Multiple modes of engrailed regulation in the progression towards cell fate determination.

Abstract:

:The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.

journal_name

Nature

journal_title

Nature

authors

Heemskerk J,DiNardo S,Kostriken R,O'Farrell PH

doi

10.1038/352404a0

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

404-10

issue

6334

eissn

0028-0836

issn

1476-4687

journal_volume

352

pub_type

杂志文章

相关文献

NATURE文献大全
  • Insulin binds to brain blood vessels in vivo.

    abstract::The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/282623a0

    authors: van Houten M,Posner BI

    更新日期:1979-12-06 00:00:00

  • Sex in flies: the splice of life.

    abstract::The discovery that the primary transcripts of many genes are processed to produce more than one kind of messenger RNA focuses attention on the control of RNA processing as a developmental regulatory mechanism. In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/340521a0

    authors: Baker BS

    更新日期:1989-08-17 00:00:00

  • alpha-Chain contacts in the polymerisation of sickle haemogloblin.

    abstract::Five new double-mutant haemoglobins composed of betaS chains and alpha chains with different substitutions, which are located at the surface of the tetramer, have been prepared. Although all the hybrids are more soluble than deoxyhaemoglobin S, the individual differences between these molecules make it possible to eva...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/260219a0

    authors: Benesch RE,Yung S,Benesch R,Mack J,Schneider RG

    更新日期:1976-03-18 00:00:00

  • Error mitigation extends the computational reach of a noisy quantum processor.

    abstract::Quantum computation, a paradigm of computing that is completely different from classical methods, benefits from theoretically proved speed-ups for certain problems and can be used to study the properties of quantum systems1. Yet, because of the inherently fragile nature of the physical computing elements (qubits), ach...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1040-7

    authors: Kandala A,Temme K,Córcoles AD,Mezzacapo A,Chow JM,Gambetta JM

    更新日期:2019-03-01 00:00:00

  • Policies designed for drugs won't work for AI.

    abstract:: ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/d41586-019-00737-2

    authors: Smallman M

    更新日期:2019-03-01 00:00:00

  • Ban bullying in science.

    abstract:: ...

    journal_title:Nature

    pub_type: 社论

    doi:10.1038/d41586-018-07529-0

    authors:

    更新日期:2018-11-01 00:00:00

  • COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.

    abstract::Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic alterations reported in human prostate cancer. However, the precise mechanism underlying how indolent tumours with PTEN alterations acquire metastatic poten...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11674

    authors: Qin J,Wu SP,Creighton CJ,Dai F,Xie X,Cheng CM,Frolov A,Ayala G,Lin X,Feng XH,Ittmann MM,Tsai SJ,Tsai MJ,Tsai SY

    更新日期:2013-01-10 00:00:00

  • Direct observation of kinesin stepping by optical trapping interferometry.

    abstract::Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/365721a0

    authors: Svoboda K,Schmidt CF,Schnapp BJ,Block SM

    更新日期:1993-10-21 00:00:00

  • A new tropomyosin essential for cytokinesis in the fission yeast S. pombe.

    abstract::Mutations in the Schizosaccharomyces pombe cdc8 gene impair cytokinesis. Here we clone cdc8+ and find that it encodes a novel tropomyosin. Gene disruption results in lethal arrest of the cell cycle, but spore germination, cell growth, DNA replication and mitosis are all unaffected. Haploid cdc8 gene disruptants are re...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/360084a0

    authors: Balasubramanian MK,Helfman DM,Hemmingsen SM

    更新日期:1992-11-05 00:00:00

  • Water transport in plants obeys Murray's law.

    abstract::The optimal water transport system in plants should maximize hydraulic conductance (which is proportional to photosynthesis) for a given investment in transport tissue. To investigate how this optimum may be achieved, we have performed computer simulations of the hydraulic conductance of a branched transport system. H...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01444

    authors: McCulloh KA,Sperry JS,Adler FR

    更新日期:2003-02-27 00:00:00

  • Competing memories of mitogen and p53 signalling control cell-cycle entry.

