当前位置： SCI文献检索 > NATURE期刊下所有文献 > Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid.

Undermethylation associated with retroelement activation and chromosome remodelling in an interspecific mammalian hybrid.

Abstract：

:Genetic models predict that genomic rearrangement in hybrids can facilitate reproductive isolation and the formation of new species by preventing gene flow between the parent species and hybrid (sunflowers are an example). The mechanism underlying hybridization-induced chromosome remodelling is as yet unknown, although mobile element activity has been shown to be involved in DNA rearrangement in some dysgenic Drosophila hybrids. It has been proposed that DNA methylation evolved as a means of repressing the movement of mobile elements (the host defence model). If such a protective mechanism were to fail, mobile elements could be activated, and could cause major and rapid genome alterations. Here we demonstrate the occurrence of genome-wide undermethylation, retroviral element amplification and chromosome remodelling in an interspecific mammalian hybrid (Macropus eugenii x Wallabia bicolor). Atypically extended centromeres of Macropus eugenii derived autosomes in the hybrid were composed primarily of an unmethylated, amplified retroviral element not detectable in either parent species. These results, taken with the observation of deficient methylation and de novo chromosome change in other mammalian hybrids, indicate that the failure of DNA methylation and subsequent mobile-element activity in hybrids could facilitate rapid karyotypic evolution.

journal_name

Nature

journal_title

Nature

authors

O'Neill RJ,O'Neill MJ,Graves JA

doi

10.1038/29985

subject

Has Abstract

pub_date

1998-05-07 00:00:00

pages

68-72

issue

6680

eissn

0028-0836

issn

1476-4687

journal_volume

393

pub_type

杂志文章

相关文献

NATURE文献大全
  • 3-A resolution structure of a protein with histone-like properties in prokaryotes.

    abstract：:The 3-A structure of DNA-binding protein II, which exhibits histone-like properties in bacteria, has been determined. The molecule is dimeric and appears to bind to the phosphate backbone of DNA through two symmetry-related arms. A mechanism by which the protein induces DNA supercoiling is proposed. ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/310376a0

    authors： Tanaka I,Appelt K,Dijk J,White SW,Wilson KS

    更新日期：1984-08-02 00:00:00

  • The banana (Musa acuminata) genome and the evolution of monocotyledonous plants.

    abstract：:Bananas (Musa spp.), including dessert and cooking types, are giant perennial monocotyledonous herbs of the order Zingiberales, a sister group to the well-studied Poales, which include cereals. Bananas are vital for food security in many tropical and subtropical countries and the most popular fruit in industrialized c...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11241

    authors： D'Hont A,Denoeud F,Aury JM,Baurens FC,Carreel F,Garsmeur O,Noel B,Bocs S,Droc G,Rouard M,Da Silva C,Jabbari K,Cardi C,Poulain J,Souquet M,Labadie K,Jourda C,Lengellé J,Rodier-Goud M,Alberti A,Bernard M,Correa M

    更新日期：2012-08-09 00:00:00

  • Milestone meetings.

    abstract：: ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/d41586-018-07781-4

    authors： Gewin V

    更新日期：2018-12-01 00:00:00

  • Transduction and rearrangement of the myc gene by feline leukaemia virus in naturally occurring T-cell leukaemias.

    abstract：:Evidence of myc gene transduction by feline leukaemia virus in several spontaneous lymphoid tumours of cats suggests that recombinant viruses carrying oncogenes may be much more involved in oncogenesis in natural conditions than previously recognized. ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/308814a0

    authors： Neil JC,Hughes D,McFarlane R,Wilkie NM,Onions DE,Lees G,Jarrett O

    更新日期：1984-04-26 00:00:00

  • The crown-of-thorns starfish genome as a guide for biocontrol of this coral reef pest.

    abstract：:The crown-of-thorns starfish (COTS, the Acanthaster planci species group) is a highly fecund predator of reef-building corals throughout the Indo-Pacific region. COTS population outbreaks cause substantial loss of coral cover, diminishing the integrity and resilience of reef ecosystems. Here we sequenced genomes of CO...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature22033

    authors： Hall MR,Kocot KM,Baughman KW,Fernandez-Valverde SL,Gauthier MEA,Hatleberg WL,Krishnan A,McDougall C,Motti CA,Shoguchi E,Wang T,Xiang X,Zhao M,Bose U,Shinzato C,Hisata K,Fujie M,Kanda M,Cummins SF,Satoh N,Degnan SM

    更新日期：2017-04-05 00:00:00

  • Large adjustments in visually guided reaching do not depend on vision of the hand or perception of target displacement.

    abstract：:When we reach towards an object that suddenly appears in our peripheral visual field, not only does our arm extend towards the object, but our eyes, head and body also move in such a way that the image of the object falls on the fovea. Popular models of how reaching movements are programmed have argued that while the ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/320748a0

    authors： Goodale MA,Pelisson D,Prablanc C

    更新日期：1986-04-24 00:00:00

  • Osmotic stress mimics effects of vasopressin on learned behaviour.

