Exploring biology with small organic molecules.

Abstract:

:Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. Such strategies involve analysing both protein binding of, and phenotypic responses to, small organic molecules. The mapping of biological-activity space using small molecules is akin to mapping the stars--uncharted territory is explored using a system of coordinates that describes where each new feature lies.

journal_name

Nature

journal_title

Nature

authors

Stockwell BR

doi

10.1038/nature03196

keywords:

subject

Has Abstract

pub_date

2004-12-16 00:00:00

pages

846-54

issue

7019

eissn

0028-0836

issn

1476-4687

pii

nature03196

journal_volume

432

pub_type

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