Inositol 1,4,5-trisphosphate activates a channel from smooth muscle sarcoplasmic reticulum.


:Inositol 1,4,5-trisphosphate (InsP3) can initiate calcium release into the cytoplasm in a variety of cells. From experiments using permeabilized cells, membrane vesicles, and patch-clamp techniques, it has been suggested that InsP3 acts by directly opening calcium channels. Here, we show that InsP3 induced openings of channels in planar lipid bilayers into which vesicles made from aortic muscle sarcoplasmic reticulum (SR) were incorporated. Activation of channels by InsP3 was not observed when vesicles made from SR of cardiac or skeletal muscle were incorporated into planar lipid bilayers. The present study demonstrates for the first time unique properties of an InsP3-gated calcium channel in sarcoplasmic reticulum vesicles from vascular smooth muscle. This InsP3-activated channel from aortic SR differs strikingly from the calcium-gated calcium channel of striated muscle SR in single-channel conductance and pharmacology.






Ehrlich BE,Watras J




Has Abstract


1988-12-08 00:00:00














  • High-frequency acoustic waves are not sufficient to heat the solar chromosphere.

    abstract::One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the c...


    pub_type: 杂志文章


    authors: Fossum A,Carlsson M

    更新日期:2005-06-16 00:00:00

  • Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines.

    abstract::Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the comple...


    pub_type: 杂志文章,评审


    authors: Galonić DP,Gin DY

    更新日期:2007-04-26 00:00:00

  • Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src.

    abstract::Growth factors such as platelet-derived growth factor (PDGF) elicit the transcriptional activation of a large number of immediate early genes (many of which encode transcription factors), and ultimately DNA synthesis. Both AP1 and Myc are activated in fibroblasts in response to growth factor stimulation, and various e...


    pub_type: 杂志文章


    authors: Barone MV,Courtneidge SA

    更新日期:1995-11-30 00:00:00

  • Observation of nuclear fusion driven by a pyroelectric crystal.

    abstract::While progress in fusion research continues with magnetic and inertial confinement, alternative approaches--such as Coulomb explosions of deuterium clusters and ultrafast laser-plasma interactions--also provide insight into basic processes and technological applications. However, attempts to produce fusion in a room t...


    pub_type: 杂志文章


    authors: Naranjo B,Gimzewski JK,Putterman S

    更新日期:2005-04-28 00:00:00

  • High-harmonic generation by resonant plasmon field enhancement.

    abstract::High-harmonic generation by focusing a femtosecond laser onto a gas is a well-known method of producing coherent extreme-ultraviolet (EUV) light. This nonlinear conversion process requires high pulse intensities, greater than 10(13) W cm(-2), which are not directly attainable using only the output power of a femtoseco...


    pub_type: 杂志文章


    authors: Kim S,Jin J,Kim YJ,Park IY,Kim Y,Kim SW

    更新日期:2008-06-05 00:00:00

  • Drosophila wingless generates cell type diversity among engrailed expressing cells.

    abstract::During embryogenesis, body pattern is established in a stepwise process. After specification of the body axis, the embryo is subdivided into smaller units. Within these units, a diverse array of cell types is then generated. The subdivisions of the Drosophila embryo, called parasegments, are defined by the interface b...


    pub_type: 杂志文章


    authors: Dougan S,DiNardo S

    更新日期:1992-11-26 00:00:00

  • Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.

    abstract::The developmental fate of immature thymocytes is determined by the specificity of their T-cell antigen receptors (TCRs). Immature CD4+8+ thymocytes are positively selected to differentiate into mature T cells by recognition of peptides associated with major histocompatibility complex (MHC) encoded molecules on thymic ...


    pub_type: 杂志文章


    authors: Takahama Y,Suzuki H,Katz KS,Grusby MJ,Singer A

    更新日期:1994-09-01 00:00:00

  • Anisotropic spinodal dewetting as a route to self-assembly of patterned surfaces

    abstract::The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...


    pub_type: 杂志文章


    authors: Higgins AM,Jones RA

    更新日期:2000-03-30 00:00:00

  • Extremely fast acceleration of cosmic rays in a supernova remnant.

    abstract::Galactic cosmic rays (CRs) are widely believed to be accelerated by shock waves associated with the expansion of supernova ejecta into the interstellar medium. A key issue in this long-standing conjecture is a theoretical prediction that the interstellar magnetic field can be substantially amplified at the shock of a ...


    pub_type: 杂志文章


    authors: Uchiyama Y,Aharonian FA,Tanaka T,Takahashi T,Maeda Y

    更新日期:2007-10-04 00:00:00

  • PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.

