Abstract:
:We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.
journal_name
Naturejournal_title
Natureauthors
Wood V,Gwilliam R,Rajandream MA,Lyne M,Lyne R,Stewart A,Sgouros J,Peat N,Hayles J,Baker S,Basham D,Bowman S,Brooks K,Brown D,Brown S,Chillingworth T,Churcher C,Collins M,Connor R,Cronin A,Davis P,Feltwell T,Frdoi
10.1038/nature724keywords:
subject
Has Abstractpub_date
2002-02-21 00:00:00pages
871-80issue
6874eissn
0028-0836issn
1476-4687pii
nature724journal_volume
415pub_type
杂志文章相关文献
NATURE文献大全abstract::The formation and guidance of specialized endothelial tip cells is essential for both developmental and pathological angiogenesis. Notch-1 signalling regulates the generation of tip cells, which respond to gradients of vascular endothelial growth factor (VEGF-A). The molecular cues and signalling pathways that control...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08995
更新日期:2010-05-27 00:00:00
abstract::The genes torso (tor) and torso-like (tsl) are two of the Drosophila maternal group genes implicated in a receptor tyrosine kinase signalling pathway that specifies terminal cell fate (reviewed in ref. 3). Loss-of-function mutations in these loci cause an identical phenotype in which pattern elements from the anterior...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/367741a0
更新日期:1994-02-24 00:00:00
abstract::Numerous studies have suggested that biodiversity reduces variability in ecosystem productivity through compensatory effects; that is, a species increases in its abundance in response to the reduction of another in a fluctuating environment. But this view has been challenged on several grounds. Because most studies ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02850
更新日期:2004-09-09 00:00:00
abstract::One of the outstanding challenges in the field of porous materials is the design and synthesis of chemical structures with exceptionally high surface areas. Such materials are of critical importance to many applications involving catalysis, separation and gas storage. The claim for the highest surface area of a disord...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02311
更新日期:2004-02-05 00:00:00
abstract::AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength, and dysregulation of AMPA receptor-mediated si...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23479
更新日期:2017-09-07 00:00:00
abstract::During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature09228
更新日期:2010-06-10 00:00:00
abstract::Molecular self-assembly offers a 'bottom-up' route to fabrication with subnanometre precision of complex structures from simple components. DNA has proved to be a versatile building block for programmable construction of such objects, including two-dimensional crystals, nanotubes, and three-dimensional wireframe nanop...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08016
更新日期:2009-05-21 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07209-z
更新日期:2018-11-01 00:00:00
abstract::A short, 14-amino-acid segment called SP1, located in the Gag structural protein1, has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the SP1 peptide and seven preceding residues fold into a six-helix bundle, which holds together the Gag hexamer and facilitates the formation o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0396-4
更新日期:2018-08-01 00:00:00
abstract::Protons participate in most biologically important reactions, as substrates, products, cofactors and modulators, and proton transport is an essential step in energy transduction. The dynamics of protonation reactions have been studied extensively in solution and in model systems involving lipid-water interfaces, but h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329243a0
更新日期:1987-09-17 00:00:00
abstract::During attempts to select nonsecretory variants from 0.467.3, and Epstein-Barr virus-transformed human lymphoblastoid cell line that secretes small amounts of IgM lambda, we exposed the cells to UV light. Cells that survived the irradiation were subcultured and their supernatants were screened for immunoglobulin produ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/306189a0
更新日期:1983-11-10 00:00:00
abstract::A consequence of relativity is that in the presence of an electric field, the spin and momentum states of an electron can be coupled; this is known as spin-orbit coupling. Such an interaction opens a pathway to the manipulation of electron spins within non-magnetic semiconductors, in the absence of applied magnetic fi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02202
更新日期:2004-01-01 00:00:00
abstract::Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information. Here we exploit advances in electron cryo-microscopy to determine t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12822
更新日期:2013-12-05 00:00:00
abstract::Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25168
更新日期:2018-01-11 00:00:00
abstract::Kin selection theory predicts that individuals will show less aggression and more altruism towards relatives. However, recent theoretical developments suggest that with limited dispersal, competition between relatives can override the effects of relatedness. The predicted and opposing influences of relatedness and com...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02721
更新日期:2004-08-05 00:00:00
