Abstract：
:During embryonic development, orderly patterns of gene expression eventually assign each cell in the embryo its particular fate. For the anteroposterior axis of the Drosophila embryo, the first step in this process depends on a spatial gradient of the maternal morphogen Bicoid (Bcd). Positional information of this gradient is transmitted to downstream gap genes, each occupying a well defined spatial domain. We determined the precision of the initial process by comparing expression domains in different embryos. Here we show that the Bcd gradient displays a high embryo-to-embryo variability, but that this noise in the positional information is strongly decreased ('filtered') at the level of hunchback (hb) gene expression. In contrast to the Bcd gradient, the hb expression pattern already includes the information about the scale of the embryo. We show that genes known to interact directly with Hb are not responsible for its spatial precision, but that the maternal gene staufen may be crucial.
journal_name
Naturejournal_title
Natureauthors
Houchmandzadeh B,Wieschaus E,Leibler Sdoi
10.1038/415798akeywords:
subject
Has Abstractpub_date
2002-02-14 00:00:00pages
798-802issue
6873eissn
0028-0836issn
1476-4687pii
415798ajournal_volume
415pub_type
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