Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

abstract：:Jupiter's atmosphere is rotating differentially, with zones and belts rotating at speeds that differ by up to 100 metres per second. Whether this is also true of the gas giant's interior has been unknown, limiting our ability to probe the structure and composition of the planet. The discovery by the Juno spacecraft th...

journal_title：Nature

authors： Guillot T,Miguel Y,Militzer B,Hubbard WB,Kaspi Y,Galanti E,Cao H,Helled R,Wahl SM,Iess L,Folkner WM,Stevenson DJ,Lunine JI,Reese DR,Biekman A,Parisi M,Durante D,Connerney JEP,Levin SM,Bolton SJ

更新日期：2018-03-07 00:00:00

abstract：:In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric chromatin to microtubules of the mitotic spindle3,4. Whereas the...

journal_title：Nature

authors： Yan K,Yang J,Zhang Z,McLaughlin SH,Chang L,Fasci D,Ehrenhofer-Murray AE,Heck AJR,Barford D

更新日期：2019-10-01 00:00:00

abstract：:Carbonates on large Solar System bodies like Earth and Mars (the latter represented by the meteorite ALH84001) form through the weathering of silicates in a watery (CO3)2- solution. The presence of carbonates in interplanetary dust particles and asteroids (again, represented by meteorites) is not completely understood...

journal_title：Nature

authors： Kemper F,Jäger C,Waters LB,Henning T,Molster FJ,Barlow MJ,Lim T,de Koter A

更新日期：2002-01-17 00:00:00

abstract：:Vitamin A is required for normal growth and development, and retinoic acid (RA) may be the active metabolite in this process. Recent evidence indicates that RA acts through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. The receptors seem to associate with hormone-resp...

journal_title：Nature

authors： Bedo G,Santisteban P,Aranda A

更新日期：1989-05-18 00:00:00

abstract：: ...

journal_title：Nature

authors： Gewin V

更新日期：2019-02-01 00:00:00

abstract：:Observations show that the seismic normal modes of the Earth at frequencies near 10 mHz are excited at a nearly constant level in the absence of large earthquakes. This background level of excitation has been called the 'hum' of the Earth, and is equivalent to the maximum excitation from a magnitude 5.75 earthquake. I...

journal_title：Nature

authors： Webb SC

更新日期：2007-02-15 00:00:00

abstract：:Specific genes can be inactivated or mutated in the mouse germ line. The phenotypic consequences of the mutation can provide pivotal information on the function of the gene in development and maintenance of the mammalian organism. The procedure entails homologous recombination in embryonic stem cells, which, on fusion...

journal_title：Nature

authors： te Riele H,Maandag ER,Clarke A,Hooper M,Berns A

更新日期：1990-12-13 00:00:00

abstract：: ...

journal_title：Nature

authors： Butchart SHM,Clements A,Gibbons DW

更新日期：2019-02-01 00:00:00

abstract：:The foundation of western civilization owes much to the high fertility of bread wheat, which results from the stability of its polyploid genome. Despite possessing multiple sets of related chromosomes, hexaploid (bread) and tetraploid (pasta) wheat both behave as diploids at meiosis. Correct pairing of homologous chro...

journal_title：Nature

authors： Griffiths S,Sharp R,Foote TN,Bertin I,Wanous M,Reader S,Colas I,Moore G

更新日期：2006-02-09 00:00:00

abstract：:Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation. This phenomenon, called senescence, is driven by telomere attrition, which triggers the induction of tumour suppressors including p16(INK4a) (ref. 5). In cultured cells, senescence can be e...

journal_title：Nature

authors： Michaloglou C,Vredeveld LC,Soengas MS,Denoyelle C,Kuilman T,van der Horst CM,Majoor DM,Shay JW,Mooi WJ,Peeper DS

更新日期：2005-08-04 00:00:00

abstract：:Angiotensin II is an important effector molecule controlling blood pressure and volume in the cardiovascular system. Its importance is manifested by the efficacy of angiotensin-converting enzyme inhibitors in the treatment of hypertension and congestive heart failure. Angiotensin II interacts with two pharmacologicall...

journal_title：Nature

authors： Murphy TJ,Alexander RW,Griendling KK,Runge MS,Bernstein KE

更新日期：1991-05-16 00:00:00

abstract：:Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6. ...

journal_title：Nature

authors： Minhas PS,Latif-Hernandez A,McReynolds MR,Durairaj AS,Wang Q,Rubin A,Joshi AU,He JQ,Gauba E,Liu L,Wang C,Linde M,Sugiura Y,Moon PK,Majeti R,Suematsu M,Mochly-Rosen D,Weissman IL,Longo FM,Rabinowitz JD,Andreasson K

更新日期：2021-01-20 00:00:00

abstract：:Immunoprecipitation and tryptic peptide analysis of newly synthesized proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both pancreatic glucagon and a 10,...

journal_title：Nature

authors： Patzelt C,Tager HS,Carroll RJ,Steiner DF

更新日期：1979-11-15 00:00:00

abstract：:Self-reproduction is central to biological life for long-term sustainability and evolutionary adaptation. Although these traits would also be desirable in many engineered systems, the principles of self-reproduction have not been exploited in machine design. Here we create simple machines that act as autonomous modula...

journal_title：Nature

authors： Zykov V,Mytilinaios E,Adams B,Lipson H

更新日期：2005-05-12 00:00:00

abstract：:Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...

journal_title：Nature

authors： Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A

更新日期：2014-07-17 00:00:00

abstract：:Is the big-bang hot, warm or cold? And are galactic masses determined by the interplay of gravitational and strong interactions in the very early universe? ...

