Gravitationally redshifted absorption lines in the X-ray burst spectra of a neutron star.

abstract：:Measuring the completeness of the fossil record is essential to understanding evolution over long timescales, particularly when comparing evolutionary patterns among biological groups with different preservational properties. Completeness measures have been presented for various groups based on gaps in the stratigraph...

journal_title：Nature

authors： Foote M,Sepkoski JJ Jr

更新日期：1999-04-01 00:00:00

abstract：:The spider mite Tetranychus urticae is a cosmopolitan agricultural pest with an extensive host plant range and an extreme record of pesticide resistance. Here we present the completely sequenced and annotated spider mite genome, representing the first complete chelicerate genome. At 90 megabases T. urticae has the sma...

journal_title：Nature

authors： Grbić M,Van Leeuwen T,Clark RM,Rombauts S,Rouzé P,Grbić V,Osborne EJ,Dermauw W,Ngoc PC,Ortego F,Hernández-Crespo P,Diaz I,Martinez M,Navajas M,Sucena É,Magalhães S,Nagy L,Pace RM,Djuranović S,Smagghe G,Iga M,Chr

更新日期：2011-11-23 00:00:00

abstract：:The current picture of galaxy evolution advocates co-evolution of galaxies and their nuclear massive black holes, through accretion and galactic merging. Pairs of quasars, each with a massive black hole at the centre of its galaxy, have separations of 6,000 to 300,000 light years (refs 2 and 3; 1 parsec = 3.26 light y...

journal_title：Nature

authors： Fabbiano G,Wang J,Elvis M,Risaliti G

更新日期：2011-08-31 00:00:00

abstract：:SEVERAL dioecious marine brown algae have been valuable in studying chemical communication during sexual reproduction. For example, female gametes of Ectocarpus siliculosus, Cutleria multifida and Fucus serratus secrete olefinic hydrocarbons into the seawater to attract male gametes(1-3). A more complex system is foun...

journal_title：Nature

authors： Müller DG,Gassmann G,Lüning K

更新日期：1979-05-31 00:00:00

abstract：:Alphabeta T lymphocytes are able to detect even a single peptide-major histocompatibility complex (MHC) on the surface of an antigen-presenting cell. This is despite clear evidence, at least with CD4+ T cells, that monomeric ligands are not stimulatory. In an effort to understand how this remarkable sensitivity is ach...

journal_title：Nature

authors： Krogsgaard M,Li QJ,Sumen C,Huppa JB,Huse M,Davis MM

更新日期：2005-03-10 00:00:00

abstract：:The sense of smell is highly evolved in mammals, allowing discrimination between a vast number of odorants, with detection thresholds as low as 10(-17) M (ref. 1). Although several features of mammalian olfactory transduction have been revealed by biochemical and molecular biological studies, the odorant-induced membr...

journal_title：Nature

authors： Lowe G,Gold GH

更新日期：1993-11-18 00:00:00

abstract：:Chemokines are chemotactic cytokines that activate and direct the migration of leukocytes. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1) is a highly efficacious lymphocyte chemoattractant. Chemokines act on responsive leukocyte ...

journal_title：Nature

authors： Bleul CC,Farzan M,Choe H,Parolin C,Clark-Lewis I,Sodroski J,Springer TA

更新日期：1996-08-29 00:00:00

abstract：:An optimal search theory, the so-called Lévy-flight foraging hypothesis, predicts that predators should adopt search strategies known as Lévy flights where prey is sparse and distributed unpredictably, but that Brownian movement is sufficiently efficient for locating abundant prey. Empirical studies have generated con...

journal_title：Nature

authors： Humphries NE,Queiroz N,Dyer JR,Pade NG,Musyl MK,Schaefer KM,Fuller DW,Brunnschweiler JM,Doyle TK,Houghton JD,Hays GC,Jones CS,Noble LR,Wearmouth VJ,Southall EJ,Sims DW

更新日期：2010-06-24 00:00:00

abstract：:Melting processes in the deep mantle have important implications for the origin of the deep-derived plumes believed to feed hotspot volcanoes such as those in Hawaii. They also provide insight into how the mantle has evolved, geochemically and dynamically, since the formation of Earth. Melt production in the shallow m...

