Abstract:
:The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.
journal_name
Naturejournal_title
Natureauthors
Heemskerk J,DiNardo S,Kostriken R,O'Farrell PHdoi
10.1038/352404a0subject
Has Abstractpub_date
1991-08-01 00:00:00pages
404-10issue
6334eissn
0028-0836issn
1476-4687journal_volume
352pub_type
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