A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.

Abstract:

:The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the protein (p21) encoded by the amplified gene are correspondingly elevated. Amplification and enhanced expression of cellular oncogenes may contribute to the genesis and/or maintenance of at least some naturally occurring tumours.

journal_name

Nature

journal_title

Nature

authors

Schwab M,Alitalo K,Varmus HE,Bishop JM,George D

doi

10.1038/303497a0

subject

Has Abstract

pub_date

1983-06-09 00:00:00

pages

497-501

issue

5917

eissn

0028-0836

issn

1476-4687

journal_volume

303

pub_type

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