    abstract::In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2...


    pub_type: 杂志文章


    authors: Kuchay S,Giorgi C,Simoneschi D,Pagan J,Missiroli S,Saraf A,Florens L,Washburn MP,Collazo-Lorduy A,Castillo-Martin M,Cordon-Cardo C,Sebti SM,Pinton P,Pagano M

    更新日期:2017-06-22 00:00:00

  • Prevention of tuberculosis in macaques after intravenous BCG immunization.

    abstract::Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette-Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission1,2. Here we show that intravenous ...


    pub_type: 杂志文章


    authors: Darrah PA,Zeppa JJ,Maiello P,Hackney JA,Wadsworth MH 2nd,Hughes TK,Pokkali S,Swanson PA 2nd,Grant NL,Rodgers MA,Kamath M,Causgrove CM,Laddy DJ,Bonavia A,Casimiro D,Lin PL,Klein E,White AG,Scanga CA,Shalek AK,Roede

    更新日期:2020-01-01 00:00:00

  • Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.

    abstract::The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors. Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses. However, antiviral ISG...


    pub_type: 杂志文章


    authors: Schoggins JW,MacDuff DA,Imanaka N,Gainey MD,Shrestha B,Eitson JL,Mar KB,Richardson RB,Ratushny AV,Litvak V,Dabelic R,Manicassamy B,Aitchison JD,Aderem A,Elliott RM,García-Sastre A,Racaniello V,Snijder EJ,Yokoyama WM,

    更新日期:2014-01-30 00:00:00

  • Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.

    abstract::Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may reconstitute lethally irradiated hosts. In steady-state, HSCs remain largely quiescent and self-renew at a constant low rate, forestalling their exhaustion during adult ...


    pub_type: 杂志文章


    authors: Hock H,Hamblen MJ,Rooke HM,Schindler JW,Saleque S,Fujiwara Y,Orkin SH

    更新日期:2004-10-21 00:00:00

  • Mutations in NOTCH1 cause aortic valve disease.

    abstract::Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population. Despite the frequency, neither the mechanisms of valve calcification nor the developmental origin of a tw...


    pub_type: 杂志文章


    authors: Garg V,Muth AN,Ransom JF,Schluterman MK,Barnes R,King IN,Grossfeld PD,Srivastava D

    更新日期:2005-09-08 00:00:00

  • Interleukin-4 mediates CD8 induction on human CD4+ T-cell clones.

    abstract::CD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex. Mature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8. Nevertheless, a small percentage of peripheral CD3+ T cell...


    pub_type: 杂志文章


    authors: Paliard X,Malefijt RW,de Vries JE,Spits H

    更新日期:1988-10-13 00:00:00

  • Identity of cells that imprint H-2-restricted T-cell specificity in the thymus.

    abstract::The thymus has two important roles in controlling the specificity of T lymphocytes. First, T cells differentiating in the thymus are rendered tolerant of 'self' antigens, particularly antigens encoded by the major histocompatibility complex, the H-2 complex in mice. Second, the thymus imbues T cells with the property ...


    pub_type: 杂志文章


    authors: Lo D,Sprent J

    更新日期:1986-02-20 00:00:00

  • A two-step fibrinogen--fibrin transition in blood coagulation.

    abstract::The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation s...


    pub_type: 杂志文章


    authors: Blombäck B,Hessel B,Hogg D,Therkildsen L

    更新日期:1978-10-12 00:00:00

  • Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.

    abstract::Endophilin I is a presynaptic protein of unknown function that binds to dynamin, a GTPase that is implicated in endocytosis and recycling of synaptic vesicles. Here we show that endophilin I is essential for the formation of synaptic-like microvesicles (SLMVs) from the plasma membrane. Endophilin I exhibits lysophosph...


    pub_type: 杂志文章


    authors: Schmidt A,Wolde M,Thiele C,Fest W,Kratzin H,Podtelejnikov AV,Witke W,Huttner WB,Söling HD

    更新日期:1999-09-09 00:00:00

  • DNA repair gene RAD3 of S. cerevisiae is essential for transcription by RNA polymerase II.

    abstract::The RAD3 gene of Saccharomyces cerevisiae is required for excision repair of ultraviolet-damaged DNA and is essential for cell viability. The RAD3-encoded protein shares a high degree of homology with the human ERCC2(XPD) gene product. Mutations in XPD, besides causing the cancer-prone syndrome xeroderma pigmentosum, ...