    abstract：:It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure. AVP administered subcutaneously (s.c.), intraventricularly or intracerebrally can prolong extinction of acti...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/315750a0

    authors： Koob GF,Dantzer R,Rodriguez F,Bloom FE,Le Moal M

    更新日期：1985-06-27 00:00:00

  • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.

    abstract：:Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated beta-catenin activity drives colon tumorigenesis, further genetic perturbations are required to elaborate full malignant transformation. To...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature07179

    authors： Firestein R,Bass AJ,Kim SY,Dunn IF,Silver SJ,Guney I,Freed E,Ligon AH,Vena N,Ogino S,Chheda MG,Tamayo P,Finn S,Shrestha Y,Boehm JS,Jain S,Bojarski E,Mermel C,Barretina J,Chan JA,Baselga J,Tabernero J,Root DE,

    更新日期：2008-09-25 00:00:00

  • Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH.

    abstract：:Ageing is a result of gradual and overall functional deteriorations across the body; however, it is unknown whether an individual tissue primarily works to mediate the ageing progress and control lifespan. Here we show that the hypothalamus is important for the development of whole-body ageing in mice, and that the un...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature12143

    authors： Zhang G,Li J,Purkayastha S,Tang Y,Zhang H,Yin Y,Li B,Liu G,Cai D

    更新日期：2013-05-09 00:00:00

  • Protein competition switches the function of COP9 from self-renewal to differentiation.

    abstract：:The balance between stem cell self-renewal and differentiation is controlled by intrinsic factors and niche signals. In the Drosophila melanogaster ovary, some intrinsic factors promote germline stem cell (GSC) self-renewal, whereas others stimulate differentiation. However, it remains poorly understood how the balanc...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13562

    authors： Pan L,Wang S,Lu T,Weng C,Song X,Park JK,Sun J,Yang ZH,Yu J,Tang H,McKearin DM,Chamovitz DA,Ni J,Xie T

    更新日期：2014-10-09 00:00:00

  • An intense stratospheric jet on Jupiter.

    abstract：:The Earth's equatorial stratosphere shows oscillations in which the east-west winds reverse direction and the temperatures change cyclically with a period of about two years. This phenomenon, called the quasi-biennial oscillation, also affects the dynamics of the mid- and high-latitude stratosphere and weather in the ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature02142

    authors： Flasar FM,Kunde VG,Achterberg RK,Conrath BJ,Simon-Miller AA,Nixon CA,Gierasch PJ,Romani PN,Bézard B,Irwin P,Bjoraker GL,Brasunas JC,Jennings DE,Pearl JC,Smith MD,Orton GS,Spilker LJ,Carlson R,Calcutt SB,Read PL,Ta

    更新日期：2004-01-08 00:00:00

  • Hybrid formation between African trypanosomes during cyclical transmission.

    abstract：:Trypanosomes of the species Trypanosoma brucei reproduce primarily by binary fission, but the frequency of enzyme electrophoretic variants in natural populations of T. brucei has provided indirect evidence for the existence of a sexual cycle. These studies, coupled with studies of restriction fragment length polymorph...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/322173a0

    authors： Jenni L,Marti S,Schweizer J,Betschart B,Le Page RW,Wells JM,Tait A,Paindavoine P,Pays E,Steinert M

    更新日期：1986-07-10 00:00:00

  • Bidirectional movement of actin filaments along tracks of myosin heads.

    abstract：:It is well established that muscle contraction results from the relative sliding of actin and myosin filaments. Both filaments have definite polarities and well-ordered structures. Thick filaments, however, are not vital for supporting movement in vitro. Previously we have demonstrated that actin filaments can move co...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/341154a0

    authors： Toyoshima YY,Toyoshima C,Spudich JA

    更新日期：1989-09-14 00:00:00

  • Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)

    abstract：:Many receptors for neuropeptides and hormones are coupled with the heterotrimeric G(i) protein, which activates the p42/44 mitogen-activated protein kinase (ERK/MAPK) cascade through both the alpha- and betagamma-subunits of G(i). The betagamma-subunit activates the ERK/MAPK cascade through tyrosine kinase. Constituti...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/23738

    authors： Mochizuki N,Ohba Y,Kiyokawa E,Kurata T,Murakami T,Ozaki T,Kitabatake A,Nagashima K,Matsuda M

    更新日期：1999-08-26 00:00:00

  • Prevention of tuberculosis in macaques after intravenous BCG immunization.

    abstract：:Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette-Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission1,2. Here we show that intravenous ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-1817-8

    authors： Darrah PA,Zeppa JJ,Maiello P,Hackney JA,Wadsworth MH 2nd,Hughes TK,Pokkali S,Swanson PA 2nd,Grant NL,Rodgers MA,Kamath M,Causgrove CM,Laddy DJ,Bonavia A,Casimiro D,Lin PL,Klein E,White AG,Scanga CA,Shalek AK,Roede

    更新日期：2020-01-01 00:00:00

  • Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion.

    abstract：:In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal am...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/324476a0

    authors： Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JD

    更新日期：1986-12-04 00:00:00

  • Chondrule formation in particle-rich nebular regions at least hundreds of kilometres across.

