Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein.

abstract：:The tuatara (Sphenodon punctatus)-the only living member of the reptilian order Rhynchocephalia (Sphenodontia), once widespread across Gondwana1,2-is an iconic species that is endemic to New Zealand2,3. A key link to the now-extinct stem reptiles (from which dinosaurs, modern reptiles, birds and mammals evolved), the ...

journal_title：Nature

authors： Gemmell NJ,Rutherford K,Prost S,Tollis M,Winter D,Macey JR,Adelson DL,Suh A,Bertozzi T,Grau JH,Organ C,Gardner PP,Muffato M,Patricio M,Billis K,Martin FJ,Flicek P,Petersen B,Kang L,Michalak P,Buckley TR,Wilson M

更新日期：2020-08-01 00:00:00

abstract：:A chimaeric gene, consisting of the 5'-flanking region of a member of the Pisum sativum gene family encoding ribulose 1,5-bisphosphate carboxylase linked to the coding region of a bacterial chloramphenicol acetyltransferase gene, has been introduced into the genome of the plant Nicotiana tabacum using a Ti plasmid of ...

journal_title：Nature

authors： Herrera-Estrella L,Van den Broeck G,Maenhaut R,Van Montagu M,Schell J,Timko M,Cashmore A

更新日期：1984-07-12 00:00:00

abstract：:Targeting of proteins to appropriate subcellular compartments is a crucial process in all living cells. Secretory and membrane proteins usually contain an amino-terminal signal peptide, which is recognized by the signal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome. The SRP-riboso...

journal_title：Nature

authors： Janda CY,Li J,Oubridge C,Hernández H,Robinson CV,Nagai K

更新日期：2010-05-27 00:00:00

abstract：:Gross chromosome rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions and inversions, are often observed in cancer cells. Spontaneous GCRs are rare in Saccharomyces cerevisiae; however, the existence of mutator mutants with increased genome instability suggests that GCRs ...

journal_title：Nature

authors： Myung K,Chen C,Kolodner RD

更新日期：2001-06-28 00:00:00

abstract：:There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...

journal_title：Nature

authors： Morgan JI,Curran T

更新日期：1986-08-07 00:00:00

abstract：:Double-walled carbon nanotubes are needed in a pure, highly crystalline form before features such as their electronic properties, thermal transport and mechanical behaviour can be investigated. Here we fabricate a paper-like material that consists of hexagonally packed bundles of clean, coaxial carbon nanotubes whose ...

journal_title：Nature

authors： Endo M,Muramatsu H,Hayashi T,Kim YA,Terrones M,Dresselhaus MS

更新日期：2005-02-03 00:00:00

abstract：:The large degeneracy of states resulting from the geometrical frustration of competing interactions is an essential ingredient of important problems in fields as diverse as magnetism, protein folding and neural networks. As first explained by Pauling, geometrical frustration of proton positions is also responsible for...

journal_title：Nature

authors： Snyder J,Slusky JS,Cava RJ,Schiffer P

更新日期：2001-09-06 00:00:00

abstract：:In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular germ cell tumour (TGCT) susceptibility in the 129 family of inbred strains, and markedly increases TGCT incidence in 129-Ter/Ter males. In 129-Ter/Ter mice, some of the r...

journal_title：Nature

authors： Youngren KK,Coveney D,Peng X,Bhattacharya C,Schmidt LS,Nickerson ML,Lamb BT,Deng JM,Behringer RR,Capel B,Rubin EM,Nadeau JH,Matin A

更新日期：2005-05-19 00:00:00

abstract：: ...

journal_title：Nature

authors： Dance A

更新日期：2018-11-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Witze A

更新日期：2018-11-01 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (InsP3) can initiate calcium release into the cytoplasm in a variety of cells. From experiments using permeabilized cells, membrane vesicles, and patch-clamp techniques, it has been suggested that InsP3 acts by directly opening calcium channels. Here, we show that InsP3 induced openings of...

