Molecular cloning of Drosophila TFIID subunits.

abstract：:Tracing the transient atomic motions that lie at the heart of chemical reactions requires high-resolution multidimensional structural information on the timescale of molecular vibrations, which commonly range from 10 fs to 1 ps. For simple chemical systems, it has been possible to map out in considerable detail the re...

journal_title：Nature

authors： Fang C,Frontiera RR,Tran R,Mathies RA

更新日期：2009-11-12 00:00:00

abstract：:Muscle force is generated by myosin crossbridges interacting with actin. As estimated from stiffness and equatorial X-ray diffraction of muscle and muscle fibres, most myosin crossbridges are attached to actin during isometric contraction, but a much smaller fraction is bound stereospecifically. To determine the fract...

journal_title：Nature

authors： Bershitsky SY,Tsaturyan AK,Bershitskaya ON,Mashanov GI,Brown P,Burns R,Ferenczi MA

更新日期：1997-07-10 00:00:00

abstract：:The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization ...

journal_title：Nature

authors： Pellegrini L,Tan S,Richmond TJ

更新日期：1995-08-10 00:00:00

abstract：:The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of the...

journal_title：Nature

authors： Gidoni D,Dynan WS,Tjian R

更新日期：1984-11-29 00:00:00

abstract：:Human activities are causing Earth's sixth major extinction event-an accelerating decline of the world's stocks of biological diversity at rates 100 to 1,000 times pre-human levels. Historically, low-impact intrusion into species habitats arose from local demands for food, fuel and living space. However, in today's in...

journal_title：Nature

authors： Lenzen M,Moran D,Kanemoto K,Foran B,Lobefaro L,Geschke A

更新日期：2012-06-06 00:00:00

abstract：:In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and ...

journal_title：Nature

authors： Andersen TG,Naseer S,Ursache R,Wybouw B,Smet W,De Rybel B,Vermeer JEM,Geldner N

更新日期：2018-07-01 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) into enucleated oocytes has emerged as a technique that can be used to derive mouse embryonic stem cell lines with defined genotypes. In this issue Byrne et al. report the derivation of two SCNT Rhesus macaca male stem cell lines designated CRES-1 and CRES-2. Molecular studies deta...

journal_title：Nature

authors： Cram DS,Song B,Trounson AO

更新日期：2007-11-22 00:00:00

abstract：:Coordinated cell migration is essential in many fundamental biological processes including embryonic development, organogenesis, wound healing and the immune response. During organogenesis, groups of cells are directed to specific locations within the embryo. Here we show that the zebrafish miles apart (mil) mutation ...

journal_title：Nature

authors： Kupperman E,An S,Osborne N,Waldron S,Stainier DY

更新日期：2000-07-13 00:00:00

abstract：:Neuronal dendrites are electrically excitable: they can generate regenerative events such as dendritic spikes in response to sufficiently strong synaptic input. Although such events have been observed in many neuronal types, it is not well understood how active dendrites contribute to the tuning of neuronal output in ...

journal_title：Nature

authors： Smith SL,Smith IT,Branco T,Häusser M

更新日期：2013-11-07 00:00:00

abstract：:High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population hi...

journal_title：Nature

authors： Pagani L,Lawson DJ,Jagoda E,Mörseburg A,Eriksson A,Mitt M,Clemente F,Hudjashov G,DeGiorgio M,Saag L,Wall JD,Cardona A,Mägi R,Wilson Sayres MA,Kaewert S,Inchley C,Scheib CL,Järve M,Karmin M,Jacobs GS,Antao T,Ilie

更新日期：2016-10-13 00:00:00

abstract：:The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T...

journal_title：Nature

authors： Watkins DI,Chen ZW,Hughes AL,Evans MG,Tedder TF,Letvin NL

更新日期：1990-07-05 00:00:00

abstract：:A magnetic field penetrates a superconductor through an array of 'vortices', each of which carries one quantum of flux that is surrounded by a circulating supercurrent. In this vortex state, the resistivity is determined by the dynamical properties of the vortex 'matter'. For the high-temperature copper oxide supercon...

journal_title：Nature

authors： Bouquet F,Marcenat C,Steep E,Calemczuk R,Kwok WK,Welp U,Crabtree GW,Fisher RA,Phillips NE,Schilling A

更新日期：2001-05-24 00:00:00

abstract：:Class-V myosin proceeds along actin filaments with large ( approximately 36 nm) steps. Myosin-V has two heads, each of which consists of a motor domain and a long (23 nm) neck domain. In accordance with the widely accepted lever-arm model, it was suggested that myosin-V steps to successive (36 nm) target zones along t...

journal_title：Nature

authors： Tanaka H,Homma K,Iwane AH,Katayama E,Ikebe R,Saito J,Yanagida T,Ikebe M

更新日期：2002-01-10 00:00:00

abstract：:Granular superconductivity occurs when microscopic superconducting grains are separated by non-superconducting regions; Josephson tunnelling between the grains establishes the macroscopic superconducting state. Although crystals of the copper oxide high-transition-temperature (high-Tc) superconductors are not granular...

journal_title：Nature

authors： Lang KM,Madhavan V,Hoffman JE,Hudson EW,Eisaki H,Uchida S,Davis JC

更新日期：2002-01-24 00:00:00

abstract：:Change history: In this Letter, the final two pages of the Supplementary Information, which included two tables listing primer and antibodies, respectively, were missing; see accompanying Amendment for the missing Supplementary Tables. This Letter has not been corrected online. ...

