Discovery central.

abstract：:Microcrystals of the lipoprotein-phosphoprotein complex which are found in the oocytes of Xenopus laevis were examined using electron microscopy. Analysis of Fourier transforms of the images of the (010) and (001) projections showed the space group to be P2(1)22(1). Ten projections were combined to produce a map of th...

journal_title：Nature

authors： Ohlendorf DH,Wrenn RF,Banaszak LJ

更新日期：1978-03-02 00:00:00

abstract：:Retinoic acid is a vitamin A derivative with striking effects on development and cell differentiation. Several nuclear retinoic acid receptors (RARs), acting as ligand-inducible transcription factors, have been characterized and indirect evidence suggests that they have distinct roles. One of the most intriguing prope...

journal_title：Nature

authors： de Thé H,Chomienne C,Lanotte M,Degos L,Dejean A

更新日期：1990-10-11 00:00:00

abstract：:The T-cell receptor has been studied intensely over the past 10 years in an effort to understand the molecular basis for major histocompatibility complex (MHC) restricted antigen recognition. The use of anti-receptor monoclonal antibodies to isolate and characterize the receptor from human and murine T-cell clones has...

journal_title：Nature

authors： Sim GK,Yagüe J,Nelson J,Marrack P,Palmer E,Augustin A,Kappler J

更新日期：1984-12-20 00:00:00

abstract：:The unusual helium-rich (type Ib) supernova SN 2005E is distinguished from all supernovae hitherto observed by its faint and rapidly fading light curve, prominent calcium lines in late-phase spectra and lack of any mark of recent star formation near the supernova location. These properties are claimed to be explained ...

journal_title：Nature

authors： Kawabata KS,Maeda K,Nomoto K,Taubenberger S,Tanaka M,Deng J,Pian E,Hattori T,Itagaki K

更新日期：2010-05-20 00:00:00

abstract：:The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convert...

journal_title：Nature

authors： Wiesmann C,Katschke KJ,Yin J,Helmy KY,Steffek M,Fairbrother WJ,McCallum SA,Embuscado L,DeForge L,Hass PE,van Lookeren Campagne M

更新日期：2006-11-09 00:00:00

abstract：:Mov13 mice carry a single Moloney murine leukaemia virus (M-MuLV) proviral copy in the first intron of the alpha 1(I) collagen gene. Virus insertion interferes with the synthesis of stable alpha 1(I) collagen messenger RNA and causes a recessive lethal mutation. The virus insertion has induced changes of the methylati...

journal_title：Nature

authors： Hartung S,Jaenisch R,Breindl M

更新日期：1986-03-27 00:00:00

abstract：:Ants travelling to and fro between their nest and a foraging area may follow stereotyped foodward and homeward routes that are guided by different visual and directional memory sequences. Honeybees are known to fly a feeder-to-hive or hive-to-feeder vector according to whether or not they have recently fed--their feed...

journal_title：Nature

authors： Harris RA,Hempel de Ibarra N,Graham P,Collett TS

更新日期：2005-11-17 00:00:00

abstract：:A grand challenge of systems biology is to predict the kinetic responses of living systems to perturbations starting from the underlying molecular interactions. Changes in the nutrient environment have long been used to study regulation and adaptation phenomena in microorganisms and they remain a topic of active inves...

journal_title：Nature

authors： Erickson DW,Schink SJ,Patsalo V,Williamson JR,Gerland U,Hwa T

更新日期：2017-11-02 00:00:00

abstract：:Recent theory on sexual selection suggests that females in species without paternal care choose mates by their secondary sexual characters because these indicate genotypic quality which will be transmitted to the offspring. These ideas are not yet empirically supported as data quantifying the relationship between fema...

journal_title：Nature

authors： von Schantz T,Göransson G,Andersson G,Fröberg I,Grahn M,Helgée A,Wittzell H

更新日期：1989-01-12 00:00:00

abstract：:During the fission yeast cell cycle, the rate of polyadenylated messenger RNA synthesis doubles when the cell reaches a critical size. This size-related control maintains average mRNA content in balance with total cell mass during exponential growth, even in cells growing at different absolute growth rates per cell. ...

