Abstract：
:Proteolysis is essential for the execution of many cellular functions. These include removal of incorrectly folded or damaged proteins, the activation of transcription factors, the ordered degradation of proteins involved in cell cycle control, and the generation of peptides destined for presentation by class I molecules of the major histocompatibility complex. A multisubunit protease complex, the proteasome, accomplishes these tasks. Here we show that in mammalian cells inactivation of the proteasome by covalent inhibitors allows the outgrowth of inhibitor-resistant cells. The growth of such adapted cells is apparently maintained by the induction of other proteolytic systems that compensate for the loss of proteasomal activity.
journal_name
Naturejournal_title
Natureauthors
Glas R,Bogyo M,McMaster JS,Gaczynska M,Ploegh HLdoi
10.1038/33443subject
Has Abstractpub_date
1998-04-09 00:00:00pages
618-22issue
6676eissn
0028-0836issn
1476-4687journal_volume
392pub_type
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