Abstract：
:Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction. Recently, however, it has been shown that curare can also block the channels opened by ACh at the frog neuromuscular junction as well as on rat and Aplysia neurones; moreover, curare is able to depolarize rat myotubes and thus behaves as an agonist for the cholinergic receptor of this preparation (see ref. 6). Using the single channel recording technique, we have now found that, on rat myotubes, curare can both open and block in the same cell the channels controlled by the cholinergic receptor.
journal_name
Naturejournal_title
Natureauthors
Trautmann Adoi
10.1038/298272a0subject
Has Abstractpub_date
1982-07-15 00:00:00pages
272-5issue
5871eissn
0028-0836issn
1476-4687journal_volume
298pub_type
杂志文章相关文献
NATURE文献大全abstract：:To communicate, spacecraft and satellites rely on microwave devices, which at present are based on relatively inefficient thermionic electron sources that require heating and cannot be switched on instantaneously. Here we describe a microwave diode that uses a cold-cathode electron source consisting of carbon nanotube...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/437968a
更新日期：2005-10-13 00:00:00
abstract：:Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35081193
更新日期：2001-06-14 00:00:00
abstract：:We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature724
更新日期：2002-02-21 00:00:00
abstract：:The separation of ON and OFF channels and the development of an antagonistic surround occur at the first synapse in the vertebrate retina. This functional differentiation is mediated by the action of the photoreceptor neurotransmitter on the ON bipolar, OFF bipolar and horizontal cells, respectively. Glutamate mimics ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/314096a0
更新日期：1985-03-07 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 评论,新闻
doi：10.1038/d41586-018-05909-0
更新日期：2018-10-01 00:00:00
abstract：:Genetic-environmental interactions probably underlie spontaneous human autoimmune disorders, a category of complex traits thought to include multiple sclerosis (MS). The geographical distribution and familial aggregation of this disease have often been ascribed to the role of infectious agents, but there is no consens...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/377150a0
更新日期：1995-09-14 00:00:00
abstract：:The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/335090a0
更新日期：1988-09-01 00:00:00
abstract：:In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors. Continuing transcription of E2F target genes beyond the G1/S tr...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/44611
更新日期：1999-10-21 00:00:00
abstract：:Germinal centres are specialized structures wherein B lymphocytes undergo clonal expansion, class switch recombination, antibody gene diversification and affinity maturation. Three to four antigen-specific B cells colonize a follicle to establish a germinal centre and become rapidly dividing germinal-centre centroblas...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05573
更新日期：2007-03-01 00:00:00
abstract：:Several viral and bacterial live recombinant vaccine vehicles are being developed to produce a new generation of vaccines against a broad spectrum of infectious diseases. The human tuberculosis vaccine Mycobacterium bovis bacillus Calmette-Guerin (BCG) has features that make it a particularly attractive live recombina...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/351479a0
更新日期：1991-06-06 00:00:00
abstract：:Sudden, large-scale and diffuse human migration can amplify localized outbreaks of disease into widespread epidemics1-4. Rapid and accurate tracking of aggregate population flows may therefore be epidemiologically informative. Here we use 11,478,484 counts of mobile phone data from individuals leaving or transiting th...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2284-y
更新日期：2020-06-01 00:00:00
abstract：:Simple mathematical models of the transmission dynamics of HIV that incorporate demographic and epidemiological processes to assess the potential impact of AIDS on human population growth and structure in developing countries suggest that AIDS is capable of changing population growth rates from positive to negative va...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/332228a0
更新日期：1988-03-17 00:00:00
abstract：:A plasmalemmal Na(+)-Ca2+ exchange mechanism is an important electrogenic determinant of contractility in cardiac cells. As in other cell types, calcium influx by Na(+)-Ca2+ exchange is secondarily activated by cytoplasmic calcium and probably ATP, but these modulatory mechanisms are either absent or altered in isolat...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/344242a0
更新日期：1990-03-15 00:00:00
abstract：:It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp stu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/311271a0
更新日期：1984-09-20 00:00:00
abstract：:Microtubules have a central role in eukaryotic cell polarity, in part through interactions between microtubule end-binding proteins and the cell cortex. In the fission yeast Schizosaccharomyces pombe, microtubules and the polarity modulator tea1p maintain cylindrical cell shape and strictly antipodal cell growth. The ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature01672
更新日期：2003-06-05 00:00:00
abstract：:Much of our current knowledge about mitochondria has come from studying patients who have respiratory chain disorders. These disorders comprise a large collection of individually rare syndromes, each presenting in a unique and often devastating way. In recent years, there has been great progress in defining their gene...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/nature11707
更新日期：2012-11-15 00:00:00
abstract：:Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22078
更新日期：2017-05-04 00:00:00
abstract：:Depleted uranium is a mildly radioactive waste product that is stockpiled worldwide. The chemical reactivity of uranium complexes is well documented, including the stoichiometric activation of small molecules of biological and industrial interest such as H2O, CO2, CO, or N2 (refs 1 - 11), but catalytic transformations...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature16530
更新日期：2016-02-18 00:00:00
abstract：:Numerous reports have emphasized the need for major changes in the global food system: agriculture must meet the twin challenge of feeding a growing population, with rising demand for meat and high-calorie diets, while simultaneously minimizing its global environmental impacts. Organic farming—a system aimed at produc...
