Regulation of lifespan by sensory perception in Caenorhabditis elegans.

abstract：:It has long been known that the 5' to 3' polarity of DNA synthesis results in both a leading and lagging strand at all replication forks. Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escheric...

journal_title：Nature

authors： White MA,Eykelenboom JK,Lopez-Vernaza MA,Wilson E,Leach DR

更新日期：2008-10-30 00:00:00

abstract：:High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...

journal_title：Nature

authors： Scaffidi P,Misteli T,Bianchi ME

更新日期：2002-07-11 00:00:00

abstract：:Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of death due to disease in young people, but the biological determinants of treatment failure remain poorly understood. Recent genome-wide profiling of structural DNA alterations in ALL have identified multiple submicroscopic somatic mutations targeting k...

journal_title：Nature

authors： Mullighan CG,Zhang J,Kasper LH,Lerach S,Payne-Turner D,Phillips LA,Heatley SL,Holmfeldt L,Collins-Underwood JR,Ma J,Buetow KH,Pui CH,Baker SD,Brindle PK,Downing JR

更新日期：2011-03-10 00:00:00

abstract：:Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis. Abiraterone is metabolized in patients to Δ(4)-abiraterone (D4A), which has even greater anti-tumour activity and is structurally similar to e...

journal_title：Nature

authors： Li Z,Alyamani M,Li J,Rogacki K,Abazeed M,Upadhyay SK,Balk SP,Taplin ME,Auchus RJ,Sharifi N

更新日期：2016-05-26 00:00:00

abstract：:In the HTML version of this Letter, the affiliations for authors Andrew S. Azman, Dhirendra Kumar and Thandavarayan Ramamurthy were inverted (the PDF and print versions of the Letter were correct); the affiliations have been corrected online. ...

journal_title：Nature

authors： Weill FX,Domman D,Njamkepo E,Almesbahi AA,Naji M,Nasher SS,Rakesh A,Assiri AM,Sharma NC,Kariuki S,Pourshafie MR,Rauzier J,Abubakar A,Carter JY,Wamala JF,Seguin C,Bouchier C,Malliavin T,Bakhshi B,Abulmaali HHN,Kuma

更新日期：2019-02-01 00:00:00

abstract：:The debate over human origins has focused on two competing theories. The single African origin model holds that anatomically modern Homo sapiens evolved in Africa 100,000-200,000 years ago. Members of this population migrated out of Africa, replacing archaic human groups through Asia and Europe, with racial differenti...

journal_title：Nature

authors： Waddle DM

更新日期：1994-03-31 00:00:00

abstract：:The ability to process microbial antigens and present them at the surface of cells is an important aspect of our innate ability to clear infections. It is generally accepted that antigens in the cytoplasm are loaded in the endoplasmic reticulum and presented at the cell surface on major histocompatibility complex (MHC...

journal_title：Nature

authors： Houde M,Bertholet S,Gagnon E,Brunet S,Goyette G,Laplante A,Princiotta MF,Thibault P,Sacks D,Desjardins M

更新日期：2003-09-25 00:00:00

abstract：:Thyroid hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily. Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding. Here we report that retinoid X receptors RXR alpha is o...

journal_title：Nature

authors： Zhang XK,Hoffmann B,Tran PB,Graupner G,Pfahl M

更新日期：1992-01-30 00:00:00

abstract：:Medulloblastoma, the most common malignant paediatric brain tumour, arises in the cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to coat the brain and spinal cord. Dissemination, a marker of poor prognosis, is found in up to 40% of children at diagnosis and in most children at ...

journal_title：Nature

authors： Wu X,Northcott PA,Dubuc A,Dupuy AJ,Shih DJ,Witt H,Croul S,Bouffet E,Fults DW,Eberhart CG,Garzia L,Van Meter T,Zagzag D,Jabado N,Schwartzentruber J,Majewski J,Scheetz TE,Pfister SM,Korshunov A,Li XN,Scherer SW,Ch

更新日期：2012-02-15 00:00:00

abstract：:Galaxies congregate in clusters and along filaments, and are missing from large regions referred to as voids. These structures are seen in maps derived from spectroscopic surveys that reveal networks of structure that are interconnected with no clear boundaries. Extended regions with a high concentration of galaxies a...

journal_title：Nature

authors： Tully RB,Courtois H,Hoffman Y,Pomarède D

更新日期：2014-09-04 00:00:00

abstract：:Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...

journal_title：Nature

authors： Wyart C,Del Bene F,Warp E,Scott EK,Trauner D,Baier H,Isacoff EY

更新日期：2009-09-17 00:00:00

abstract：:Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid ...

journal_title：Nature

authors： Hohmann AG,Suplita RL,Bolton NM,Neely MH,Fegley D,Mangieri R,Krey JF,Walker JM,Holmes PV,Crystal JD,Duranti A,Tontini A,Mor M,Tarzia G,Piomelli D

更新日期：2005-06-23 00:00:00

abstract：:Mountain glaciers and ice caps are contributing significantly to present rates of sea level rise and will continue to do so over the next century and beyond. The Canadian Arctic Archipelago, located off the northwestern shore of Greenland, contains one-third of the global volume of land ice outside the ice sheets, but...

journal_title：Nature

authors： Gardner AS,Moholdt G,Wouters B,Wolken GJ,Burgess DO,Sharp MJ,Cogley JG,Braun C,Labine C