journal_title：Nature

authors： Ehrlich BE,Watras J

更新日期：1988-12-08 00:00:00

abstract：:Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. Modification of the cell surface in this way can alter the cell's responsiveness to its environment and release potent soluble regulatory factors. The release of soluble tumour-necrosis factor-alpha (TNF-alpha) from...

journal_title：Nature

authors： Black RA,Rauch CT,Kozlosky CJ,Peschon JJ,Slack JL,Wolfson MF,Castner BJ,Stocking KL,Reddy P,Srinivasan S,Nelson N,Boiani N,Schooley KA,Gerhart M,Davis R,Fitzner JN,Johnson RS,Paxton RJ,March CJ,Cerretti DP

更新日期：1997-02-20 00:00:00

abstract：:Oscillations in cyclin-dependent kinase (CDK) activity drive the somatic cell cycle. After entry into mitosis, CDKs activate the anaphase-promoting complex (APC), which then promotes cyclin degradation and mitotic exit. The re-accumulation of cyclin A causes the inactivation of APC and entry into S phase, but how cycl...

journal_title：Nature

authors： Rape M,Kirschner MW

更新日期：2004-12-02 00:00:00

abstract：:Thermodynamics predicts that transmembrane voltage modulates membrane tension and that this will cause movement. The magnitude and polarity of movement is governed by cell stiffness and surface potentials. Here we confirm these predictions using the atomic force microscope to dynamically follow the movement of voltage...

journal_title：Nature

authors： Zhang PC,Keleshian AM,Sachs F

更新日期：2001-09-27 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse nervous system by influencing the expression of many specific genes that promote differentiation, cell survival, synapse formation and, later, synaptic plasticity. Although nitric oxide (NO) is kn...

journal_title：Nature

authors： Nott A,Watson PM,Robinson JD,Crepaldi L,Riccio A

更新日期：2008-09-18 00:00:00

abstract：:Steroid hormone receptors are a class of cell-specific trans-acting transcription regulatory factors whose activity is controlled by specific binding of the hormone. The hormone-receptor complex appears to associate with promoter/enhancer elements of specific target genes, resulting in activation of transcription (see...

journal_title：Nature

authors： Green S,Chambon P

更新日期：1987-01-01 00:00:00

abstract：:The angle between the spin of a star and the orbital planes of its planets traces the history of the planetary system. Exoplanets orbiting close to cool stars are expected to be on circular, aligned orbits because of strong tidal interactions with the stellar convective envelope. Spin-orbit alignment can be measured w...

journal_title：Nature

authors： Bourrier V,Lovis C,Beust H,Ehrenreich D,Henry GW,Astudillo-Defru N,Allart R,Bonfils X,Ségransan D,Delfosse X,Cegla HM,Wyttenbach A,Heng K,Lavie B,Pepe F

更新日期：2018-01-25 00:00:00

abstract：:Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hith...

journal_title：Nature

authors： Barclay T,Rowe JF,Lissauer JJ,Huber D,Fressin F,Howell SB,Bryson ST,Chaplin WJ,Désert JM,Lopez ED,Marcy GW,Mullally F,Ragozzine D,Torres G,Adams ER,Agol E,Barrado D,Basu S,Bedding TR,Buchhave LA,Charbonneau D,Ch

更新日期：2013-02-28 00:00:00

abstract：:Photosystem II is the site of photosynthetic water oxidation and contains 20 subunits with a total molecular mass of 350 kDa. The structure of photosystem II has been reported at resolutions from 3.8 to 2.9 Å. These resolutions have provided much information on the arrangement of protein subunits and cofactors but are...

journal_title：Nature

authors： Umena Y,Kawakami K,Shen JR,Kamiya N

更新日期：2011-05-05 00:00:00

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00

abstract：:Extant vertebrates form two clades, the jawless Cyclostomata (lampreys and hagfishes) and the jawed Gnathostomata (all other vertebrates), with contrasting facial architectures. These arise during development from just a few key differences in the growth patterns of the cranial primordia: notably, the nasal sacs and h...

journal_title：Nature

authors： Dupret V,Sanchez S,Goujet D,Tafforeau P,Ahlberg PE

更新日期：2014-03-27 00:00:00

abstract：:Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interr...

