Abstract：
:Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males but suppresses courtship in D. simulans males. Here we compare pheromone-processing pathways in D. melanogaster and D. simulans males to define how these sister species endow 7,11-heptacosadiene with the opposite behavioural valence to underlie species discrimination. We show that males of both species detect 7,11-heptacosadiene using homologous peripheral sensory neurons, but this signal is differentially propagated to P1 neurons, which control courtship behaviour. A change in the balance of excitation and inhibition onto courtship-promoting neurons transforms an excitatory pheromonal cue in D. melanogaster into an inhibitory cue in D. simulans. Our results reveal how species-specific pheromone responses can emerge from conservation of peripheral detection mechanisms and diversification of central circuitry, and demonstrate how flexible nodes in neural circuits can contribute to behavioural evolution.
journal_name
Naturejournal_title
Natureauthors
Seeholzer LF,Seppo M,Stern DL,Ruta Vdoi
10.1038/s41586-018-0322-9subject
Has Abstractpub_date
2018-07-01 00:00:00pages
564-569issue
7715eissn
0028-0836issn
1476-4687pii
10.1038/s41586-018-0322-9journal_volume
559pub_type
杂志文章相关文献
NATURE文献大全abstract：:Many planktonic organisms produce 'resting' stages when the environmental conditions deteriorate. Like seeds, resting stages can survive unfavourable conditions. The crustacean Daphnia normally reproduces by means of parthenogenetically produced normal, not resting, eggs-but occasionally switches to bisexual reproduct...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/414899a
更新日期：2001-12-20 00:00:00
abstract：:More than 99 per cent of the roughly 58,000 living vertebrate species have jaws. This major clade, whose members are collectively known as gnathostomes ('jawed mouths'), made its earliest definitive appearance in the Silurian period, 444-416 million years (Myr) ago, with both the origin of the modern (crown-group) rad...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature10207
更新日期：2011-07-06 00:00:00
abstract：:The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional in vitro human distal lung culture systems would strongly facilitate the investigation of pathologies such as interstitial lung disease, cancer and coronavirus disease 2019 (COVID-19) pneumonia caused by severe ac...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-3014-1
更新日期：2020-12-01 00:00:00
abstract：:The 37-amino-acid calcitonin gene-related peptide (CGRP) occurs as a result of alternative processing of mRNA from the calcitonin gene. The potency of CGRP as a vasodilator and the occurrence of the peptide in nerves associated with blood vessels suggest an important role for CGRP in the regulation of blood flow. The ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/335073a0
更新日期：1988-09-01 00:00:00
abstract：:Animal viruses are broadly categorized structurally by the presence or absence of an envelope composed of a lipid-bilayer membrane, attributes that profoundly affect stability, transmission and immune recognition. Among those lacking an envelope, the Picornaviridae are a large and diverse family of positive-strand RNA...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12029
更新日期：2013-04-18 00:00:00
abstract：:The midbrain region periaqueductal grey (PAG) is rich in opioid receptors and endogenous opioids and is a major target of analgesic action in the central nervous system. It has been proposed that the analgesic effect of opioids on the PAG works by suppressing the inhibitory influence of the neurotransmitter GABA (gamm...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/37610
更新日期：1997-12-11 00:00:00
abstract：:The IKKalpha and IKKbeta catalytic subunits of IkappaB kinase (IKK) share 51% amino-acid identity and similar biochemical activities: they both phosphorylate IkappaB proteins at serines that trigger their degradation. IKKalpha and IKKbeta differ, however, in their physiological functions. IKKbeta and the IKKgamma/NEMO...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35070605
更新日期：2001-04-05 00:00:00
abstract：:The human alpha-interferon (IFN-alpha) gene family consists of at least 14 potentially functional non-allelic members; the amino acid sequences they encode differ from each other by up to approximately 20% of their residues. Human IFN-beta, which is encoded by a single gene, is distantly related to the IFN-alpha famil...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/313698a0
更新日期：1985-02-21 00:00:00
abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/337709a0
更新日期：1989-02-23 00:00:00
abstract：:Neurons develop a highly polarized morphology consisting of dendrites and a long axon. Both axons and dendrites contain microtubules and microtubule-associated proteins (MAPs) with characteristic structures. Among MAPs, MAP2 is specifically expressed in dendrites whereas MAP2C and tau are abundant in the axon. But the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/360674a0
更新日期：1992-12-17 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 新闻
doi：10.1038/d41586-018-07324-x
更新日期：2018-11-01 00:00:00
abstract：:Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression. Angiostatin, a proteolytic fragment of plasminogen that was first isolated from the serum and urine of tumour-bearing mice, inhibits angiogenesis and thereby growth of primary and metastatic tumours. Radiothe...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/28412
