Mapping human visual cortex with positron emission tomography.

abstract：:Spermiogenesis is a complex process by which postmeiotic male germ cells differentiate into mature spermatozoa. This process involves remarkable structural and biochemical changes including nuclear DNA compaction and acrosome formation. Transcription activator CREM (cyclic AMP-responsive element modulator) is highly e...

journal_title：Nature

authors： Nantel F,Monaco L,Foulkes NS,Masquilier D,LeMeur M,Henriksén K,Dierich A,Parvinen M,Sassone-Corsi P

更新日期：1996-03-14 00:00:00

abstract：:Topological insulators-materials that are insulating in the bulk but allow electrons to flow on their surface-are striking examples of materials in which topological invariants are manifested in robustness against perturbations such as defects and disorder1. Their most prominent feature is the emergence of edge states...

journal_title：Nature

authors： Klembt S,Harder TH,Egorov OA,Winkler K,Ge R,Bandres MA,Emmerling M,Worschech L,Liew TCH,Segev M,Schneider C,Höfling S

更新日期：2018-10-01 00:00:00

abstract：:Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide an interesting example, defined by the classic phenomenon of crossover interference. Here we identify a molecular pathway for interference by analysing crossover patterns in budding yeast. Topoisomerase II plays a central role...

journal_title：Nature

authors： Zhang L,Wang S,Yin S,Hong S,Kim KP,Kleckner N

更新日期：2014-07-31 00:00:00

abstract：:First-order difference equations arise in many contexts in the biological, economic and social sciences. Such equations, even though simple and deterministic, can exhibit a surprising array of dynamical behaviour, from stable points, to a bifurcating hiearchy of stable cycles, to apparently random fluctuations. There ...

journal_title：Nature

authors： May RM

更新日期：1976-06-10 00:00:00

abstract：:Slower recovery from perturbations near a tipping point and its indirect signatures in fluctuation patterns have been suggested to foreshadow catastrophes in a wide variety of systems. Recent studies of populations in the field and in the laboratory have used time-series data to confirm some of the theoretically predi...

journal_title：Nature

authors： Dai L,Korolev KS,Gore J

更新日期：2013-04-18 00:00:00

abstract：:The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly ...

journal_title：Nature

authors： DiTullio GR,Grebmeier JM,Arrigo KR,Lizotte MP,Robinson DH,Leventer A,Barry JP,VanWoert ML,Dunbar RB

更新日期：2000-04-06 00:00:00

abstract：:FokI is a member of an unusual class of bipartite restriction enzymes that recognize a specific DNA sequence and cleave DNA nonspecifically a short distance away from that sequence. Because of its unusual bipartite nature, FokI has been used to create artificial enzymes with new specificities. We have determined the c...

journal_title：Nature

authors： Wah DA,Hirsch JA,Dorner LF,Schildkraut I,Aggarwal AK

更新日期：1997-07-03 00:00:00

abstract：:The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor po...

journal_title：Nature

authors： Derynck R,Jarrett JA,Chen EY,Eaton DH,Bell JR,Assoian RK,Roberts AB,Sporn MB,Goeddel DV

更新日期：1985-08-22 00:00:00

abstract：:Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, ...

journal_title：Nature

authors： Hannum CH,Wilcox CJ,Arend WP,Joslin FG,Dripps DJ,Heimdal PL,Armes LG,Sommer A,Eisenberg SP,Thompson RC

更新日期：1990-01-25 00:00:00

abstract：:It is a controversial issue whether 'real' movement, seen from the successive stimulation of retinal receptors by a moving image, and 'apparent' (phi) movement, which is produced by stimuli separated in space and time, are transmitted by the same or different neural channels. With this question in mind, we have devise...

journal_title：Nature

authors： Gregory RL,Harris JP

更新日期：1984-02-23 00:00:00

abstract：:Saturn's moon Titan has a nitrogen atmosphere comparable to Earth's, with a surface pressure of 1.4 bar. Numerical models reproduce the tropospheric conditions very well but have trouble explaining the observed middle-atmosphere temperatures, composition and winds. The top of the middle-atmosphere circulation has been...

