Abstract：
:The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
journal_name
Naturejournal_title
Natureauthors
Mouse Genome Sequencing Consortium.,Waterston RH,Lindblad-Toh K,Birney E,Rogers J,Abril JF,Agarwal P,Agarwala R,Ainscough R,Alexandersson M,An P,Antonarakis SE,Attwood J,Baertsch R,Bailey J,Barlow K,Beck S,Berry E,Birdoi
10.1038/nature01262keywords:
subject
Has Abstractpub_date
2002-12-05 00:00:00pages
520-62issue
6915eissn
0028-0836issn
1476-4687pii
nature01262journal_volume
420pub_type
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