journal_title：Nature

authors： Andrault D,Petitgirard S,Lo Nigro G,Devidal JL,Veronesi G,Garbarino G,Mezouar M

更新日期：2012-07-18 00:00:00

abstract：:Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with ≥50% of tumours expressing the BRAF(V600E) oncoprotein. Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemurafenib demonstrates the ess...

journal_title：Nature

authors： Das Thakur M,Salangsang F,Landman AS,Sellers WR,Pryer NK,Levesque MP,Dummer R,McMahon M,Stuart DD

更新日期：2013-02-14 00:00:00

abstract：:Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their s...

journal_title：Nature

authors： Correa-Gallegos D,Jiang D,Christ S,Ramesh P,Ye H,Wannemacher J,Kalgudde Gopal S,Yu Q,Aichler M,Walch A,Mirastschijski U,Volz T,Rinkevich Y

更新日期：2019-12-01 00:00:00

abstract：:Inhibin is a hypophysiotropic hormone which selectively suppresses the secretion of pituitary follicle-stimulating hormone. It has been isolated from gonadal fluids and characterized as a protein heterodimer consisting of an alpha subunit and one of two beta subunits (beta A or beta B). FSH-releasing protein (FRP), al...

journal_title：Nature

authors： Yu J,Shao LE,Lemas V,Yu AL,Vaughan J,Rivier J,Vale W

更新日期：1987-12-24 00:00:00

abstract：:Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...

journal_title：Nature

authors： de Godoy LM,Olsen JV,Cox J,Nielsen ML,Hubner NC,Fröhlich F,Walther TC,Mann M

更新日期：2008-10-30 00:00:00

abstract：:As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture underlying this regulation is critical for understanding cellular signalling events and responses to environmental cues. Using random mutagenesis in haploid human...

journal_title：Nature

authors： Brockmann M,Blomen VA,Nieuwenhuis J,Stickel E,Raaben M,Bleijerveld OB,Altelaar AFM,Jae LT,Brummelkamp TR

更新日期：2017-06-08 00:00:00

abstract：:The spectral purity of an oscillator is central to many applications, such as detecting gravity waves, defining the second, ground-state cooling and quantum manipulation of nanomechanical objects, and quantum computation. Recent proposals suggest that laser oscillators which use very narrow optical transitions in atom...

journal_title：Nature

authors： Bohnet JG,Chen Z,Weiner JM,Meiser D,Holland MJ,Thompson JK

更新日期：2012-04-04 00:00:00

abstract：:CRISPR-Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications1-6 but identifying unwanted off-target mutations is important for clinical translation7. A well-validated method that can reliably identify off-targets in vivo has not been described to date, which means it is cu...

journal_title：Nature

authors： Akcakaya P,Bobbin ML,Guo JA,Malagon-Lopez J,Clement K,Garcia SP,Fellows MD,Porritt MJ,Firth MA,Carreras A,Baccega T,Seeliger F,Bjursell M,Tsai SQ,Nguyen NT,Nitsch R,Mayr LM,Pinello L,Bohlooly-Y M,Aryee MJ,Maresca

更新日期：2018-09-01 00:00:00

abstract：:Features that were once considered exclusive to modern birds, such as feathers and a furcula, are now known to have first appeared in non-avian dinosaurs. However, relatively little is known of the early evolutionary history of the hyperinflated brain that distinguishes birds from other living reptiles and provides th...

journal_title：Nature

authors： Balanoff AM,Bever GS,Rowe TB,Norell MA

更新日期：2013-09-05 00:00:00

abstract：:T lymphocytes of the alpha/beta T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical and medullary thymic stroma cells. In parallel, interactions of the ...

journal_title：Nature

authors： Holländer GA,Wang B,Nichogiannopoulou A,Platenburg PP,van Ewijk W,Burakoff SJ,Gutierrez-Ramos JC,Terhorst C

更新日期：1995-01-26 00:00:00

abstract：:Mitochondria take up and extrude various inorganic and organic ions, as well as larger substances such as proteins. The technique of patch clamping should provide real-time information on such transport and on energy transduction in oxidative phosphorylation. It has been applied to detect microscopic currents from mit...