journal_title：Nature

authors： Fraser RS,Nurse P

更新日期：1978-02-23 00:00:00

abstract：:It is generally accepted that the specific function of a gene depends on its coding sequence. The three paired-box and homeobox genes paired (prd), gooseberry (gsb) and gooseberry neuro (gsbn) have distinct developmental functions in Drosophila embryogenesis. During the syncytial blastoderm stage, the pair-rule gene p...

journal_title：Nature

authors： Li X,Noll M

更新日期：1994-01-06 00:00:00

abstract：:The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data. Long-term follow-up is especially important for those with oestrogen-receptor (ER)-positive breast cancers, which can recur up to t...

journal_title：Nature

authors： Rueda OM,Sammut SJ,Seoane JA,Chin SF,Caswell-Jin JL,Callari M,Batra R,Pereira B,Bruna A,Ali HR,Provenzano E,Liu B,Parisien M,Gillett C,McKinney S,Green AR,Murphy L,Purushotham A,Ellis IO,Pharoah PD,Rueda C,Apari

更新日期：2019-03-01 00:00:00

abstract：:Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago and describes the behaviour of fibroblast cells confronting each other in vitro, where they retract their protrusions and change direction on contact. Its failure was suggested to contribute to malignant invasion. However, the molecu...

journal_title：Nature

authors： Carmona-Fontaine C,Matthews HK,Kuriyama S,Moreno M,Dunn GA,Parsons M,Stern CD,Mayor R

更新日期：2008-12-18 00:00:00

abstract：:Red colobus are one of a small number of primate species in which females have been reported to transfer between breeding groups more commonly than males. Several authors have hypothesised that in such species transference may serve to reduce the risk to females of producing offspring of lower fitness through inbreedi...

journal_title：Nature

authors： Marsh CW

更新日期：1979-10-18 00:00:00

abstract：:Brevetoxin A is the most potent neurotoxin secreted by Gymnodinium breve Davis, a marine organism often associated with harmful algal blooms known as 'red tides'. The compound, whose mechanism of action involves binding to and opening of sodium channels, is sufficiently toxic to kill fish at concentrations of nanogram...

journal_title：Nature

authors： Nicolaou KC,Yang Z,Shi G,Gunzner JL,Agrios KA,Gärtner P

更新日期：1998-03-19 00:00:00

abstract：:Chameleons are arboral lizards that spot their prey visually and catch it by highly precise shots with their long sticky tongue. They scan their environment by large-amplitude independent saccadic eye movements; once an insect is detected, the head axis is aligned towards the target ('head tracking', both eyes come fo...

journal_title：Nature

authors： Ott M,Schaeffel F

更新日期：1995-02-23 00:00:00

abstract：:The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...

journal_title：Nature

authors： Widmer MB,Grabstein KH

更新日期：1987-04-23 00:00:00

abstract：:The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively hig...

journal_title：Nature

authors： Kisielow P,Blüthmann H,Staerz UD,Steinmetz M,von Boehmer H

更新日期：1988-06-23 00:00:00

abstract：:In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and ...

journal_title：Nature

authors： Andersen TG,Naseer S,Ursache R,Wybouw B,Smet W,De Rybel B,Vermeer JEM,Geldner N

更新日期：2018-07-01 00:00:00

abstract：:Multiple sulphatase deficiency disease is an unusual autosomal recessive disorder characterised biochemically by a deficiency of several sulphohydrolase activities. The laboratory diagnosis of this combined neurological connective tissue disorder is made on the basis of decreased activities of the lysosomal enzymes, a...

journal_title：Nature

authors： Fiddler MB,Vine D,Shapira E,Nadler HL

更新日期：1979-11-01 00:00:00

abstract：:Only 17% of 111 reef-building coral genera and none of the 18 coral families with reef-builders are considered endemic to the Atlantic, whereas the corresponding percentages for the Indo-west Pacific are 76% and 39%. These figures depend on the assumption that genera and families spanning the two provinces belong to t...

