Abstract:
:Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. Such strategies involve analysing both protein binding of, and phenotypic responses to, small organic molecules. The mapping of biological-activity space using small molecules is akin to mapping the stars--uncharted territory is explored using a system of coordinates that describes where each new feature lies.
journal_name
Naturejournal_title
Natureauthors
Stockwell BRdoi
10.1038/nature03196keywords:
subject
Has Abstractpub_date
2004-12-16 00:00:00pages
846-54issue
7019eissn
0028-0836issn
1476-4687pii
nature03196journal_volume
432pub_type
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