journal_title：Nature

authors： Inoue I,Nagase H,Kishi K,Higuti T

更新日期：1991-07-18 00:00:00

abstract：:We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness...

journal_title：Nature

authors： Le Chatelier E,Nielsen T,Qin J,Prifti E,Hildebrand F,Falony G,Almeida M,Arumugam M,Batto JM,Kennedy S,Leonard P,Li J,Burgdorf K,Grarup N,Jørgensen T,Brandslund I,Nielsen HB,Juncker AS,Bertalan M,Levenez F,Pons N,

更新日期：2013-08-29 00:00:00

abstract：:Leks have traditionally been considered as arenas where males compete to attract females and secure matings. Thus, direct fitness benefits mediated through competition between males to fertilize females have been considered to be the primary force driving the evolution of lekking behaviour. Inclusive fitness benefits ...

journal_title：Nature

authors： Shorey L,Piertney S,Stone J,Höglund J

更新日期：2000-11-16 00:00:00

abstract：:Below water depths of about 300 metres, pressure and temperature conditions cause methane to form ice-like crystals of methane hydrate. Marine deposits of methane hydrate are estimated to be large, amassing about 10,000 gigatonnes of carbon, and are thought to be important to global change and seafloor stability, as w...

journal_title：Nature

authors： Wood WT,Gettrust JF,Chapman NR,Spence GD,Hyndman RD

更新日期：2002-12-12 00:00:00

abstract：:Learning through trial-and-error interactions allows animals to adapt innate behavioural ‘rules of thumb’ to the local environment, improving their prospects for survival and reproduction. Naive Drosophila melanogaster males, for example, court both virgin and mated females, but learn through experience to selectively...

journal_title：Nature

authors： Keleman K,Vrontou E,Krüttner S,Yu JY,Kurtovic-Kozaric A,Dickson BJ

更新日期：2012-09-06 00:00:00

abstract：:(S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin. Enzymes of this class typically catalyse oxygenation reactions that proceed via the formation of substrate radic...

journal_title：Nature

authors： Chang WC,Dey M,Liu P,Mansoorabadi SO,Moon SJ,Zhao ZK,Drennan CL,Liu HW

更新日期：2013-04-04 00:00:00

abstract：:The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...

journal_title：Nature

authors： Reymond CD,Gomer RH,Nellen W,Theibert A,Devreotes P,Firtel RA

更新日期：1986-09-25 00:00:00

abstract：:DNA-binding repressor proteins mediate regulation of yeast genes by cell type (Mcm1/alpha 2 and a1/alpha 2), glucose (Mig1) and oxygen (Rox1) (refs 1-4 respectively). An unusual feature of all these regulatory pathways is that transcriptional repression requires two physically associated proteins that do not bind DNA ...

journal_title：Nature

authors： Tzamarias D,Struhl K

更新日期：1994-06-30 00:00:00

abstract：:The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a ...

journal_title：Nature

authors： Reijns MAM,Kemp H,Ding J,de Procé SM,Jackson AP,Taylor MS

更新日期：2015-02-26 00:00:00

abstract：:Genetic-environmental interactions probably underlie spontaneous human autoimmune disorders, a category of complex traits thought to include multiple sclerosis (MS). The geographical distribution and familial aggregation of this disease have often been ascribed to the role of infectious agents, but there is no consens...

journal_title：Nature

authors： Ebers GC,Sadovnick AD,Risch NJ

更新日期：1995-09-14 00:00:00

abstract：:The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an i...

journal_title：Nature

authors： Khaminets A,Heinrich T,Mari M,Grumati P,Huebner AK,Akutsu M,Liebmann L,Stolz A,Nietzsche S,Koch N,Mauthe M,Katona I,Qualmann B,Weis J,Reggiori F,Kurth I,Hübner CA,Dikic I

更新日期：2015-06-18 00:00:00

abstract：:A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has been used to treat post-traumatic stress disorder. However, the neural basis that underlies the long-lasting effect of this treatment-described as eye movement desensitization and reprocessing-has not been identified. Here we des...

journal_title：Nature

authors： Baek J,Lee S,Cho T,Kim SW,Kim M,Yoon Y,Kim KK,Byun J,Kim SJ,Jeong J,Shin HS

更新日期：2019-02-01 00:00:00