Abstract:
:The "Gardner hypothesis" suggests that an excess of childhood leukaemia near a nuclear reprocessing plant is caused by paternal exposure to ionizing radiation. But the evidence shows that this explanation is wrong.
journal_name
Naturejournal_title
Natureauthors
Doll R,Evans HJ,Darby SCdoi
10.1038/367678a0subject
Has Abstractpub_date
1994-02-24 00:00:00pages
678-80issue
6465eissn
0028-0836issn
1476-4687journal_volume
367pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::Neurotransmitter release is initiated by influx of Ca2+ through voltage-gated Ca2+ channels, within 200 microseconds of the action potential arriving at the synaptic terminal, as the Ca2+ concentration increases from 100 nM to > 200 microM. Exocytosis requires high Ca2+ concentration, with a threshold of 20-50 microM ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379451a0
更新日期:1996-02-01 00:00:00
abstract::Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin1-3. Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cycl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2182-3
更新日期:2020-04-01 00:00:00
abstract::The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13772
更新日期:2014-11-13 00:00:00
abstract::Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25462
更新日期:2018-02-07 00:00:00
abstract::The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death. Naturally occurring cell death aids tissue remodelling, eliminates supernumerary cell populations and provides structural elements such as hair and skin. In the nervous system, selec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363166a0
更新日期:1993-05-13 00:00:00
abstract::Mov13 mice carry a single Moloney murine leukaemia virus (M-MuLV) proviral copy in the first intron of the alpha 1(I) collagen gene. Virus insertion interferes with the synthesis of stable alpha 1(I) collagen messenger RNA and causes a recessive lethal mutation. The virus insertion has induced changes of the methylati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320365a0
更新日期:1986-03-27 00:00:00
abstract::The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11837
更新日期:2013-03-21 00:00:00
abstract::Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering a...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature04164
更新日期:2005-09-29 00:00:00
abstract::The rat hippocampus receives a strong cholinergic innervation from the medial septum; information about the development and function of this pathway could help to elucidate the mechanisms of memory functions. Previous electrophysiological studies have shown that septal stimulation in vivo facilitates commissural and p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/313577a0
更新日期:1985-02-14 00:00:00
abstract::Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverag...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14659
更新日期:2015-07-30 00:00:00
abstract::Ants travelling to and fro between their nest and a foraging area may follow stereotyped foodward and homeward routes that are guided by different visual and directional memory sequences. Honeybees are known to fly a feeder-to-hive or hive-to-feeder vector according to whether or not they have recently fed--their feed...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/438302a
更新日期:2005-11-17 00:00:00
abstract::Human fibroblast cells produce beta-type interferon only in response to viral infection or treatment with an inducer such as poly(rI) X poly(rC); this event is most probably controlled at the transcriptional level (for review see ref. 1). To study the induction process, we inserted the human fibroblast interferon (IFN...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301634a0
更新日期:1983-02-17 00:00:00
abstract::Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers. Not much is known of sphingolipids binding to transmembrane domains (TMDs) of...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10742
更新日期:2012-01-09 00:00:00
abstract::Vertebrate and invertebrate digestive systems show extensive similarities in their development, cellular makeup and genetic control. The Drosophila midgut is typical: enterocytes make up the majority of the intestinal epithelial monolayer, but are interspersed with hormone-producing enteroendocrine cells. Human (and m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04333
更新日期:2006-01-26 00:00:00
abstract::Electromagnetically induced transparency is a quantum interference effect that permits the propagation of light through an otherwise opaque atomic medium; a 'coupling' laser is used to create the interference necessary to allow the transmission of resonant pulses from a 'probe' laser. This technique has been used to s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35054017
更新日期:2001-01-25 00:00:00
abstract::Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumours according to their clinical behaviour. Chemotherapy or ho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415530a
更新日期:2002-01-31 00:00:00
abstract::The molecular mechanisms controlling the process of myelination by Schwann cells remain elusive, despite recent progress in the identification and characterization of genes encoding myelin components (reviewed in ref. 1). We have created a null allele in the mouse Krox-20 gene, which encodes a zinc-finger transcriptio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/371796a0
更新日期:1994-10-27 00:00:00
abstract::Long-term reconstitution of the lymphohaematopoietic cells of a mouse after lethal irradiation requires the transplantation of at least (5-10) x 10(3) bone marrow cells. Several cell-separation techniques based on cell-surface characteristics have been used in attempts to identify the pluripotent haematopoietic stem c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347188a0
更新日期:1990-09-13 00:00:00
abstract::Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the dele...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12618
更新日期:2013-11-14 00:00:00
abstract::Spin dynamics in antiferromagnets has much shorter timescales than in ferromagnets, offering attractive properties for potential applications in ultrafast devices1-3. However, spin-current generation via antiferromagnetic resonance and simultaneous electrical detection by the inverse spin Hall effect in heavy metals h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1950-4
更新日期:2020-02-01 00:00:00
abstract::Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. Dopam...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347080a0
更新日期:1990-09-06 00:00:00
abstract::Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, which in many models is generated by action potentials that propagate back from the soma into dendrites. However, local d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13664
更新日期:2014-11-06 00:00:00
abstract::Throughout the lifespan of a plant, which in some cases can last more than one thousand years, the stem cell niches in the root and shoot apical meristems provide cells for the formation of complete root and shoot systems, respectively. Both niches are superficially different and it has remained unclear whether common...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05703
更新日期:2007-04-12 00:00:00
abstract::The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323728a0
更新日期:1986-10-23 00:00:00
abstract::Activity in the motor cortex predicts movements, seconds before they are initiated. This preparatory activity has been observed across cortical layers, including in descending pyramidal tract neurons in layer 5. A key question is how preparatory activity is maintained without causing movement, and is ultimately conver...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0642-9
更新日期:2018-11-01 00:00:00
abstract::Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13995
更新日期:2015-01-08 00:00:00
abstract::Modern chitons (Mollusca: Polyplacophora) possess a highly conserved skeleton of eight shell plates (valves) surrounded by spicules or scales, and fossil evidence suggests that the chiton skeleton has changed little since the first appearance of the class in the Late Cambrian period (about 500 million years before pre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02548
更新日期:2004-05-20 00:00:00
abstract::Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/46045
更新日期:1999-11-11 00:00:00
abstract::Molecular spectroscopy offers opportunities for the exploration of the fundamental laws of nature and the search for new particle physics beyond the standard model1-4. Radioactive molecules-in which one or more of the atoms possesses a radioactive nucleus-can contain heavy and deformed nuclei, offering high sensitivit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2299-4
更新日期:2020-05-01 00:00:00
abstract::Mineralocorticoid secretion is predominantly controlled by the octapeptide angiotensin II, which exerts trophic actions on the adrenal glomerulosa and acute regulatory effects on aldosterone biosynthesis. The trophic actions include stimulation of angiotensin II receptors and enzymes of the aldosterone biosynthetic pa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289507a0
更新日期:1981-02-05 00:00:00