Glutamate locally activates dendritic outputs of thalamic interneurons.

Abstract:

:The relay of information through thalamus to cortex is dynamically gated, as illustrated by the retinogeniculocortical pathway. Important to this is the inhibitory interneuron in the lateral geniculate nucleus (LGN). For the typical neuron, synaptic information arrives through postsynaptic dendrites and is transmitted by axon terminals. However, the typical thalamic interneuron, in addition to conventional axonal outputs, has distal dendrites that serve both pre- and postsynaptic roles. These dendritic terminals participate in curious and enigmatic triadic arrangements, in which each contacts a relay cell dendrite and is contacted by a glutamatergic retinal terminal that innervates the same relay cell dendrite. Here we show that agonists of the metabotropic glutamate receptor (mGluR) activate dendritic terminals of interneurons in the absence of action potentials, thereby inhibiting the postsynaptic relay neuron. Somatic recordings from LGN interneurons reveal that there is no response to mGluR agonists, suggesting that their dendritic terminals are electrically isolated from their somata and axons, consistent with anatomical modelling of these cells. Our results offer insight into the functioning of triadic circuitry and indicate that thalamic interneurons can perform independent computations expressed through axonal as opposed to dendritic outputs.

journal_name

Nature

journal_title

Nature

authors

Cox CL,Zhou Q,Sherman SM

doi

10.1038/28855

subject

Has Abstract

pub_date

1998-07-30 00:00:00

pages

478-82

issue

6692

eissn

0028-0836

issn

1476-4687

journal_volume

394

pub_type

杂志文章

相关文献

NATURE文献大全
  • Fossil mammals and artefacts from the Middle Awash Valley, Ethiopia.

    abstract::A review of fossil mammalian faunas from the Middle Awash indicates they span most of the later Neogene and document evolutionary change in several mammalian groups, especially Primates, Proboscidea and Artiodactyla. Oldowan artefacts first appear in the late Pliocene, while Acheulian and later industries and apparent...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/298025a0

    authors: Kalb JE,Jolly CJ,Mebrate A,Tebedge S,Smart C,Oswald EB,Cramer D,Whitehead P,Wood CB,Conroy GC,Adefris T,Sperling L,Kana B

    更新日期:1982-07-01 00:00:00

  • A key piece in the exoplanet puzzle.

    abstract:: ...

    journal_title:Nature

    pub_type: 评论,新闻

    doi:10.1038/d41586-018-07328-7

    authors: Díaz RF

    更新日期:2018-11-01 00:00:00

  • Identification of a distinct synaptic glutamate receptor on horizontal cells in mudpuppy retina.

    abstract::The separation of ON and OFF channels and the development of an antagonistic surround occur at the first synapse in the vertebrate retina. This functional differentiation is mediated by the action of the photoreceptor neurotransmitter on the ON bipolar, OFF bipolar and horizontal cells, respectively. Glutamate mimics ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/314096a0

    authors: Slaughter MM,Miller RF

    更新日期:1985-03-07 00:00:00

  • Phenotypic consequences of 1,000 generations of selection at elevated CO2 in a green alga.

    abstract::Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02945

    authors: Collins S,Bell G

    更新日期:2004-09-30 00:00:00

  • Recent Northern Hemisphere stratospheric HCl increase due to atmospheric circulation changes.

    abstract::The abundance of chlorine in the Earth's atmosphere increased considerably during the 1970s to 1990s, following large emissions of anthropogenic long-lived chlorine-containing source gases, notably the chlorofluorocarbons. The chemical inertness of chlorofluorocarbons allows their transport and mixing throughout the t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13857

    authors: Mahieu E,Chipperfield MP,Notholt J,Reddmann T,Anderson J,Bernath PF,Blumenstock T,Coffey MT,Dhomse SS,Feng W,Franco B,Froidevaux L,Griffith DW,Hannigan JW,Hase F,Hossaini R,Jones NB,Morino I,Murata I,Nakajima H,Pa

    更新日期:2014-11-06 00:00:00

  • Sexual selection and the maintenance of sex.

    abstract::Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35079578

    authors: Siller S,Department of Zoology, University of Oxford, UK. steven.siller@zoo.ox.ac.uk.

