Abstract:
:The arrest of dorsal root axonal regeneration at the transitional zone between the peripheral and central nervous system has been repeatedly described since the early twentieth century. Here we show that, with trophic support to damaged sensory axons, this regenerative barrier is surmountable. In adult rats with injured dorsal roots, treatment with nerve growth factor (NGF), neurotrophin-3 (NT3) and glial-cell-line-derived neurotrophic factor (GDNF), but not brain-derived neurotrophic factor (BDNF), resulted in selective regrowth of damaged axons across the dorsal root entry zone and into the spinal cord. Dorsal horn neurons were found to be synaptically driven by peripheral nerve stimulation in rats treated with NGF, NT3 and GDNF, demonstrating functional reconnection. In behavioural studies, rats treated with NGF and GDNF recovered sensitivity to noxious heat and pressure. The observed effects of neurotrophic factors corresponded to their known actions on distinct subpopulations of sensory neurons. Neurotrophic factor treatment may thus serve as a viable treatment in promoting recovery from root avulsion injuries. I
journal_name
Naturejournal_title
Natureauthors
Ramer MS,Priestley JV,McMahon SBdoi
10.1038/35002084keywords:
subject
Has Abstractpub_date
2000-01-20 00:00:00pages
312-6issue
6767eissn
0028-0836issn
1476-4687journal_volume
403pub_type
杂志文章相关文献
NATURE文献大全abstract::Haemophilia B (Christmas disease) is an inherited, recessive, sex-linked, haemorrhagic condition caused by a defect in the intrinsic clotting factor IX. This disease occurs in males at a frequency of approximately 1 in 30,000. Patients differ in the severity of their clinical symptoms, and variation in the clotting ac...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316643a0
更新日期:1985-08-15 00:00:00
abstract::During embryonic development, orderly patterns of gene expression eventually assign each cell in the embryo its particular fate. For the anteroposterior axis of the Drosophila embryo, the first step in this process depends on a spatial gradient of the maternal morphogen Bicoid (Bcd). Positional information of this gra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415798a
更新日期:2002-02-14 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are curre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2575-3
更新日期:2020-09-01 00:00:00
abstract::Mice of the AKR strain are characterised by a high incidence of spontaneous thymic lymphomas. AKR chromosomes contain the genomes of ecotropic murine leukaemia virus (MuLV) at two loci, termed Akv-1 and Akv-2 (refs 2-6). Shortly after birth, the normal tissues of AKR mice begin to produce high levels of this XC-positi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282753a0
更新日期:1979-12-13 00:00:00
abstract::The tropics have been suggested as the drivers of global ocean and atmosphere circulation and biogeochemical cycling during the extreme warmth of the Cretaceous period; but the links between orbital forcing, freshwater runoff and the biogeochemistry of continental margins in extreme greenhouse conditions are not fully...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature03976
更新日期:2005-09-08 00:00:00
abstract::Carbon-carbon (C-C) bond formation is paramount in the synthesis of biologically relevant molecules, modern synthetic materials and commodity chemicals such as fuels and lubricants. Traditionally, the presence of a functional group is required at the site of C-C bond formation. Strategies that allow C-C bond formation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19810
更新日期:2016-11-10 00:00:00
abstract::Recurring outbursts associated with matter flowing onto compact stellar remnants (such as black holes, neutron stars and white dwarfs) in close binary systems provide a way of constraining the poorly understood accretion process. The light curves of these outbursts are shaped by the efficiency of angular-momentum (and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25159
更新日期:2018-02-01 00:00:00
abstract::For more than 140 years, pollen tube guidance in flowering plants has been thought to be mediated by chemoattractants derived from target ovules. However, there has been no convincing evidence of any particular molecule being the true attractant that actually controls the navigation of pollen tubes towards ovules. Eme...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07882
更新日期:2009-03-19 00:00:00
abstract::The tuatara (Sphenodon punctatus)-the only living member of the reptilian order Rhynchocephalia (Sphenodontia), once widespread across Gondwana1,2-is an iconic species that is endemic to New Zealand2,3. A key link to the now-extinct stem reptiles (from which dinosaurs, modern reptiles, birds and mammals evolved), the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2561-9
更新日期:2020-08-01 00:00:00
abstract::That animals and humans can accomplish the same goal using different effectors and different goals using the same effectors attests to the remarkable flexibility of the central nervous system. This phenomenon has been termed 'motor equivalence', an example being the writing of a name with a pencil held between the toe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/33922
更新日期:1998-04-23 00:00:00
abstract::A quantum internet that connects remote quantum processors1,2 should enable a number of revolutionary applications such as distributed quantum computing. Its realization will rely on entanglement of remote quantum memories over long distances. Despite enormous progress3-12, at present the maximal physical separation a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1976-7
更新日期:2020-02-01 00:00:00
abstract::Cosmid, yeast artificial chromosome (YAC), P1 and complementary DNA (cDNA) libraries are distributed on high-density filters to the scientific community and experimental results are stored in a common object-based database accessible through the Internet. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/367489a0
更新日期:1994-02-03 00:00:00
abstract::Growing concern about how loss of biodiversity will affect ecosystems has stimulated numerous studies. Although most studies have assumed that species go extinct randomly, species often go extinct in order of their sensitivity to a stress that intensifies through time (such as climate change). Here we show that the co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02515
更新日期:2004-05-13 00:00:00
abstract::Observations of galaxies and primordial radiation suggest that the Universe is made mostly of non-luminous dark matter1,2. Several new types of fundamental particle have been proposed as candidates for dark matter3, such as weakly interacting massive particles (WIMPs)4,5. These particles would be expected to interact ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0739-1
更新日期:2018-12-01 00:00:00
abstract::In this Letter, owing to a copying error in Illustrator, the two centre panels in Extended Data Fig. 7a were identical. This error has been corrected online. The old, incorrect Extended Data Fig. 7 is shown in the Supplementary Information to this Amendment for transparency. Some typos ('occurence') in Figs. 1, 2 and ...
