A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.

abstract：:Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...

journal_title：Nature

authors： Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba

更新日期：2009-08-13 00:00:00

abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...

journal_title：Nature

authors： Castillo PE,Janz R,Südhof TC,Tzounopoulos T,Malenka RC,Nicoll RA

更新日期：1997-08-07 00:00:00

abstract：:Protein chains coil into alpha-helices and beta-sheet structures. Knowing the timescales and mechanism of formation of these basic structural elements is essential for understanding how proteins fold. For the past 40 years, alpha-helix formation has been extensively investigated in synthetic and natural peptides, incl...

journal_title：Nature

authors： Muñoz V,Thompson PA,Hofrichter J,Eaton WA

更新日期：1997-11-13 00:00:00

abstract：:The large degeneracy of states resulting from the geometrical frustration of competing interactions is an essential ingredient of important problems in fields as diverse as magnetism, protein folding and neural networks. As first explained by Pauling, geometrical frustration of proton positions is also responsible for...

journal_title：Nature

authors： Snyder J,Slusky JS,Cava RJ,Schiffer P

更新日期：2001-09-06 00:00:00

abstract：:The proto-oncogene c-myc is the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such as c-myc in tumorogenesis. Here we report that comparison of the structure of...

journal_title：Nature

authors： Morse B,Rotherg PG,South VJ,Spandorfer JM,Astrin SM

更新日期：1988-05-05 00:00:00

abstract：:The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...

journal_title：Nature

authors： Higgins AM,Jones RA

更新日期：2000-03-30 00:00:00

abstract：:The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New a...

journal_title：Nature

authors： Barker RA,Götz M,Parmar M

更新日期：2018-05-01 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are voltage-independent, amiloride-sensitive channels involved in diverse physiological processes ranging from nociception to taste. Despite the importance of ASICs in physiology, we know little about the mechanism of channel activation. Here we show that psalmotoxin activates non-sel...

journal_title：Nature

authors： Baconguis I,Gouaux E

更新日期：2012-09-20 00:00:00

abstract：:Classical crystallography can determine structures as complicated as multi-component ribosomal assemblies with atomic resolution, but is inadequate for disordered systems--even those as simple as water ice--that occupy the complex middle ground between liquid-like randomness and crystalline periodic order. Correlated ...

journal_title：Nature

authors： Keen DA,Goodwin AL

更新日期：2015-05-21 00:00:00

abstract：:Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, offering unrivalled accuracy in allele design and access to conditional mutagenesis. To bring these advantages to the wider research community, large-scale mouse knockout programmes are producing a permanen...

journal_title：Nature

authors： Skarnes WC,Rosen B,West AP,Koutsourakis M,Bushell W,Iyer V,Mujica AO,Thomas M,Harrow J,Cox T,Jackson D,Severin J,Biggs P,Fu J,Nefedov M,de Jong PJ,Stewart AF,Bradley A

更新日期：2011-06-15 00:00:00

abstract：:Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3....

journal_title：Nature

authors： Welker F,Ramos-Madrigal J,Kuhlwilm M,Liao W,Gutenbrunner P,de Manuel M,Samodova D,Mackie M,Allentoft ME,Bacon AM,Collins MJ,Cox J,Lalueza-Fox C,Olsen JV,Demeter F,Wang W,Marques-Bonet T,Cappellini E

更新日期：2019-12-01 00:00:00

abstract：:The arrest of dorsal root axonal regeneration at the transitional zone between the peripheral and central nervous system has been repeatedly described since the early twentieth century. Here we show that, with trophic support to damaged sensory axons, this regenerative barrier is surmountable. In adult rats with injur...

journal_title：Nature

authors： Ramer MS,Priestley JV,McMahon SB

更新日期：2000-01-20 00:00:00

abstract：:Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserves immune self-tolerance and prevents chronic inflammation and autoimmune pathologies. The diverse array of phagocytes that reside within different tissues, combined with the necessarily prompt natu...

journal_title：Nature

authors： Cummings RJ,Barbet G,Bongers G,Hartmann BM,Gettler K,Muniz L,Furtado GC,Cho J,Lira SA,Blander JM

更新日期：2016-11-24 00:00:00

abstract：:Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by 'reader' proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood....

journal_title：Nature

authors： Wan L,Chong S,Xuan F,Liang A,Cui X,Gates L,Carroll TS,Li Y,Feng L,Chen G,Wang SP,Ortiz MV,Daley SK,Wang X,Xuan H,Kentsis A,Muir TW,Roeder RG,Li H,Li W,Tjian R,Wen H,Allis CD

更新日期：2020-01-01 00:00:00

abstract：:Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, largely because of small numbers of hosts and parasites studied and uncertainty over rates of evolutionary change. Co-speciation is especially rare in RNA viruses, in which cross-species tra...

journal_title：Nature

authors： Switzer WM,Salemi M,Shanmugam V,Gao F,Cong ME,Kuiken C,Bhullar V,Beer BE,Vallet D,Gautier-Hion A,Tooze Z,Villinger F,Holmes EC,Heneine W

更新日期：2005-03-17 00:00:00

abstract：:Three-wave mixing in nonlinear materials--the interaction of two light waves to produce a third--is a convenient way of generating new optical frequencies from common laser sources. However, the resulting optical conversion yield is generally poor, because the relative phases of the three interacting waves change cont...