更新日期：1998-07-16 00:00:00
abstract：:Blood vessel growth in the skeletal system and osteogenesis seem to be coupled, suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells. Understanding the nature of the mechanisms linking angiogenesis and bone formation should be of great relevance for improved fracture healing or pr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13146
更新日期：2014-03-20 00:00:00
abstract：:Recognition of self-antigen-derived epitopes presented by major histocompatibility complex class II (MHC II) molecules on thymic epithelial cells (TECs) is critical for the generation of a functional and self-tolerant CD4 T-cell repertoire. Whereas haematopoietic antigen-presenting cells generate MHC-II-peptide comple...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07208
更新日期：2008-09-18 00:00:00
abstract：:The Suzuki-Miyaura cross-coupling of organoboron nucleophiles with aryl halide electrophiles is one of the most widely used carbon-carbon bond-forming reactions in organic and medicinal chemistry1,2. A key challenge associated with these transformations is that they generally require the addition of an exogenous base,...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0628-7
更新日期：2018-11-01 00:00:00
abstract：:A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer c...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature06487
更新日期：2008-01-10 00:00:00
abstract：:Support-free high-speed countercurrent liquid chromatography provides a rich domain of applications, some beyond reach of conventional liquid chromatography. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/326419a0
更新日期：1987-03-26 00:00:00
abstract：:The assessment of uncertainties in global warming projections is often based on expert judgement, because a number of key variables in climate change are poorly quantified. In particular, the sensitivity of climate to changing greenhouse-gas concentrations in the atmosphere and the radiative forcing effects by aerosol...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/416719a
更新日期：2002-04-18 00:00:00
abstract：:The primary action of a family of mitogens including bombesin, bradykinin, vasopressin and alpha-thrombin is to activate the hydrolysis of polyphosphoinositides. Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phospholipase C is mediated through coupling of surface receptors to a GTP-binding pro...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/326800a0
更新日期：1987-04-23 00:00:00
abstract：:The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper-proliferative cells. Here we explore the contribution of the mechanical pressure exerted by tumour growth onto non-tumorous adjacent epithelium. In t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14329
更新日期：2015-07-02 00:00:00
abstract：:High-pressure transitions are thought to modify hydrogen molecules to a molecular metallic solid and finally to an atomic metal1, which is predicted to have exotic physical properties and the topology of a two-component (electron and proton) superconducting superfluid condensate2,3. Therefore, understanding such trans...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-019-1565-9
更新日期：2019-09-01 00:00:00
abstract：:The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05042
更新日期：2006-08-24 00:00:00
abstract：:Suppressor of cytokine signalling-2 (SOCS-2) is a member of the suppressor of cytokine signalling family, a group of related proteins implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) signal transducers and activators of transcription (STAT) signal-transduction pathw...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35016611
更新日期：2000-06-29 00:00:00
abstract：:Electric-field-induced charge separation (polarization) is the most fundamental manifestation of the interaction of light with matter and a phenomenon of great technological relevance. Nonlinear optical polarization produces coherent radiation in spectral ranges inaccessible by lasers and constitutes the key to ultima...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature17650
更新日期：2016-06-02 00:00:00
abstract：:The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/349717a0
更新日期：1991-02-21 00:00:00
abstract：:Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring abou...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09529
更新日期：2010-11-11 00:00:00
abstract：:In 1928, Dirac published an equation 1 that combined quantum mechanics and special relativity. Negative-energy solutions to this equation, rather than being unphysical as initially thought, represented a class of hitherto unobserved and unimagined particles-antimatter. The existence of particles of antimatter was conf...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-018-0017-2
更新日期：2018-05-01 00:00:00
abstract：:The human gene for the hepatic enzyme phenylalanine hydroxylase has been cloned and used to analyse the phenylalanine hydroxylase locus in the human genome. The detection of polymorphisms in this locus by several restriction enzymes has allowed feasibility studies of prenatal diagnosis of classical phenylketonuria and...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/306151a0
更新日期：1983-11-10 00:00:00
abstract：:The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium, and the ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature20173
更新日期：2017-01-12 00:00:00
abstract：:This corrects the article DOI: 10.1038/nature24295. ...
journal_title：Nature
pub_type： 杂志文章,已发布勘误
doi：10.1038/nature25017
更新日期：2018-01-25 00:00:00
