Abstract:
:Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist.
journal_name
Naturejournal_title
Natureauthors
Hannum CH,Wilcox CJ,Arend WP,Joslin FG,Dripps DJ,Heimdal PL,Armes LG,Sommer A,Eisenberg SP,Thompson RCdoi
10.1038/343336a0subject
Has Abstractpub_date
1990-01-25 00:00:00pages
336-40issue
6256eissn
0028-0836issn
1476-4687journal_volume
343pub_type
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