Secreted transcription factor controls Mycobacterium tuberculosis virulence.

abstract：:Enveloped viruses have evolved complex glycoprotein machinery that drives the fusion of viral and cellular membranes, permitting entry of the viral genome into the cell. For the paramyxoviruses, the fusion (F) protein catalyses this membrane merger and entry step, and it has been postulated that the F protein undergoe...

journal_title：Nature

authors： Yin HS,Wen X,Paterson RG,Lamb RA,Jardetzky TS

更新日期：2006-01-05 00:00:00

abstract：:Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and experimental studies have demonstrated a causal relationship between neutr...

journal_title：Nature

authors： Wellenstein MD,Coffelt SB,Duits DEM,van Miltenburg MH,Slagter M,de Rink I,Henneman L,Kas SM,Prekovic S,Hau CS,Vrijland K,Drenth AP,de Korte-Grimmerink R,Schut E,van der Heijden I,Zwart W,Wessels LFA,Schumacher TN,Jonk

更新日期：2019-08-01 00:00:00

abstract：:Mistranslation arising from confusion of serine for alanine by alanyl-tRNA synthetases (AlaRSs) has profound functional consequences. Throughout evolution, two editing checkpoints prevent disease-causing mistranslation from confusing glycine or serine for alanine at the active site of AlaRS. In both bacteria and mice,...

journal_title：Nature

authors： Guo M,Chong YE,Shapiro R,Beebe K,Yang XL,Schimmel P

更新日期：2009-12-10 00:00:00

abstract：:The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...

journal_title：Nature

authors： Rossier J,Audigier Y,Ling N,Cros J,Udenfriend S

更新日期：1980-11-06 00:00:00

abstract：:SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) and Rab-GTPases, together with their cofactors, mediate the attachment step in the membrane fusion of vesicles. But how bilayer mixing--the subsequent core process of fusion--is catalysed remains unclear. Ca2+/calmodulin controls this term...

journal_title：Nature

authors： Peters C,Bayer MJ,Bühler S,Andersen JS,Mann M,Mayer A

更新日期：2001-02-01 00:00:00

abstract：:Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore 'biological-activity space'. ...

journal_title：Nature

authors： Stockwell BR

更新日期：2004-12-16 00:00:00

abstract：:Specific genes can be inactivated or mutated in the mouse germ line. The phenotypic consequences of the mutation can provide pivotal information on the function of the gene in development and maintenance of the mammalian organism. The procedure entails homologous recombination in embryonic stem cells, which, on fusion...

journal_title：Nature

authors： te Riele H,Maandag ER,Clarke A,Hooper M,Berns A

更新日期：1990-12-13 00:00:00

abstract：:The response of tropical cyclone activity to global warming is widely debated. It is often assumed that warmer sea surface temperatures provide a more favourable environment for the development and intensification of tropical cyclones, but cyclone genesis and intensity are also affected by the vertical thermodynamic p...

journal_title：Nature

authors： Vecchi GA,Soden BJ

更新日期：2007-12-13 00:00:00

abstract：:p97 is a 97,000 molecular weight cell-surface glycoprotein, which is present in human melanomas but in only trace amounts in normal adult tissues. Amino acid sequence and iron binding studies have shown that p97 is structurally and functionally related to transferrin. Reports that the genes for the transferrin recepto...

journal_title：Nature

authors： Plowman GD,Brown JP,Enns CA,Schröder J,Nikinmaa B,Sussman HH,Hellström KE,Hellström I

更新日期：1983-05-05 00:00:00

abstract：:Concern about the levels of lead in blood is widespread. There is uncertainty, however, about the relative importance of the various environmental sources. Lead in petrol is widely assumed to be one of the most important sources and air and dust have been identified as the main routes to man. Water is regarded as an i...

journal_title：Nature

authors： Elwood PC,Gallacher JE,Phillips KM,Davies BE,Toothill C

更新日期：1984-07-12 00:00:00

abstract：:Retrospective epidemiological data have indicated that cutaneous malignant melanoma may arise as a consequence of intense, intermittent exposure of the skin to ultraviolet radiation, particularly in children, rather than from the cumulative lifetime exposure that is associated with other forms of skin cancer. Here we ...

journal_title：Nature

authors： Noonan FP,Recio JA,Takayama H,Duray P,Anver MR,Rush WL,De Fabo EC,Merlino G

