Abstract:
:The bithorax gene complex in Drosophila contains a minimum of eight genes that seem to code for substances controlling levels of thoracic and abdominal development. The state of repression of at least four of these genes is controlled by cis-regulatory elements and a separate locus (Polycomb) seems to code for a repressor of the complex. The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
journal_name
Naturejournal_title
Natureauthors
Lewis EBdoi
10.1038/276565a0keywords:
subject
Has Abstractpub_date
1978-12-07 00:00:00pages
565-70issue
5688eissn
0028-0836issn
1476-4687journal_volume
276pub_type
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