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NATURE文献大全abstract::Pathfinding by growing axons in the developing nervous system is guided by diffusible or bound factors that attract or repel the axonal growth cone. The cytoplasmic signalling mechanisms that trigger the responses of the growth cone to guidance factors are mostly unknown. Previous studies have shown that the level and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/47507
更新日期:2000-01-06 00:00:00
abstract::Recent theory on sexual selection suggests that females in species without paternal care choose mates by their secondary sexual characters because these indicate genotypic quality which will be transmitted to the offspring. These ideas are not yet empirically supported as data quantifying the relationship between fema...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337166a0
更新日期:1989-01-12 00:00:00
abstract::Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 times more potent in this respect than prostaglandin E1. PGX contracted some gastrointestinal smooth muscle and relaxed certain isolated blood vess...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/263663a0
更新日期:1976-10-21 00:00:00
abstract::Bioluminescent symbioses range from facultative associations to highly adapted, apparently obligate ones. The family Anomalopidae (flashlight fishes) encompasses five genera of tropical reef fishes that have large suborbital light organs. The suborder Ceratioidei (deep-sea anglerfishes) contains 11 families. In nine o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/363154a0
更新日期:1993-05-13 00:00:00
abstract::A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic u...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337525a0
更新日期:1989-02-09 00:00:00
abstract::The cell adhesion molecules L1, N-CAM and Ng-CAM have been implicated in cell-cell interactions among developing neural cells. L1 and N-CAM are structurally and functionally distinct molecular entities and act synergistically in mediating Ca2+-independent adhesion between re-aggregating early postnatal cerebellar cell...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316728a0
更新日期:1985-08-22 00:00:00
abstract::Several discoveries of Late Devonian tetrapods (limbed vertebrates) have been made during the past two decades, but each has been confined to one locality. Here we describe a tetrapod jaw of about 365 million years (Myr) old from the Famennian of Belgium, which is the first from western continental Europe. The jaw clo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/427412a
更新日期:2004-01-29 00:00:00
abstract::Stable associations of more than one species of symbiont within a single host cell or tissue are assumed to be rare in metazoans because competition for space and resources between symbionts can be detrimental to the host. In animals with multiple endosymbionts, such as mussels from deep-sea hydrothermal vents and ree...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35077067
更新日期:2001-05-17 00:00:00
abstract::The genetic relationships of human populations have been studied by comparing gene frequency data for protein and blood-group loci of different populations. DNA analysis now promises to be more informative since not only do the DNA coding sequences have more variation than their corresponding proteins but, in addition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/319491a0
更新日期:1986-02-06 00:00:00
abstract::The variable (V) regions of heavy and light immunoglobulin chains are encoded by multiple germline DNA elements which are assembled into complete variable-region genes in precursor(pre-) B lymphocytes. The heavy-chain V region (VH) is assembled from three separate germline DNA elements, the variable (VH), diversity (D...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317353a0
更新日期:1985-09-26 00:00:00
abstract::The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as the normal epidermis and several non-malignant skin diseases. A similar increase in S phase duration seems to occur in tumours of the human oesophagus, larynx and recto-colon. At the molecular level, the overall ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285265a0
更新日期:1980-05-22 00:00:00
abstract::The M13 coat protein spans the Escherichia coli plasma membrane with its amino-terminus facing the periplasm. It is made as a precursor--the procoat--with a typical leader peptide. Mutations which destroy the basic character of the carboxy-terminal domain of procoat, a domain which is oriented towards the cytoplasm, b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322335a0
更新日期:1986-07-24 00:00:00
abstract::Earthquakes radiate from slip on discrete faults, but also commonly involve distributed deformation within a broader fault zone, especially near the surface. Variations in rock strain during an earthquake are caused by heterogeneity in the elastic stress before the earthquake, by variable material properties and geome...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07817
更新日期:2009-03-05 00:00:00
abstract::Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352431a0
更新日期:1991-08-01 00:00:00
abstract::The dehydration of subducting oceanic crust and upper mantle has been inferred both to promote the partial melting leading to arc magmatism and to induce intraslab intermediate-depth earthquakes, at depths of 50-300 km. Yet there is still no consensus about how slab hydration occurs or where and how much chemically bo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01961
更新日期:2003-09-25 00:00:00
abstract::Planetary aurorae are formed by energetic charged particles streaming along the planet's magnetic field lines into the upper atmosphere from the surrounding space environment. Earth's main auroral oval is formed through interactions with the solar wind, whereas that at Jupiter is formed through interactions with plasm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07077
更新日期:2008-06-19 00:00:00
abstract::AFTER exposure to secretagogues the small intestine changes from a tissue that absorbs fluid and electrolyte from lumen to blood into a tissue that secretes electrolyte and fluid into the lumen(1-4). It has been shown that this secretion results from an increase in the passive Cl(-) permeability of the mucosal border,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279446a0
更新日期:1979-05-31 00:00:00
abstract::More than twenty types of retinal ganglion cells conduct visual information from the eye to the rest of the brain. Each retinal ganglion cell type tessellates the retina in a regular mosaic, so that every point in visual space is processed for visual primitives such as contrast and motion. This information flows to tw...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14103
更新日期:2015-03-12 00:00:00
abstract::DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35037509
更新日期:2000-10-12 00:00:00
abstract::The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35097083
更新日期:2001-10-04 00:00:00
abstract::Mammalian sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis. Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345734a0
更新日期:1990-06-21 00:00:00
abstract::In the frog Xenopus, the somatic-type 5S ribosomal RNA genes are active in all cells; the oocyte-type 5S genes are active in oocytes but not in somatic cells. A new method of native gel electrophoresis resolves the two types of 5S RNA which are of the same length but different sequence. When somatic nuclei were inject...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289461a0
更新日期:1981-02-05 00:00:00
abstract::Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the Golgi apparatus. It is well established that the remodelling process is aided by specialized proteins that can sense as well...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05840
更新日期:2007-05-24 00:00:00
abstract::Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09058
更新日期:2010-07-22 00:00:00
abstract::It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16544
更新日期:2016-02-25 00:00:00
abstract::The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilonRI. Crosslinking of Fc epsilonRI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. The interaction of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018500
更新日期:2000-07-20 00:00:00
abstract::Angiosperms developed floral nectaries that reward pollinating insects. Although nectar function and composition have been characterized, the mechanism of nectar secretion has remained unclear. Here we identify SWEET9 as a nectary-specific sugar transporter in three eudicot species: Arabidopsis thaliana, Brassica rapa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13082
更新日期:2014-04-24 00:00:00
abstract::Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/387422a0
更新日期:1997-05-22 00:00:00
abstract::Temperature and fluid pressure conditions control rock deformation and mineralization on geological faults, and hence the distribution of earthquakes. Typical intraplate continental crust has hydrostatic fluid pressure and a near-surface thermal gradient of 31 ± 15 degrees Celsius per kilometre. At temperatures above ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22355
更新日期:2017-06-01 00:00:00
abstract::Recent advances in understanding the molecular basis of human X-linked muscular dystrophies have come from the identification of dystrophin, a cytoskeletal protein associated with the surface membrane. Although there is little or virtually no dystrophin in affected individuals, it is not known how this causes muscle d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344670a0
更新日期:1990-04-12 00:00:00