Transduction and rearrangement of the myc gene by feline leukaemia virus in naturally occurring T-cell leukaemias.

abstract：:Little is known about the organic component of Lower and Middle Palaeolithic technologies, particular with respect to wooden tools. Here I describe some wooden throwing spears about 400,000 years old that were discovered in 1995 at the Pleistocene site at Schöningen, Germany. They are thought to be the oldest complete...

journal_title：Nature

authors： Thieme H

更新日期：1997-02-27 00:00:00

abstract：:Language is a uniquely human ability that evolved at some point in the roughly 6,000,000 years since human and chimpanzee lines diverged. Even in the most linguistically impoverished environments, children naturally develop sophisticated language systems. In contrast, reading is a learnt skill that does not develop wi...

journal_title：Nature

authors： Carreiras M,Seghier ML,Baquero S,Estévez A,Lozano A,Devlin JT,Price CJ

更新日期：2009-10-15 00:00:00

abstract：:Many animals are regarded as relatively sedentary and specialized in marginal parts of their geographical distributions. They are expected to be slow at colonizing new habitats. Despite this, the cool margins of many species' distributions have expanded rapidly in association with recent climate warming. We examined f...

journal_title：Nature

authors： Thomas CD,Bodsworth EJ,Wilson RJ,Simmons AD,Davies ZG,Musche M,Conradt L

更新日期：2001-05-31 00:00:00

abstract：:Although individuals age and die with time, an animal species can continue indefinitely, because of its immortal germ-cell lineage. How the germline avoids transmitting damage from one generation to the next remains a fundamental question in biology. Here we identify a lysosomal switch that enhances germline proteosta...

journal_title：Nature

authors： Bohnert KA,Kenyon C

更新日期：2017-11-30 00:00:00

abstract：:Using numerical simulation, Holmström et al. proposed a plausible alternative explanation of the observed Lyman-alpha absorption that was seen during the transit of HD 209458b (ref. 2). They conclude that radiation pressure alone cannot explain the observations and that a peculiar stellar wind is needed. Here we show ...

journal_title：Nature

authors： Lecavelier des Etangs A,Vidal-Madjar A,Désert JM

更新日期：2008-11-13 00:00:00

abstract：:The developmental fate of immature thymocytes is determined by the specificity of their T-cell antigen receptors (TCRs). Immature CD4+8+ thymocytes are positively selected to differentiate into mature T cells by recognition of peptides associated with major histocompatibility complex (MHC) encoded molecules on thymic ...

journal_title：Nature

authors： Takahama Y,Suzuki H,Katz KS,Grusby MJ,Singer A

更新日期：1994-09-01 00:00:00

abstract：:Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic da...

journal_title：Nature

authors： Joshi PK,Esko T,Mattsson H,Eklund N,Gandin I,Nutile T,Jackson AU,Schurmann C,Smith AV,Zhang W,Okada Y,Stančáková A,Faul JD,Zhao W,Bartz TM,Concas MP,Franceschini N,Enroth S,Vitart V,Trompet S,Guo X,Chasman DI,

更新日期：2015-07-23 00:00:00

abstract：:The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by stochastic deregulation of gene expression. Here we directly test for increased transcriptional noise in aged tissue by di...

journal_title：Nature

authors： Bahar R,Hartmann CH,Rodriguez KA,Denny AD,Busuttil RA,Dollé ME,Calder RB,Chisholm GB,Pollock BH,Klein CA,Vijg J

更新日期：2006-06-22 00:00:00

abstract：:The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the...

journal_title：Nature

authors： Xiao K,Zhai J,Feng Y,Zhou N,Zhang X,Zou JJ,Li N,Guo Y,Li X,Shen X,Zhang Z,Shu F,Huang W,Li Y,Zhang Z,Chen RA,Wu YJ,Peng SM,Huang M,Xie WJ,Cai QH,Hou FH,Chen W,Xiao L,Shen Y

更新日期：2020-07-01 00:00:00

abstract：:Activity in the motor cortex predicts movements, seconds before they are initiated. This preparatory activity has been observed across cortical layers, including in descending pyramidal tract neurons in layer 5. A key question is how preparatory activity is maintained without causing movement, and is ultimately conver...