abstract::DNA winds about itself in a right-handed or left-handed fashion at several structural levels. The double helix is generally right-handed and is given a (+) sign by convention, whereas supercoiling of the helix axis is always (-) in the cell. The winding in higher -order forms such as knots and catenanes is unknown, an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304559a0
更新日期:1983-08-11 00:00:00
abstract::The alpha-like and beta-like globin genes have provided a paradigm for the study of molecular evolution and regulation of multigene families in eukaryotes. The human alpha-globin gene cluster, which is on chromosome 16 (ref. 1), consists of six genes arranged in the order 5'-zeta(embryonic)-psi zeta-psi alpha 2-psi al...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321785a0
更新日期:1986-06-19 00:00:00
abstract::Sheep learn to recognize the odours of their lambs within two hours of giving birth, and this learning involves synaptic changes within the olfactory bulb. Specifically, mitral cells become increasingly responsive to the learned odour, which stimulates release of both glutamate and GABA (gamma-aminobutyric acid) neuro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/41765
更新日期:1997-08-14 00:00:00
abstract::Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances i...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature03723
更新日期:2005-06-02 00:00:00
abstract::Many receptors for neuropeptides and hormones are coupled with the heterotrimeric G(i) protein, which activates the p42/44 mitogen-activated protein kinase (ERK/MAPK) cascade through both the alpha- and betagamma-subunits of G(i). The betagamma-subunit activates the ERK/MAPK cascade through tyrosine kinase. Constituti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/23738
更新日期:1999-08-26 00:00:00
abstract::Courtship is an innate sexually dimorphic behaviour that can be observed in naive animals without previous learning or experience, suggesting that the neural circuits that mediate this behaviour are developmentally programmed. In Drosophila, courtship involves a complex yet stereotyped array of dimorphic behaviours th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06808
更新日期:2008-03-27 00:00:00
abstract::Arteries and veins are morphologically, functionally and molecularly very different, but how this distinction is established during vasculogenesis is unknown. Here we show, by lineage tracking in zebrafish embryos, that angioblast precursors for the trunk artery and vein are spatially mixed in the lateral posterior me...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35102599
更新日期:2001-11-08 00:00:00
abstract::Theoretical and empirical research highlights the role of punishment in promoting collaborative efforts. However, both the emergence and the stability of costly punishment are problematic issues. It is not clear how punishers can invade a society of defectors by social learning or natural selection, or how second-orde...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09203
更新日期:2010-08-12 00:00:00
abstract::Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation. During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, Cys-X...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/42491
更新日期:1997-06-05 00:00:00
abstract::Holliday junctions (HJs) are key intermediates in homologous recombination and are especially important for the production of crossover recombinants. Bacterial RecA family proteins promote the formation and branch migration of HJs in vitro by catalysing a reciprocal DNA-strand exchange reaction between two duplex DNA ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06609
更新日期:2008-02-21 00:00:00
abstract::Jupiter's aurora is the most powerful in the Solar System. It is powered largely by energy extracted from planetary rotation, although there seems also to be a contribution from the solar wind. This contrasts with Earth's aurora, which is generated through the interaction of the solar wind with the magnetosphere. The ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35071018
更新日期:2001-04-12 00:00:00
abstract::Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis, immunity and wound healing. Focal adhesions are multifunctional organelles that mediate cell-ECM adhesion, force transmission, cytoskeletal regulation and signalling. Focal adhesions consist of a complex network of trans-plasma-membrane ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09621
更新日期:2010-11-25 00:00:00
abstract::Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35050141
更新日期:2000-12-21 00:00:00
abstract::Long-term depletion of the stratospheric ozone layer contributes to an increase in terrestrial solar ultraviolet-B radiation. This has deleterious effects on living organisms, such as DNA damage. When exposed to elevated ultraviolet-B radiation (UV-B; 280-315 nm), plants display a wide variety of physiological and mor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35017595
更新日期:2000-07-06 00:00:00
abstract::T-lymphocyte co-recognition of antigen and major histocompatibility complex (MHC)-encoded molecules (such as murine Ia molecules) is thought to be mediated by a single cell-surface receptor, although the molecular mechanism by which this occurs is controversial (reviewed in ref. 1). One possibility is that the antigen...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/320176a0
更新日期:1986-03-13 00:00:00