Abstract:
:In adult animals, sensory neurons innervating the skin are phenotypically diverse. We have now investigated whether nerve growth factor (NGF) has a physiological role in the development of this diversity. We gave antisera against NGF to rats from postnatal day 1 (PND 1) to adulthood (5 weeks). We found a virtually complete depletion of high threshold mechanoreceptors conducting in the A delta range (2-13 ms-1) in the sural nerve. This afferent type, normally present in large numbers, appeared to have been replaced by D-hair afferents, sensitive mechanoreceptors which normally are relatively rare. NGF deprivation had this effect only in early postnatal life; treatment from postnatal day 14 to adulthood had no effect. We conclude that the presence of NGF postnatally in skin is necessary for the proper phenotypic development of A delta cutaneous nociceptors.
journal_name
Naturejournal_title
Natureauthors
Ritter AM,Lewin GR,Kremer NE,Mendell LMdoi
10.1038/350500a0subject
Has Abstractpub_date
1991-04-11 00:00:00pages
500-2issue
6318eissn
0028-0836issn
1476-4687journal_volume
350pub_type
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