相关文献
NATURE文献大全abstract::As the extracellular matrix at the original site of a neuromuscular junction seems to play a major part in the specificity of synaptic regeneration, considerable attention has been paid to unique molecules localized to this region. Here we describe an extracellular matrix glycoprotein of the elasmobranch electric orga...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314441a0
更新日期:1985-04-04 00:00:00
abstract::The emergence of HIV-1 group M subtype B in North American men who have sex with men was a key turning point in the HIV/AIDS pandemic. Phylogenetic studies have suggested cryptic subtype B circulation in the United States (US) throughout the 1970s and an even older presence in the Caribbean. However, these temporal an...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature19827
更新日期:2016-11-03 00:00:00
abstract::Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/272028a0
更新日期:1978-03-02 00:00:00
abstract::Bilingual individuals need effective mechanisms to prevent interference from one language while processing material in the other. Here we show, using event-related brain potentials and functional magnetic resonance imaging (fMRI), that words from the non-target language are rejected at an early stage before semantic a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/4151026a
更新日期:2002-02-28 00:00:00
abstract::Large low-velocity seismic anomalies have been detected in the Earth's lower mantle beneath Africa and the Pacific Ocean that are not easily explained by temperature variations alone. The African anomaly has been interpreted to be a northwest-southeast-trending structure with a sharp-edged linear, ridge-like morpholog...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04066
更新日期:2005-10-20 00:00:00
abstract::In several well-characterized site-specific recombination systems it has been shown that, for efficient recombination, the two recombining sites must have identical DNA sequences across the region between the staggered points of exchange. The precise DNA sequence of this overlap region, however, appears to be of littl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332861a0
更新日期:1988-04-28 00:00:00
abstract::Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09058
更新日期:2010-07-22 00:00:00
abstract::Mitogen-activated protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors. In turn, ERKs phosphorylate and regulate key intracellular enzymes and transcription factors involved in the control of cellu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369418a0
更新日期:1994-06-02 00:00:00
abstract::Planetary aurorae are formed by energetic charged particles streaming along the planet's magnetic field lines into the upper atmosphere from the surrounding space environment. Earth's main auroral oval is formed through interactions with the solar wind, whereas that at Jupiter is formed through interactions with plasm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07077
更新日期:2008-06-19 00:00:00
abstract::Normal cellular function requires that organelles be positioned in specific locations. The direction in which molecular motors move organelles is based in part on the polarity of microtubules and actin filaments. However, this alone does not determine the intracellular destination of organelles. For example, the yeast...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01453
更新日期:2003-03-06 00:00:00
abstract::Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382829a0
更新日期:1996-08-29 00:00:00
abstract::Prostaglandins have wide-ranging effects in the body and are thought to be important mediators of inflammation. Cyclooxygenase (COX) plays a key regulatory role in prostaglandin synthesis, and occurs in both constitutive (COX-1) and inducible (COX-2) isoforms. COX-1 is thought to provide cytoprotective effects, wherea...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/378406a0
更新日期:1995-11-23 00:00:00
abstract::The "Gardner hypothesis" suggests that an excess of childhood leukaemia near a nuclear reprocessing plant is caused by paternal exposure to ionizing radiation. But the evidence shows that this explanation is wrong. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/367678a0
更新日期:1994-02-24 00:00:00
abstract::During animal development, cells have to respond appropriately to localized secreted signals. Proper responses to Hedgehog, transforming growth factor-beta, epidermal growth factor and fibroblast growth factor/Ras signals require cognate inducible antagonists such as Patched, Dad, Argos and Sprouty. Wnt signals are cr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35001615
更新日期:2000-02-17 00:00:00
abstract::Excitation-contraction coupling in skeletal muscle involves a voltage sensor in the plasma membrane which, in response to depolarization, causes an intracellular calcium-release channel to open. The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine recepto...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/380072a0
更新日期:1996-03-07 00:00:00
abstract::The sequencing of ancient DNA has enabled the reconstruction of speciation, migration and admixture events for extinct taxa1. However, the irreversible post-mortem degradation2 of ancient DNA has so far limited its recovery-outside permafrost areas-to specimens that are not older than approximately 0.5 million years (...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/s41586-019-1555-y
