相关文献
NATURE文献大全abstract::Actin is one of the most ubiquitous, abundant and well-conserved proteins of eukaryotes, participating in many crucial cellular processes including the maintenance of cell shape, motility and cell division. Actins from the most divergent sources still share amino-acid identities in excess of 70% (ref. 3). This may wel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/359246a0
更新日期:1992-09-17 00:00:00
abstract::Observing and controlling macroscopic quantum systems has long been a driving force in quantum physics research. In particular, strong coupling between individual quantum systems and mechanical oscillators is being actively studied1-3. Whereas both read-out of mechanical motion using coherent control of spin systems4-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2133-z
更新日期:2020-04-01 00:00:00
abstract::Multiplicative operations are important in sensory processing, but their biophysical implementation remains largely unknown. We investigated an identified neuron (the lobula giant movement detector, LGMD, of locusts) whose output firing rate in response to looming visual stimuli has been described by two models, one o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01190
更新日期:2002-11-21 00:00:00
abstract::The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and the development of a transformation system have facilitated the use of A. oryzae in modern biotechnology. Although both...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04300
更新日期:2005-12-22 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) promotes the survival of several populations of neurons, including sensory and motor neurons. Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; therefore, it has been proposed to act as a lesion factor. The identificatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365253a0
更新日期:1993-09-16 00:00:00
abstract::Quantum light is characterized by distinctive statistical distributions that are possible only because of quantum mechanical effects. For example, single photons and correlated photon pairs exhibit photon number distributions with variance lower than classically allowed limits. This enables high-fidelity transmission ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0478-3
更新日期:2018-09-01 00:00:00
abstract::A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305600a0
更新日期:1983-10-13 00:00:00
abstract::High-harmonic generation by focusing a femtosecond laser onto a gas is a well-known method of producing coherent extreme-ultraviolet (EUV) light. This nonlinear conversion process requires high pulse intensities, greater than 10(13) W cm(-2), which are not directly attainable using only the output power of a femtoseco...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07012
更新日期:2008-06-05 00:00:00
abstract::After an earthquake, numerous smaller shocks are triggered over distances comparable to the dimensions of the mainshock fault rupture, although they are rare at larger distances. Here we analyse the scaling of dynamic deformations (the stresses and strains associated with seismic waves) with distance from, and magnitu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/437830a
更新日期:2005-10-06 00:00:00
abstract::On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain which falls into three distinct domains. Only the central domain (approximately 80 residues) is in a folded conformation. It is protected from trypsin digestion in chromatin and corresponds ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288675a0
更新日期:1980-12-25 00:00:00
abstract::5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04130
更新日期:2005-11-10 00:00:00
abstract::Proteolysis is essential for the execution of many cellular functions. These include removal of incorrectly folded or damaged proteins, the activation of transcription factors, the ordered degradation of proteins involved in cell cycle control, and the generation of peptides destined for presentation by class I molecu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33443
更新日期:1998-04-09 00:00:00
abstract::Mutations or amplification of the MET proto-oncogene are involved in the pathogenesis of several tumours, which rely on the constitutive engagement of this pathway for their growth and survival. However, MET is expressed not only by cancer cells but also by tumour-associated stromal cells, although its precise role in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14407
更新日期:2015-06-18 00:00:00
abstract::Excitatory synaptic transmission in the central nervous system is mediated primarily by the release of glutamate from presynaptic terminals onto postsynaptic channels gated by N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors. The myriad intracellular responses arisi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/39062
更新日期:1997-10-02 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-020-2691-0
更新日期:2020-09-01 00:00:00
abstract::The histocompatibility-Y (H-Y) antigen is a minor histocompatibility antigen which has been detected on cell surfaces from the heterogametic sexes of mammalian, bird, amphibian, teleost and invertebrate species. H-Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290503a0
更新日期:1981-04-09 00:00:00
