Abstract:
:Soft machines are a promising design paradigm for human-centric devices1,2 and systems required to interact gently with their environment3,4. To enable soft machines to respond intelligently to their surroundings, compliant sensory feedback mechanisms are needed. Specifically, soft alternatives to strain gauges-with high resolution at low strain (less than 5 per cent)-could unlock promising new capabilities in soft systems. However, currently available sensing mechanisms typically possess either high strain sensitivity or high mechanical resilience, but not both. The scarcity of resilient and compliant ultra-sensitive sensing mechanisms has confined their operation to laboratory settings, inhibiting their widespread deployment. Here we present a versatile and compliant transduction mechanism for high-sensitivity strain detection with high mechanical resilience, based on strain-mediated contact in anisotropically resistive structures (SCARS). The mechanism relies upon changes in Ohmic contact between stiff, micro-structured, anisotropically conductive meanders encapsulated by stretchable films. The mechanism achieves high sensitivity, with gauge factors greater than 85,000, while being adaptable for use with high-strength conductors, thus producing sensors resilient to adverse loading conditions. The sensing mechanism also exhibits high linearity, as well as insensitivity to bending and twisting deformations-features that are important for soft device applications. To demonstrate the potential impact of our technology, we construct a sensor-integrated, lightweight, textile-based arm sleeve that can recognize gestures without encumbering the hand. We demonstrate predictive tracking and classification of discrete gestures and continuous hand motions via detection of small muscle movements in the arm. The sleeve demonstration shows the potential of the SCARS technology for the development of unobtrusive, wearable biomechanical feedback systems and human-computer interfaces.
journal_name
Naturejournal_title
Natureauthors
Araromi OA,Graule MA,Dorsey KL,Castellanos S,Foster JR,Hsu WH,Passy AE,Vlassak JJ,Weaver JC,Walsh CJ,Wood RJdoi
10.1038/s41586-020-2892-6subject
Has Abstractpub_date
2020-11-01 00:00:00pages
219-224issue
7833eissn
0028-0836issn
1476-4687pii
10.1038/s41586-020-2892-6journal_volume
587pub_type
杂志文章相关文献
NATURE文献大全abstract::Considerable evidence points to a role for G1 cyclin-dependent kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S phase of the cell cycle. Numerous experiments have also demonstrated a critical role for both Myc and Ras activities in allowing cell-cycle progression. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/387422a0
更新日期:1997-05-22 00:00:00
abstract::Large, actively swimming suspension feeders evolved several times in Earth's history, arising independently from groups as diverse as sharks, rays and stem teleost fishes, and in mysticete whales. However, animals occupying this niche have not been identified from the early Palaeozoic era. Anomalocarids, a group of st...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13010
更新日期:2014-03-27 00:00:00
abstract::When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352544a0
更新日期:1991-08-08 00:00:00
abstract::It has been suggested that the initiation step in mouse skin carcinogenesis involves an alteration in epidermal-differentiation, as mouse basal keratinocytes exposed to initiators resist the arrest of cell growth that is normally associated with the induction of terminal differentiation by calcium ions. The growth of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314459a0
更新日期:1985-04-04 00:00:00
abstract::The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/282623a0
更新日期:1979-12-06 00:00:00
abstract::We have obtained evidence that poliovirus and other picornavirus particles are specifically modified by having myristic acid covalently bound to a capsid protein. The electron density map of poliovirus confirms the position of the myristate molecule and defines its location in the virus particle. Analogies with other ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/327482a0
更新日期:1987-06-11 00:00:00
abstract::The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to significant improvements in both monitoring and treatment. During chronic infection the process of T-cell exhaustion in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14468
更新日期:2015-07-30 00:00:00
abstract::A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived imm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-021-03275-y
更新日期:2021-02-01 00:00:00
abstract::The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14366
更新日期:2015-04-30 00:00:00
abstract::Promoters are DNA sequences that have an essential role in controlling gene expression. While recent whole cancer genome analyses have identified numerous hotspots of somatic point mutations within promoters, many have not yet been shown to perturb gene expression or drive cancer development. As such, positive selecti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17437
更新日期:2016-04-14 00:00:00
abstract::There is ample evidence that the secretion of follicle stimulating hormone (FSH) by the pituitary gland is regulated by a nonsteroidal hormone of gonadal origin, termed inhibin. In several species, testicular extracts, gonadal lymph and seminal plasma have been shown to contain proteins which inhibit FSH release; lack...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285246a0
更新日期:1980-05-22 00:00:00
abstract::The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Ka...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/34193
更新日期:1998-01-01 00:00:00
abstract::Manic depression is a severe cyclic mental illness that can be unipolar or bipolar and has a lifetime risk of approximately 7 per 1,000 in most populations. Families with multiple cases of manic depression have been described that are compatible with both autosomal dominant and X-linked modes of genetic transmission. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/325805a0
