Spatio-temporal transcriptome of the human brain.

abstract：:Body size is intrinsically linked to metabolic rate and life-history traits, and is a crucial determinant of food webs and community dynamics1,2. The increased temperatures associated with the urban-heat-island effect result in increased metabolic costs and are expected to drive shifts to smaller body sizes 3 . Urban ...

journal_title：Nature

authors： Merckx T,Souffreau C,Kaiser A,Baardsen LF,Backeljau T,Bonte D,Brans KI,Cours M,Dahirel M,Debortoli N,De Wolf K,Engelen JMT,Fontaneto D,Gianuca AT,Govaert L,Hendrickx F,Higuti J,Lens L,Martens K,Matheve H,Matthysen

更新日期：2018-06-01 00:00:00

abstract：:The diverse functions of RNA, which include enzymatic activities, regulatory roles in transcription and translation, are made possible by tertiary structure. Computer algorithms can predict the secondary structure of an RNA molecule using free-energy parameters for base pairing and stacking, loops and bulges. However,...

journal_title：Nature

authors： Puglisi JD,Wyatt JR,Tinoco I Jr

更新日期：1988-01-21 00:00:00

abstract：:The three-dimensional structure of intact human rhinovirus 14 (HRV-14) complexed with Fab fragments (Fab17-IA) from a strongly neutralizing antibody that binds bivalently to the virion has been determined to 4.0 angstrom resolution by a combination of X-ray crystallography and cryo-electron microscopy. In contradictio...

journal_title：Nature

authors： Smith TJ,Chase ES,Schmidt TJ,Olson NH,Baker TS

更新日期：1996-09-26 00:00:00

abstract：:The 20S cyclosome complex (also known as the anaphase-promoting complex) has ubiquitin ligase activity and is required for mitotic cyclin destruction and sister chromatid separation. The formation and activation of the 20S cyclosome complex is regulated by an unknown mechanism. Here we show that Cut4 (ref. 6) is an es...

journal_title：Nature

authors： Yamashita YM,Nakaseko Y,Samejima I,Kumada K,Yamada H,Michaelson D,Yanagida M

更新日期：1996-11-21 00:00:00

abstract：:'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...

journal_title：Nature

authors： Sutcliffe JG,Milner RJ,Gottesfeld JM,Lerner RA

更新日期：1984-03-15 00:00:00

abstract：:Temperature-sensitive paralysis is the most striking defect of adult Drosophila carrying the shibire mutation. This is believed to be due to a reversible block of endocytosis, which prevents membrane cycling and thus depletes synaptic vesicles. The shibire mutation also affects many tissues outside the nervous system....

journal_title：Nature

authors： van der Bliek AM,Meyerowitz EM

更新日期：1991-05-30 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:Ia antigens are membrane-bound glycoproteins that play a part in antigen recognition and subsequent cell-cell interactions in the immune response. In the mouse they are coded for by the I region of the major histocompatibility complex H-2 and have been demonstrated on B lymphocytes, monocytes, activated T cells, macro...

journal_title：Nature

authors： de Waal RM,Bogman MJ,Maass CN,Cornelissen LM,Tax WJ,Koene RA

更新日期：1983-06-02 00:00:00

abstract：:Scientific fraud, much in the news recently, is not a new phenomenon. What follows is a personal account of a particular case. ...

journal_title：Nature

authors： Rossiter EJ

更新日期：1992-06-11 00:00:00

abstract：:The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...

journal_title：Nature

authors： Taufiq-Ur-Rahman,Skupin A,Falcke M,Taylor CW

更新日期：2009-04-02 00:00:00

abstract：:The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and...

journal_title：Nature

authors： Carmeliet P

更新日期：2005-12-15 00:00:00

abstract：:Regular mesoporous oxide materials have been widely studied and have a range of potential applications, such as catalysis, absorption and separation. They are not generally considered for their optical and electronic properties. Elemental semiconductors with nanopores running through them represent a different form of...

journal_title：Nature

authors： Armatas GS,Kanatzidis MG

更新日期：2006-06-29 00:00:00

abstract：:Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly d...

journal_title：Nature

authors： Ng SW,Mitchell A,Kennedy JA,Chen WC,McLeod J,Ibrahimova N,Arruda A,Popescu A,Gupta V,Schimmer AD,Schuh AC,Yee KW,Bullinger L,Herold T,Görlich D,Büchner T,Hiddemann W,Berdel WE,Wörmann B,Cheok M,Preudhomme C,Domb

更新日期：2016-12-15 00:00:00

abstract：:CD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex. Mature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8. Nevertheless, a small percentage of peripheral CD3+ T cell...

journal_title：Nature

authors： Paliard X,Malefijt RW,de Vries JE,Spits H

更新日期：1988-10-13 00:00:00

abstract：:Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by developing small-scale Tn5-assisted chromatin cleavage with sequencing (Stacc-seq), we investigated the landscapes of RNA polymerase II (Pol II) binding...

journal_title：Nature

authors： Liu B,Xu Q,Wang Q,Feng S,Lai F,Wang P,Zheng F,Xiang Y,Wu J,Nie J,Qiu C,Xia W,Li L,Yu G,Lin Z,Xu K,Xiong Z,Kong F,Liu L,Huang C,Yu Y,Na J,Xie W

更新日期：2020-11-01 00:00:00

abstract：:Statistical dependencies in the responses of sensory neurons govern both the amount of stimulus information conveyed and the means by which downstream neurons can extract it. Although a variety of measurements indicate the existence of such dependencies, their origin and importance for neural coding are poorly underst...

