Tunable spin-spin interactions and entanglement of ions in separate potential wells.

abstract：:Rab GTPases regulate all stages of membrane trafficking, including vesicle budding, cargo sorting, transport, tethering and fusion. In the inactive (GDP-bound) conformation, accessory factors facilitate the targeting of Rab GTPases to intracellular compartments. After nucleotide exchange to the active (GTP-bound) conf...

journal_title：Nature

authors： Eathiraj S,Pan X,Ritacco C,Lambright DG

更新日期：2005-07-21 00:00:00

abstract：:Exchange dynamics between molecules free in solution and bound to the surface of a large supramolecular structure, a polymer, a membrane or solid support are important in many phenomena in biology and materials science. Here we present a novel and generally applicable solution NMR technique, known as dark-state exchan...

journal_title：Nature

authors： Fawzi NL,Ying J,Ghirlando R,Torchia DA,Clore GM

更新日期：2011-10-30 00:00:00

abstract：:Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller th...

journal_title：Nature

authors： Barth RK,Kim BS,Lan NC,Hunkapiller T,Sobieck N,Winoto A,Gershenfeld H,Okada C,Hansburg D,Weissman IL

更新日期：1985-08-08 00:00:00

abstract：:Only three elements are ferromagnetic at room temperature: the transition metals iron, cobalt and nickel. The Stoner criterion explains why iron is ferromagnetic but manganese, for example, is not, even though both elements have an unfilled 3d shell and are adjacent in the periodic table: according to this criterion, ...

journal_title：Nature

authors： Ma'Mari FA,Moorsom T,Teobaldi G,Deacon W,Prokscha T,Luetkens H,Lee S,Sterbinsky GE,Arena DA,MacLaren DA,Flokstra M,Ali M,Wheeler MC,Burnell G,Hickey BJ,Cespedes O

更新日期：2015-08-06 00:00:00

abstract：:Vaccination has proved a powerful defence against a range of infectious diseases of humans and animals. However, its potential to control major epidemics of foot-and-mouth disease (FMD) in livestock is contentious. Using an individual farm-based model, we consider either national prophylactic vaccination campaigns in ...

journal_title：Nature

authors： Keeling MJ,Woolhouse ME,May RM,Davies G,Grenfell BT

更新日期：2003-01-09 00:00:00

abstract：:The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death l...

journal_title：Nature

authors： Shalapour S,Lin XJ,Bastian IN,Brain J,Burt AD,Aksenov AA,Vrbanac AF,Li W,Perkins A,Matsutani T,Zhong Z,Dhar D,Navas-Molina JA,Xu J,Loomba R,Downes M,Yu RT,Evans RM,Dorrestein PC,Knight R,Benner C,Anstee QM,Kar

更新日期：2017-11-16 00:00:00

abstract：:Concentrating urine is mandatory for most mammals to prevent water loss from the body. Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. In this nephron segment, vasopressin regulat...

journal_title：Nature

authors： Fushimi K,Uchida S,Hara Y,Hirata Y,Marumo F,Sasaki S

更新日期：1993-02-11 00:00:00

abstract：:The tyrosine phosphatase SHP2, encoded by PTPN11, is required for the survival, proliferation and differentiation of various cell types. Germline activating mutations in PTPN11 cause Noonan syndrome, whereas somatic PTPN11 mutations cause childhood myeloproliferative disease and contribute to some solid tumours. Recen...

journal_title：Nature

authors： Yang W,Wang J,Moore DC,Liang H,Dooner M,Wu Q,Terek R,Chen Q,Ehrlich MG,Quesenberry PJ,Neel BG

更新日期：2013-07-25 00:00:00

abstract：:Bananas (Musa spp.), including dessert and cooking types, are giant perennial monocotyledonous herbs of the order Zingiberales, a sister group to the well-studied Poales, which include cereals. Bananas are vital for food security in many tropical and subtropical countries and the most popular fruit in industrialized c...

journal_title：Nature

authors： D'Hont A,Denoeud F,Aury JM,Baurens FC,Carreel F,Garsmeur O,Noel B,Bocs S,Droc G,Rouard M,Da Silva C,Jabbari K,Cardi C,Poulain J,Souquet M,Labadie K,Jourda C,Lengellé J,Rodier-Goud M,Alberti A,Bernard M,Correa M

更新日期：2012-08-09 00:00:00

abstract：:Protein G is a cell-surface protein from Streptococcus which binds to IgG molecules from a wide range of species with an affinity comparable to that of antigen. The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass...

journal_title：Nature

authors： Derrick JP,Wigley DB

更新日期：1992-10-22 00:00:00

abstract：:Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a di...

journal_title：Nature

authors： Wu W,Wong K,Chen J,Jiang Z,Dupuis S,Wu JY,Rao Y

更新日期：1999-07-22 00:00:00

abstract：:Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone receptor (MC1-R), thus explaining the inhibitory effect of ag...

journal_title：Nature

authors： Fan W,Boston BA,Kesterson RA,Hruby VJ,Cone RD

更新日期：1997-01-09 00:00:00

abstract：: ...

journal_title：Nature

authors： Witze A

更新日期：2019-01-01 00:00:00

abstract：:Phosphorylation of membrane components is thought to be an important process in membrane function. Phosphorylated proteins and a special class of phospholipids, the (poly)phosphoinositides (poly PI), are implicated in the regulation of membrane permeability and synaptic transmission in neurones. For many years, protei...

journal_title：Nature

authors： Jolles J,Zwiers H,van Dongen CJ,Schotman P,Wirtz KW,Gispen WH

更新日期：1980-08-07 00:00:00

abstract：:A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The ge...