journal_title：Nature

authors： Economo MN,Viswanathan S,Tasic B,Bas E,Winnubst J,Menon V,Graybuck LT,Nguyen TN,Smith KA,Yao Z,Wang L,Gerfen CR,Chandrashekar J,Zeng H,Looger LL,Svoboda K

更新日期：2018-11-01 00:00:00

abstract：:There seems a real prospect that one of the infectious scourges of the past half century will not persist much beyond the present century, but polio will be only the second infection of human beings to be eradicated. Many more remain. ...

journal_title：Nature

authors：

更新日期：1995-04-20 00:00:00

abstract：:Presenilin and signal peptide peptidase (SPP) are intramembrane aspartyl proteases that regulate important biological functions in eukaryotes. Mechanistic understanding of presenilin and SPP has been hampered by lack of relevant structural information. Here we report the crystal structure of a presenilin/SPP homologue...

journal_title：Nature

authors： Li X,Dang S,Yan C,Gong X,Wang J,Shi Y

更新日期：2013-01-03 00:00:00

abstract：: ...

journal_title：Nature

authors： Butchart SHM,Clements A,Gibbons DW

更新日期：2019-02-01 00:00:00

abstract：:L-GLUTAMATE and L-aspartate are thought to have a widespread function as synaptic transmitters in the mammalian central nervous system and there are at least three types of neuronal glutamate receptors, which can be activated by the selective agonists N-methyl-D-aspartate (NMDA), quisqualate and kainate. Recent experi...

journal_title：Nature

authors： Usowicz MM,Gallo V,Cull-Candy SG

更新日期：1989-06-01 00:00:00

abstract：:Efficient long-distance quantum teleportation is crucial for quantum communication and quantum networking schemes. Here we describe the high-fidelity teleportation of photons over a distance of 600 metres across the River Danube in Vienna, with the optimal efficiency that can be achieved using linear optics. Our resul...

journal_title：Nature

authors： Ursin R,Jennewein T,Aspelmeyer M,Kaltenbaek R,Lindenthal M,Walther P,Zeilinger A

更新日期：2004-08-19 00:00:00

abstract：:Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal t...

journal_title：Nature

authors： Wiesner T,Lee W,Obenauf AC,Ran L,Murali R,Zhang QF,Wong EW,Hu W,Scott SN,Shah RH,Landa I,Button J,Lailler N,Sboner A,Gao D,Murphy DA,Cao Z,Shukla S,Hollmann TJ,Wang L,Borsu L,Merghoub T,Schwartz GK,Postow MA

更新日期：2015-10-15 00:00:00

abstract：:A wide range of receptors are located at the blood sinusoidal aspect of the hepatocyte plasma membrane. Many circulating ligands that bind to receptors on the cell surfaces are interiorized along two pathways. Asialoglycoproteins are transferred from the plasma membrane to lysosomes and degraded, whereas immunoglobuli...

journal_title：Nature

authors： Debanne MT,Evans WH,Flint N,Regoeczi E

更新日期：1982-07-22 00:00:00

abstract：:Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especi...

journal_title：Nature

authors： Zaidi MR,Davis S,Noonan FP,Graff-Cherry C,Hawley TS,Walker RL,Feigenbaum L,Fuchs E,Lyakh L,Young HA,Hornyak TJ,Arnheiter H,Trinchieri G,Meltzer PS,De Fabo EC,Merlino G

更新日期：2011-01-27 00:00:00

abstract：:The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to man...

journal_title：Nature

authors： Stuber GD,Sparta DR,Stamatakis AM,van Leeuwen WA,Hardjoprajitno JE,Cho S,Tye KM,Kempadoo KA,Zhang F,Deisseroth K,Bonci A

更新日期：2011-06-29 00:00:00

abstract：:Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins. The...

