Abstract：
:Targeted gene disruption in the mouse shows that the Sonic hedgehog (Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs. Early defects are observed in the establishment or maintenance of midline structures, such as the notochord and the floorplate, and later defects include absence of distal limb structures, cyclopia, absence of ventral cell types within the neural tube, and absence of the spinal column and most of the ribs. Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres.
journal_name
Naturejournal_title
Natureauthors
Chiang C,Litingtung Y,Lee E,Young KE,Corden JL,Westphal H,Beachy PAdoi
10.1038/383407a0subject
Has Abstractpub_date
1996-10-03 00:00:00pages
407-13issue
6599eissn
0028-0836issn
1476-4687journal_volume
383pub_type
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