Abstract：
:Recent studies in which cloned immunoglobulin genes were introduced into cultured cells have produced two significant findings. First, the genes are expressed after transfection into lymphoid cells but not non-lymphoid cells. Second, transcription of an immunoglobulin gene requires, in addition to the promoter region, an enhancer element located downstream of the transcription start site. These findings raise the question of whether it is the promoter or the enhancer region that is responsible for the observed cell-type specificity. It has, in fact, been shown that immunoglobulin enhancers function only in lymphoid cells. We show here that the promoter for an immunoglobulin kappa light-chain gene also is strongly specific for lymphoid cells. Our result reemphasizes the importance of promoters relative to enhancers in determining which cells express which genes.
journal_name
Naturejournal_title
Natureauthors
Foster J,Stafford J,Queen Cdoi
10.1038/315423a0subject
Has Abstractpub_date
1985-05-30 00:00:00pages
423-5issue
6018eissn
0028-0836issn
1476-4687journal_volume
315pub_type
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