更新日期：2001-09-20 00:00:00

abstract：:Glycine is an important inhibitory transmitter in the brainstem and spinal cord. In the trigeminal subnucleus caudalis (medullary dorsal horn) and in the spinal dorsal horn (the relaying centres for processing pain and sensory information), glycine inhibits the glutamate-evoked depolarization and depresses firing of n...

journal_title：Nature

authors： Song YM,Huang LY

更新日期：1990-11-15 00:00:00

abstract：:Systems of colour vision are normally identical in all members of a species, but a single design may not be adequate for species living in a diverse range of light environments. Here we show that in the mantis shrimp Haptosquilla trispinosa, which occupies a range of depths in the ocean, long-wavelength colour recepto...

journal_title：Nature

authors： Cronin TW,Caldwell RL,Marshall J

更新日期：2001-05-31 00:00:00

abstract：:Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. Neurovascular dysfunction is present in normal APOE4 carriers and i...

journal_title：Nature

authors： Bell RD,Winkler EA,Singh I,Sagare AP,Deane R,Wu Z,Holtzman DM,Betsholtz C,Armulik A,Sallstrom J,Berk BC,Zlokovic BV

更新日期：2012-05-16 00:00:00

abstract：:Transformation of the well-studied maize transposable elements into other plant species should enable transposon tagging methodology to be used for the isolation of interesting genes in the heterologous host. Here we describe the isolation of a transposon-tagged male sterile mutant in Arabidopsis thaliana using the ma...

journal_title：Nature

authors： Aarts MG,Dirkse WG,Stiekema WJ,Pereira A

更新日期：1993-06-24 00:00:00

abstract：:Interactions between animal viruses and antiviral antisera may exceptionally result in an apparent increase in viral infectivity. Halstead and coworkers demonstrated enhanced replication of dengue virus (a Flavivirus, family Togaviridae) in human or simian peripheral blood leucocytes carrying Fc receptors at subneutra...

journal_title：Nature

authors： Peiris JS,Porterfield JS

更新日期：1979-11-29 00:00:00

abstract：:Evolutionary adaptation can be rapid and potentially help species counter stressful conditions or realize ecological opportunities arising from climate change. The challenges are to understand when evolution will occur and to identify potential evolutionary winners as well as losers, such as species lacking adaptive c...

journal_title：Nature

authors： Hoffmann AA,Sgrò CM

更新日期：2011-02-24 00:00:00

abstract：:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we ...

journal_title：Nature

authors： Jiang L,Liu X,Xiong G,Liu H,Chen F,Wang L,Meng X,Liu G,Yu H,Yuan Y,Yi W,Zhao L,Ma H,He Y,Wu Z,Melcher K,Qian Q,Xu HE,Wang Y,Li J

更新日期：2013-12-19 00:00:00

abstract：:Volcanic eruptions contribute to climate variability, but quantifying these contributions has been limited by inconsistencies in the timing of atmospheric volcanic aerosol loading determined from ice cores and subsequent cooling from climate proxies such as tree rings. Here we resolve these inconsistencies and show th...

journal_title：Nature

authors： Sigl M,Winstrup M,McConnell JR,Welten KC,Plunkett G,Ludlow F,Büntgen U,Caffee M,Chellman N,Dahl-Jensen D,Fischer H,Kipfstuhl S,Kostick C,Maselli OJ,Mekhaldi F,Mulvaney R,Muscheler R,Pasteris DR,Pilcher JR,Salzer M,

更新日期：2015-07-30 00:00:00

abstract：:Transition-metal perovskite oxides exhibit a wide range of extraordinary but imperfectly understood phenomena. The best known examples are high-temperature superconductivity in copper oxides, and colossal magnetoresistance in manganese oxides ('manganites'). All of these materials undergo a range of order-disorder tra...

journal_title：Nature

authors： Renner Ch,Aeppli G,Kim BG,Soh YA,Cheong SW

更新日期：2002-04-04 00:00:00

abstract：:Recent observations have revealed streams of gas and stars in the halo of the Milky Way that are the debris from interactions between our Galaxy and some of its dwarf companion galaxies; the Sagittarius dwarf galaxy and the Magellanic clouds. Analysis of the material has shown that much of the halo is made up of canni...

