Global plasticity in adult visual cortex following reversal of visual input.


:The reversal or displacement of the retinal image by prism spectacles leads to extreme disruption of visually guided behaviour, but after an extended period of visual transformation normal behaviour is gradually restored. It is unclear whether this adaptation involves a change in visual perception, the learning of new motor responses, a modification of the sensori-motor control system or a proprioceptive change in the perceived positions of the body parts. Here I describe the effects of visual field reversal on neuronal activity in the monkey visual cortex. After a few months of wearing reversing spectacles, some cells in the primary visual cortex began to respond to stimuli presented not only in the contralateral visual field but also in the ipsilateral field. These cells were not selective for orientation or direction of motion, but responded well to a light flash. This result suggests that adaptation to visual field reversal is mediated, at least in part, by a large-scale functional reorganization at an early stage in the visual processing pathway.






Sugita Y




Has Abstract


1996-04-11 00:00:00














  • Allograft theory: transmission of devil facial-tumour disease.

    abstract::The Tasmanian devil, a large carnivorous Australian marsupial, is under threat from a widespread fatal disease in which a malignant oral-facial tumour obstructs the animal's ability to feed. Here we show that the chromosomes in these tumours have undergone a complex rearrangement that is identical for every animal stu...


    pub_type: 杂志文章


    authors: Pearse AM,Swift K

    更新日期:2006-02-02 00:00:00

  • Evidence for extremely rapid magma ocean crystallization and crust formation on Mars.

    abstract::The formation of a primordial crust is a critical step in the evolution of terrestrial planets but the timing of this process is poorly understood. The mineral zircon is a powerful tool for constraining crust formation because it can be accurately dated with the uranium-to-lead (U-Pb) isotopic decay system and is resi...


    pub_type: 杂志文章


    authors: Bouvier LC,Costa MM,Connelly JN,Jensen NK,Wielandt D,Storey M,Nemchin AA,Whitehouse MJ,Snape JF,Bellucci JJ,Moynier F,Agranier A,Gueguen B,Schönbächler M,Bizzarro M

    更新日期:2018-06-01 00:00:00

  • Binding of disease-associated prion protein to plasminogen.

    abstract::Transmissible spongiform encephalopathies are associated with accumulation of PrP(Sc), a conformer of a cellular protein called PrP(C). PrP(Sc) is thought to replicate by imparting its conformation onto PrP(C) (ref. 1), yet conformational discrimination between PrP(C) and PrP(Sc) has remained elusive. Because depositi...


    pub_type: 杂志文章


    authors: Fischer MB,Roeckl C,Parizek P,Schwarz HP,Aguzzi A

    更新日期:2000-11-23 00:00:00

  • Break-induced telomere synthesis underlies alternative telomere maintenance.

    abstract::Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10-15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (brea...


    pub_type: 杂志文章


    authors: Dilley RL,Verma P,Cho NW,Winters HD,Wondisford AR,Greenberg RA

    更新日期:2016-11-03 00:00:00

  • Global warming and climate forcing by recent albedo changes on Mars.

    abstract::For hundreds of years, scientists have tracked the changing appearance of Mars, first by hand drawings and later by photographs. Because of this historical record, many classical albedo patterns have long been known to shift in appearance over time. Decadal variations of the martian surface albedo are generally attrib...


    pub_type: 杂志文章


    authors: Fenton LK,Geissler PE,Haberle RM

    更新日期:2007-04-05 00:00:00

  • Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes.

    abstract::The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T...


    pub_type: 杂志文章


    authors: Watkins DI,Chen ZW,Hughes AL,Evans MG,Tedder TF,Letvin NL

    更新日期:1990-07-05 00:00:00

  • Suppressor effects and cyclic AMP accumulation by the CD29 molecule of CD4+ lymphocytes.

    abstract::Integrins are a superfamily of related molecules whose function, where known, is to mediate adhesion. The so-called very-late-activation antigen (VLA) family includes at least five distinct heterodimers, each composed of a unique alpha-subunit non-covalently associated with a common beta-subunit. Several members of th...


    pub_type: 杂志文章


    authors: Groux H,Huet S,Valentin H,Pham D,Bernard A

    更新日期:1989-05-11 00:00:00

  • Sound velocity of CaSiO3 perovskite suggests the presence of basaltic crust in the Earth's lower mantle.

    abstract::Laboratory measurements of sound velocities of high-pressure minerals provide crucial information on the composition and constitution of the deep mantle via comparisons with observed seismic velocities. Calcium silicate (CaSiO3) perovskite (CaPv) is a high-pressure phase that occurs at depths greater than about 560 ki...


    pub_type: 杂志文章


    authors: Gréaux S,Irifune T,Higo Y,Tange Y,Arimoto T,Liu Z,Yamada A

    更新日期:2019-01-01 00:00:00

  • Colloidal nanocrystal heterostructures with linear and branched topology.