    更新日期:2001-06-07 00:00:00

  • Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.

    abstract::The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to man...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10194

    authors: Stuber GD,Sparta DR,Stamatakis AM,van Leeuwen WA,Hardjoprajitno JE,Cho S,Tye KM,Kempadoo KA,Zhang F,Deisseroth K,Bonci A

    更新日期:2011-06-29 00:00:00

  • Strong magnetic fields in normal galaxies at high redshift.

    abstract::The origin and growth of magnetic fields in galaxies is still something of an enigma. It is generally assumed that seed fields are amplified over time through the dynamo effect, but there are few constraints on the timescale. It was recently demonstrated that field strengths as traced by rotation measures of distant (...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07105

    authors: Bernet ML,Miniati F,Lilly SJ,Kronberg PP,Dessauges-Zavadsky M

    更新日期:2008-07-17 00:00:00

  • Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.

    abstract::Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/338557a0

    authors: Ishikawa F,Miyazono K,Hellman U,Drexler H,Wernstedt C,Hagiwara K,Usuki K,Takaku F,Risau W,Heldin CH

    更新日期:1989-04-13 00:00:00

  • Cool heliosheath plasma and deceleration of the upstream solar wind at the termination shock.

    abstract::The solar wind blows outward from the Sun and forms a bubble of solar material in the interstellar medium. The termination shock occurs where the solar wind changes from being supersonic (with respect to the surrounding interstellar medium) to being subsonic. The shock was crossed by Voyager 1 at a heliocentric radius...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07024

    authors: Richardson JD,Kasper JC,Wang C,Belcher JW,Lazarus AJ

    更新日期:2008-07-03 00:00:00

  • Transport dynamics in a glutamate transporter homologue.

    abstract::Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate bin...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature12265

    authors: Akyuz N,Altman RB,Blanchard SC,Boudker O

    更新日期:2013-10-03 00:00:00

  • Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant.

    abstract::Peroxisomes are among the intracellular organelles of eukaryotic cells that contain specialized sets of enzymes with specific functions. Little is known of membranous components involved in assembly of the intracellular compartments. We isolated two peroxisome-deficient and mutually complementary, Chinese hamster ovar...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/350077a0

    authors: Tsukamoto T,Miura S,Fujiki Y

    更新日期:1991-03-07 00:00:00

  • Retinoblastoma protein represses transcription by recruiting a histone deacetylase.

    abstract::The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation by repressing a subset of genes that are controlled by the E2F family of transcription factors and which are involved in progression from the G1 to the S phase of the cell cycle. Rb, which is recruited to target promoters by E2F1, represses tr...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35410

    authors: Magnaghi-Jaulin L,Groisman R,Naguibneva I,Robin P,Lorain S,Le Villain JP,Troalen F,Trouche D,Harel-Bellan A

    更新日期:1998-02-05 00:00:00

  • Crystal structure of the motor domain of the kinesin-related motor ncd.

    abstract::Microtubule-based ATPases of the kinesin superfamily provide the motile force for many animated features of living cells. Kinesin motors differ in their direction of movement along microtubules. Kinesin and ncd, a kinesin-related motor involved in formation and maintenance of mitotic and meiotic spindles, move in oppo...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/380555a0

    authors: Sablin EP,Kull FJ,Cooke R,Vale RD,Fletterick RJ

    更新日期:1996-04-11 00:00:00

  • Tax fossil-fuel production, not emissions.

    abstract:: ...

    journal_title:Nature

    pub_type: 评论,信件

    doi:10.1038/d41586-019-00764-z

    authors: Roduner E

    更新日期:2019-03-01 00:00:00

  • Targeting C-reactive protein for the treatment of cardiovascular disease.

    abstract::Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04672

    authors: Pepys MB,Hirschfield GM,Tennent GA,Gallimore JR,Kahan MC,Bellotti V,Hawkins PN,Myers RM,Smith MD,Polara A,Cobb AJ,Ley SV,Aquilina JA,Robinson CV,Sharif I,Gray GA,Sabin CA,Jenvey MC,Kolstoe SE,Thompson D,Wood SP

    更新日期:2006-04-27 00:00:00

  • Complex societies precede moralizing gods throughout world history.

    abstract::The origins of religion and of complex societies represent evolutionary puzzles1-8. The 'moralizing gods' hypothesis offers a solution to both puzzles by proposing that belief in morally concerned supernatural agents culturally evolved to facilitate cooperation among strangers in large-scale societies9-13. Although pr...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41586-019-1043-4

    authors: Whitehouse H,François P,Savage PE,Currie TE,Feeney KC,Cioni E,Purcell R,Ross RM,Larson J,Baines J,Ter Haar B,Covey A,Turchin P

    更新日期:2019-04-01 00:00:00

  • Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.

    abstract::Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structu...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10143

    authors: Mishra SK,Ammon T,Popowicz GM,Krajewski M,Nagel RJ,Ares M Jr,Holak TA,Jentsch S

    更新日期:2011-05-25 00:00:00

  • In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietic stem cell population.

