subunits, α...

journal_title：Nature

authors： Ruschak AM,Religa TL,Breuer S,Witt S,Kay LE

更新日期：2010-10-14 00:00:00

abstract：:Opsin, the ligand-free form of the G-protein-coupled receptor rhodopsin, at low pH adopts a conformationally distinct, active G-protein-binding state known as Ops*. A synthetic peptide derived from the main binding site of the heterotrimeric G protein-the carboxy terminus of the alpha-subunit (GalphaCT)-stabilizes Ops...

journal_title：Nature

authors： Scheerer P,Park JH,Hildebrand PW,Kim YJ,Krauss N,Choe HW,Hofmann KP,Ernst OP

更新日期：2008-09-25 00:00:00

abstract：:Chromosomal replication machines contain coupled DNA polymerases that simultaneously replicate the leading and lagging strands. However, coupled replication presents a largely unrecognized topological problem. Because DNA polymerase must travel a helical path during synthesis, the physical connection between leading- ...

journal_title：Nature

authors： Kurth I,Georgescu RE,O'Donnell ME

更新日期：2013-04-04 00:00:00

abstract：:Interfaces in heterostructures have been a key point of interest in condensed-matter physics for decades owing to a plethora of distinctive phenomena-such as rectification1, the photovoltaic effect2, the quantum Hall effect3 and high-temperature superconductivity4-and their critical roles in present-day technical devi...

journal_title：Nature

authors： Yang MM,Luo ZD,Mi Z,Zhao J,E SP,Alexe M

更新日期：2020-08-01 00:00:00

abstract：:Real-time investigations of the rearrangement of bonds during chemical transformations require femtosecond temporal resolution, so that the atomic vibrations within the reacting molecules can be observed. Following the development of lasers capable of emitting ultrashort laser flashes on this timescale, chemical react...

journal_title：Nature

authors： Kobayashi T,Saito T,Ohtani H

更新日期：2001-11-29 00:00:00

abstract：:The human B cell-specific alloantigen which is closely linked genetically to HLA contains two non-covalently associated, sialogycoprotein subunits of molecular weight (MW) 29,000 (p29), and 34,000 (p34). Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable sim...

journal_title：Nature

authors： Springer TA,Kaufman JF,Terhorst C,Strominger JL

更新日期：1977-07-21 00:00:00

abstract：:In standard fluid dynamics, the density change associated with flow is often assumed to be negligible, implying that the fluid is incompressible. For example, this has been established for simple shear flows, where no pressure change is associated with flow: there is no volume deformation due to viscous stress and ine...

journal_title：Nature

authors： Furukawa A,Tanaka H

更新日期：2006-09-28 00:00:00

abstract：:Flaviviruses, when complexed with antibody at subneutralizing concentrations, show enhanced replication in human and simian peripheral blood leukocytes (ref. 1, and J.S.M.P. and J.S.P., unpublished observations) and in P388 D1 and other macrophage cell lines. A comparable phenomenon has been demonstrated with alphavir...

journal_title：Nature

authors： Peiris JS,Gordon S,Unkeless JC,Porterfield JS

更新日期：1981-01-15 00:00:00

abstract：:Molecules capable of mimicking the function of a wide range of mechanical devices have been fabricated, with motors that can induce mechanical movement attracting particular attention. Such molecular motors convert light or chemical energy into directional rotary or linear motion, and are usually prepared and operated...

journal_title：Nature

authors： van Delden RA,ter Wiel MK,Pollard MM,Vicario J,Koumura N,Feringa BL

更新日期：2005-10-27 00:00:00

abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

journal_title：Nature

authors： Derrick JP,Wigley DB

更新日期：1992-10-22 00:00:00

abstract：:Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and multicellular organisms, and is produced extracellularly in response to external stresses and internal cues1-4. H2O2 enters cells through aquaporin membrane proteins and covalently modifies cytoplasmic proteins to regulate signalling and ce...

journal_title：Nature

authors： Wu F,Chi Y,Jiang Z,Xu Y,Xie L,Huang F,Wan D,Ni J,Yuan F,Wu X,Zhang Y,Wang L,Ye R,Byeon B,Wang W,Zhang S,Sima M,Chen S,Zhu M,Pei J,Johnson DM,Zhu S,Cao X,Pei C,Zai Z,Liu Y,Liu T,Swift GB,Zhang W,Y

更新日期：2020-02-01 00:00:00

abstract：:The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...

journal_title：Nature

authors： Taufiq-Ur-Rahman,Skupin A,Falcke M,Taylor CW

更新日期：2009-04-02 00:00:00

abstract：:Transposable elements are viewed as 'selfish genetic elements', yet they contribute to gene regulation and genome evolution in diverse ways. More than half of the human genome consists of transposable elements. Alu elements belong to the short interspersed nuclear element (SINE) family of repetitive elements, and with...

journal_title：Nature

authors： Aktaş T,Avşar Ilık İ,Maticzka D,Bhardwaj V,Pessoa Rodrigues C,Mittler G,Manke T,Backofen R,Akhtar A

更新日期：2017-04-06 00:00:00

abstract：:Paired-associate learning is often used to examine episodic memory in humans. Animal models include the recall of food-cache locations by scrub jays and sequential memory. Here we report a model in which rats encode, during successive sample trials, two paired associates (flavours of food and their spatial locations) ...

journal_title：Nature

authors： Day M,Langston R,Morris RG

更新日期：2003-07-10 00:00:00