    abstract：:Chondrules are millimetre-sized spherules (mostly silicate) that dominate the texture of primitive meteorites. Their formation mechanism is debated, but their sheer abundance suggests that the mechanism was both energetic and ubiquitous in the early inner Solar System. The processes suggested--such as shock waves, sol...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature04834

    authors： Cuzzi JN,Alexander CM

    更新日期：2006-05-25 00:00:00

  • Forensics: age written in teeth by nuclear tests.

    abstract：:Establishing the age at death of individuals is an important step in their identification and can be done with high precision up to adolescence by analysis of dentition, but it is more difficult in adults. Here we show that the amount of radiocarbon present in tooth enamel as a result of nuclear bomb testing during 19...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/437333a

    authors： Spalding KL,Buchholz BA,Bergman LE,Druid H,Frisén J

    更新日期：2005-09-15 00:00:00

  • Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein.

    abstract：:Excitatory amino acids (EAAs) are important neurotransmitters in the vertebrate central nervous system. Electrophysiological and ligand-binding studies indicate that at least three different receptor subtypes for EAAs exist--N-methyl-D-aspartate, kainate and quisqualate receptor subtypes--on the basis of the preferred...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/342684a0

    authors： Wada K,Dechesne CJ,Shimasaki S,King RG,Kusano K,Buonanno A,Hampson DR,Banner C,Wenthold RJ,Nakatani Y

    更新日期：1989-12-07 00:00:00

  • Cross-neutralization of influenza A viruses mediated by a single antibody loop.

    abstract：:Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a mech...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11414

    authors： Ekiert DC,Kashyap AK,Steel J,Rubrum A,Bhabha G,Khayat R,Lee JH,Dillon MA,O'Neil RE,Faynboym AM,Horowitz M,Horowitz L,Ward AB,Palese P,Webby R,Lerner RA,Bhatt RR,Wilson IA

    更新日期：2012-09-27 00:00:00

  • Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides.

    abstract：:Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processi...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/295206a0

    authors： Gubler U,Seeburg P,Hoffman BJ,Gage LP,Udenfriend S

    更新日期：1982-01-21 00:00:00

  • A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.

    abstract：:The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the p...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/303497a0

    authors： Schwab M,Alitalo K,Varmus HE,Bishop JM,George D

    更新日期：1983-06-09 00:00:00

  • Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex.

    abstract：:Secretory-protein translocation into the endoplasmic reticulum (ER) is thought to be catalysed by integral membrane proteins. Genetic selections uncovered three Saccharomyces cerevisiae genes (SEC61, SEC62 and SEC63), mutations in which block import of precursor proteins into the ER lumen in vivo and in vitro. The DNA...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/349806a0

    authors： Deshaies RJ,Sanders SL,Feldheim DA,Schekman R

    更新日期：1991-02-28 00:00:00

  • Observation of coherent optical information storage in an atomic medium using halted light pulses.

    abstract：:Electromagnetically induced transparency is a quantum interference effect that permits the propagation of light through an otherwise opaque atomic medium; a 'coupling' laser is used to create the interference necessary to allow the transmission of resonant pulses from a 'probe' laser. This technique has been used to s...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35054017

    authors： Liu C,Dutton Z,Behroozi CH,Hau LV

    更新日期：2001-01-25 00:00:00

  • Conceptual model of the Bahamian Platform for the last 135 million years.

    abstract：:The subsidence history of the Bahamian Platform points to a non-uniform rate of sea-floor spreading since the beginning of the Cretaceous. Lower Cretaceous rates of perhaps 5 cm/yr led to an active trench system at the boundary between the American and Caribbean lithosphere plates, and the rapid subsidence of the cont...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/2251226a0

    authors： Lynts GW

    更新日期：1970-03-28 00:00:00

  • Inositol trisphosphate and calcium signalling.

    abstract：:Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels disp...

    journal_title：Nature

    pub_type： 杂志文章,评审

    doi：10.1038/361315a0

    authors： Berridge MJ

    更新日期：1993-01-28 00:00:00

  • Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin.

    abstract：:Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/311678a0

    authors： Knossow M,Daniels RS,Douglas AR,Skehel JJ,Wiley DC

    更新日期：1984-10-18 00:00:00

  • Lagging-strand replication shapes the mutational landscape of the genome.

    abstract：:The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature14183

    authors： Reijns MAM,Kemp H,Ding J,de Procé SM,Jackson AP,Taylor MS

    更新日期：2015-02-26 00:00:00

  • Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.

    abstract：:Blood vessel growth in the skeletal system and osteogenesis seem to be coupled, suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells. Understanding the nature of the mechanisms linking angiogenesis and bone formation should be of great relevance for improved fracture healing or pr...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13146

    authors： Ramasamy SK,Kusumbe AP,Wang L,Adams RH

    更新日期：2014-03-20 00:00:00

  • Patterns of colonization in a metapopulation of grey seals.

    abstract：:The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/416424a

    authors： Gaggiotti OE,Jones F,Lee WM,Amos W,Harwood J,Nichols RA

    更新日期：2002-03-28 00:00:00