    abstract::The development of colloidal quantum dots has led to practical applications of quantum confinement, such as in solution-processed solar cells, lasers and as biological labels. Further scientific and technological advances should be achievable if these colloidal quantum systems could be electronically coupled in a gene...


    pub_type: 杂志文章


    authors: Milliron DJ,Hughes SM,Cui Y,Manna L,Li J,Wang LW,Alivisatos AP

    更新日期:2004-07-08 00:00:00

  • Key role of chemistry versus bias in electrocatalytic oxygen evolution.

    abstract::The oxygen evolution reaction has an important role in many alternative-energy schemes because it supplies the protons and electrons required for converting renewable electricity into chemical fuels1-3. Electrocatalysts accelerate the reaction by facilitating the required electron transfer4, as well as the formation a...


    pub_type: 杂志文章


    authors: Nong HN,Falling LJ,Bergmann A,Klingenhof M,Tran HP,Spöri C,Mom R,Timoshenko J,Zichittella G,Knop-Gericke A,Piccinin S,Pérez-Ramírez J,Cuenya BR,Schlögl R,Strasser P,Teschner D,Jones TE

    更新日期:2020-11-01 00:00:00

  • Sparse whole-genome sequencing identifies two loci for major depressive disorder.

    abstract::Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverag...


    pub_type: 杂志文章


    authors: CONVERGE consortium.

    更新日期:2015-07-30 00:00:00

  • Support for a synaptic chain model of neuronal sequence generation.

    abstract::In songbirds, the remarkable temporal precision of song is generated by a sparse sequence of bursts in the premotor nucleus HVC. To distinguish between two possible classes of models of neural sequence generation, we carried out intracellular recordings of HVC neurons in singing zebra finches (Taeniopygia guttata). We...


    pub_type: 杂志文章


    authors: Long MA,Jin DZ,Fee MS

    更新日期:2010-11-18 00:00:00

  • CD95 promotes tumour growth.

    abstract::CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant, raising the possibility that loss of CD95 is part of ...


    pub_type: 杂志文章


    authors: Chen L,Park SM,Tumanov AV,Hau A,Sawada K,Feig C,Turner JR,Fu YX,Romero IL,Lengyel E,Peter ME

    更新日期:2010-05-27 00:00:00

  • Bcl-2 promotes regeneration of severed axons in mammalian CNS.

    abstract::Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development. At least part of this loss in regenerative potential is intrinsic to neurons. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, mos...


    pub_type: 杂志文章


    authors: Chen DF,Schneider GE,Martinou JC,Tonegawa S

    更新日期:1997-01-30 00:00:00

  • Animal behaviour: fair refusal by capuchin monkeys.

    abstract::Brosnan and de Waal report that capuchin monkeys show evidence of a sense of fairness or 'inequity aversion' because they rejected a less preferred reward when they saw a partner monkey receive a preferred reward for the same task. However, this does not show that monkeys are averse to inequity, only that they reject ...


    pub_type: 评论,杂志文章


    authors: Wynne CD

    更新日期:2004-03-11 00:00:00

  • Chromothripsis from DNA damage in micronuclei.

    abstract::Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromot...


    pub_type: 杂志文章


    authors: Zhang CZ,Spektor A,Cornils H,Francis JM,Jackson EK,Liu S,Meyerson M,Pellman D

    更新日期:2015-06-11 00:00:00

  • Intronic microRNA precursors that bypass Drosha processing.

    abstract::MicroRNAs (miRNAs) are approximately 22-nucleotide endogenous RNAs that often repress the expression of complementary messenger RNAs. In animals, miRNAs derive from characteristic hairpins in primary transcripts through two sequential RNase III-mediated cleavages; Drosha cleaves near the base of the stem to liberate a...


    pub_type: 杂志文章


    authors: Ruby JG,Jan CH,Bartel DP

    更新日期:2007-07-05 00:00:00

  • Decoding the development of the human hippocampus.

    abstract::The hippocampus is an important part of the limbic system in the human brain that has essential roles in spatial navigation and the consolidation of information from short-term memory to long-term memory1,2. Here we use single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-se...


    pub_type: 杂志文章


    authors: Zhong S,Ding W,Sun L,Lu Y,Dong H,Fan X,Liu Z,Chen R,Zhang S,Ma Q,Tang F,Wu Q,Wang X

    更新日期:2020-01-01 00:00:00

  • Androgenetic haploid embryonic stem cells produce live transgenic mice.

    abstract::Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing ha...


    pub_type: 杂志文章


    authors: Li W,Shuai L,Wan H,Dong M,Wang M,Sang L,Feng C,Luo GZ,Li T,Li X,Wang L,Zheng QY,Sheng C,Wu HJ,Liu Z,Liu L,Wang L,Wang XJ,Zhao XY,Zhou Q

    更新日期:2012-10-18 00:00:00

  • Changes in the tooth enamel of early Paleocene mammals allowing increased diet diversity.