journal_title：Nature
pub_type： 杂志文章,meta分析
doi：10.1038/nature11069
更新日期：2012-05-10 00:00:00
abstract：:Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/282260a0
更新日期：1979-11-15 00:00:00
abstract：:Bilingual individuals need effective mechanisms to prevent interference from one language while processing material in the other. Here we show, using event-related brain potentials and functional magnetic resonance imaging (fMRI), that words from the non-target language are rejected at an early stage before semantic a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/4151026a
更新日期：2002-02-28 00:00:00
abstract：:The horizontal separation of the eyes means that objects nearer or farther than the fixation point project to different locations on the two retinae, differing principally in their horizontal coordinates (horizontal binocular disparity). Disparity-selective neurons have generally been studied with disparities applied ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature00909
更新日期：2002-08-08 00:00:00
abstract：:The limited ranges of the wild progenitors of many of the primary European domestic species point to their origins further east in Anatolia or the fertile crescent. The wild ox (Bos primigenius), however, ranged widely and it is unknown whether it was domesticated within Europe as one feature of a local contribution t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35074088
更新日期：2001-04-26 00:00:00
abstract：:Kinetoplastid RNA editing alters mitochondrial RNA transcripts by addition and deletion of uridine residues, producing open reading frames that may be twice as long as the original RNA. Although the COIII gene encoding cytochrome c oxidase subunit III in Trypanosoma brucei is edited along its entire length, the presum...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/363179a0
更新日期：1993-05-13 00:00:00
abstract：:Quantum simulation--the use of one quantum system to simulate a less controllable one--may provide an understanding of the many quantum systems which cannot be modelled using classical computers. Considerable progress in control and manipulation has been achieved for various quantum systems, but one of the remaining c...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13565
更新日期：2014-08-07 00:00:00
abstract：:Lipoxygenase metabolites of arachidonic acid have recently been shown to modulate the activity of ion channels in nerve and muscle cells. The mechanism of action of these metabolites is, however, unknown. In sensory neurons of Aplysia, the S-K- channel is under the dual modulatory control of 5-hydroxytryptamine (5-HT)...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/342553a0
更新日期：1989-11-30 00:00:00
abstract：:Historically, the study of speech processing has emphasized a strong link between auditory perceptual input and motor production output. A kind of 'parity' is essential, as both perception- and production-based representations must form a unified interface to facilitate access to higher-order language processes such a...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12935
更新日期：2014-03-06 00:00:00
abstract：:Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/295206a0
更新日期：1982-01-21 00:00:00
abstract：:On 12 May 2008, the devastating magnitude 7.9 (Wenchuan) earthquake struck the eastern edge of the Tibetan plateau, collapsing buildings and killing thousands in major cities aligned along the western Sichuan basin in China. After such a large-magnitude earthquake, rearrangement of stresses in the crust commonly leads...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07177
更新日期：2008-07-24 00:00:00
abstract：:Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35079184
更新日期：2001-05-31 00:00:00