更新日期:2019-10-01 00:00:00
abstract::The making and breaking of atomic bonds are essential processes in chemical reactions. Although the ultrafast dynamics of bond breaking have been studied intensively using time-resolved techniques, it is very difficult to study the structural dynamics of bond making, mainly because of its bimolecular nature. It is esp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14163
更新日期:2015-02-19 00:00:00
abstract::B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the demonstration that these tumours are dependent on the RAF/MEK/ERK pathway, offered hope that inhibition of B-RAF kinase activity could benefit melanoma patients. He...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09454
更新日期:2010-09-30 00:00:00
abstract::Proximal spinal muscular atrophies represent the second most common fatal, autosomal recessive disorder after cystic fibrosis. The childhood form is classically subdivided into three groups: acute Werdnig-Hoffmann (type I), intermediate Werdnig-Hoffmann disease (type II) and Kugelberg-Welander disease (type III). Thes...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344767a0
更新日期:1990-04-19 00:00:00
abstract::Called the "mystery of mysteries" by Darwin, speciation is still a little-understood area of evolution. Genetic analysis, however, has yielded new generalizations about speciation and suggests promising avenues of research. ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/355511a0
更新日期:1992-02-06 00:00:00
abstract::The age of dense interstellar cloud cores, where stars and planets form, is a crucial parameter in star formation and difficult to measure. Some models predict rapid collapse, whereas others predict timescales of more than one million years (ref. 3). One possible approach to determining the age is through chemical cha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13924
更新日期:2014-12-11 00:00:00
abstract::Humoral immune responses to immunization and infection and susceptibilities to antibody-mediated autoimmunity are generally lower in males1-3. However, the mechanisms underlying such sexual dimorphism are not well understood. Here we show that there are intrinsic differences between the B cells that produce germinal c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1873-0
更新日期:2020-01-01 00:00:00
abstract::Recent studies have suggested that actomyosin threads may provide a useful model for studying the properties of contractile systems. The development of highly sensitive positional feedback transducers has enabled the properties of these threads to be measured reproducibly. Potential applications include such systems a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287338a0
更新日期:1980-09-25 00:00:00
abstract::Reorganizations of the Atlantic meridional overturning circulation were associated with large and abrupt climatic changes in the North Atlantic region during the last glacial period. Projections with climate models suggest that similar reorganizations may also occur in response to anthropogenic global warming. Here I ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03476
更新日期:2005-03-31 00:00:00
abstract::Bacteria living within eukaryotic cells can be essential for the survival or reproduction of the host but in other cases are among the most successful pathogens. Environmental Chlamydiae, including strain UWE25, thrive as obligate intracellular symbionts within protozoa; are recently discovered relatives of major bact...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03131
更新日期:2004-12-02 00:00:00
abstract::In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus satellite RNA has allowed definition of an RNA segment with endoribonuclease activity. General rules have been deduced for the design of new RNA enzymes capable of highly specific RNA cleavage, and have been successfully tested...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334585a0
更新日期:1988-08-18 00:00:00
abstract::It has long been known that the 5' to 3' polarity of DNA synthesis results in both a leading and lagging strand at all replication forks. Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escheric...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07282
更新日期:2008-10-30 00:00:00
abstract::Emerging infectious diseases present a formidable challenge to the conservation of native species in the twenty-first century. Diseases caused by introduced pathogens have had large impacts on species abundances, including the American chestnut, Hawaiian bird species and many amphibians. Changes in host population siz...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05829
更新日期:2007-06-07 00:00:00
abstract::Nuclear exclusion of the PTEN (phosphatase and tensin homologue deleted in chromosome 10) tumour suppressor has been associated with cancer progression. However, the mechanisms leading to this aberrant PTEN localization in human cancers are currently unknown. We have previously reported that ubiquitinylation of PTEN a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07290
更新日期:2008-10-09 00:00:00
abstract::Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/s41586-019-1677-2
更新日期:2019-11-01 00:00:00