Structure of the human 80S ribosome.

abstract：:In contrast to activated CD4+ T cells, resting human CD4+ T cells circulating in blood are highly resistant to infection with human immunodeficiency virus (HIV). Whether the inability of HIV to infect these resting CD4+ T cells is due to the lack of a key factor, or alternatively reflects the presence of an efficient ...

journal_title：Nature

authors： Chiu YL,Soros VB,Kreisberg JF,Stopak K,Yonemoto W,Greene WC

更新日期：2005-05-05 00:00:00

abstract：:The evolution of animal personalities is a topic of primary importance in behavioural ecology. An intriguing empirical fact is the consistency of animal responses to repeated stresses or threats. Wolf et al. propose an evolutionary model to explain the emergence of consistent personalities. They show that a population...

journal_title：Nature

authors： Massol F,Crochet PA

更新日期：2008-02-28 00:00:00

abstract：:Many marine invertebrates and fish respond to hydrostatic pressure in order to regulate their depth and synchronize their behaviour to tidal cycles. Here we investigate the effect of hydrostatic pressure on the vestibular hair cells located in the labyrinth of the dogfish Scyliorhinus canicula, and find that it modula...

journal_title：Nature

authors： Fraser PJ,Shelmerdine RL

更新日期：2002-01-31 00:00:00

abstract：:Some Pacific island societies, such as those of Easter Island and Mangareva, inadvertently contributed to their own collapse by causing massive deforestation. Others retained forest cover and survived. How can those fateful differences be explained? Although the answers undoubtedly involve both different cultural resp...

journal_title：Nature

authors： Rolett B,Diamond J

更新日期：2004-09-23 00:00:00

abstract：:The Earth's equatorial stratosphere shows oscillations in which the east-west winds reverse direction and the temperatures change cyclically with a period of about two years. This phenomenon, called the quasi-biennial oscillation, also affects the dynamics of the mid- and high-latitude stratosphere and weather in the ...

journal_title：Nature

authors： Flasar FM,Kunde VG,Achterberg RK,Conrath BJ,Simon-Miller AA,Nixon CA,Gierasch PJ,Romani PN,Bézard B,Irwin P,Bjoraker GL,Brasunas JC,Jennings DE,Pearl JC,Smith MD,Orton GS,Spilker LJ,Carlson R,Calcutt SB,Read PL,Ta

更新日期：2004-01-08 00:00:00

abstract：:Growing concern about how loss of biodiversity will affect ecosystems has stimulated numerous studies. Although most studies have assumed that species go extinct randomly, species often go extinct in order of their sensitivity to a stress that intensifies through time (such as climate change). Here we show that the co...

journal_title：Nature

authors： Ives AR,Cardinale BJ

更新日期：2004-05-13 00:00:00

abstract：:The major excitatory amino acids, glutamate (Glu) and aspartate (Asp), are thought to act at three receptor subtypes in the mammalian central nervous system (CNS). These are termed quisqualate (QA), N-methyl-D-aspartate (NMDA) and kainate (KA) receptors according to the specific agonist properties of these compounds r...

journal_title：Nature

authors： Sladeczek F,Pin JP,Récasens M,Bockaert J,Weiss S

更新日期：1985-10-24 00:00:00

abstract：:Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...

journal_title：Nature

authors： Yu W,Gius D,Onyango P,Muldoon-Jacobs K,Karp J,Feinberg AP,Cui H

更新日期：2008-01-10 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) are ancient asexually reproducing organisms that form symbioses with the majority of plant species, improving plant nutrition and promoting plant diversity. Little is known about the evolution or organization of the genomes of any eukaryotic symbiont or ancient asexual organism. Dire...

journal_title：Nature

authors： Hijri M,Sanders IR

更新日期：2005-01-13 00:00:00

abstract：:DNA sequences containing the 5'-flanking regions of the insulin and chymotrypsin genes were linked to the coding sequence of the chloramphenicol acetyltransferase (CAT) gene. The insulin gene recombinant elicits preferential expression of CAT activity when introduced into cells producing insulin; similarly, the chymot...

journal_title：Nature

authors： Walker MD,Edlund T,Boulet AM,Rutter WJ

更新日期：1983-12-08 00:00:00

abstract：:The efficiency of generating electricity from heat using concentrated solar power plants (which use mirrors or lenses to concentrate sunlight in order to drive heat engines, usually involving turbines) may be appreciably increased by operating with higher turbine inlet temperatures, but this would require improved hea...

journal_title：Nature

authors： Caccia M,Tabandeh-Khorshid M,Itskos G,Strayer AR,Caldwell AS,Pidaparti S,Singnisai S,Rohskopf AD,Schroeder AM,Jarrahbashi D,Kang T,Sahoo S,Kadasala NR,Marquez-Rossy A,Anderson MH,Lara-Curzio E,Ranjan D,Henry A,Sandhag

更新日期：2018-10-01 00:00:00

abstract：:Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans and mice. The rapid development of a safe and effective ZIKV vaccine is a global ...

journal_title：Nature

authors： Larocca RA,Abbink P,Peron JP,Zanotto PM,Iampietro MJ,Badamchi-Zadeh A,Boyd M,Ng'ang'a D,Kirilova M,Nityanandam R,Mercado NB,Li Z,Moseley ET,Bricault CA,Borducchi EN,Giglio PB,Jetton D,Neubauer G,Nkolola JP,Maxfield

更新日期：2016-08-25 00:00:00

abstract：:The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chambe...