    abstract::Regulation of cell proliferation is necessary for immune responses, tissue repair, and upkeep of organ function to maintain human health. When proliferating cells complete mitosis, a fraction of newly born daughter cells immediately enter the next cell cycle, while the remaining cells in the same population exit to a ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature23880

    authors: Yang HW,Chung M,Kudo T,Meyer T

    更新日期:2017-09-21 00:00:00

  • Soft-mode hardening in SrTiO3 thin films

    abstract::Understanding the behaviour of the dielectric constant in ferroelectric thin films remains a challenging problem. These ferroelectric materials have high static dielectric constants, and so are important for their applications in high-storage-density capacitor structures such as dynamic random access memory (DRAM). Bu...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35006023

    authors: Sirenko AA,Bernhard C,Golnik A,Clark AM,Hao J,Si W,Xi XX

    更新日期:2000-03-23 00:00:00

  • Enamel proteome shows that Gigantopithecus was an early diverging pongine.

    abstract::Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3....

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1728-8

    authors: Welker F,Ramos-Madrigal J,Kuhlwilm M,Liao W,Gutenbrunner P,de Manuel M,Samodova D,Mackie M,Allentoft ME,Bacon AM,Collins MJ,Cox J,Lalueza-Fox C,Olsen JV,Demeter F,Wang W,Marques-Bonet T,Cappellini E

    更新日期:2019-12-01 00:00:00

  • Evolution of the 87A and 87C heat-shock loci in Drosophila.

    abstract::Several species related to Drosophila melanogaster have two loci containing sequences which code for the major heat-shock protein of molecular weight 70,000 (hsp70). These sequences are arranged as two pairs of inverted repeats. The structure of the 87C locus in D. melanogaster seems to have arisen through DNA inserti...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/290677a0

    authors: Leigh Brown AJ,Ish-Horowicz D

    更新日期:1981-04-23 00:00:00

  • T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

    abstract::The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to significant improvements in both monitoring and treatment. During chronic infection the process of T-cell exhaustion in...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14468

    authors: McKinney EF,Lee JC,Jayne DR,Lyons PA,Smith KG

    更新日期:2015-07-30 00:00:00

  • Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.

    abstract::Ribosome-driven protein biosynthesis is comprised of four phases: initiation, elongation, termination and recycling. In bacteria, ribosome recycling requires ribosome recycling factor and elongation factor G, and several structures of bacterial recycling complexes have been determined. In the eukaryotic and archaeal k...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature10829

    authors: Becker T,Franckenberg S,Wickles S,Shoemaker CJ,Anger AM,Armache JP,Sieber H,Ungewickell C,Berninghausen O,Daberkow I,Karcher A,Thomm M,Hopfner KP,Green R,Beckmann R

    更新日期:2012-02-22 00:00:00

  • Coupled dynamics of body mass and population growth in response to environmental change.

    abstract::Environmental change has altered the phenology, morphological traits and population dynamics of many species. However, the links underlying these joint responses remain largely unknown owing to a paucity of long-term data and the lack of an appropriate analytical framework. Here we investigate the link between phenoty...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09210

    authors: Ozgul A,Childs DZ,Oli MK,Armitage KB,Blumstein DT,Olson LE,Tuljapurkar S,Coulson T

    更新日期:2010-07-22 00:00:00

  • Single neurons in prefrontal cortex encode abstract rules.

    abstract::The ability to abstract principles or rules from direct experience allows behaviour to extend beyond specific circumstances to general situations. For example, we learn the 'rules' for restaurant dining from specific experiences and can then apply them in new restaurants. The use of such rules is thought to depend on ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35082081

    authors: Wallis JD,Anderson KC,Miller EK

    更新日期:2001-06-21 00:00:00

  • Quantitative flux analysis reveals folate-dependent NADPH production.

    abstract::ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidat...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13236

    authors: Fan J,Ye J,Kamphorst JJ,Shlomi T,Thompson CB,Rabinowitz JD

    更新日期:2014-06-12 00:00:00

  • Mentorship training curbs academic abuse.

    abstract:: ...

    journal_title:Nature

    pub_type: 信件

    doi:10.1038/d41586-018-07308-x

    authors: Liao SE

    更新日期:2018-11-01 00:00:00

  • Modular and tunable biological feedback control using a de novo protein switch.

    abstract::De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein o...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1425-7

    authors: Ng AH,Nguyen TH,Gómez-Schiavon M,Dods G,Langan RA,Boyken SE,Samson JA,Waldburger LM,Dueber JE,Baker D,El-Samad H