更新日期:1987-02-26 00:00:00
abstract::The amount of energy used to run a mile is nearly the same whether it is run at top speed or at a leisurely pace (although it is used more rapidly at the higher speed). This puzzling independence of energy cost and speed is found generally among running animals, although, on a per gram basis, cost is much higher for s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346265a0
更新日期:1990-07-19 00:00:00
abstract::N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter receptors in the central nervous system. They form glutamate-gated ion channels that are highly permeable to calcium and mediate activity-dependent synaptic plasticity. NMDAR dysfunction is implicated in multiple brain diso...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07993
更新日期:2009-06-04 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07631-3
更新日期:2018-12-01 00:00:00
abstract::Government policies currently commit us to surface warming of three to four degrees Celsius above pre-industrial levels by 2100, which will lead to enhanced ice-sheet melt. Ice-sheet discharge was not explicitly included in Coupled Model Intercomparison Project phase 5, so effects on climate from this melt are not cur...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0889-9
更新日期:2019-02-01 00:00:00
abstract::Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/374421a0
更新日期:1995-03-30 00:00:00
abstract::The NMDA (N-methyl-D-aspartate) receptor transduces the binding of glutamate and glycine, coupling it to the opening of a calcium-permeable ion channel 1 . Owing to the lack of high-resolution structural studies of the NMDA receptor, the mechanism by which ion-channel blockers occlude ion permeation is not well unders...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0039-9
更新日期:2018-04-01 00:00:00
abstract::The HLA-D region of the human major histocompatibility complex (MHC) has been shown to be homologous to the murine I region in terms of both structure and function. Both regions encode class II MHC molecules which restrict T-lymphocyte interactions with antigen-presenting cells. We have recently described the MHC rest...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301716a0
更新日期:1983-02-24 00:00:00
abstract::Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1794-y
更新日期:2019-12-01 00:00:00
abstract::The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11413
更新日期:2012-10-04 00:00:00
abstract::Regulatory aspects of the Warnock Committee's report on reproductive technologies are summarized. A licensing authority with "substantial lay representation" would license practitioners and approve experimentation. Artificial insemination by donor would become a regulated service, and resulting children would be leg...
journal_title:Nature
pub_type: 新闻
doi:10.1038/310266b0
更新日期:1984-07-26 00:00:00
abstract::Most stars become white dwarfs after they have exhausted their nuclear fuel (the Sun will be one such). Between one-quarter and one-half of white dwarfs have elements heavier than helium in their atmospheres, even though these elements ought to sink rapidly into the stellar interiors (unless they are occasionally repl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15527
更新日期:2015-10-22 00:00:00
abstract::During embryogenesis, body pattern is established in a stepwise process. After specification of the body axis, the embryo is subdivided into smaller units. Within these units, a diverse array of cell types is then generated. The subdivisions of the Drosophila embryo, called parasegments, are defined by the interface b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360347a0
更新日期:1992-11-26 00:00:00
abstract::The classical strength profile of continents is derived from a quasi-static view of their rheological response to stress--one that does not consider dynamic interactions between brittle and ductile layers. Such interactions result in complexities of failure in the brittle-ductile transition and the need to couple ener...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04868
更新日期:2006-07-06 00:00:00
abstract::Sex in birds is chromosomally based, as in mammals, but the sex chromosomes are different and the mechanism of avian sex determination has been a long-standing mystery. In the chicken and all other birds, the homogametic sex is male (ZZ) and the heterogametic sex is female (ZW). Two hypotheses have been proposed for t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08298
更新日期:2009-09-10 00:00:00
abstract::Platelet-derived growth factor (PDGF), as purified from fresh human platelets, is a protein of relative molecular mass (Mr) 30,000 composed of two disulphide-linked subunit chains of similar size, named A and B (ref. 1). The dimer structure of PDGRF seems to be important for its biological effects, as reduction irreve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/319511a0
更新日期:1986-02-06 00:00:00
abstract::Stable associations of more than one species of symbiont within a single host cell or tissue are assumed to be rare in metazoans because competition for space and resources between symbionts can be detrimental to the host. In animals with multiple endosymbionts, such as mussels from deep-sea hydrothermal vents and ree...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35077067
更新日期:2001-05-17 00:00:00
abstract::A long-sought goal in structural biology has been the imaging of membrane proteins in their membrane environments. This goal has been achieved with electron crystallography in those special cases where a protein forms highly ordered arrays in lipid bilayers. It has also been achieved by NMR methods in proteins up to 5...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08291
更新日期:2009-09-10 00:00:00