journal_title：Nature

authors： Kuro-o M,Matsumura Y,Aizawa H,Kawaguchi H,Suga T,Utsugi T,Ohyama Y,Kurabayashi M,Kaname T,Kume E,Iwasaki H,Iida A,Shiraki-Iida T,Nishikawa S,Nagai R,Nabeshima YI

更新日期：1997-11-06 00:00:00

abstract：:Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast. However, the function or occurrence of this specific histone mark has not been studied in multicellular e...

journal_title：Nature

authors： Das C,Lucia MS,Hansen KC,Tyler JK

更新日期：2009-05-07 00:00:00

abstract：:Quantum states of mechanical motion can be important resources for quantum information, metrology and studies of fundamental physics. Recent demonstrations of superconducting qubits coupled to acoustic resonators have opened up the possibility of performing quantum operations on macroscale motional modes1-3, which can...

journal_title：Nature

authors： Chu Y,Kharel P,Yoon T,Frunzio L,Rakich PT,Schoelkopf RJ

更新日期：2018-11-01 00:00:00

abstract：:The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolic receptors. However, it remains unknown whether a mechanism exists that integrates these nucleic-acid-sensing systems. Here we sho...

journal_title：Nature

authors： Yanai H,Ban T,Wang Z,Choi MK,Kawamura T,Negishi H,Nakasato M,Lu Y,Hangai S,Koshiba R,Savitsky D,Ronfani L,Akira S,Bianchi ME,Honda K,Tamura T,Kodama T,Taniguchi T

更新日期：2009-11-05 00:00:00

abstract：:As an approach to the study of the kind of chemical process that might have contributed to the origin of life, attempts have been made to develop purely chemical systems in which oligonucleotides self-replicate. Although performed oligonucleotides have been shown to facilitate the formation of their complements from a...

journal_title：Nature

authors： Zielinski WS,Orgel LE

更新日期：1987-05-28 00:00:00

abstract：:DEET (N,N-diethyl-meta-toluamide) is a synthetic chemical identified by the US Department of Agriculture in 1946 in a screen for repellents to protect soldiers from mosquito-borne diseases1,2. Since its discovery, DEET has become the world's most widely used arthropod repellent and is effective against invertebrates s...

journal_title：Nature

authors： Dennis EJ,Dobosiewicz M,Jin X,Duvall LB,Hartman PS,Bargmann CI,Vosshall LB

更新日期：2018-10-01 00:00:00

abstract：:Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride concentrations in surface water are low and fluorinated metabolites are extremely rare. The fluoride ion is a potent nucleophile in its desolvated state, but is tightly hydrated in water and effectively inert. Low availability and a la...

journal_title：Nature

authors： Dong C,Huang F,Deng H,Schaffrath C,Spencer JB,O'Hagan D,Naismith JH

更新日期：2004-02-05 00:00:00

abstract：:Arbuscular mycorrhizal (AM) fungi (Glomeromycota) reproduce asexually, are multinucleate, and have high genetic variation within single cells. Pawlowska and Taylor find that genetic variation within AM fungal cells is not lost as a result of segregation, and they interpret this as evidence that the variation is presen...

journal_title：Nature

authors： Bever JD,Wang M

更新日期：2005-01-13 00:00:00

abstract：:The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic facto...

journal_title：Nature

authors： Kirkwood TB,Austad SN

更新日期：2000-11-09 00:00:00

abstract：:The low concentration of atmospheric CO2 inferred to have been present during glacial periods is thought to have been partly caused by an increased supply of iron-bearing dust to the ocean surface. This is supported by a recent model that attributes half of the CO2 reduction during past glacial stages to iron-stimulat...

journal_title：Nature

authors： Maher BA,Dennis PF

更新日期：2001-05-10 00:00:00

abstract：:Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn's disease. Numerous studies have dem...

journal_title：Nature

authors： Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M

更新日期：2014-02-27 00:00:00

abstract：:The promoters of eukaryotic genes are being increasingly defined through the identification of consensus DNA sequences, by mutational analysis, and by in vitro and in vivo studies of transcription. Whereas the TATA sequence (Goldberg-Hogness box) has been largely conserved among protein encoding genes (transcribed by ...

journal_title：Nature

authors： Russell PR

更新日期：1983-01-13 00:00:00

abstract：:Since the pioneering work of the Millers it has become clear that most chemical carcinogens require metabolism to reactive electrophiles and then exhibit their carcinogenic potential by reacting chemically with, and modifying, cellular macromolecules. At first modification of proteins was considered most likely to be ...

journal_title：Nature

authors： Allen JA,Coombs MM

更新日期：1980-09-18 00:00:00

abstract：: ...

journal_title：Nature

authors： Savage N

更新日期：2018-12-01 00:00:00

abstract：:The spacing of opening-mode fractures in layered materials--such as certain sedimentary rocks and laminated engineering materials--is often proportional to the thickness of the fractured layer. Experimental studies of this phenomenon show that the spacing initially decreases as extensional strain increases in the dire...

journal_title：Nature

authors： Bai T,Pollard DD,Gao H

更新日期：2000-02-17 00:00:00

abstract：:The signature of Dansgaard-Oeschger events--millennial-scale abrupt climate oscillations during the last glacial period--is well established in ice cores and marine records. But the effects of such events in continental settings are not as clear, and their absolute chronology is uncertain beyond the limit of (14)C dat...

journal_title：Nature

authors： Genty D,Blamart D,Ouahdi R,Gilmour M,Baker A,Jouzel J,Van-Exter S

更新日期：2003-02-20 00:00:00