    abstract::It is well established that the osteoclast is formed by fusion of post-mitotic, mononuclear precursors derived from circulating progenitor cells. However, the precise haematopoietic origin of the osteoclast is unknown. We have investigated this here by fractionating mouse bone marrow and isolating haematopoietic stem ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/321079a0

    authors: Scheven BA,Visser JW,Nijweide PJ

    更新日期:1986-05-01 00:00:00

  • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.

    abstract::Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senesc...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/344126a0

    authors: Yu GL,Bradley JD,Attardi LD,Blackburn EH

    更新日期:1990-03-08 00:00:00

  • Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

    abstract::The disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by abnormally high blood glucose resulting from a relative deficiency of insulin. It affects about 2% of the world's population and treatment of diabetes and its complications are an increasing health-care burden. Genetic factors are...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/384455a0

    authors: Yamagata K,Oda N,Kaisaki PJ,Menzel S,Furuta H,Vaxillaire M,Southam L,Cox RD,Lathrop GM,Boriraj VV,Chen X,Cox NJ,Oda Y,Yano H,Le Beau MM,Yamada S,Nishigori H,Takeda J,Fajans SS,Hattersley AT,Iwasaki N,Hansen T,

    更新日期:1996-12-05 00:00:00

  • Nucleation and growth of fibres and gel formation in sickle cell haemoglobin.

    abstract::Deoxygenated sickle haemoglobin polymerizes into long 210-A diameter fibres that distort and decrease the deformability of red blood cells, and cause sickle cell disease. The fibres consist of seven intertwined double strands. They can form birefringent nematic liquid crystals (tactoids) and spherulites. Rheologically...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/345833a0

    authors: Samuel RE,Salmon ED,Briehl RW

    更新日期:1990-06-28 00:00:00

  • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.

    abstract::In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose-Glut4(-/-)) mice show insulin resistance secondarily in muscle and liver. Here we show, using DNA arrays, that expression of retinol bindin...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature03711

    authors: Yang Q,Graham TE,Mody N,Preitner F,Peroni OD,Zabolotny JM,Kotani K,Quadro L,Kahn BB

    更新日期:2005-07-21 00:00:00

  • Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting.

    abstract::In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online. ...

    journal_title:Nature

    pub_type: 已发布勘误

    doi:10.1038/s41586-019-1343-8

    authors: Matsumoto S,Cavadini S,Bunker RD,Grand RS,Potenza A,Rabl J,Yamamoto J,Schenk AD,Schübeler D,Iwai S,Sugasawa K,Kurumizaka H,Thomä NH

    更新日期:2019-07-01 00:00:00

  • Microconversion between murine H-2 genes integrated into yeast.

    abstract::Patchwork homology observed between divergent members of polymorphic multigene families is thought to reflect evolution by short-tract gene conversion (nonreciprocal recombination), although this mechanism cannot usually be confirmed in higher organisms. In contrast to meiotic conversions observed in laboratory yeast ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/347192a0

    authors: Wheeler CJ,Maloney D,Fogel S,Goodenow RS

    更新日期:1990-09-13 00:00:00

  • Hard-tip, soft-spring lithography.

    abstract::Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a regist...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09697

    authors: Shim W,Braunschweig AB,Liao X,Chai J,Lim JK,Zheng G,Mirkin CA

    更新日期:2011-01-27 00:00:00

  • Seismic evidence for convection-driven motion of the North American plate.

    abstract::Since the discovery of plate tectonics, the relative importance of driving forces of plate motion has been debated. Resolution of this issue has been hindered by uncertainties in estimates of basal traction, which controls the coupling between lithospheric plates and underlying mantle convection. Hotspot tracks preser...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature05675

    authors: Eaton DW,Frederiksen A

    更新日期:2007-03-22 00:00:00

  • From the archive.

    abstract:: ...

    journal_title:Nature

    pub_type: 新闻

    doi:10.1038/d41586-018-07356-3

    authors:

    更新日期:2018-11-01 00:00:00

  • Explaining the excess of rare species in natural species abundance distributions.

    abstract::The observation that a few species in ecological communities are exceptionally abundant, whereas most are rare, prompted the development of species abundance models. Nevertheless, despite the large literature on the commonness and rarity of species inspired by these pioneering studies, some widespread empirical patter...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01547

    authors: Magurran AE,Henderson PA

    更新日期:2003-04-17 00:00:00

  • Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus.

    abstract::The glyceraldehyde 3-phosphate dehydogenase holoenzyme of Bacillus stearothermophilus possesses precise 222 symmetry: in this respect it differs from the reported structure of the lobster muscle enzyme. Pairs of active sites are linked through a flexible polypeptide loop which probably mediates the structural changes ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/266328a0

    authors: Biesecker G,Harris JI,Thierry JC,Walker JE,Wonacott AJ

    更新日期:1977-03-24 00:00:00