更新日期：2011-05-19 00:00:00

abstract：:Group selection may be defined as selection caused by the differential extinction or proliferation of groups. The socially polymorphic spider Anelosimus studiosus exhibits a behavioural polymorphism in which females exhibit either a 'docile' or 'aggressive' behavioural phenotype. Natural colonies are composed of a mix...

journal_title：Nature

authors： Pruitt JN,Goodnight CJ

更新日期：2014-10-16 00:00:00

abstract：:One of us has previously reported that treatment of the Keilin and Hartree heart-muscle preparation with 2,3-dimercaptopropanol (BAL), in the presence of air, leads to the complete inactivation of the succinate oxidase system with little if any effect on the activities of succinate dehydrogenase (until more than half ...

journal_title：Nature

authors： Slater EC,de Vries S

更新日期：1980-12-25 00:00:00

abstract：:In nature, organisms are exposed to chronic low-dose ultraviolet light (CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA repair by the nucleotide excision repair pathway and for checkpoin...

journal_title：Nature

authors： Hishida T,Kubota Y,Carr AM,Iwasaki H

更新日期：2009-01-29 00:00:00

abstract：:Extant vertebrates form two clades, the jawless Cyclostomata (lampreys and hagfishes) and the jawed Gnathostomata (all other vertebrates), with contrasting facial architectures. These arise during development from just a few key differences in the growth patterns of the cranial primordia: notably, the nasal sacs and h...

journal_title：Nature

authors： Dupret V,Sanchez S,Goujet D,Tafforeau P,Ahlberg PE

更新日期：2014-03-27 00:00:00

abstract：:Finite element analysis (FEA) is used by industrial designers and biomechanicists to estimate the performance of engineered structures or human skeletal and soft tissues subjected to varying regimes of stress and strain. FEA is rarely applied to problems of biomechanical design in animals, despite its potential to inf...

journal_title：Nature

authors： Rayfield EJ,Norman DB,Horner CC,Horner JR,Smith PM,Thomason JJ,Upchurch P

更新日期：2001-02-22 00:00:00

abstract：:The embryos and larvae of stalked crinoids, which are considered the most basal group of extant echinoderms, have not previously been described. In contrast, much is known about the development of the more accessible stalkless crinoids (feather stars), which are phylogenetically derived from stalked forms. Here we des...

journal_title：Nature

authors： Nakano H,Hibino T,Oji T,Hara Y,Amemiya S

更新日期：2003-01-09 00:00:00

abstract：:The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance ar...

journal_title：Nature

authors： Gros P,Ben Neriah YB,Croop JM,Housman DE

更新日期：1986-10-23 00:00:00

abstract：:Five new double-mutant haemoglobins composed of betaS chains and alpha chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to eva...

journal_title：Nature

authors： Benesch RE,Yung S,Benesch R,Mack J,Schneider RG

更新日期：1976-03-18 00:00:00

abstract：:Brosnan and de Waal report that capuchin monkeys show evidence of a sense of fairness or 'inequity aversion' because they rejected a less preferred reward when they saw a partner monkey receive a preferred reward for the same task. However, this does not show that monkeys are averse to inequity, only that they reject ...

journal_title：Nature

authors： Wynne CD

更新日期：2004-03-11 00:00:00

abstract：:The angle between the spin of a star and the orbital planes of its planets traces the history of the planetary system. Exoplanets orbiting close to cool stars are expected to be on circular, aligned orbits because of strong tidal interactions with the stellar convective envelope. Spin-orbit alignment can be measured w...

journal_title：Nature

authors： Bourrier V,Lovis C,Beust H,Ehrenreich D,Henry GW,Astudillo-Defru N,Allart R,Bonfils X,Ségransan D,Delfosse X,Cegla HM,Wyttenbach A,Heng K,Lavie B,Pepe F

更新日期：2018-01-25 00:00:00

abstract：:RNA ligases have essential roles in many cellular processes in eukaryotes, archaea and bacteria, including in RNA repair and stress-induced splicing of messenger RNA. In archaea and eukaryotes, RNA ligases also have a role in transfer RNA splicing to generate functional tRNAs required for protein synthesis. We recentl...

journal_title：Nature

authors： Popow J,Jurkin J,Schleiffer A,Martinez J

更新日期：2014-07-03 00:00:00

abstract：:In the Caenorhabditis elegans hermaphrodite germ line, sperm and then oocytes are made from a common pool of germ-cell precursors. The decision to differentiate as a sperm or an oocyte is regulated by the sex-determining gene, fem-3. Expression of fem-3 in the hermaphrodite germ line directs spermatogenesis and must b...

journal_title：Nature

authors： Ahringer J,Kimble J

更新日期：1991-01-24 00:00:00

abstract：:Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have used time-series data to confirm some of the theoretically predi...

journal_title：Nature

authors： Dai L,Korolev KS,Gore J

更新日期：2013-04-18 00:00:00

abstract：:A major effect of insulin is to increase glucose transport in muscle and fat. A family of genes encoding distinct mammalian glucose transporters has recently been elucidated. One of these, the insulin-regulatable glucose transporter (IRGT), is primarily expressed in muscle and fat, tissues that exhibit insulin-depende...

journal_title：Nature

authors： Slot JW,Moxley R,Geuze HJ,James DE

更新日期：1990-07-26 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Ka...

journal_title：Nature

authors： Bais C,Santomasso B,Coso O,Arvanitakis L,Raaka EG,Gutkind JS,Asch AS,Cesarman E,Gershengorn MC,Mesri EA

更新日期：1998-01-01 00:00:00