journal_title：Nature

authors： Fukami H,Budd AF,Paulay G,Solé-Cava A,Allen Chen C,Iwao K,Knowlton N

更新日期：2004-02-26 00:00:00

abstract：:A connection between thunderstorms and the ionosphere has been hypothesized since the mid-1920s. Several mechanisms have been proposed to explain this connection, and evidence from modelling as well as various types of measurements demonstrate that lightning can interact with the lower ionosphere. It has been proposed...

journal_title：Nature

authors： Davis CJ,Johnson CG

更新日期：2005-06-09 00:00:00

abstract：:The observation of the superfluid to Mott insulator phase transition of ultracold atoms in optical lattices was an enabling discovery in experimental many-body physics, providing the first tangible example of a quantum phase transition (one that occurs even at zero temperature) in an ultracold atomic gas. For a trappe...

journal_title：Nature

authors： Gemelke N,Zhang X,Hung CL,Chin C

更新日期：2009-08-20 00:00:00

abstract：:Real-time investigations of the rearrangement of bonds during chemical transformations require femtosecond temporal resolution, so that the atomic vibrations within the reacting molecules can be observed. Following the development of lasers capable of emitting ultrashort laser flashes on this timescale, chemical react...

journal_title：Nature

authors： Kobayashi T,Saito T,Ohtani H

更新日期：2001-11-29 00:00:00

abstract：:Animal viruses are broadly categorized structurally by the presence or absence of an envelope composed of a lipid-bilayer membrane, attributes that profoundly affect stability, transmission and immune recognition. Among those lacking an envelope, the Picornaviridae are a large and diverse family of positive-strand RNA...

journal_title：Nature

authors： Feng Z,Hensley L,McKnight KL,Hu F,Madden V,Ping L,Jeong SH,Walker C,Lanford RE,Lemon SM

更新日期：2013-04-18 00:00:00

abstract：:Hypermethylation of the promoters of tumour suppressor genes represses transcription of these genes, conferring growth advantages to cancer cells. How these changes arise is poorly understood. Here we show that the activity of oxygen-dependent ten-eleven translocation (TET) enzymes is reduced by tumour hypoxia in huma...

journal_title：Nature

authors： Thienpont B,Steinbacher J,Zhao H,D'Anna F,Kuchnio A,Ploumakis A,Ghesquière B,Van Dyck L,Boeckx B,Schoonjans L,Hermans E,Amant F,Kristensen VN,Peng Koh K,Mazzone M,Coleman M,Carell T,Carmeliet P,Lambrechts D

更新日期：2016-09-01 00:00:00

abstract：:Classical population-genetics theory suggests that reproductive isolation will evolve fastest in small isolated populations. In contrast, recent theory suggests that divergence should occur fastest in larger allopatric populations. The rationale behind this is that sexual conflict, potentially the strongest driver of ...

journal_title：Nature

authors： Martin OY,Hosken DJ

更新日期：2003-06-26 00:00:00

abstract：:The global mid-ocean ridge system is the most extensive magmatic system on our planet and is the site of 75 per cent of Earth's volcanism1. The vertical extent of mid-ocean-ridge magmatic systems has been considered to be restricted: even at the ultraslow-spreading Gakkel mid-ocean ridge under the Arctic Ocean, where ...

journal_title：Nature

authors： Bennett EN,Jenner FE,Millet MA,Cashman KV,Lissenberg CJ

更新日期：2019-08-01 00:00:00

abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...

journal_title：Nature

authors： Acharya R,Fry E,Stuart D,Fox G,Rowlands D,Brown F

更新日期：1989-02-23 00:00:00

abstract：:Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and form the basis of some of the world's most productive marine food webs. The diatom nuclear genome contains genes with bacterial and plastid origins as well as genes of the secondary endosymbiotic host (the exosymbiont), yet little is known a...

journal_title：Nature

authors： Allen AE,Dupont CL,Oborník M,Horák A,Nunes-Nesi A,McCrow JP,Zheng H,Johnson DA,Hu H,Fernie AR,Bowler C

更新日期：2011-05-12 00:00:00