Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9.

abstract：:Past sea-level records provide invaluable information about the response of ice sheets to climate forcing. Some such records suggest that the last deglaciation was punctuated by a dramatic period of sea-level rise, of about 20 metres, in less than 500 years. Controversy about the amplitude and timing of this meltwater...

journal_title：Nature

authors： Deschamps P,Durand N,Bard E,Hamelin B,Camoin G,Thomas AL,Henderson GM,Okuno J,Yokoyama Y

更新日期：2012-03-28 00:00:00

abstract：:Over the last twenty years, there has been rapid growth of a new approach to understanding the evolution of organismic form. This evolutionary developmental biology, or 'evo-devo', is focused on the developmental genetic machinery that lies behind embryological phenotypes, which were all that could be studied in the p...

journal_title：Nature

authors： Arthur W

更新日期：2002-02-14 00:00:00

abstract：:Membrane-enclosed organelles, a defining characteristic of eukaryotic cells, are lost during differentiation of specific cell types such as reticulocytes (an intermediate in differentiation of erythrocytes), central fibre cells of the eye lens, and keratinocytes. The degradation of these organelles must be tightly reg...

journal_title：Nature

authors： van Leyen K,Duvoisin RM,Engelhardt H,Wiedmann M

更新日期：1998-09-24 00:00:00

abstract：:Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...

journal_title：Nature

authors： Seeholzer LF,Seppo M,Stern DL,Ruta V

更新日期：2018-07-01 00:00:00

abstract：:Carbon exchange between the terrestrial biosphere and the atmosphere is one of the key processes that need to be assessed in the context of the Kyoto Protocol. Several studies suggest that the terrestrial biosphere is gaining carbon, but these estimates are obtained primarily by indirect methods, and the factors that ...

journal_title：Nature

authors： Valentini R,Matteucci G,Dolman AJ,Schulze ED,Rebmann C,Moors EJ,Granier A,Gross P,Jensen NO,Pilegaard K,Lindroth A,Grelle A,Bernhofer C,Grünwald T,Aubinet M,Ceulemans R,Kowalski AS,Vesala T,Rannik U,Berbigier P,Lo

更新日期：2000-04-20 00:00:00

abstract：:A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer c...

journal_title：Nature

authors： Tavazoie SF,Alarcón C,Oskarsson T,Padua D,Wang Q,Bos PD,Gerald WL,Massagué J

更新日期：2008-01-10 00:00:00

abstract：:In vitro studies of muscle mitochondrial metabolism in patients with mitochondrial myopathy have identified a variety of functional defects of the mitochondrial respiratory chain, predominantly affecting complex I (NADH-CoQ reductase) or complex III (ubiquinol-cytochrome c reductase) in adult cases. These two enzymes ...

journal_title：Nature

authors： Holt IJ,Harding AE,Morgan-Hughes JA

更新日期：1988-02-25 00:00:00

abstract：:Haemophilia B (Christmas disease) is an inherited, recessive, sex-linked, haemorrhagic condition caused by a defect in the intrinsic clotting factor IX. This disease occurs in males at a frequency of approximately 1 in 30,000. Patients differ in the severity of their clinical symptoms, and variation in the clotting ac...

journal_title：Nature

authors： Rees DJ,Rizza CR,Brownlee GG

更新日期：1985-08-15 00:00:00

abstract：:Water striders Gerridae are insects of characteristic length 1 cm and weight 10 dynes that reside on the surface of ponds, rivers, and the open ocean. Their weight is supported by the surface tension force generated by curvature of the free surface, and they propel themselves by driving their central pair of hydrophob...

journal_title：Nature

authors： Hu DL,Chan B,Bush JW

更新日期：2003-08-07 00:00:00

abstract：:Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide constituent (relative molecular mass 4,200) of the deposits is derived from the beta-amyloid precursor protein (beta-APP) which is expressed in several different isoforms. The two most prevalent b...