    更新日期:2019-08-01 00:00:00

  • A new route for synthesis of dimethylsulphoniopropionate in marine algae.

    abstract::The 3-dimethylsulphoniopropionate (DMSP) produced by marine algae is the main biogenic precursor of atmospheric dimethylsulphide (DMS). This biogenic DMS, formed by bacterial and algal degradation of DMSP, contributes about 1.5 x 10(13) g of sulphur to the atmosphere annually, and plays a major part in the global sulp...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/43160

    authors: Gage DA,Rhodes D,Nolte KD,Hicks WA,Leustek T,Cooper AJ,Hanson AD

    更新日期:1997-06-26 00:00:00

  • Palaeo-altimetry of the late Eocene to Miocene Lunpola basin, central Tibet.

    abstract::The elevation history of the Tibetan plateau provides direct insight into the tectonic processes associated with continent-continent collisions. Here we present oxygen-isotope-based estimates of the palaeo-altimetry of late Eocene and younger deposits of the Lunpola basin in the centre of the plateau, which indicate t...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature04506

    authors: Rowley DB,Currie BS

    更新日期:2006-02-09 00:00:00

  • Pioneer axons lose directed growth after selective killing of guidepost cells.

    abstract::The first nerve cells to appear in the limb buds of embryonic grasshoppers are a pair which lie at the distal tip and project axons along the length of the limb to the central nervous system (CNS). The stereotyped route navigated by these 'pioneer' axons is followed by other neurones and eventually becomes that of a m...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/304062a0

    authors: Bentley D,Caudy M

    更新日期:1983-07-07 00:00:00

  • Reconstitution of the oocyte transcriptional network with transcription factors.

    abstract::During female germline development, oocytes become a highly specialized cell type and form a maternal cytoplasmic store of crucial factors. Oocyte growth is triggered at the transition from primordial to primary follicle and is accompanied by dynamic changes in gene expression1, but the gene regulatory network that co...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-3027-9

    authors: Hamazaki N,Kyogoku H,Araki H,Miura F,Horikawa C,Hamada N,Shimamoto S,Hikabe O,Nakashima K,Kitajima TS,Ito T,Leitch HG,Hayashi K

    更新日期:2021-01-01 00:00:00

  • Brain control of humoral immune responses amenable to behavioural modulation.

    abstract::It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2235-7

    authors: Zhang X,Lei B,Yuan Y,Zhang L,Hu L,Jin S,Kang B,Liao X,Sun W,Xu F,Zhong Y,Hu J,Qi H

    更新日期:2020-05-01 00:00:00

  • Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel.

    abstract::Large-conductance Ca(2+)-gated K(+) (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release. This group of channels can be activated synergistically by both voltage and intracellular Ca(2+), with the large carboxy-terminal intracellular portion being res...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature09252

    authors: Wu Y,Yang Y,Ye S,Jiang Y

    更新日期:2010-07-15 00:00:00

  • Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.

    abstract::The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/323340a0

    authors: Reymond CD,Gomer RH,Nellen W,Theibert A,Devreotes P,Firtel RA

    更新日期:1986-09-25 00:00:00

  • Femtosecond time-delay X-ray holography.

    abstract::Extremely intense and ultrafast X-ray pulses from free-electron lasers offer unique opportunities to study fundamental aspects of complex transient phenomena in materials. Ultrafast time-resolved methods usually require highly synchronized pulses to initiate a transition and then probe it after a precisely defined tim...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06049

    authors: Chapman HN,Hau-Riege SP,Bogan MJ,Bajt S,Barty A,Boutet S,Marchesini S,Frank M,Woods BW,Benner WH,London RA,Rohner U,Szöke A,Spiller E,Möller T,Bostedt C,Shapiro DA,Kuhlmann M,Treusch R,Plönjes E,Burmeister F,Ber

    更新日期:2007-08-09 00:00:00

  • Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid.

    abstract::The fundus of the guinea-pig stomach actively dilates in response to low increases in intragastric pressure. This physiological response, now called adaptive relaxation, accommodates the intake of liquid or food. It is independent of external innervation, resistant to ganglion blockade, but reflex in origin. The nerve...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/351477a0

    authors: Desai KM,Sessa WC,Vane JR

    更新日期:1991-06-06 00:00:00