Abstract:
:Proviruses of avian leukosis virus (ALV) are located in the vicinity of a putative cellular oncogene (c-myc) in ALV-induced bursal lymphomas. Enhanced expression of c-myc occurs in association with proviruses found in any of three configurations: (I) on the 5' side ('upstream') of c-myc in the same transcriptional orientation; (II) on the 3' side ('downstream') of c-myc in the same orientation; (III) upstream, in the transcriptional orientation opposite to that of c-myc. Thus, activation of adjacent cellular genes by retroviral DNA can involve mechanisms other than provision of a transcriptional promoter.
journal_name
Naturejournal_title
Natureauthors
Payne GS,Bishop JM,Varmus HEdoi
10.1038/295209a0subject
Has Abstractpub_date
1982-01-21 00:00:00pages
209-14issue
5846eissn
0028-0836issn
1476-4687journal_volume
295pub_type
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