journal_title：Nature

authors： He Y,Zeng MY,Yang D,Motro B,Núñez G

更新日期：2016-02-18 00:00:00

abstract：:Many natural habitats exist on privately owned land outside protected areas, but few governments can afford to enforce or subsidize conservation of this biodiversity. Even in some developed countries, conservation subsidy schemes have only achieved limited success. Fortunately, some landowners may be willing to accept...

journal_title：Nature

authors： Oldfield TE,Smith RJ,Harrop SR,Leader-Williams N

更新日期：2003-05-29 00:00:00

abstract：:Compared with atoms, molecules have a rich internal structure that offers many opportunities for technological and scientific advancement. The study of this structure could yield critical insights into quantum chemistry, new methods for manipulating quantum information, and improved tests of discrete symmetry violatio...

journal_title：Nature

authors： Rellergert WG,Sullivan ST,Schowalter SJ,Kotochigova S,Chen K,Hudson ER

更新日期：2013-03-28 00:00:00

abstract：:Astrophysical observations indicate that there is roughly five times more dark matter in the Universe than ordinary baryonic matter1, and an even larger amount of the Universe's energy content is attributed to dark energy2. However, the microscopic properties of these dark components remain unknown. Moreover, even ord...

journal_title：Nature

authors： Smorra C,Stadnik YV,Blessing PE,Bohman M,Borchert MJ,Devlin JA,Erlewein S,Harrington JA,Higuchi T,Mooser A,Schneider G,Wiesinger M,Wursten E,Blaum K,Matsuda Y,Ospelkaus C,Quint W,Walz J,Yamazaki Y,Budker D,Ulmer S

更新日期：2019-11-01 00:00:00

abstract：:The immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions. The Ca(2+)-dependent protein phosphatase, calcineurin, binds...

journal_title：Nature

authors： Steiner JP,Dawson TM,Fotuhi M,Glatt CE,Snowman AM,Cohen N,Snyder SH

更新日期：1992-08-13 00:00:00

abstract：:It is possible to infer aspects of an organism's lifestyle from its gene content. Can the reverse also be done? Here we consider this issue by modelling evolution of the reduced genomes of endosymbiotic bacteria. The diversity of gene content in these bacteria may reflect both variation in selective forces and conting...

journal_title：Nature

authors： Pál C,Papp B,Lercher MJ,Csermely P,Oliver SG,Hurst LD

更新日期：2006-03-30 00:00:00

abstract：:About one-third of human breast cancers require hormones for their continued growth and endocrine ablation or anti-hormone therapy can cause regression of these tumours. As a consequence, ovariectomy in premenopausal women or administration of an anti-oestrogen (tamoxifen) in postmenopausal women represent major optio...

journal_title：Nature

authors： Miller WR,Scott WN,Morris R,Fraser HM,Sharpe RM

更新日期：1985-01-17 00:00:00

abstract：:The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...

journal_title：Nature

authors： Vogel US,Dixon RA,Schaber MD,Diehl RE,Marshall MS,Scolnick EM,Sigal IS,Gibbs JB

更新日期：1988-09-01 00:00:00

abstract：:It is a controversial issue whether 'real' movement, seen from the successive stimulation of retinal receptors by a moving image, and 'apparent' (phi) movement, which is produced by stimuli separated in space and time, are transmitted by the same or different neural channels. With this question in mind, we have devise...

journal_title：Nature

authors： Gregory RL,Harris JP

更新日期：1984-02-23 00:00:00

abstract：:IN 1969, Murozumi et al.1 demonstrated that the concentration of lead in Greenland snow had increased by a factor of 200 since ancient times, and concluded that most of this increase was a result of the use of alkyl-leaded petrol. Partly because of these findings, the United States and other western countries limited ...

journal_title：Nature

authors： Rosman KJR,Chisholm W,Boutron CF,Candelone JP,Görlach U

更新日期：1993-03-25 00:00:00

abstract：:Group I and II introns are mobile elements that propagate by insertion into different genes. Some introns of both types self-splice in vitro by transesterification reactions catalysed by the intron RNA. These transesterifications are reversible, and it has been suggested that reverse splicing followed by reverse trans...

journal_title：Nature

authors： Mohr G,Lambowitz AM

更新日期：1991-11-14 00:00:00