journal_title：Nature

authors： Lam YA,Lawson TG,Velayutham M,Zweier JL,Pickart CM

更新日期：2002-04-18 00:00:00

abstract：:The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic s...

journal_title：Nature

authors： Hochedlinger K,Jaenisch R

更新日期：2006-06-29 00:00:00

abstract：:MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants c...

journal_title：Nature

authors： Sassoon D,Lyons G,Wright WE,Lin V,Lassar A,Weintraub H,Buckingham M

更新日期：1989-09-28 00:00:00

abstract：:Oligomerization of membrane proteins in response to lipid binding has a critical role in many cell-signalling pathways but is often difficult to define or predict. Here we report the development of a mass spectrometry platform to determine simultaneously the presence of interfacial lipids and oligomeric stability and ...

journal_title：Nature

authors： Gupta K,Donlan JAC,Hopper JTS,Uzdavinys P,Landreh M,Struwe WB,Drew D,Baldwin AJ,Stansfeld PJ,Robinson CV

更新日期：2017-01-19 00:00:00

abstract：:Tectal polarity for retinal connections remains reversible long after the anatomical pattern of neural structures has been determined. Cells in the diencephalon seem to control this polarity. Following certain embryonic operations, the diencephalon developed behind the tectum. In such cases, the polarity of the retino...

journal_title：Nature

authors： Chung SH,Cooke J

更新日期：1975-11-13 00:00:00

abstract：:Transport vesicles derived from the Golgi apparatus are thought to mediate biosynthetic transport across the Golgi stack. These vesicles are surrounded by a protein coat whose principal constituents are coatomer (a complex of seven distinct subunits or COPs) and ADP-ribosylation factor (ARF, an N-myristylated small GT...

journal_title：Nature

authors： Orcl L,Palmer DJ,Amherdt M,Rothman JE

更新日期：1993-08-19 00:00:00

abstract：:Ultraluminous X-ray sources are extragalactic objects located outside the nucleus of the host galaxy with bolometric luminosities exceeding 10(39) erg s(-1). These extreme luminosities-if the emission is isotropic and below the theoretical (Eddington) limit, where the radiation pressure is balanced by the gravitationa...

journal_title：Nature

authors： Farrell SA,Webb NA,Barret D,Godet O,Rodrigues JM

更新日期：2009-07-02 00:00:00

abstract：:The proto-oncogene c-jun is the cellular homologue of v-jun, the transforming oncogene of the avian sarcoma virus 17 (ref. 1). c-jun encodes one major component of the AP-1 transcription factor complex and is expressed in many organs during mouse development and in the adult. Because of its rapid induction in cells fo...

journal_title：Nature

authors： Hilberg F,Aguzzi A,Howells N,Wagner EF

更新日期：1993-09-09 00:00:00

abstract：:Interleukin-2 (IL-2) is a regulatory peptide important for the growth and differentiation of antigen-specific T lymphocytes and large granular lymphocytes. Interaction of IL-2 with its specific receptor results in the promotion of S-phase progression as well as, in certain circumstances, the production and release of ...

journal_title：Nature

authors： Farrar WL,Anderson WB

更新日期：1985-05-16 00:00:00

abstract：:Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...

journal_title：Nature

authors： de Brito OM,Scorrano L

更新日期：2008-12-04 00:00:00

abstract：:The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene. A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromos...

journal_title：Nature

authors： Bodmer M,Ashburner M

更新日期：1984-05-31 00:00:00

abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...

journal_title：Nature

authors： Carter P,Wells JA

更新日期：1988-04-07 00:00:00

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00

abstract：:The brain has generally been considered an insulin-independent organ, because insulin does not apparently exert a direct effect on brain glucose consumption. Recently, however, insulin receptors have been detected throughout the central nervous system (CNS) of several species. Since important insights into the functio...

journal_title：Nature

authors： van Houten M,Posner BI

更新日期：1979-12-06 00:00:00

abstract：:A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The ge...

journal_title：Nature

authors： Kuro-o M,Matsumura Y,Aizawa H,Kawaguchi H,Suga T,Utsugi T,Ohyama Y,Kurabayashi M,Kaname T,Kume E,Iwasaki H,Iida A,Shiraki-Iida T,Nishikawa S,Nagai R,Nabeshima YI

更新日期：1997-11-06 00:00:00

abstract：:The separation of cells into populations that do not intermix, termed compartments, is a fundamental organizing principle during development. Dorsal-ventral compartmentalization of the Drosophila wing is regulated downstream of the apterous (ap) gene, which encodes a transcription factor that specifies dorsal wing fat...

journal_title：Nature

authors： Rauskolb C,Correia T,Irvine KD

更新日期：1999-09-30 00:00:00

abstract：:Population-level analyses often use average quantities to describe heterogeneous systems, particularly when variation does not arise from identifiable groups. A prominent example, central to our current understanding of epidemic spread, is the basic reproductive number, R(0), which is defined as the mean number of inf...

journal_title：Nature

authors： Lloyd-Smith JO,Schreiber SJ,Kopp PE,Getz WM

更新日期：2005-11-17 00:00:00

abstract：:CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant, raising the possibility that loss of CD95 is part of ...

journal_title：Nature

authors： Chen L,Park SM,Tumanov AV,Hau A,Sawada K,Feig C,Turner JR,Fu YX,Romero IL,Lengyel E,Peter ME

更新日期：2010-05-27 00:00:00