journal_title：Nature

authors： Ibata R,Irwin M,Lewis G,Ferguson AM,Tanvir N

更新日期：2001-07-05 00:00:00

abstract：:The small martian satellites Phobos and Deimos orbit in synchronous rotation with inclinations of only 0.01 degrees and 0.92 degrees , respectively, relative to the planet's equatorial plane. Thus, an observer at near-equatorial latitudes on Mars could occasionally observe solar eclipses by these satellites (see ref. ...

journal_title：Nature

authors： Bell JF 3rd,Lemmon MT,Duxbury TC,Hubbard MY,Wolff MJ,Squyres SW,Craig L,Ludwinski JM

更新日期：2005-07-07 00:00:00

abstract：:Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...

journal_title：Nature

authors： Qian H,Kang X,Hu J,Zhang D,Liang Z,Meng F,Zhang X,Xue Y,Maimon R,Dowdy SF,Devaraj NK,Zhou Z,Mobley WC,Cleveland DW,Fu XD

更新日期：2020-06-01 00:00:00

abstract：:Excitatory amino acids (EAAs) are important neurotransmitters in the vertebrate central nervous system. Electrophysiological and ligand-binding studies indicate that at least three different receptor subtypes for EAAs exist--N-methyl-D-aspartate, kainate and quisqualate receptor subtypes--on the basis of the preferred...

journal_title：Nature

authors： Wada K,Dechesne CJ,Shimasaki S,King RG,Kusano K,Buonanno A,Hampson DR,Banner C,Wenthold RJ,Nakatani Y

更新日期：1989-12-07 00:00:00

abstract：:Carbonates on large Solar System bodies like Earth and Mars (the latter represented by the meteorite ALH84001) form through the weathering of silicates in a watery (CO3)2- solution. The presence of carbonates in interplanetary dust particles and asteroids (again, represented by meteorites) is not completely understood...

journal_title：Nature

authors： Kemper F,Jäger C,Waters LB,Henning T,Molster FJ,Barlow MJ,Lim T,de Koter A

更新日期：2002-01-17 00:00:00

abstract：:Critical issues in the cognitive neuroscience of language are whether there are multiple systems for the representation of meaning, perhaps organized by processing system (such as vision or language), and whether further subsystems are distinguishable within these larger ones. We describe here a patient (K.R.) with ce...

journal_title：Nature

authors： Hart J Jr,Gordon B

更新日期：1992-09-03 00:00:00

abstract：:The recent discovery of CD4(+) T cells characterized by secretion of interleukin (IL)-17 (T(H)17 cells) and the naturally occurring regulatory FOXP3(+) CD4 T cell (nT(reg)) has had a major impact on our understanding of immune processes not readily explained by the T(H)1/T(H)2 paradigm. T(H)17 and nT(reg) cells have b...

journal_title：Nature

authors： Yang L,Anderson DE,Baecher-Allan C,Hastings WD,Bettelli E,Oukka M,Kuchroo VK,Hafler DA

更新日期：2008-07-17 00:00:00

abstract：:The spread of antibiotic resistance in Gram-negative bacteria has sustained a continuing search for new agents with antibacterial activity against this important class of bacterial pathogen. Because the biosynthesis of lipopolysaccharide (LPS) is unique to Gram-negative bacteria and required by them for growth and vir...

journal_title：Nature

authors： Goldman R,Kohlbrenner W,Lartey P,Pernet A

更新日期：1987-09-10 00:00:00

abstract：:Although the nuclear properties of the late actinides (plutonium, americium and curium) are fully understood and widely applied to energy generation, their solid-state properties do not fit within standard models and are the subject of active research. Plutonium displays phases with enormous volume differences, and bo...

journal_title：Nature

authors： Shim JH,Haule K,Kotliar G

更新日期：2007-03-29 00:00:00

abstract：:The Earth's equatorial stratosphere shows oscillations in which the east-west winds reverse direction and the temperatures change cyclically with a period of about two years. This phenomenon, called the quasi-biennial oscillation, also affects the dynamics of the mid- and high-latitude stratosphere and weather in the ...

journal_title：Nature

authors： Flasar FM,Kunde VG,Achterberg RK,Conrath BJ,Simon-Miller AA,Nixon CA,Gierasch PJ,Romani PN,Bézard B,Irwin P,Bjoraker GL,Brasunas JC,Jennings DE,Pearl JC,Smith MD,Orton GS,Spilker LJ,Carlson R,Calcutt SB,Read PL,Ta

更新日期：2004-01-08 00:00:00