journal_title：Nature

authors： Khodadoust MS,Olsson N,Wagar LE,Haabeth OA,Chen B,Swaminathan K,Rawson K,Liu CL,Steiner D,Lund P,Rao S,Zhang L,Marceau C,Stehr H,Newman AM,Czerwinski DK,Carlton VE,Moorhead M,Faham M,Kohrt HE,Carette J,Green MR

更新日期：2017-03-30 00:00:00

abstract：:Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision1,2. Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss; however, the generation of sensory neuronal subtypes such as photore...

journal_title：Nature

authors： Mahato B,Kaya KD,Fan Y,Sumien N,Shetty RA,Zhang W,Davis D,Mock T,Batabyal S,Ni A,Mohanty S,Han Z,Farjo R,Forster MJ,Swaroop A,Chavala SH

更新日期：2020-05-01 00:00:00

abstract：:Proteolysis is essential for the execution of many cellular functions. These include removal of incorrectly folded or damaged proteins, the activation of transcription factors, the ordered degradation of proteins involved in cell cycle control, and the generation of peptides destined for presentation by class I molecu...

journal_title：Nature

authors： Glas R,Bogyo M,McMaster JS,Gaczynska M,Ploegh HL

更新日期：1998-04-09 00:00:00

abstract：:Classical population-genetics theory suggests that reproductive isolation will evolve fastest in small isolated populations. In contrast, recent theory suggests that divergence should occur fastest in larger allopatric populations. The rationale behind this is that sexual conflict, potentially the strongest driver of ...

journal_title：Nature

authors： Martin OY,Hosken DJ

更新日期：2003-06-26 00:00:00

abstract：:Quantum criticality is associated with a system composed of a nearly infinite number of interacting quantum degrees of freedom at zero temperature, and it implies that the system looks on average the same regardless of the time- and length scale on which it is observed. Electrons on the atomic scale do not exhibit suc...

journal_title：Nature

authors： van der Marel D,Molegraaf HJ,Zaanen J,Nussinov Z,Carbone F,Damascelli A,Eisaki H,Greven M,Kes PH,Li M

更新日期：2003-09-18 00:00:00

abstract：:Numerous studies have suggested that biodiversity reduces variability in ecosystem productivity through compensatory effects; that is, a species increases in its abundance in response to the reduction of another in a fluctuating environment. But this view has been challenged on several grounds. Because most studies ha...

journal_title：Nature

authors： Bai Y,Han X,Wu J,Chen Z,Li L

更新日期：2004-09-09 00:00:00

abstract：:Differentiation of bone marrow derived precursors into mature T cells takes place in the thymus. During differentiation, T cells develop the receptor repertoire which allows them to recognize antigen in the context of self major histocompatibility complex (MHC) molecules. Mature T helper cells (mostly CD4+ CD8-) recog...

journal_title：Nature

authors： Maruŝić-Galesić S,Stephany DA,Longo DL,Kruisbeek AM

更新日期：1988-05-12 00:00:00

abstract：:Proteins are inherently plastic molecules, whose function often critically depends on excursions between different molecular conformations (conformers). However, a rigorous understanding of the relation between a protein's structure, dynamics and function remains elusive. This is because many of the conformers on its ...

journal_title：Nature

authors： Bouvignies G,Vallurupalli P,Hansen DF,Correia BE,Lange O,Bah A,Vernon RM,Dahlquist FW,Baker D,Kay LE

更新日期：2011-08-21 00:00:00

abstract：:Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However, the similarity of the brain sodium channel 1 (BNC1) to nematode proteins involved in mechanotransduction indicated that ...

journal_title：Nature

authors： Price MP,Lewin GR,McIlwrath SL,Cheng C,Xie J,Heppenstall PA,Stucky CL,Mannsfeldt AG,Brennan TJ,Drummond HA,Qiao J,Benson CJ,Tarr DE,Hrstka RF,Yang B,Williamson RA,Welsh MJ

更新日期：2000-10-26 00:00:00