journal_title：Nature

authors： Quon D,Wang Y,Catalano R,Scardina JM,Murakami K,Cordell B

更新日期：1991-07-18 00:00:00

abstract：:During endocytosis, clathrin and the clathrin adaptor protein AP-2, assisted by a variety of accessory factors, help to generate an invaginated bud at the cell membrane. One of these factors is Eps15, a clathrin-coat-associated protein that binds the alpha-adaptin subunit of AP-2. Here we investigate the function of E...

journal_title：Nature

authors： Chen H,Fre S,Slepnev VI,Capua MR,Takei K,Butler MH,Di Fiore PP,De Camilli P

更新日期：1998-08-20 00:00:00

abstract：:Vasopressin (VP) potentiates the effect of corticotropin-releasing factor (CRF) on the secretion of adrenocorticotropic hormone (ACTH) from anterior pituitary cells in vitro, and both CRF and VP have been found in portal blood. These data support the hypothesis that VP acts synergistically with CRF to cause the secret...

journal_title：Nature

authors： Whitnall MH,Mezey E,Gainer H

更新日期：1985-09-19 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...

journal_title：Nature

authors： Landweber LF,Gilbert W

更新日期：1993-05-13 00:00:00

abstract：:During platelet activation there is a major reorganization in the platelet cytoskeleton that accompanies a rapid change in platelet shape. Many of the events associated with activation are attributed to a rise in calcium concentration within the platelet cytoplasm. One direct consequence of the elevated calcium is the...

journal_title：Nature

authors： O'Halloran T,Beckerle MC,Burridge K

更新日期：1985-10-03 00:00:00

abstract：:The tyrosine phosphatase SHP2, encoded by PTPN11, is required for the survival, proliferation and differentiation of various cell types. Germline activating mutations in PTPN11 cause Noonan syndrome, whereas somatic PTPN11 mutations cause childhood myeloproliferative disease and contribute to some solid tumours. Recen...

journal_title：Nature

authors： Yang W,Wang J,Moore DC,Liang H,Dooner M,Wu Q,Terek R,Chen Q,Ehrlich MG,Quesenberry PJ,Neel BG

更新日期：2013-07-25 00:00:00

abstract：:Topological physics relies on the structure of the eigenstates of the Hamiltonians. The geometry of the eigenstates is encoded in the quantum geometric tensor1-comprising the Berry curvature2 (crucial for topological matter)3 and the quantum metric4, which defines the distance between the eigenstates. Knowledge of the...

journal_title：Nature

authors： Gianfrate A,Bleu O,Dominici L,Ardizzone V,De Giorgi M,Ballarini D,Lerario G,West KW,Pfeiffer LN,Solnyshkov DD,Sanvitto D,Malpuech G

更新日期：2020-02-01 00:00:00

abstract：:Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per a...

journal_title：Nature

authors： Marouli E,Graff M,Medina-Gomez C,Lo KS,Wood AR,Kjaer TR,Fine RS,Lu Y,Schurmann C,Highland HM,Rüeger S,Thorleifsson G,Justice AE,Lamparter D,Stirrups KE,Turcot V,Young KL,Winkler TW,Esko T,Karaderi T,Locke AE,Mas

更新日期：2017-02-09 00:00:00

abstract：:Large-conductance Ca(2+)-gated K(+) (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release. This group of channels can be activated synergistically by both voltage and intracellular Ca(2+), with the large carboxy-terminal intracellular portion being res...

journal_title：Nature

authors： Wu Y,Yang Y,Ye S,Jiang Y

更新日期：2010-07-15 00:00:00

abstract：:It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...

journal_title：Nature

authors： Cheour M,Martynova O,Näätänen R,Erkkola R,Sillanpää M,Kero P,Raz A,Kaipio ML,Hiltunen J,Aaltonen O,Savela J,Hämäläinen H

更新日期：2002-02-07 00:00:00

abstract：:The ATP-dependent chromatin assembly and remodelling factor (ACF) functions to generate regularly spaced nucleosomes, which are required for heritable gene silencing. The mechanism by which ACF mobilizes nucleosomes remains poorly understood. Here we report a single-molecule FRET study that monitors the remodelling of...