journal_title:Nature
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41586-018-0231-y
更新日期:2018-07-01 00:00:00
abstract::Transmission of obligate bacterial symbionts between generations is vital for the survival of the host. Although the larvae of certain hydrothermal vent tubeworms (Vestimentifera, Siboglinidae) are symbiont-free and possess a transient digestive system, these structures are lost during development, resulting in adult ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04793
更新日期:2006-05-18 00:00:00
abstract::Many-body systems in nature exhibit complexity and self-organization arising from seemingly simple laws. For example, the long-range Coulomb interaction between electrical charges has a simple form, yet is responsible for a plethora of bound states in matter, ranging from the hydrogen atom to complex biochemical struc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01676
更新日期:2003-06-12 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07268-2
更新日期:2018-11-01 00:00:00
abstract::Particle acceleration based on high intensity laser systems (a process known as laser-plasma acceleration) has achieved high quality particle beams that compare favourably with conventional acceleration techniques in terms of emittance, brightness and pulse duration. A long-term difficulty associated with laser-plasma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04492
更新日期:2006-01-26 00:00:00
abstract::Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variation. To explore this issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11629
更新日期:2012-12-20 00:00:00
abstract::In order to direct a movement towards a visual stimulus, visual spatial information must be combined with postural information. For example, directing gaze (eye plus head) towards a visible target requires the combination of retinal image location with eye and head position to determine the location of the target rela...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/29777
更新日期:1998-08-27 00:00:00
abstract::Epithelial organs undergo steady-state turnover throughout adult life, with old cells being continually replaced by the progeny of stem cell divisions. To avoid hyperplasia or atrophy, organ turnover demands strict equilibration of cell production and loss. However, the mechanistic basis of this equilibrium is unknown...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23678
更新日期:2017-08-31 00:00:00
abstract::The brain cholecystokinin-B/gastrin receptor (CCK-B/gastrin) has been implicated in mediating anxiety, panic attacks, satiety, and the perception of pain. The canine and human CCK-B/gastrin receptors share 90% amino-acid identity and have similar agonist affinities. These receptors can be selectively blocked by the no...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/362348a0
更新日期:1993-03-25 00:00:00
abstract::After an earthquake, numerous smaller shocks are triggered over distances comparable to the dimensions of the mainshock fault rupture, although they are rare at larger distances. Here we analyse the scaling of dynamic deformations (the stresses and strains associated with seismic waves) with distance from, and magnitu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/437830a
更新日期:2005-10-06 00:00:00
abstract::Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction. Recently, however, it has been shown that curare can also block the channels opened by ACh at the frog neuromuscular junction as well as on rat and Aplysia neurones; moreover, curare is ab...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298272a0
更新日期:1982-07-15 00:00:00
abstract::Cells are organized on length scales ranging from ångström to micrometres. However, the mechanisms by which ångström-scale molecular properties are translated to micrometre-scale macroscopic properties are not well understood. Here we show that interactions between diverse synthetic, multivalent macromolecules (includ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10879
更新日期:2012-03-07 00:00:00
abstract::Apart from the retroviral gag, pol and env the HIV genome contains the F (3' orf) gene which encodes a polypeptide of 206 amino acids which is myristylated at the N-terminal and whose function is unknown. We have expressed the F gene in Escherichia coli and from a recombinant vaccinia virus, VVTGfHIV. The F-protein pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/330266a0
更新日期:1987-11-19 00:00:00
abstract::The North Atlantic Oscillation (NAO) is the major source of variability in winter atmospheric circulation in the Northern Hemisphere, with large impacts on temperature, precipitation and storm tracks, and therefore also on strategic sectors such as insurance, renewable energy production, crop yields and water manageme...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14518
更新日期:2015-07-02 00:00:00
abstract::To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415156a
更新日期:2002-01-10 00:00:00
abstract::Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression. Angiostatin, a proteolytic fragment of plasminogen that was first isolated from the serum and urine of tumour-bearing mice, inhibits angiogenesis and thereby growth of primary and metastatic tumours. Radiothe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/28412
更新日期:1998-07-16 00:00:00