journal_title：Nature

authors： Harrison ER

更新日期：1970-10-17 00:00:00

abstract：:A model catalyst is described which has properties in common with carbonic anhydrase. The model demonstrates the availability of a mechanism, previously only hypothetical, for the action of the enzyme. It also shows, however, that this mechanism alone is not adequate to produce the high activity of the enzyme. ...

journal_title：Nature

authors： Woolley P

更新日期：1975-12-25 00:00:00

abstract：:The first open meeting to discuss the growing issue of commercialism in academic research was convened by the New York Bar Association's patent committee. Participants included Steven Muller, president of Johns Hopkins University, Joshua Lederberg, president of Rockefeller University, and A. Thomas Bartlett, presiden...

journal_title：Nature

authors： Stein MD

更新日期：1982-04-29 00:00:00

abstract：:The reversal or displacement of the retinal image by prism spectacles leads to extreme disruption of visually guided behaviour, but after an extended period of visual transformation normal behaviour is gradually restored. It is unclear whether this adaptation involves a change in visual perception, the learning of new...

journal_title：Nature

authors： Sugita Y

更新日期：1996-04-11 00:00:00

abstract：:Most tetrapods have retained terrestrial locomotion since it evolved in the Palaeozoic era, but bats have become so specialized for flight that they have almost lost the ability to manoeuvre on land at all. Vampire bats, which sneak up on their prey along the ground, are an important exception. Here we show that commo...

journal_title：Nature

authors： Riskin DK,Hermanson JW

更新日期：2005-03-17 00:00:00

abstract：:To trigger class II-restricted T cells, antigen presenting cells have to capture antigens, process them and display their fragments in association with class II molecules. In most species, activated T cells express class II molecules; however, no evidence has been found that these cells can present soluble antigens. T...

journal_title：Nature

authors： Lanzavecchia A,Roosnek E,Gregory T,Berman P,Abrignani S

更新日期：1988-08-11 00:00:00

abstract：:Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show that presenilin-1 forms a complex with beta-catenin in vivo that incr...

journal_title：Nature

authors： Zhang Z,Hartmann H,Do VM,Abramowski D,Sturchler-Pierrat C,Staufenbiel M,Sommer B,van de Wetering M,Clevers H,Saftig P,De Strooper B,He X,Yankner BA

更新日期：1998-10-15 00:00:00

abstract：:Viruses are the most abundant biological organisms of the world's oceans. Viral infections are a substantial source of mortality in a range of organisms-including autotrophic and heterotrophic plankton-but their impact on the deep ocean and benthic biosphere is completely unknown. Here we report that viral production ...

journal_title：Nature

authors： Danovaro R,Dell'Anno A,Corinaldesi C,Magagnini M,Noble R,Tamburini C,Weinbauer M

更新日期：2008-08-28 00:00:00

abstract：:The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants dep...

journal_title：Nature

authors： Rutherford SL,Lindquist S

更新日期：1998-11-26 00:00:00

abstract：:The extensive literature on the origin of the ratites focuses mainly on three questions: are the ratites mono- or polyphyletic, did they evolve from flying ancestors, and are they primitive or advanced? Opinion tends to accept a common descent from flying ancestors for the large ratites (for a summary of ideas see ref...

journal_title：Nature

authors： de Boer LE

更新日期：1980-09-04 00:00:00

abstract：:Direct lineage reprogramming represents a remarkable conversion of cellular and transcriptome states. However, the intermediate stages through which individual cells progress during reprogramming are largely undefined. Here we use single-cell RNA sequencing at multiple time points to dissect direct reprogramming from ...

journal_title：Nature

authors： Treutlein B,Lee QY,Camp JG,Mall M,Koh W,Shariati SA,Sim S,Neff NF,Skotheim JM,Wernig M,Quake SR

更新日期：2016-06-16 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the brain. The principal component of amyloid fibrils is beta/A4 amyloid protein, which can be generated by the aberrant processing of a large membrane-bound glycoprotein, the beta/A4 amyloid protein precursor (APP)3. To test whethe...

journal_title：Nature

authors： Yoshikawa K,Aizawa T,Hayashi Y

更新日期：1992-09-03 00:00:00

abstract：:Multicomponent reactions are relied on in both academic and industrial synthetic organic chemistry owing to their step- and atom-economy advantages over traditional synthetic sequences1. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular...

journal_title：Nature

authors： Zhang X,Smith RT,Le C,McCarver SJ,Shireman BT,Carruthers NI,MacMillan DWC

更新日期：2020-04-01 00:00:00

abstract：:Most of the progress in human culture has required the exploitation of energy resources. About 100 years ago, the major source of energy shifted from recent solar to fossil hydrocarbons, including liquid and gaseous petroleum. Technology has generally led to a greater use of hydrocarbon fuels for most human activities...

journal_title：Nature

authors： Hall C,Tharakan P,Hallock J,Cleveland C,Jefferson M

更新日期：2003-11-20 00:00:00

abstract：:Groundwater drawn daily from shallow alluvial sands by millions of wells over large areas of south and southeast Asia exposes an estimated population of over a hundred million people to toxic levels of arsenic. Holocene aquifers are the source of widespread arsenic poisoning across the region. In contrast, Pleistocene...

journal_title：Nature

authors： van Geen A,Bostick BC,Pham TK,Vi ML,Nguyen-Ngoc M,Phu DM,Pham HV,Radloff K,Aziz Z,Mey JL,Stahl MO,Harvey CF,Oates P,Weinman B,Stengel C,Frei F,Kipfer R,Berg M

更新日期：2013-09-12 00:00:00