journal_title：Nature

authors： Teanby NA,Irwin PG,Nixon CA,de Kok R,Vinatier S,Coustenis A,Sefton-Nash E,Calcutt SB,Flasar FM

更新日期：2012-11-29 00:00:00

abstract：:For life to be sustained, mistakes in DNA repair must be tolerated when damage obscures the genetic information. In bacteria such as Escherichia coli, DNA damage elicits the well regulated 'SOS response'. For the extreme case of damage that cannot be repaired by conventional enzymes, there are proteins that allow the ...

journal_title：Nature

authors： Peat TS,Frank EG,McDonald JP,Levine AS,Woodgate R,Hendrickson WA

更新日期：1996-04-25 00:00:00

abstract：:The adult mammalian heart is incapable of regeneration following cardiomyocyte loss, which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become clear that the mammalian heart is not a post-mitotic organ. For example, the neonatal heart is capable of regenerating lost myocardium, and the ...

journal_title：Nature

authors： Nakada Y,Canseco DC,Thet S,Abdisalaam S,Asaithamby A,Santos CX,Shah AM,Zhang H,Faber JE,Kinter MT,Szweda LI,Xing C,Hu Z,Deberardinis RJ,Schiattarella G,Hill JA,Oz O,Lu Z,Zhang CC,Kimura W,Sadek HA

更新日期：2017-01-12 00:00:00

abstract：:Outbreaks of haemorrhagic fever caused by the Ebola virus are associated with high mortality rates that are a distinguishing feature of this human pathogen. The highest lethality is associated with the Zaire subtype, one of four strains identified to date. Its rapid progression allows little opportunity to develop nat...

journal_title：Nature

authors： Sullivan NJ,Sanchez A,Rollin PE,Yang ZY,Nabel GJ

更新日期：2000-11-30 00:00:00

abstract：:As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture underlying this regulation is critical for understanding cellular signalling events and responses to environmental cues. Using random mutagenesis in haploid human...

journal_title：Nature

authors： Brockmann M,Blomen VA,Nieuwenhuis J,Stickel E,Raaben M,Bleijerveld OB,Altelaar AFM,Jae LT,Brummelkamp TR

更新日期：2017-06-08 00:00:00

abstract：:The genes torso (tor) and torso-like (tsl) are two of the Drosophila maternal group genes implicated in a receptor tyrosine kinase signalling pathway that specifies terminal cell fate (reviewed in ref. 3). Loss-of-function mutations in these loci cause an identical phenotype in which pattern elements from the anterior...

journal_title：Nature

authors： Martin JR,Raibaud A,Ollo R

更新日期：1994-02-24 00:00:00

abstract：:Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...

journal_title：Nature

authors： Iino Y,Sawada T,Yamaguchi K,Tajiri M,Ishii S,Kasai H,Yagishita S

更新日期：2020-03-01 00:00:00

abstract：:The appendage primordia of Drosophila are subdivided into compartments by the localized expression of transcription factors. Interaction between cells in adjacent compartments establishes organizing centres responsible for generating spatial pattern and promoting cell proliferation in the developing appendages. Locali...

journal_title：Nature

authors： Diaz-Benjumea FJ,Cohen B,Cohen SM

更新日期：1994-11-10 00:00:00

abstract：:A serine/threonine kinase, named protein kinase B (PKB) for its sequence homology to both protein kinase A and C, has previously been isolated. PKB, which is identical to the kinase Rac, was later found to be the cellular homologue of the transforming v-Akt. Here we show that PKB is activated by stimuli such as insuli...

journal_title：Nature

authors： Burgering BM,Coffer PJ

更新日期：1995-08-17 00:00:00

abstract：:Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and dimethyl marks from lysine 4 of histone H3 (H3K4). In contrast, during ...

journal_title：Nature

authors： Metzger E,Imhof A,Patel D,Kahl P,Hoffmeyer K,Friedrichs N,Müller JM,Greschik H,Kirfel J,Ji S,Kunowska N,Beisenherz-Huss C,Günther T,Buettner R,Schüle R