journal_title：Nature

authors： Baudrier-Raybaut M,Haïdar R,Kupecek P,Lemasson P,Rosencher E

更新日期：2004-11-18 00:00:00

abstract：:Lyman-alpha emitters are thought to be young, low-mass galaxies with ages of approximately 10(8) yr (refs 1, 2). An overdensity of them in one region of the sky (the SSA 22 field) traces out a filamentary structure in the early Universe at a redshift of z approximately 3.1 (equivalent to 15 per cent of the age of the ...

journal_title：Nature

authors： Tamura Y,Kohno K,Nakanishi K,Hatsukade B,Iono D,Wilson GW,Yun MS,Takata T,Matsuda Y,Tosaki T,Ezawa H,Perera TA,Scott KS,Austermann JE,Hughes DH,Aretxaga I,Chung A,Oshima T,Yamaguchi N,Tanaka K,Kawabe R

更新日期：2009-05-07 00:00:00

abstract：:The European Commission has made good progress in gathering support for its new programme of basic and applied research. Now Europe's industries and heads of state need to fulfill promises made two years ago. ...

journal_title：Nature

authors：

更新日期：2002-01-31 00:00:00

abstract：:With the discovery1 of superconductivity at 203 kelvin in H3S, attention returned to conventional superconductors with properties that can be described by the Bardeen-Cooper-Schrieffer and the Migdal-Eliashberg theories. Although these theories predict the possibility of room-temperature superconductivity in metals th...

journal_title：Nature

authors： Drozdov AP,Kong PP,Minkov VS,Besedin SP,Kuzovnikov MA,Mozaffari S,Balicas L,Balakirev FF,Graf DE,Prakapenka VB,Greenberg E,Knyazev DA,Tkacz M,Eremets MI

更新日期：2019-05-01 00:00:00

abstract：:Electronic devices have advanced from their heavy, bulky origins to become smart, mobile appliances. Nevertheless, they remain rigid, which precludes their intimate integration into everyday life. Flexible, textile and stretchable electronics are emerging research areas and may yield mainstream technologies. Rollable ...

journal_title：Nature

authors： Kaltenbrunner M,Sekitani T,Reeder J,Yokota T,Kuribara K,Tokuhara T,Drack M,Schwödiauer R,Graz I,Bauer-Gogonea S,Bauer S,Someya T

更新日期：2013-07-25 00:00:00

abstract：:Elongation factor Tu is present in a fourfold excess over the amount seemingly involved in protein synthesis. It is identical to a major protein which we have found associated with the plasma membrane. The possibility of a specific role in that location is considered. ...

journal_title：Nature

authors： Jacobson GR,Rosenbusch JP

更新日期：1976-05-06 00:00:00

abstract：:Few intergalactic, plausibly primordial clouds of neutral atomic hydrogen (H(i)) have been found in the local Universe, suggesting that such structures have either dispersed, become ionized or produced a stellar population on gigayear timescales. The Leo ring, a massive (M(H(i)) approximately 1.8 x 10(9)M[symbol: see ...

journal_title：Nature

authors： Thilker DA,Donovan J,Schiminovich D,Bianchi L,Boissier S,de Paz AG,Madore BF,Martin DC,Seibert M

更新日期：2009-02-19 00:00:00

abstract：:The lack of a reliable theory of glass physics has led to the pursuit of correlations between various glass or viscous liquid parameters, one of which is the slope m of the plot of log(viscosity) against Tg/T, extrapolated at the glass-transition temperature, Tg, also termed 'fragility'. Novikov and Sokolov conclude t...

journal_title：Nature

authors： Yannopoulos SN,Johari GP

更新日期：2006-08-03 00:00:00

abstract：:P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human, which are subdivided into P2Y1-like receptors and P2Y12-like receptors. Their ligands are generally charged molecules w...

journal_title：Nature

authors： Zhang K,Zhang J,Gao ZG,Zhang D,Zhu L,Han GW,Moss SM,Paoletta S,Kiselev E,Lu W,Fenalti G,Zhang W,Müller CE,Yang H,Jiang H,Cherezov V,Katritch V,Jacobson KA,Stevens RC,Wu B,Zhao Q

更新日期：2014-05-01 00:00:00

abstract：:Lord Rothschild presents his personal views about the terminology used to describe research and development. ...

journal_title：Nature

authors： Rothschild L

更新日期：1972-10-13 00:00:00

abstract：:Many chemical and physical systems can occur in two forms distinguished solely by being mirror images of each other. This phenomenon, known as chirality, is important in biochemistry, where reactions involving chiral molecules often require the participation of one specific enantiomer (mirror image) of the two possibl...

journal_title：Nature

authors： Rikken GL,Raupach E

更新日期：2000-06-22 00:00:00

abstract：:Recent studies in which cloned immunoglobulin genes were introduced into cultured cells have produced two significant findings. First, the genes are expressed after transfection into lymphoid cells but not non-lymphoid cells. Second, transcription of an immunoglobulin gene requires, in addition to the promoter region,...

journal_title：Nature

authors： Foster J,Stafford J,Queen C

更新日期：1985-05-30 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 ...

journal_title：Nature

authors： Park J,Lee SB,Lee S,Kim Y,Song S,Kim S,Bae E,Kim J,Shong M,Kim JM,Chung J

更新日期：2006-06-29 00:00:00

abstract：:A large impact by a comet or meteorite releases an enormous amount of energy, which evaporates, melts and fractures the surrounding rocks. Distinctive features of such impacts are 'shatter cones', deformed rocks characterized by hierarchical striated features. Although such features have been used for decades as unequ...

journal_title：Nature

authors： Sagy A,Reches Z,Fineberg J

更新日期：2002-07-18 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2019-01-01 00:00:00