journal_title：Nature

authors： Pillow JW,Shlens J,Paninski L,Sher A,Litke AM,Chichilnisky EJ,Simoncelli EP

更新日期：2008-08-21 00:00:00

abstract：:To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression ...

journal_title：Nature

authors： Bloss TA,Witze ES,Rothman JH

更新日期：2003-08-28 00:00:00

abstract：:Genotypic variation among independent isolates of human immunodeficiency virus type-1 (HIV-1) is well known, but its molecular basis and biological consequences are poorly understood. We examined the genesis of molecular variation in HIV-1 by sequential virus isolations from two chronically infected individuals and an...

journal_title：Nature

authors： Saag MS,Hahn BH,Gibbons J,Li Y,Parks ES,Parks WP,Shaw GM

更新日期：1988-08-04 00:00:00

abstract：:Novel capsomeric complexes, pentamers and hexamers were detected as chemical entities in phage Q beta. Both were composed of identical protein subunits and stabilized by intermolecular disulphide bonds. Their numbers per particle were about 12 for pentamers and about 20 for hexamers--consistent with theoretical expect...

journal_title：Nature

authors： Takamatsu H,Iso K

更新日期：1982-08-26 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Apffel B,Novkoski F,Eddi A,Fort E

更新日期：2020-10-01 00:00:00

abstract：:Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are poorly understood. The prototypic DNA methyltransferase, DNMT1, has been widely assumed to be responsible for most of the methylation of the...

journal_title：Nature

authors： Rhee I,Jair KW,Yen RW,Lengauer C,Herman JG,Kinzler KW,Vogelstein B,Baylin SB,Schuebel KE

更新日期：2000-04-27 00:00:00

abstract：:The Ndc80 complex is a key site of regulated kinetochore-microtubule attachment (a process required for cell division), but the molecular mechanism underlying its function remains unknown. Here we present a subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules...

journal_title：Nature

authors： Alushin GM,Ramey VH,Pasqualato S,Ball DA,Grigorieff N,Musacchio A,Nogales E

更新日期：2010-10-14 00:00:00

abstract：:Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their s...

journal_title：Nature

authors： Correa-Gallegos D,Jiang D,Christ S,Ramesh P,Ye H,Wannemacher J,Kalgudde Gopal S,Yu Q,Aichler M,Walch A,Mirastschijski U,Volz T,Rinkevich Y

更新日期：2019-12-01 00:00:00

abstract：:Macrophages are considered to contribute to chronic inflammatory diseases such as rheumatoid arthritis1. However, both the exact origin and the role of macrophages in inflammatory joint disease remain unclear. Here we use fate-mapping approaches in conjunction with three-dimensional light-sheet fluorescence microscopy...

journal_title：Nature

authors： Culemann S,Grüneboom A,Nicolás-Ávila JÁ,Weidner D,Lämmle KF,Rothe T,Quintana JA,Kirchner P,Krljanac B,Eberhardt M,Ferrazzi F,Kretzschmar E,Schicht M,Fischer K,Gelse K,Faas M,Pfeifle R,Ackermann JA,Pachowsky M,Renner

更新日期：2019-08-01 00:00:00

abstract：:Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop nat...

journal_title：Nature

authors： Sullivan NJ,Sanchez A,Rollin PE,Yang ZY,Nabel GJ

更新日期：2000-11-30 00:00:00

abstract：:Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller th...

journal_title：Nature

authors： Barth RK,Kim BS,Lan NC,Hunkapiller T,Sobieck N,Winoto A,Gershenfeld H,Okada C,Hansburg D,Weissman IL

更新日期：1985-08-08 00:00:00

abstract：:Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deficient mice have shown that this lipid chaperone has a significant role in several aspects of metabolic syndrome, including type 2 diabetes and atheroscle...

journal_title：Nature

authors： Furuhashi M,Tuncman G,Görgün CZ,Makowski L,Atsumi G,Vaillancourt E,Kono K,Babaev VR,Fazio S,Linton MF,Sulsky R,Robl JA,Parker RA,Hotamisligil GS

更新日期：2007-06-21 00:00:00

abstract：:Climate change is predicted to increase both drought frequency and duration, and when coupled with substantial warming, will establish a new hydroclimatological model for many regions. Large-scale, warm droughts have recently occurred in North America, Africa, Europe, Amazonia and Australia, resulting in major effects...

journal_title：Nature

authors： Ponce Campos GE,Moran MS,Huete A,Zhang Y,Bresloff C,Huxman TE,Eamus D,Bosch DD,Buda AR,Gunter SA,Scalley TH,Kitchen SG,McClaran MP,McNab WH,Montoya DS,Morgan JA,Peters DP,Sadler EJ,Seyfried MS,Starks PJ

更新日期：2013-02-21 00:00:00

abstract：:There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the Drosophila melanogaster antenna called t...

journal_title：Nature

authors： Kain P,Boyle SM,Tharadra SK,Guda T,Pham C,Dahanukar A,Ray A

更新日期：2013-10-24 00:00:00

abstract：:Integration of information between tyrosine kinase and G-protein-mediated pathways is necessary, but remains poorly understood. Here we use cells from transgenic mice harbouring inducible expression of RNA antisense to the gene encoding G ialpha2 to show that G ialpha2 is critical for insulin action. G ialpha2 deficie...

journal_title：Nature

authors： Moxham CM,Malbon CC

更新日期：1996-02-29 00:00:00