abstract::Digital organisms are computer programs that self-replicate, mutate and adapt by natural selection. They offer an opportunity to test generalizations about living systems that may extend beyond the organic life that biologists usually study. Here we have generated two classes of digital organism: simple programs selec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/23245
更新日期:1999-08-12 00:00:00
abstract::The satellites Rhea and Dione orbit within the magnetosphere of Saturn, where they are exposed to particle irradiation from trapped ions. A similar situation applies to the galilean moons Europa, Ganymede and Callisto, which reside within Jupiter's radiation belts. All of these satellites have surfaces rich in water i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/40348
更新日期:1997-07-03 00:00:00
abstract::The recent discovery of a pterosaur egg with embryonic skeleton and soft tissues from the Yixian Formation confirmed that the flying pterosaurs were oviparous. Here we describe another pterosaur egg whose exquisite preservation indicates that the shell structure was soft and leathery. ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/432572a
更新日期:2004-12-02 00:00:00
abstract::Understanding the nature and origin of the asteroid population in Earth's vicinity (near-Earth asteroids, and its subset of potentially hazardous asteroids) is a matter of both scientific interest and practical importance. It is generally expected that the compositions of the asteroids that are most likely to hit Eart...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07154
更新日期:2008-08-14 00:00:00
abstract::X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of motorneuron disease which may be associated with signs of androgen insensitivity. We have now investigated whether the androgen receptor gene on the proximal long arm of the X chromosome is a candidate gene for this disease. In p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352077a0
更新日期:1991-07-04 00:00:00
abstract::Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologically relevant molecules, modern synthetic materials and commodity chemicals such as fuels and lubricants. Traditionally, the presence of a functional group is required at the site of C-C bond formation. Strategies that allow C-C bond formation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19810
更新日期:2016-11-10 00:00:00
abstract::Self-incompatibility in flowering plants is often controlled by a single nuclear gene (the S-gene) having several alleles. This gene prevents fertilization by self-pollen or by pollen bearing either of the two S-alleles expressed in the style. Sequence analysis shows that three alleles of the S gene of Nicotiana alata...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342955a0
更新日期:1989-12-21 00:00:00
abstract::The gal operon of Escherichia coli is controlled by two independent promotors--one is activated and the other inhibited by cyclic AMP and cyclic AMP receptor protein. The two promotors are modulated, however, by the same operator locus and receptor protein. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/279492a0
更新日期:1979-06-07 00:00:00
abstract::Biochemical and structural studies have shown that the initiation of RNA polymerase II transcription proceeds in the following stages: assembly of the polymerase with general transcription factors and promoter DNA in a 'closed' preinitiation complex (PIC); unwinding of about 15 base pairs of the promoter DNA to form a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14882
更新日期:2015-09-10 00:00:00
abstract::Self-replication has been demonstrated in synthetic chemical systems based on oligonucleotides, peptides and complementary molecules without natural analogues. However, within a living cell virtually no molecule catalyses its own formation, and the search for chemical systems in which both auto- and cross-catalysis ca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/24814
更新日期:1998-12-03 00:00:00
abstract::Non-volcanic tremor is a weak, extended duration seismic signal observed episodically on some major faults, often in conjunction with slow slip events. Such tremor may hold the key to understanding fundamental processes at the deep roots of faults, and could signal times of accelerated slip and hence increased seismic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05666
更新日期:2007-03-15 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-020-2351-4
更新日期:2020-06-01 00:00:00
abstract::In adult animals, sensory neurons innervating the skin are phenotypically diverse. We have now investigated whether nerve growth factor (NGF) has a physiological role in the development of this diversity. We gave antisera against NGF to rats from postnatal day 1 (PND 1) to adulthood (5 weeks). We found a virtually com...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/350500a0
更新日期:1991-04-11 00:00:00
abstract::Magnetic interactions and magnetic impurities are destructive to superconductivity in conventional superconductors. By contrast, in some unconventional macroscopic quantum systems (such as superfluid 3He and superconducting UGe2), the superconductivity (or superfluidity) is actually mediated by magnetic interactions. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35082019
更新日期:2001-06-21 00:00:00