Abstract:
:Males and females share many traits that have a common genetic basis; however, selection on these traits often differs between the sexes, leading to sexual conflict. Under such sexual antagonism, theory predicts the evolution of genetic architectures that resolve this sexual conflict. Yet, despite intense theoretical and empirical interest, the specific loci underlying sexually antagonistic phenotypes have rarely been identified, limiting our understanding of how sexual conflict impacts genome evolution and the maintenance of genetic diversity. Here we identify a large effect locus controlling age at maturity in Atlantic salmon (Salmo salar), an important fitness trait in which selection favours earlier maturation in males than females, and show it is a clear example of sex-dependent dominance that reduces intralocus sexual conflict and maintains adaptive variation in wild populations. Using high-density single nucleotide polymorphism data across 57 wild populations and whole genome re-sequencing, we find that the vestigial-like family member 3 gene (VGLL3) exhibits sex-dependent dominance in salmon, promoting earlier and later maturation in males and females, respectively. VGLL3, an adiposity regulator associated with size and age at maturity in humans, explained 39% of phenotypic variation, an unexpectedly large proportion for what is usually considered a highly polygenic trait. Such large effects are predicted under balancing selection from either sexually antagonistic or spatially varying selection. Our results provide the first empirical example of dominance reversal allowing greater optimization of phenotypes within each sex, contributing to the resolution of sexual conflict in a major and widespread evolutionary trade-off between age and size at maturity. They also provide key empirical evidence for how variation in reproductive strategies can be maintained over large geographical scales. We anticipate these findings will have a substantial impact on population management in a range of harvested species where trends towards earlier maturation have been observed.
journal_name
Naturejournal_title
Natureauthors
Barson NJ,Aykanat T,Hindar K,Baranski M,Bolstad GH,Fiske P,Jacq C,Jensen AJ,Johnston SE,Karlsson S,Kent M,Moen T,Niemelä E,Nome T,Næsje TF,Orell P,Romakkaniemi A,Sægrov H,Urdal K,Erkinaro J,Lien S,Primmer CRdoi
10.1038/nature16062subject
Has Abstractpub_date
2015-12-17 00:00:00pages
405-8issue
7582eissn
0028-0836issn
1476-4687pii
nature16062journal_volume
528pub_type
杂志文章相关文献
NATURE文献大全abstract::Multiple sclerosis is thought to be an autoimmune disease of the central nervous system mediated by T cells specific for a myelin antigen. Myelin basic protein has been studied as a potential autoantigen in the disease because of its role as an encephalitogen in experimental autoimmune encephalomyelitis and post-viral...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346183a0
更新日期:1990-07-12 00:00:00
abstract::Early-life dietary transitions reflect fundamental aspects of primate evolution and are important determinants of health in contemporary human populations. Weaning is critical to developmental and reproductive rates; early weaning can have detrimental health effects but enables shorter inter-birth intervals, which inf...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature12169
更新日期:2013-06-13 00:00:00
abstract::Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature18624
更新日期:2016-07-21 00:00:00
abstract::In yeast and somatic cells, mechanisms ensure cell-cycle events are initiated only when preceding events have been completed. In contrast, interruption of specific cell-cycle processes in early embryonic cells of many organisms does not affect the timing of subsequent events, indicating that cell-cycle events are trig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/43927
更新日期:1999-09-23 00:00:00
abstract::The reversal or displacement of the retinal image by prism spectacles leads to extreme disruption of visually guided behaviour, but after an extended period of visual transformation normal behaviour is gradually restored. It is unclear whether this adaptation involves a change in visual perception, the learning of new...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/380523a0
更新日期:1996-04-11 00:00:00
abstract::Collagen fibrils have been extensively studied by electron microscopy, but only scant evidence has yet been obtained about their transverse structure. A transverse pediodicity of about 40 or 80 A might be expected if the microfibril model (until recently the common preference) is correct, but little direct evidence fo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288410a0
更新日期:1980-11-27 00:00:00
abstract::For unknown reasons, autoimmune diseases such as type 1 diabetes develop after prolonged periods of inflammation of mononuclear cells in target tissues. Here we show that progression of pancreatic islet inflammation to overt diabetes in nonobese diabetic (NOD) mice is driven by the 'avidity maturation' of a prevailing...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35021081
更新日期:2000-08-17 00:00:00
abstract::It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16544
更新日期:2016-02-25 00:00:00
abstract::The wavelength of light represents a fundamental technological barrier to the production of increasingly smaller features on integrated circuits. New technologies that allow the replication of patterns on scales less than 100 nm need to be developed if increases in computing power are to continue at the present rate. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35002540
更新日期:2000-02-24 00:00:00
abstract::Historical ecologists working in the Neotropics argue that the present natural environment is an historical product of human intentionality and ingenuity, a creation that is imposed, built, managed and maintained by the collective multigenerational knowledge and experience of Native Americans. In the past 12,000 years...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/35041555
更新日期:2000-11-09 00:00:00
abstract::Oxygen isotope analyses of Spondylus shells from neolithic sites suggest that the source for the shells used as ornaments in the Balkans and central Europe during the fourth millennium BC was the Aegean and not the Black Sea. The trade in Spondylus may have taken the form of an exchange of gifts. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/2281062a0
更新日期:1970-12-12 00:00:00
abstract::The Milankovitch theory states that global climate variability on orbital timescales from tens to hundreds of thousands of years is dominated by the summer insolation at high northern latitudes. The supporting evidence includes reconstructed air temperatures in Antarctica that are nearly in phase with boreal summer in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09825