    pub_type: 杂志文章


    authors: Guzder SN,Qiu H,Sommers CH,Sung P,Prakash L,Prakash S

    更新日期:1994-01-06 00:00:00

  • Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation.

    abstract::Scrapie and related animal and human disorders are neurodegenerative diseases characterized by the formation of a modified, partly proteinase-resistant protein (PrP) of the host, which tends to aggregate as amyloid fibrils and accumulate in the brain of infected individuals. There is a general consensus that the patho...


    pub_type: 杂志文章


    authors: Xi YG,Ingrosso L,Ladogana A,Masullo C,Pocchiari M

    更新日期:1992-04-16 00:00:00

  • Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

    abstract::Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-...


    pub_type: 杂志文章


    authors: Cole ST,Brosch R,Parkhill J,Garnier T,Churcher C,Harris D,Gordon SV,Eiglmeier K,Gas S,Barry CE 3rd,Tekaia F,Badcock K,Basham D,Brown D,Chillingworth T,Connor R,Davies R,Devlin K,Feltwell T,Gentles S,Hamlin N,Hol

    更新日期:1998-06-11 00:00:00

  • Re-analysis of radiation-induced specific locus mutations in the mouse.

    abstract::A re-analysis of published data on mouse mutation rates induced by X and gamma rays suggests that the kinetics of induction can be analysed by fitting the data to a parabolic curve. We interpret this to mean that a substantial proportion of the induced mutations results from gross chromosomal changes such as deletions...


    pub_type: 杂志文章


    authors: Abrahamson S,Wolff S

    更新日期:1976-12-23 00:00:00

  • Water and its influence on the lithosphere-asthenosphere boundary.

    abstract::The Earth has distinctive convective behaviour, described by the plate tectonics model, in which lateral motion of the oceanic lithosphere of basaltic crust and peridotitic uppermost mantle is decoupled from the underlying mechanically weaker upper mantle (asthenosphere). The reason for differentiation at the lithosph...


    pub_type: 杂志文章


    authors: Green DH,Hibberson WO,Kovács I,Rosenthal A

    更新日期:2010-09-23 00:00:00

  • Recruitment of cytosolic proteins to a secretory granule membrane depends on Ca2+-calmodulin.

    abstract::An increase in free calcium triggers catecholamine secretion from chromaffin cells and calmodulin is strongly implicated as the intracellular Ca2+ receptor. In our recent studies of calmodulin action in the chromaffin cell, micromolar Ca2+ concentrations resulted in calmodulin and cytosolic proteins becoming bound to ...


    pub_type: 杂志文章


    authors: Geisow MJ,Burgoyne RD

    更新日期:1983-02-03 00:00:00

  • Phenotypic consequences of 1,000 generations of selection at elevated CO2 in a green alga.

    abstract::Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...


    pub_type: 杂志文章


    authors: Collins S,Bell G

    更新日期:2004-09-30 00:00:00

  • U.S. biotechnology: living with regulation.

    abstract::A brief account is provided of a meeting between federal officials and representatives of the Industrial Biotechnology Association (IBA), a consortium of companies concerned about the regulatory outlook for their industry. Current regulatory interest is focused on the Environmental Protection Agency, which has declar...


    pub_type: 新闻


    authors: David P

    更新日期:1983-10-27 00:00:00

  • Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins.

    abstract::The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the...


    pub_type: 杂志文章


    authors: Xiao K,Zhai J,Feng Y,Zhou N,Zhang X,Zou JJ,Li N,Guo Y,Li X,Shen X,Zhang Z,Shu F,Huang W,Li Y,Zhang Z,Chen RA,Wu YJ,Peng SM,Huang M,Xie WJ,Cai QH,Hou FH,Chen W,Xiao L,Shen Y

    更新日期:2020-07-01 00:00:00

  • Topoisomerase II mediates meiotic crossover interference.

    abstract::Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide an interesting example, defined by the classic phenomenon of crossover interference. Here we identify a molecular pathway for interference by analysing crossover patterns in budding yeast. Topoisomerase II plays a central role...


    pub_type: 杂志文章


    authors: Zhang L,Wang S,Yin S,Hong S,Kim KP,Kleckner N

    更新日期:2014-07-31 00:00:00

  • Ghrelin induces adiposity in rodents.

    abstract::The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion along...


    pub_type: 杂志文章


    authors: Tschöp M,Smiley DL,Heiman ML

    更新日期:2000-10-19 00:00:00

  • Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens.

    abstract::The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product. ...


    pub_type: 杂志文章


    authors: Bouck N,di Mayorca G

    更新日期:1976-12-23 00:00:00