journal_title：Nature

authors： Wculek SK,Malanchi I

更新日期：2019-07-01 00:00:00

abstract：:Sea ice and dust flux increased greatly in the Southern Ocean during the last glacial period. Palaeorecords provide contradictory evidence about marine productivity in this region, but beyond one glacial cycle, data were sparse. Here we present continuous chemical proxy data spanning the last eight glacial cycles (740...

journal_title：Nature

authors： Wolff EW,Fischer H,Fundel F,Ruth U,Twarloh B,Littot GC,Mulvaney R,Röthlisberger R,de Angelis M,Boutron CF,Hansson M,Jonsell U,Hutterli MA,Lambert F,Kaufmann P,Stauffer B,Stocker TF,Steffensen JP,Bigler M,Siggaard-An

更新日期：2006-03-23 00:00:00

abstract：:Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isola...

journal_title：Nature

authors： Liao HX,Lynch R,Zhou T,Gao F,Alam SM,Boyd SD,Fire AZ,Roskin KM,Schramm CA,Zhang Z,Zhu J,Shapiro L,NISC Comparative Sequencing Program.,Mullikin JC,Gnanakaran S,Hraber P,Wiehe K,Kelsoe G,Yang G,Xia SM,Montefiori DC

更新日期：2013-04-25 00:00:00

abstract：:Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...

journal_title：Nature

authors： Rausher MD

更新日期：2001-06-14 00:00:00

abstract：:We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (10(2)-10(120)) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following ...

journal_title：Nature

authors： Hirst SJ,Hayes NA,Burridge J,Pearce FL,Foreman JC

更新日期：1993-12-09 00:00:00

abstract：:Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein p53 (also known as TP53) influences a range of cellular metabolic processes, including glycolysis, oxidative phosphorylation, glutamino...

journal_title：Nature

authors： Maddocks OD,Berkers CR,Mason SM,Zheng L,Blyth K,Gottlieb E,Vousden KH

更新日期：2013-01-24 00:00:00

abstract：:Quasicrystals are unique structures with long-range order but no periodicity. Their properties have intrigued scientists ever since their discovery and initial theoretical analysis. The lack of periodicity excludes the possibility of describing quasicrystal structures with well-established analytical tools, including ...

journal_title：Nature

authors： Freedman B,Bartal G,Segev M,Lifshitz R,Christodoulides DN,Fleischer JW

更新日期：2006-04-27 00:00:00

abstract：:Homopyrimidine oligonucleotides bind to homopurine-homopyrimidine sequences of duplex DNA forming a local triple helix. This binding can be demonstrated either directly by a footprinting technique, gel assays, or indirectly by inducing irreversible reactions in the target sequence, such as photocrosslinking or cleavag...

journal_title：Nature

authors： Perrouault L,Asseline U,Rivalle C,Thuong NT,Bisagni E,Giovannangeli C,Le Doan T,Hélène C

更新日期：1990-03-22 00:00:00

abstract：:The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need...

journal_title：Nature

authors： Pääbo S

更新日期：2003-01-23 00:00:00

abstract：:In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferato...

journal_title：Nature

authors： Kersten S,Desvergne B,Wahli W

更新日期：2000-05-25 00:00:00

abstract：:The largest products of magmatic activity on Earth, the great bodies of granite and their corresponding large eruptions, have a dual nature: homogeneity at the large scale and spatial and temporal heterogeneity at the small scale. This duality calls for a mechanism that selectively removes the large-scale heterogeneit...

journal_title：Nature

authors： Burgisser A,Bergantz GW

更新日期：2011-03-10 00:00:00

abstract：:In the Northern Hemisphere, ozone levels in the troposphere have increased by 35 per cent over the past century, with detrimental impacts on forest and agricultural productivity, even when forest productivity has been stimulated by increased carbon dioxide levels. In addition to reducing productivity, increased tropos...

journal_title：Nature

authors： Loya WM,Pregitzer KS,Karberg NJ,King JS,Giardina CP

更新日期：2003-10-16 00:00:00

abstract：:The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a mo...

journal_title：Nature

authors： Marinari E,Mehonic A,Curran S,Gale J,Duke T,Baum B

更新日期：2012-04-15 00:00:00

abstract：:The extreme resistance of bacterial endospores to heat may result from dehydration of the central protoplast brought about and maintained by osmotic activity of expanded electronegative peptidoglycan polymer, and positively charged counterions associated with it, in the surrounding cortex. The cortex may thus act as a...

journal_title：Nature

authors： Gould GW,Dring GJ

更新日期：1975-12-04 00:00:00

abstract：:In the adult brain, new synapses are formed and pre-existing ones are lost, but the function of this structural plasticity has remained unclear. Learning of new skills is correlated with formation of new synapses. These may directly encode new memories, but they may also have more general roles in memory encoding and ...

journal_title：Nature

authors： Ruediger S,Vittori C,Bednarek E,Genoud C,Strata P,Sacchetti B,Caroni P

更新日期：2011-05-26 00:00:00

abstract：:In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...

journal_title：Nature

authors： Payre F,Vincent A,Carreno S

更新日期：1999-07-15 00:00:00