journal_title：Nature

authors： Blosser TR,Yang JG,Stone MD,Narlikar GJ,Zhuang X

更新日期：2009-12-24 00:00:00

abstract：:Why infer evolution when you can watch it happen in real time? This is the basic premise of using populations of fast-replicating microorganisms in test tubes to study evolution. The approach, known as experimental evolution, has provided a way of testing many of the key hypotheses that arose from the modern evolution...

journal_title：Nature

authors： Buckling A,Craig Maclean R,Brockhurst MA,Colegrave N

更新日期：2009-02-12 00:00:00

abstract：:We have shown previously that chemically skinned fibre bundles from scallop muscle can be desensitized to the action of calcium by the removal of the regulatory light chains of myosin and that sensitivity can be restored by the re-addition of scallop light chains. We have now confirmed these results and extended our o...

journal_title：Nature

authors： Simmons RM,Szent-Györgyi AG

更新日期：1980-08-07 00:00:00

abstract：:We have previously identified a structurally abnormal insulin in the serum and pancreas of a middle-aged man with diabetes mellitus which arose from a leucine for phenylalanine substitution at position 24 or 25 of the insulin B chain; further analysis of the patient's leukocyte DNA showed that one of the patient's ins...

journal_title：Nature

authors： Shoelson S,Haneda M,Blix P,Nanjo A,Sanke T,Inouye K,Steiner D,Rubenstein A,Tager H

更新日期：1983-04-07 00:00:00

abstract：:Phototransduction in invertebrate microvillar photoreceptors is thought to be mediated by the activation of phospholipase C (PLC), but how this leads to gating of the light-sensitive channels is unknown. Most attention has focused on inositol-1,4,5-trisphosphate, a second messenger produced by PLC from phosphatidylino...

journal_title：Nature

authors： Chyb S,Raghu P,Hardie RC

更新日期：1999-01-21 00:00:00

abstract：:Phylogenetic analysis of early tetrapod evolution has resulted in a consensus across diverse data sets in which the tetrapod stem group is a relatively homogenous collection of medium- to large-sized animals showing a progressive loss of 'fish' characters as they become increasingly terrestrial, whereas the crown grou...

journal_title：Nature

authors： Pardo JD,Szostakiwskyj M,Ahlberg PE,Anderson JS

更新日期：2017-06-29 00:00:00

abstract：:Replication of multipotential stem cells in long-term murine bone marrow cell culture is known to depend on the development of an adherent stromal cell layer. In these conditions, restricted haematopoietic progenitor cells have also been generated for up to several months1-3. However, maturation is observed only in th...

journal_title：Nature

authors： Wendling F,Shreeve MM,McLeod DL,Axelrad AA

更新日期：1983-10-13 00:00:00

abstract：:The Environmental Protection Agency is preparing to regulate the biotechnology industry, claiming authority under the provisions of the Federal Toxic Substances Control Act (TOSCA) and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). In the agency's view, the products of recombinant DNA techniques can...

journal_title：Nature

authors： Earl C

更新日期：1983-11-03 00:00:00

abstract：:A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates caspase-1 to process the proinflammatory cytokines interleukin (IL)-1beta and IL-18. The adaptor protein ASC is essential for inflammasome function, binding directly to caspase-1 (refs 3, 4)...

journal_title：Nature

authors： Mariathasan S,Weiss DS,Newton K,McBride J,O'Rourke K,Roose-Girma M,Lee WP,Weinrauch Y,Monack DM,Dixit VM

更新日期：2006-03-09 00:00:00

abstract：:Holliday junctions (HJs) are key intermediates in homologous recombination and are especially important for the production of crossover recombinants. Bacterial RecA family proteins promote the formation and branch migration of HJs in vitro by catalysing a reciprocal DNA-strand exchange reaction between two duplex DNA ...

journal_title：Nature

authors： Murayama Y,Kurokawa Y,Mayanagi K,Iwasaki H

更新日期：2008-02-21 00:00:00