    abstract::Hunter-Schreger bands (HSB) are seen in teeth that are composed of crossed sets of enamel prisms. They are present in the teeth of man and many other mammals, but absent in most insectivores and multituberculates. It has been suggested that the presence of HSB makes the tooth enamel less likely to split and is associa...


    pub_type: 杂志文章


    authors: von Koenigswald W,Rensberger JM,Pretzschner HU

    更新日期:1987-07-09 00:00:00

  • Subtractive and divisive adaptation in the human visual system.

    abstract::Sensory systems can adapt to the conditions imposed on them. In the visual system, adapting to a pattern increases the threshold of the ability to see that pattern, and reduces the perceived contrast of the pattern above threshold. Most neurons of the striate cortex reduce their responsiveness after being stimulated f...


    pub_type: 杂志文章


    authors: Snowden RJ,Hammett ST

    更新日期:1992-01-16 00:00:00

  • Energy spectra of quantum rings.

    abstract::Quantum mechanical experiments in ring geometries have long fascinated physicists. Open rings connected to leads, for example, allow the observation of the Aharonov-Bohm effect, one of the best examples of quantum mechanical phase coherence. The phase coherence of electrons travelling through a quantum dot embedded in...


    pub_type: 杂志文章


    authors: Fuhrer A,Lüscher S,Ihn T,Heinzel T,Ensslin K,Wegscheider W,Bichler M

    更新日期:2001-10-25 00:00:00

  • Peripheral modulation of mechano-sensitivity in primary afferent neurons.

    abstract::Considerable attention has centered recently on the changes in neuron excitability and synaptic efficacy caused by certain biogenic amines and neuropeptides. These neuromodulators act at a wide variety of both central and peripheral targets, and bring about diverse biological results. In sensory pathways, modulation o...


    pub_type: 杂志文章


    authors: Pasztor VM,Bush BM

    更新日期:1987-04-23 00:00:00

  • Role of spectral detail in sound-source localization.

    abstract::Sounds heard over headphones are typically perceived inside the head (internalized), unlike real sound sources which are perceived outside the head (externalized). If the acoustical waveforms from a real sound source are reproduced precisely using headphones, auditory images are appropriately externalized and localize...


    pub_type: 杂志文章


    authors: Kulkarni A,Colburn HS

    更新日期:1998-12-24 00:00:00

  • Rapid gating and anion permeability of an intracellular aquaporin.

    abstract::Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...


    pub_type: 杂志文章


    authors: Yasui M,Hazama A,Kwon TH,Nielsen S,Guggino WB,Agre P

    更新日期:1999-11-11 00:00:00

  • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6.

    abstract::Wild-type p53 protein has many properties consistent with its being the product of a tumour suppressor gene. Although the normal roles of tumour suppressor genes are still largely unknown, it seems that they could be involved in promoting cell differentiation as well as in mediating growth arrest by growth-inhibitory ...


    pub_type: 杂志文章


    authors: Yonish-Rouach E,Resnitzky D,Lotem J,Sachs L,Kimchi A,Oren M

    更新日期:1991-07-25 00:00:00

  • Faulting induced by precipitation of water at grain boundaries in hot subducting oceanic crust.

    abstract::Dehydration embrittlement has been proposed to explain both intermediate- and deep-focus earthquakes in subduction zones. Because such earthquakes primarily occur at shallow depths or within the core of the subducting plate, dehydration at relatively low temperatures has been emphasized. However, recent careful reloca...


    pub_type: 杂志文章


    authors: Zhang J,Green HW,Bozhilov K,Jin Z

    更新日期:2004-04-08 00:00:00

  • A stomatin-domain protein essential for touch sensation in the mouse.

    abstract::Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified th...


    pub_type: 杂志文章


    authors: Wetzel C,Hu J,Riethmacher D,Benckendorff A,Harder L,Eilers A,Moshourab R,Kozlenkov A,Labuz D,Caspani O,Erdmann B,Machelska H,Heppenstall PA,Lewin GR

    更新日期:2007-01-11 00:00:00

  • Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice.

    abstract::Tuberculosis is the leading cause of death in the world resulting from a single bacterial infection. Despite its enormous burden on world health, little is known about the molecular mechanisms of pathogenesis of Mycobacterium tuberculosis. Bacterial multiplication and concomitant tissue damage within an infected host,...


    pub_type: 杂志文章


    authors: Cox JS,Chen B,McNeil M,Jacobs WR Jr

    更新日期:1999-11-04 00:00:00

  • Closing yield gaps through nutrient and water management.

    abstract::In the coming decades, a crucial challenge for humanity will be meeting future food demands without undermining further the integrity of the Earth's environmental systems. Agricultural systems are already major forces of global environmental degradation, but population growth and increasing consumption of calorie- and...


    pub_type: 杂志文章


    authors: Mueller ND,Gerber JS,Johnston M,Ray DK,Ramankutty N,Foley JA

    更新日期:2012-10-11 00:00:00