Abstract：
:Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and experimental studies have demonstrated a causal relationship between neutrophils and metastasis4,5. However, the cancer-cell-intrinsic mechanisms that dictate the substantial heterogeneity in systemic neutrophilic inflammation between tumour-bearing hosts are largely unresolved. Here, using a panel of 16 distinct genetically engineered mouse models for breast cancer, we uncover a role for cancer-cell-intrinsic p53 as a key regulator of pro-metastatic neutrophils. Mechanistically, loss of p53 in cancer cells induced the secretion of WNT ligands that stimulate tumour-associated macrophages to produce IL-1β, thus driving systemic inflammation. Pharmacological and genetic blockade of WNT secretion in p53-null cancer cells reverses macrophage production of IL-1β and subsequent neutrophilic inflammation, resulting in reduced metastasis formation. Collectively, we demonstrate a mechanistic link between the loss of p53 in cancer cells, secretion of WNT ligands and systemic neutrophilia that potentiates metastatic progression. These insights illustrate the importance of the genetic makeup of breast tumours in dictating pro-metastatic systemic inflammation, and set the stage for personalized immune intervention strategies for patients with cancer.
journal_name
Naturejournal_title
Natureauthors
Wellenstein MD,Coffelt SB,Duits DEM,van Miltenburg MH,Slagter M,de Rink I,Henneman L,Kas SM,Prekovic S,Hau CS,Vrijland K,Drenth AP,de Korte-Grimmerink R,Schut E,van der Heijden I,Zwart W,Wessels LFA,Schumacher TN,Jonkdoi
10.1038/s41586-019-1450-6subject
Has Abstractpub_date
2019-08-01 00:00:00pages
538-542issue
7770eissn
0028-0836issn
1476-4687pii
10.1038/s41586-019-1450-6journal_volume
572pub_type
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