更新日期:2011-03-03 00:00:00
abstract::The hydrosulphide ion (HS(-)) and its undissociated form, hydrogen sulphide (H(2)S), which are believed to have been critical to the origin of life on Earth, remain important in physiology and cellular signalling. As a major metabolite in anaerobic bacterial growth, hydrogen sulphide is a product of both assimilatory ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10881
更新日期:2012-03-11 00:00:00
abstract::Over the past eight hundred thousand years, glacial-interglacial cycles oscillated with a period of one hundred thousand years ('100k world'1). Ice core and ocean sediment data have shown that atmospheric carbon dioxide, Antarctic temperature, deep ocean temperature, and global ice volume correlated strongly with each...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1692-3
更新日期:2019-10-01 00:00:00
abstract::Light absorption by the visual pigment rhodopsin triggers, through G-protein coupling, a cascade of events in the outer segment of the rod cell of the vertebrate retina that results in membrane hyperpolarization and nerve excitation. Rhodopsin, which contains 348 amino acids, has seven helices that cross the disk memb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362770a0
更新日期:1993-04-22 00:00:00
abstract::The nucleosome subunit of chromatin consists of DNA folded around a histone core as a 1.8-turn left-handed solenoid. The crystal structure of the nucleosome core particle revealed that it has a dyad symmetry axis and that the minor helix groove faces outwards from the protein core. Richmond et al. noticed that the pat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328554a0
更新日期:1987-08-06 00:00:00
abstract::The observed number counts of high-redshift galaxy candidates have been used to build up a statistical description of star-forming activity at redshift z ≳ 7, when galaxies reionized the Universe. Standard models predict that a high incidence of gravitational lensing will probably distort measurements of flux and numb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09619
更新日期:2011-01-13 00:00:00
abstract::Mechanical milling is an effective technique for the preparation of fine metallic and ceramic powders and can also be used to drive a wide range of chemical reactions. Milling devices include planetary machines, attritors and vibrational mills; products include amorphous, nanocrystalline and quasicrystalline materials...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00985
更新日期:2002-09-12 00:00:00
abstract::Humans and other animals must often make decisions on the basis of imperfect evidence. Statisticians use measures such as P values to assign degrees of confidence to propositions, but little is known about how the brain computes confidence estimates about decisions. We explored this issue using behavioural analysis an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07200
更新日期:2008-09-11 00:00:00
abstract::The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07024
更新日期:2008-07-03 00:00:00
abstract::Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13995
更新日期:2015-01-08 00:00:00
abstract::It has been suggested, on the basis of modern hydrology and fully coupled palaeoclimate simulations, that the warm greenhouse conditions that characterized the early Palaeogene period (55-45 Myr ago) probably induced an intensified hydrological cycle with precipitation exceeding evaporation at high latitudes. Little f...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature04692
更新日期:2006-06-01 00:00:00
abstract::The Gulf Stream transports large amounts of heat from the tropics to middle and high latitudes, and thereby affects weather phenomena such as cyclogenesis and low cloud formation. But its climatic influence, on monthly and longer timescales, remains poorly understood. In particular, it is unclear how the warm current ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06690
更新日期:2008-03-13 00:00:00
abstract::Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T cells. However, it is not known which proteases are required for antigen processing. To investigate this, we e...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/25379
更新日期:1998-12-17 00:00:00
abstract::Applications are emerging that require the creation of fine-scale structures in three dimensions--examples include scaffolds for tissue engineering, micro-fluidic devices and photonic materials that control light propagation over a range of frequencies. But writing methods such as dip-pen nanolithography and ink-jet p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/428386a
更新日期:2004-03-25 00:00:00
abstract::Recent studies have suggested a critical role of specific gene loss in several embryonic tumours and certain adult cancers. In retinoblastoma, hemizygosity or homozygosity of a recessive mutant allele results in the loss of normal gene product, and this seems to cause the manifestation of the disorder. Familial polypo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/331273a0
更新日期:1988-01-21 00:00:00
abstract::The insulins of New World hystricomorph rodents exhibit many novel amino acid changes in primary structure when compared with other mammalian insulins. These changes give rise to unusual properties (low potency, failure to self-associate) not shared by other naturally-occurring insulins. We report here on the primary ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/286822a0
更新日期:1980-08-21 00:00:00
abstract::Bilingual individuals need effective mechanisms to prevent interference from one language while processing material in the other. Here we show, using event-related brain potentials and functional magnetic resonance imaging (fMRI), that words from the non-target language are rejected at an early stage before semantic a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/4151026a
更新日期:2002-02-28 00:00:00
abstract::Prostaglandins have wide-ranging effects in the body and are thought to be important mediators of inflammation. Cyclooxygenase (COX) plays a key regulatory role in prostaglandin synthesis, and occurs in both constitutive (COX-1) and inducible (COX-2) isoforms. COX-1 is thought to provide cytoprotective effects, wherea...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/378406a0
更新日期:1995-11-23 00:00:00
abstract::Because their molecular signatures are often prominent in extracts of sediments, bacteria are thought to be important contributors to petroleum source beds. It has been shown recently, however, that abundances of biomarkers do not always reflect relative contributions to sedimentary organic carbon (Corg). The contrib...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369224a0
更新日期:1994-05-19 00:00:00