更新日期：2010-04-01 00:00:00

abstract：:The mechanism by which insulin regulates cellular metabolism remains unknown although indirect evidence suggests that alterations in intracellular calcium are important. More specifically, it has been proposed that insulin triggers an increase in intracellular calcium which is responsible for the subsequent modificati...

journal_title：Nature

authors： Pershadsingh HA,McDonald JM

更新日期：1979-10-11 00:00:00

abstract：:Observing and controlling macroscopic quantum systems has long been a driving force in quantum physics research. In particular, strong coupling between individual quantum systems and mechanical oscillators is being actively studied1-3. Whereas both read-out of mechanical motion using coherent control of spin systems4-...

journal_title：Nature

authors： Delord T,Huillery P,Nicolas L,Hétet G

更新日期：2020-04-01 00:00:00

abstract：:Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a mech...

journal_title：Nature

authors： Ekiert DC,Kashyap AK,Steel J,Rubrum A,Bhabha G,Khayat R,Lee JH,Dillon MA,O'Neil RE,Faynboym AM,Horowitz M,Horowitz L,Ward AB,Palese P,Webby R,Lerner RA,Bhatt RR,Wilson IA

更新日期：2012-09-27 00:00:00

abstract：:In the prehistoric green Sahara of Holocene North Africa-in contrast to the Neolithic of Europe and Eurasia-a reliance on cattle, sheep and goats emerged as a stable and widespread way of life, long before the first evidence for domesticated plants or settled village farming communities. The remarkable rock art found ...

journal_title：Nature

authors： Dunne J,Evershed RP,Salque M,Cramp L,Bruni S,Ryan K,Biagetti S,di Lernia S

更新日期：2012-06-20 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the cl...

journal_title：Nature

authors： Fling SP,Arp B,Pious D

更新日期：1994-04-07 00:00:00

abstract：:Stimulation of transient increases in intracellular calcium (Cai2+) activates protein kinases, regulates transcription and influences motility and morphology. Developing neurons generate spontaneous Cai2+ transients, but their role in directing neuronal differentiation and the way in which they encode information are ...

journal_title：Nature

authors： Gu X,Spitzer NC

更新日期：1995-06-29 00:00:00

abstract：:Single-stranded RNA viruses encompass broad classes of infectious agents and cause the common cold, cancer, AIDS and other serious health threats. Viral replication is regulated at many levels, including the use of conserved genomic RNA structures. Most potential regulatory elements in viral RNA genomes are uncharacte...

journal_title：Nature

authors： Watts JM,Dang KK,Gorelick RJ,Leonard CW,Bess JW Jr,Swanstrom R,Burch CL,Weeks KM

更新日期：2009-08-06 00:00:00

abstract：:Estimates of the effect of increasing atmospheric CO2 concentrations on future global plant production rely on the physiological response of individual plants or plant communities when exposed to high CO2 (refs 1-6). Plant populations may adapt to the changing atmosphere, however, such that the evolved plant communiti...

journal_title：Nature

authors： Collins S,Bell G

更新日期：2004-09-30 00:00:00

abstract：:Temperature-dependent transition of conductance in ionic channels has been described in several membrane systems. We report here an abrupt change in the maximal rate of rise of the action potentials of the rat extensor digitorum longus (EDL) at 32 degrees C, indicating alteration in the functional characteristics of t...

journal_title：Nature

authors： Cheung DW,Daniel EE

更新日期：1980-01-31 00:00:00

abstract：:The Colorado plateau is a large, tectonically intact, physiographic province in the southwestern North American Cordillera that stands at ∼1,800-2,000 m elevation and has long been thought to be in isostatic equilibrium. The origin of these high elevations is unclear because unlike the surrounding provinces, which hav...

journal_title：Nature

authors： Levander A,Schmandt B,Miller MS,Liu K,Karlstrom KE,Crow RS,Lee CT,Humphreys ED

更新日期：2011-04-28 00:00:00